CHUK (Inhibitor of nuclear factor kappa-B kinase subunit alpha)

Group: OTHER
Uniprot: IKKA_HUMAN
Domain boundary: 15 - 309


Total number of chains: 19
Spatial Dihedral Chains Representative
DFGin BLAminus 13 AF-O15111-K1A
None None 6 5TQYA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
AF-O15111-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 7 - 317 None None 0
5EBZA 4.5 Inactive DFGin BLAminus in-out in-out 5TL Type1 10 - 660 S176E,S180E None 0
5EBZB 4.5 Inactive DFGin BLAminus in-out in-out 5TL Type1 10 - 660 S176E,S180E None 0
5EBZC 4.5 Inactive DFGin BLAminus in-out in-out 5TL Type1 10 - 660 S176E,S180E None 0
5EBZD 4.5 Inactive DFGin BLAminus in-out in-out 5TL Type1 10 - 660 S176E,S180E None 0
5EBZE 4.5 Inactive DFGin BLAminus in-out in-out 5TL Type1 10 - 660 S176E,S180E None 0
5EBZF 4.5 Inactive DFGin BLAminus in-out in-out 5TL Type1 10 - 660 S176E,S180E None 0
5EBZG 4.5 Inactive DFGin BLAminus in-out in-out 5TL Type1 10 - 660 S176E,S180E None 0
5EBZH 4.5 Inactive DFGin BLAminus in-out in-out 5TL Type1 10 - 660 S176E,S180E None 0
5EBZI 4.5 Inactive DFGin BLAminus in-out in-out 5TL Type1 10 - 660 S176E,S180E None 0
5EBZJ 4.5 Inactive DFGin BLAminus in-out in-out 5TL Type1 10 - 660 S176E,S180E None 0
5EBZK 4.5 Inactive DFGin BLAminus in-out in-out 5TL Type1 10 - 660 S176E,S180E None 0
5EBZL 4.5 Inactive DFGin BLAminus in-out in-out 5TL Type1 10 - 660 S176E,S180E None 0
5TQWA 5.6 Inactive None None in-in none-none No_ligand No_ligand 14 - 660 S176E,S180E None 20
5TQWB 5.6 Inactive None None in-in none-none No_ligand No_ligand 14 - 660 S176E,S180E None 20
5TQXA 5.4 Inactive None None in-out none-none No_ligand No_ligand 14 - 660 S176E,S180E None 19
5TQXB 5.4 Inactive None None in-out none-none No_ligand No_ligand 14 - 660 S176E,S180E None 19
5TQYA 5.2 Inactive None None in-out none-none No_ligand No_ligand 14 - 660 S176E,S180E None 19
5TQYB 5.2 Inactive None None in-out none-none No_ligand No_ligand 14 - 660 S176E,S180E None 19

CHUK (Inhibitor of nuclear factor kappa-B kinase subunit alpha)

Group: OTHER
Total number of chains: 19
Spatial Dihedral Chains Representative
DFGin BLAminus 13 AF-O15111-K1A
None None 6 5TQYA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens IKKA_HUMAN AF-O15111-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 7 - 317 None None 0
Homo sapiens IKKA_HUMAN 5EBZA 4.5 Inactive DFGin BLAminus in-out in-out 5TL Type1 10 - 660 S176E,S180E None 0
Homo sapiens IKKA_HUMAN 5EBZB 4.5 Inactive DFGin BLAminus in-out in-out 5TL Type1 10 - 660 S176E,S180E None 0
Homo sapiens IKKA_HUMAN 5EBZC 4.5 Inactive DFGin BLAminus in-out in-out 5TL Type1 10 - 660 S176E,S180E None 0
Homo sapiens IKKA_HUMAN 5EBZD 4.5 Inactive DFGin BLAminus in-out in-out 5TL Type1 10 - 660 S176E,S180E None 0
Homo sapiens IKKA_HUMAN 5EBZE 4.5 Inactive DFGin BLAminus in-out in-out 5TL Type1 10 - 660 S176E,S180E None 0
Homo sapiens IKKA_HUMAN 5EBZF 4.5 Inactive DFGin BLAminus in-out in-out 5TL Type1 10 - 660 S176E,S180E None 0
Homo sapiens IKKA_HUMAN 5EBZG 4.5 Inactive DFGin BLAminus in-out in-out 5TL Type1 10 - 660 S176E,S180E None 0
Homo sapiens IKKA_HUMAN 5EBZH 4.5 Inactive DFGin BLAminus in-out in-out 5TL Type1 10 - 660 S176E,S180E None 0
Homo sapiens IKKA_HUMAN 5EBZI 4.5 Inactive DFGin BLAminus in-out in-out 5TL Type1 10 - 660 S176E,S180E None 0
Homo sapiens IKKA_HUMAN 5EBZJ 4.5 Inactive DFGin BLAminus in-out in-out 5TL Type1 10 - 660 S176E,S180E None 0
Homo sapiens IKKA_HUMAN 5EBZK 4.5 Inactive DFGin BLAminus in-out in-out 5TL Type1 10 - 660 S176E,S180E None 0
Homo sapiens IKKA_HUMAN 5EBZL 4.5 Inactive DFGin BLAminus in-out in-out 5TL Type1 10 - 660 S176E,S180E None 0
Homo sapiens IKKA_HUMAN 5TQWA 5.6 Inactive None None in-in none-none No_ligand No_ligand 14 - 660 S176E,S180E None 20
Homo sapiens IKKA_HUMAN 5TQWB 5.6 Inactive None None in-in none-none No_ligand No_ligand 14 - 660 S176E,S180E None 20
Homo sapiens IKKA_HUMAN 5TQXA 5.4 Inactive None None in-out none-none No_ligand No_ligand 14 - 660 S176E,S180E None 19
Homo sapiens IKKA_HUMAN 5TQXB 5.4 Inactive None None in-out none-none No_ligand No_ligand 14 - 660 S176E,S180E None 19
Homo sapiens IKKA_HUMAN 5TQYA 5.2 Inactive None None in-out none-none No_ligand No_ligand 14 - 660 S176E,S180E None 19
Homo sapiens IKKA_HUMAN 5TQYB 5.2 Inactive None None in-out none-none No_ligand No_ligand 14 - 660 S176E,S180E None 19

CHUK (Inhibitor of nuclear factor kappa-B kinase subunit alpha)

No non-human structures known.