ERBB2 (Receptor tyrosine-protein kinase erbB-2)

Group: TYR
Uniprot: ERBB2_HUMAN
Domain boundary: 720 - 978


Total number of chains: 16
Spatial Dihedral Chains Representative
DFGin BLAminus 3 AF-P04626-K1A
DFGin BLBminus 2 7PCDA
DFGin BLBplus 1 7JXHE
DFGin None 10 3PP0A
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
AF-P04626-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 712 - 986 None None 0
3RCDB 3.21 None DFGin BLAminus out-out none-out No_ligand No_ligand 713 - 1010 None None 18
3RCDD 3.21 None DFGin BLAminus out-out none-out No_ligand No_ligand 713 - 1010 None None 18
7PCDA 1.77 Inactive DFGin BLBminus out-out out-in 70I Type1.5_Back 710 - 991 None None 10
7JXHA 3.27 Inactive DFGin BLBminus out-out out-out VOY Type1.5_Back 706 - 992 None None 15
7JXHE 3.27 Inactive DFGin BLBplus out-out out-none VOY Type1.5_Back 709 - 992 None None 16
7JXHB 3.27 Inactive DFGin None out-out none-in VOY Type1.5_Back 707 - 996 None None 14
7JXHC 3.27 Inactive DFGin None out-out in-in VOY Type1.5_Back 707 - 992 None None 12
7JXHD 3.27 Inactive DFGin None out-out in-in VOY Type1.5_Back 707 - 992 None None 3
7JXHF 3.27 Inactive DFGin None out-out out-in VOY Type1.5_Back 713 - 991 None None 12
7JXHG 3.27 Inactive DFGin None out-out in-in VOY Type1.5_Back 706 - 992 None None 14
7JXHH 3.27 Inactive DFGin None out-out in-in VOY Type1.5_Back 707 - 992 None None 0
3PP0A 2.25 Inactive DFGin None out-out in-in 03Q Type1.5_Back 706 - 993 M706A,Q711L,M712L None 2
3PP0B 2.25 Inactive DFGin None out-out in-in 03Q Type1.5_Back 706 - 1009 M706A,Q711L,M712L None 2
3RCDA 3.21 Inactive DFGin None out-out none-out 03P Type1.5_Back 713 - 1022 None None 17
3RCDC 3.21 Inactive DFGin None out-out none-out 03P Type1.5_Back 713 - 1022 None None 17

ERBB2 (Receptor tyrosine-protein kinase erbB-2)

Group: TYR
Total number of chains: 16
Spatial Dihedral Chains Representative
DFGin BLAminus 3 AF-P04626-K1A
DFGin BLBminus 2 7PCDA
DFGin BLBplus 1 7JXHE
DFGin None 10 3PP0A
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens ERBB2_HUMAN AF-P04626-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 712 - 986 None None 0
Homo sapiens ERBB2_HUMAN 3RCDB 3.21 None DFGin BLAminus out-out none-out No_ligand No_ligand 713 - 1010 None None 18
Homo sapiens ERBB2_HUMAN 3RCDD 3.21 None DFGin BLAminus out-out none-out No_ligand No_ligand 713 - 1010 None None 18
Homo sapiens ERBB2_HUMAN 7PCDA 1.77 Inactive DFGin BLBminus out-out out-in 70I Type1.5_Back 710 - 991 None None 10
Homo sapiens ERBB2_HUMAN 7JXHA 3.27 Inactive DFGin BLBminus out-out out-out VOY Type1.5_Back 706 - 992 None None 15
Homo sapiens ERBB2_HUMAN 7JXHE 3.27 Inactive DFGin BLBplus out-out out-none VOY Type1.5_Back 709 - 992 None None 16
Homo sapiens ERBB2_HUMAN 7JXHB 3.27 Inactive DFGin None out-out none-in VOY Type1.5_Back 707 - 996 None None 14
Homo sapiens ERBB2_HUMAN 7JXHC 3.27 Inactive DFGin None out-out in-in VOY Type1.5_Back 707 - 992 None None 12
Homo sapiens ERBB2_HUMAN 7JXHD 3.27 Inactive DFGin None out-out in-in VOY Type1.5_Back 707 - 992 None None 3
Homo sapiens ERBB2_HUMAN 7JXHF 3.27 Inactive DFGin None out-out out-in VOY Type1.5_Back 713 - 991 None None 12
Homo sapiens ERBB2_HUMAN 7JXHG 3.27 Inactive DFGin None out-out in-in VOY Type1.5_Back 706 - 992 None None 14
Homo sapiens ERBB2_HUMAN 7JXHH 3.27 Inactive DFGin None out-out in-in VOY Type1.5_Back 707 - 992 None None 0
Homo sapiens ERBB2_HUMAN 3PP0A 2.25 Inactive DFGin None out-out in-in 03Q Type1.5_Back 706 - 993 M706A,Q711L,M712L None 2
Homo sapiens ERBB2_HUMAN 3PP0B 2.25 Inactive DFGin None out-out in-in 03Q Type1.5_Back 706 - 1009 M706A,Q711L,M712L None 2
Homo sapiens ERBB2_HUMAN 3RCDA 3.21 Inactive DFGin None out-out none-out 03P Type1.5_Back 713 - 1022 None None 17
Homo sapiens ERBB2_HUMAN 3RCDC 3.21 Inactive DFGin None out-out none-out 03P Type1.5_Back 713 - 1022 None None 17

ERBB2 (Receptor tyrosine-protein kinase erbB-2)

No non-human structures known.