FGFR4 (Fibroblast growth factor receptor 4)

Group: TYR
Uniprot: FGFR4_HUMAN
Domain boundary: 467 - 745


Total number of chains: 47
Spatial Dihedral Chains Representative
DFGin BLAminus 1 AF-P22455-K1A
DFGin BLAplus 35 7YC3A
DFGin BLBplus 1 5NWZA
DFGin None 4 4TYEA
DFGout BBAminus 4 4UXQA
DFGout None 1 4QRCA
None None 1 5NUDB
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
AF-P22455-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 459 - 753 None None 0
4QQJA 1.682 Inactive DFGin BLAplus in-in out-out No_ligand No_ligand 454 - 752 C477A,V550L,R664E None 0
4QQTA 1.501 Inactive DFGin BLAplus in-in out-out No_ligand No_ligand 454 - 750 C477A,R664E None 0
4TYGA 2.4 Inactive DFGin BLAplus in-in out-out No_ligand No_ligand 447 - 751 None None 0
7WCXA 2.175 Inactive DFGin BLAplus in-in out-out 90F Type1 453 - 752 C477A,R664E None 0
7YBXA 2.233 Inactive DFGin BLAplus in-in out-out IH7 Type1 453 - 752 V550M,R664E None 0
7WCWA 2.317 Inactive DFGin BLAplus in-in out-out 90F Type1 453 - 752 C477A,R664E None 0
7YBPA 2.243 Inactive DFGin BLAplus in-in out-out IH7 Type1 453 - 752 V550L,R664E None 0
6JPJA 2.638 Inactive DFGin BLAplus in-in out-out FGF Type1 454 - 752 C477A,R664E None 0
7VJLA 2.9 Inactive DFGin BLAplus in-in none-none 7IF Type1 454 - 753 None None 19
7VJLB 2.9 Inactive DFGin BLAplus in-in none-none 7IF Type1 453 - 753 None None 19
6YI8A 2.13 Inactive DFGin BLAplus in-in none-out FGF Type1 453 - 753 None None 15
6YI8B 2.13 Inactive DFGin BLAplus in-in none-out FGF Type1 451 - 752 None None 18
5NUDA 2.5 Inactive DFGin BLAplus in-none none-out 99K Type1 453 - 753 None None 17
4TYIA 3.4 Inactive DFGin BLAplus in-out out-out 38O Type1 447 - 750 None None 14
7WCTA 2.106 Inactive DFGin BLAplus in-in out-out 90F Type1 453 - 752 R664E None 0
7YBOA 2.307 Inactive DFGin BLAplus in-in out-out IH7 Type1 453 - 752 R664E None 0
7YC1A 2.535 Inactive DFGin BLAplus in-in out-out IIQ Type1 453 - 752 R664E None 0
7YC3A 1.987 Inactive DFGin BLAplus in-in out-out IIW Type1 453 - 752 R664E None 0
6IUOA 2.3 Inactive DFGin BLAplus in-in none-out AWX Type1 445 - 750 R664E None 17
6IUPA 2.0 Inactive DFGin BLAplus in-in out-out AX0 Type1 452 - 750 R664E None 0
4XCUA 1.71 Inactive DFGin BLAplus in-in out-out 40M Type1.5_Back 453 - 751 L449M None 0
6NVGA 1.99 Inactive DFGin BLAplus in-in none-none XL8 Type1.5_Back 453 - 751 None None 18
6NVHA 1.9 Inactive DFGin BLAplus in-in out-out XL6 Type1.5_Back 453 - 750 None None 15
6NVIA 2.117 Inactive DFGin BLAplus in-in out-out XL7 Type1.5_Back 453 - 750 None None 13
6NVJA 2.3 Inactive DFGin BLAplus in-in none-none XL5 Type1.5_Back 453 - 751 None None 18
6NVKA 2.3 Inactive DFGin BLAplus in-in none-none XL9 Type1.5_Back 453 - 750 None None 18
6V9CA 1.9 Inactive DFGin BLAplus in-in none-out QS7 Type1.5_Back 453 - 751 None None 6
7DTZA 2.01 Inactive DFGin BLAplus in-in out-out HHL Type1.5_Back 453 - 751 C477A,R664E None 0
6JPEA 1.601 Inactive DFGin BLAplus in-in out-out BYU Type1.5_Back 452 - 751 C477A,R664E None 0
5NWZB 2.37 Inactive DFGin BLAplus in-in none-out 9CT Type1.5_Back 454 - 752 None None 17
7F3MA 2.289 Inactive DFGin BLAplus in-in out-out GX3 Type1.5_Back 453 - 753 R664E None 0
7V29A 1.983 Inactive DFGin BLAplus in-in out-out 5JR Type1.5_Back 454 - 750 R664E None 0
7V29B 1.983 Inactive DFGin BLAplus in-in out-out 5JR Type1.5_Back 454 - 750 R664E None 0
8XLQA 1.95 Inactive DFGin BLAplus in-in none-out A1LVQ Type1.5_Back 453 - 751 R664E None 3
4QQCA 2.4 Inactive DFGin BLAplus in-in none-out 37O Type1.5_Back 445 - 750 R664E None 17
5NWZA 2.37 Inactive DFGin BLBplus in-out none-in 9CT Type1.5_Back 454 - 752 None None 18
4TYEA 2.8 Inactive DFGin None in-in out-out No_ligand No_ligand 451 - 753 None None 7
5XFJA 3.25 Inactive DFGin None in-out none-out 6LF Type1 453 - 750 V550M None 17
5XFFA 2.7 Inactive DFGin None in-in none-out 6LF Type1 453 - 750 V550L None 17
5JKGA 2.352 Inactive DFGin None in-in none-out 6LF Type1 453 - 750 None None 17
4QQ5A 2.203 Inactive DFGout BBAminus in-in none-out 37O Type1.5_Back 445 - 750 V550L,R664E None 16
4R6VA 2.353 Inactive DFGout BBAminus in-in none-none FI3 Type1.5_Back 445 - 750 V550L,R664E None 17
4UXQA 1.85 Inactive DFGout BBAminus in-in out-out 0LI Type2 452 - 750 C477A None 0
4TYJA 2.45 Inactive DFGout BBAminus in-in out-out 0LI Type2 447 - 753 None None 15
4QRCA 1.901 Inactive DFGout None in-in out-out 0LI Type2 454 - 750 C477A,R664E None 0
5NUDB 2.5 Inactive None None in-in none-out 99K Type1 449 - 750 None None 18

