CDK6 (Cyclin-dependent kinase 6)

Group: CMGC
Uniprot: CDK6_HUMAN
Domain boundary: 13 - 300


Total number of chains: 22
Spatial Dihedral Chains Representative
DFGin BLAminus 6 AF-Q00534-K1A
DFGin BLBplus 11 1BLXA
DFGout BBAminus 2 1G3NA
None None 3 1BI7A
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
AF-Q00534-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 5 - 308 None None 0
1JOWB 3.1 Active DFGin BLAminus in-in in-in No_ligand No_ligand 10 - 300 None None 0
1XO2B 2.9 Active DFGin BLAminus in-in in-in FSE Type1 11 - 305 None None 0
2EUFB 3.0 Active DFGin BLAminus in-in in-in LQQ Type1 10 - 305 None None 0
2F2CB 2.8 Active DFGin BLAminus in-in in-in AP9 Type1 9 - 305 None None 0
4TTHB 2.9 Active DFGin BLAminus in-in in-in 24V Type1 15 - 304 None None 0
1BLXA 1.9 Inactive DFGin BLBplus out-out out-out No_ligand No_ligand 5 - 309 None None 0
6OQLA 2.707 Inactive DFGin BLBplus out-out none-out N1A Type1 11 - 301 None None 13
6OQOA 1.977 Inactive DFGin BLBplus out-out none-out N1J Type1 11 - 301 None None 13
8I0MA 2.777 Inactive DFGin BLBplus out-none none-out NJ6 Type1 11 - 301 None None 13
3NUPA 2.6 Inactive DFGin BLBplus out-out none-out 3NU Type1 12 - 300 None None 14
3NUXA 2.7 Inactive DFGin BLBplus out-out none-out 3NV Type1 10 - 301 None None 13
4AUAA 2.31 Inactive DFGin BLBplus out-out none-none 4AU Type1 11 - 301 None None 14
4EZ5A 2.7 Inactive DFGin BLBplus out-out none-out 0RS Type1 11 - 301 None None 13
5L2IA 2.75 Inactive DFGin BLBplus out-out none-out LQQ Type1 10 - 301 None None 14
5L2SA 2.27 Inactive DFGin BLBplus out-out none-out 6ZV Type1 11 - 301 None None 13
5L2TA 2.37 Inactive DFGin BLBplus out-out none-out 6ZZ Type1 11 - 301 None None 13
1G3NA 2.9 Inactive DFGout BBAminus out-out out-out No_ligand No_ligand 9 - 301 None None 0
1G3NE 2.9 Inactive DFGout BBAminus out-out out-out No_ligand No_ligand 9 - 301 None None 0
1BI7A 3.4 Inactive None None none-none out-out No_ligand No_ligand 10 - 301 None None 0
1BI8A 2.8 Inactive None None none-none out-out No_ligand No_ligand 11 - 301 None None 0
1BI8C 2.8 Inactive None None none-none out-out No_ligand No_ligand 11 - 301 None None 0

CDK6 (Cyclin-dependent kinase 6)

Group: CMGC
Total number of chains: 22
Spatial Dihedral Chains Representative
DFGin BLAminus 6 AF-Q00534-K1A
DFGin BLBplus 11 1BLXA
DFGout BBAminus 2 1G3NA
None None 3 1BI7A
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens CDK6_HUMAN AF-Q00534-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 5 - 308 None None 0
Homo sapiens CDK6_HUMAN 1JOWB 3.1 Active DFGin BLAminus in-in in-in No_ligand No_ligand 10 - 300 None None 0
Homo sapiens CDK6_HUMAN 1XO2B 2.9 Active DFGin BLAminus in-in in-in FSE Type1 11 - 305 None None 0
Homo sapiens CDK6_HUMAN 2EUFB 3.0 Active DFGin BLAminus in-in in-in LQQ Type1 10 - 305 None None 0
Homo sapiens CDK6_HUMAN 2F2CB 2.8 Active DFGin BLAminus in-in in-in AP9 Type1 9 - 305 None None 0
Homo sapiens CDK6_HUMAN 4TTHB 2.9 Active DFGin BLAminus in-in in-in 24V Type1 15 - 304 None None 0
Homo sapiens CDK6_HUMAN 1BLXA 1.9 Inactive DFGin BLBplus out-out out-out No_ligand No_ligand 5 - 309 None None 0
Homo sapiens CDK6_HUMAN 6OQLA 2.707 Inactive DFGin BLBplus out-out none-out N1A Type1 11 - 301 None None 13
Homo sapiens CDK6_HUMAN 6OQOA 1.977 Inactive DFGin BLBplus out-out none-out N1J Type1 11 - 301 None None 13
Homo sapiens CDK6_HUMAN 8I0MA 2.777 Inactive DFGin BLBplus out-none none-out NJ6 Type1 11 - 301 None None 13
Homo sapiens CDK6_HUMAN 3NUPA 2.6 Inactive DFGin BLBplus out-out none-out 3NU Type1 12 - 300 None None 14
Homo sapiens CDK6_HUMAN 3NUXA 2.7 Inactive DFGin BLBplus out-out none-out 3NV Type1 10 - 301 None None 13
Homo sapiens CDK6_HUMAN 4AUAA 2.31 Inactive DFGin BLBplus out-out none-none 4AU Type1 11 - 301 None None 14
Homo sapiens CDK6_HUMAN 4EZ5A 2.7 Inactive DFGin BLBplus out-out none-out 0RS Type1 11 - 301 None None 13
Homo sapiens CDK6_HUMAN 5L2IA 2.75 Inactive DFGin BLBplus out-out none-out LQQ Type1 10 - 301 None None 14
Homo sapiens CDK6_HUMAN 5L2SA 2.27 Inactive DFGin BLBplus out-out none-out 6ZV Type1 11 - 301 None None 13
Homo sapiens CDK6_HUMAN 5L2TA 2.37 Inactive DFGin BLBplus out-out none-out 6ZZ Type1 11 - 301 None None 13
Homo sapiens CDK6_HUMAN 1G3NA 2.9 Inactive DFGout BBAminus out-out out-out No_ligand No_ligand 9 - 301 None None 0
Homo sapiens CDK6_HUMAN 1G3NE 2.9 Inactive DFGout BBAminus out-out out-out No_ligand No_ligand 9 - 301 None None 0
Homo sapiens CDK6_HUMAN 1BI7A 3.4 Inactive None None none-none out-out No_ligand No_ligand 10 - 301 None None 0
Homo sapiens CDK6_HUMAN 1BI8A 2.8 Inactive None None none-none out-out No_ligand No_ligand 11 - 301 None None 0
Homo sapiens CDK6_HUMAN 1BI8C 2.8 Inactive None None none-none out-out No_ligand No_ligand 11 - 301 None None 0

CDK6 (Cyclin-dependent kinase 6)

No non-human structures known.