FGFR4 (Fibroblast growth factor receptor 4)

Group: TYR
Total number of chains: 47
Spatial Dihedral Chains Representative
DFGin BLAminus 1 AF-P22455-K1A
DFGin BLAplus 35 7YC3A
DFGin BLBplus 1 5NWZA
DFGin None 4 4TYEA
DFGout BBAminus 4 4UXQA
DFGout None 1 4QRCA
None None 1 5NUDB
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens FGFR4_HUMAN AF-P22455-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 459 - 753 None None 0
Homo sapiens FGFR4_HUMAN 4QQJA 1.682 Inactive DFGin BLAplus in-in out-out No_ligand No_ligand 454 - 752 C477A,V550L,R664E None 0
Homo sapiens FGFR4_HUMAN 4QQTA 1.501 Inactive DFGin BLAplus in-in out-out No_ligand No_ligand 454 - 750 C477A,R664E None 0
Homo sapiens FGFR4_HUMAN 4TYGA 2.4 Inactive DFGin BLAplus in-in out-out No_ligand No_ligand 447 - 751 None None 0
Homo sapiens FGFR4_HUMAN 7WCXA 2.175 Inactive DFGin BLAplus in-in out-out 90F Type1 453 - 752 C477A,R664E None 0
Homo sapiens FGFR4_HUMAN 7YBXA 2.233 Inactive DFGin BLAplus in-in out-out IH7 Type1 453 - 752 V550M,R664E None 0
Homo sapiens FGFR4_HUMAN 7WCWA 2.317 Inactive DFGin BLAplus in-in out-out 90F Type1 453 - 752 C477A,R664E None 0
Homo sapiens FGFR4_HUMAN 7YBPA 2.243 Inactive DFGin BLAplus in-in out-out IH7 Type1 453 - 752 V550L,R664E None 0
Homo sapiens FGFR4_HUMAN 6JPJA 2.638 Inactive DFGin BLAplus in-in out-out FGF Type1 454 - 752 C477A,R664E None 0
Homo sapiens FGFR4_HUMAN 7VJLA 2.9 Inactive DFGin BLAplus in-in none-none 7IF Type1 454 - 753 None None 19
Homo sapiens FGFR4_HUMAN 7VJLB 2.9 Inactive DFGin BLAplus in-in none-none 7IF Type1 453 - 753 None None 19
Homo sapiens FGFR4_HUMAN 6YI8A 2.13 Inactive DFGin BLAplus in-in none-out FGF Type1 453 - 753 None None 15
Homo sapiens FGFR4_HUMAN 6YI8B 2.13 Inactive DFGin BLAplus in-in none-out FGF Type1 451 - 752 None None 18
Homo sapiens FGFR4_HUMAN 5NUDA 2.5 Inactive DFGin BLAplus in-none none-out 99K Type1 453 - 753 None None 17
Homo sapiens FGFR4_HUMAN 4TYIA 3.4 Inactive DFGin BLAplus in-out out-out 38O Type1 447 - 750 None None 14
Homo sapiens FGFR4_HUMAN 7WCTA 2.106 Inactive DFGin BLAplus in-in out-out 90F Type1 453 - 752 R664E None 0
Homo sapiens FGFR4_HUMAN 7YBOA 2.307 Inactive DFGin BLAplus in-in out-out IH7 Type1 453 - 752 R664E None 0
Homo sapiens FGFR4_HUMAN 7YC1A 2.535 Inactive DFGin BLAplus in-in out-out IIQ Type1 453 - 752 R664E None 0
Homo sapiens FGFR4_HUMAN 7YC3A 1.987 Inactive DFGin BLAplus in-in out-out IIW Type1 453 - 752 R664E None 0
Homo sapiens FGFR4_HUMAN 6IUOA 2.3 Inactive DFGin BLAplus in-in none-out AWX Type1 445 - 750 R664E None 17
Homo sapiens FGFR4_HUMAN 6IUPA 2.0 Inactive DFGin BLAplus in-in out-out AX0 Type1 452 - 750 R664E None 0
Homo sapiens FGFR4_HUMAN 4XCUA 1.71 Inactive DFGin BLAplus in-in out-out 40M Type1.5_Back 453 - 751 L449M None 0
Homo sapiens FGFR4_HUMAN 6NVGA 1.99 Inactive DFGin BLAplus in-in none-none XL8 Type1.5_Back 453 - 751 None None 18
Homo sapiens FGFR4_HUMAN 6NVHA 1.9 Inactive DFGin BLAplus in-in out-out XL6 Type1.5_Back 453 - 750 None None 15
Homo sapiens FGFR4_HUMAN 6NVIA 2.117 Inactive DFGin BLAplus in-in out-out XL7 Type1.5_Back 453 - 750 None None 13
Homo sapiens FGFR4_HUMAN 6NVJA 2.3 Inactive DFGin BLAplus in-in none-none XL5 Type1.5_Back 453 - 751 None None 18
Homo sapiens FGFR4_HUMAN 6NVKA 2.3 Inactive DFGin BLAplus in-in none-none XL9 Type1.5_Back 453 - 750 None None 18
Homo sapiens FGFR4_HUMAN 6V9CA 1.9 Inactive DFGin BLAplus in-in none-out QS7 Type1.5_Back 453 - 751 None None 6
Homo sapiens FGFR4_HUMAN 7DTZA 2.01 Inactive DFGin BLAplus in-in out-out HHL Type1.5_Back 453 - 751 C477A,R664E None 0
Homo sapiens FGFR4_HUMAN 6JPEA 1.601 Inactive DFGin BLAplus in-in out-out BYU Type1.5_Back 452 - 751 C477A,R664E None 0
Homo sapiens FGFR4_HUMAN 5NWZB 2.37 Inactive DFGin BLAplus in-in none-out 9CT Type1.5_Back 454 - 752 None None 17
Homo sapiens FGFR4_HUMAN 7F3MA 2.289 Inactive DFGin BLAplus in-in out-out GX3 Type1.5_Back 453 - 753 R664E None 0
Homo sapiens FGFR4_HUMAN 7V29A 1.983 Inactive DFGin BLAplus in-in out-out 5JR Type1.5_Back 454 - 750 R664E None 0
Homo sapiens FGFR4_HUMAN 7V29B 1.983 Inactive DFGin BLAplus in-in out-out 5JR Type1.5_Back 454 - 750 R664E None 0
Homo sapiens FGFR4_HUMAN 8XLQA 1.95 Inactive DFGin BLAplus in-in none-out A1LVQ Type1.5_Back 453 - 751 R664E None 3
Homo sapiens FGFR4_HUMAN 4QQCA 2.4 Inactive DFGin BLAplus in-in none-out 37O Type1.5_Back 445 - 750 R664E None 17
Homo sapiens FGFR4_HUMAN 5NWZA 2.37 Inactive DFGin BLBplus in-out none-in 9CT Type1.5_Back 454 - 752 None None 18
Homo sapiens FGFR4_HUMAN 4TYEA 2.8 Inactive DFGin None in-in out-out No_ligand No_ligand 451 - 753 None None 7
Homo sapiens FGFR4_HUMAN 5XFJA 3.25 Inactive DFGin None in-out none-out 6LF Type1 453 - 750 V550M None 17
Homo sapiens FGFR4_HUMAN 5XFFA 2.7 Inactive DFGin None in-in none-out 6LF Type1 453 - 750 V550L None 17
Homo sapiens FGFR4_HUMAN 5JKGA 2.352 Inactive DFGin None in-in none-out 6LF Type1 453 - 750 None None 17
Homo sapiens FGFR4_HUMAN 4QQ5A 2.203 Inactive DFGout BBAminus in-in none-out 37O Type1.5_Back 445 - 750 V550L,R664E None 16
Homo sapiens FGFR4_HUMAN 4R6VA 2.353 Inactive DFGout BBAminus in-in none-none FI3 Type1.5_Back 445 - 750 V550L,R664E None 17
Homo sapiens FGFR4_HUMAN 4UXQA 1.85 Inactive DFGout BBAminus in-in out-out 0LI Type2 452 - 750 C477A None 0
Homo sapiens FGFR4_HUMAN 4TYJA 2.45 Inactive DFGout BBAminus in-in out-out 0LI Type2 447 - 753 None None 15
Homo sapiens FGFR4_HUMAN 4QRCA 1.901 Inactive DFGout None in-in out-out 0LI Type2 454 - 750 C477A,R664E None 0
Homo sapiens FGFR4_HUMAN 5NUDB 2.5 Inactive None None in-in none-out 99K Type1 449 - 750 None None 18

FGFR4 (Fibroblast growth factor receptor 4)

No non-human structures known.