CDK5 (Cyclin-dependent kinase 5)

Group: CMGC
Uniprot: CDK5_HUMAN
Domain boundary: 4 - 286


Total number of chains: 21
Spatial Dihedral Chains Representative
DFGin BLAminus 21 AF-Q00535-K1A
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
1H4LA 2.65 Active DFGin BLAminus in-in in-in No_ligand No_ligand 2 - 287 None None 0
1H4LB 2.65 Active DFGin BLAminus in-in in-in No_ligand No_ligand 2 - 287 None None 0
AF-Q00535-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 1 - 292 None None 0
7VDSB 3.05 Active DFGin BLAminus in-in in-in No_ligand No_ligand 3 - 288 None None 0
1UNLB 2.2 Active DFGin BLAminus in-in in-in No_ligand No_ligand 1 - 292 D144N None 0
3O0GA 1.95 Active DFGin BLAminus in-in in-in No_ligand No_ligand 1 - 289 D144N None 0
7VDPA 2.09 Inactive DFGin BLAminus in-out in-in 65L Type1 2 - 291 None None 0
7VDPB 2.09 Inactive DFGin BLAminus in-out in-in 65L Type1 3 - 288 None None 0
7VDQA 2.91 Active DFGin BLAminus in-in in-in 64V Type1 2 - 291 None None 0
7VDQB 2.91 Active DFGin BLAminus in-in in-in 64V Type1 3 - 288 None None 0
7VDRA 2.55 Active DFGin BLAminus in-in in-in 63I Type1 2 - 291 None None 0
7VDRB 2.55 Active DFGin BLAminus in-in in-in 63I Type1 3 - 288 None None 0
7VDSA 3.05 Active DFGin BLAminus in-in in-in 61U Type1 2 - 291 None None 0
4AU8A 1.9 Active DFGin BLAminus in-in in-in Z3R Type1 2 - 289 None None 2
4AU8B 1.9 Active DFGin BLAminus in-in in-in Z3R Type1 2 - 289 None None 6
1UNGA 2.3 Active DFGin BLAminus in-in in-in ALH Type1 1 - 292 D144N None 0
1UNGB 2.3 Active DFGin BLAminus in-in in-in ALH Type1 2 - 288 D144N None 0
1UNHA 2.35 Active DFGin BLAminus in-in in-in IXM Type1 2 - 288 D144N None 0
1UNHB 2.35 Active DFGin BLAminus in-in in-in IXM Type1 2 - 288 D144N None 0
1UNLA 2.2 Active DFGin BLAminus in-in in-in RRC Type1 1 - 292 D144N None 0
3O0GB 1.95 Active DFGin BLAminus in-in in-in 3O0 Type1 6 - 288 D144N None 0

CDK5 (Cyclin-dependent kinase 5)

Group: CMGC
Total number of chains: 21
Spatial Dihedral Chains Representative
DFGin BLAminus 21 AF-Q00535-K1A
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens CDK5_HUMAN 1H4LA 2.65 Active DFGin BLAminus in-in in-in No_ligand No_ligand 2 - 287 None None 0
Homo sapiens CDK5_HUMAN 1H4LB 2.65 Active DFGin BLAminus in-in in-in No_ligand No_ligand 2 - 287 None None 0
Homo sapiens CDK5_HUMAN AF-Q00535-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 1 - 292 None None 0
Homo sapiens CDK5_HUMAN 7VDSB 3.05 Active DFGin BLAminus in-in in-in No_ligand No_ligand 3 - 288 None None 0
Homo sapiens CDK5_HUMAN 1UNLB 2.2 Active DFGin BLAminus in-in in-in No_ligand No_ligand 1 - 292 D144N None 0
Homo sapiens CDK5_HUMAN 3O0GA 1.95 Active DFGin BLAminus in-in in-in No_ligand No_ligand 1 - 289 D144N None 0
Homo sapiens CDK5_HUMAN 7VDPA 2.09 Inactive DFGin BLAminus in-out in-in 65L Type1 2 - 291 None None 0
Homo sapiens CDK5_HUMAN 7VDPB 2.09 Inactive DFGin BLAminus in-out in-in 65L Type1 3 - 288 None None 0
Homo sapiens CDK5_HUMAN 7VDQA 2.91 Active DFGin BLAminus in-in in-in 64V Type1 2 - 291 None None 0
Homo sapiens CDK5_HUMAN 7VDQB 2.91 Active DFGin BLAminus in-in in-in 64V Type1 3 - 288 None None 0
Homo sapiens CDK5_HUMAN 7VDRA 2.55 Active DFGin BLAminus in-in in-in 63I Type1 2 - 291 None None 0
Homo sapiens CDK5_HUMAN 7VDRB 2.55 Active DFGin BLAminus in-in in-in 63I Type1 3 - 288 None None 0
Homo sapiens CDK5_HUMAN 7VDSA 3.05 Active DFGin BLAminus in-in in-in 61U Type1 2 - 291 None None 0
Homo sapiens CDK5_HUMAN 4AU8A 1.9 Active DFGin BLAminus in-in in-in Z3R Type1 2 - 289 None None 2
Homo sapiens CDK5_HUMAN 4AU8B 1.9 Active DFGin BLAminus in-in in-in Z3R Type1 2 - 289 None None 6
Homo sapiens CDK5_HUMAN 1UNGA 2.3 Active DFGin BLAminus in-in in-in ALH Type1 1 - 292 D144N None 0
Homo sapiens CDK5_HUMAN 1UNGB 2.3 Active DFGin BLAminus in-in in-in ALH Type1 2 - 288 D144N None 0
Homo sapiens CDK5_HUMAN 1UNHA 2.35 Active DFGin BLAminus in-in in-in IXM Type1 2 - 288 D144N None 0
Homo sapiens CDK5_HUMAN 1UNHB 2.35 Active DFGin BLAminus in-in in-in IXM Type1 2 - 288 D144N None 0
Homo sapiens CDK5_HUMAN 1UNLA 2.2 Active DFGin BLAminus in-in in-in RRC Type1 1 - 292 D144N None 0
Homo sapiens CDK5_HUMAN 3O0GB 1.95 Active DFGin BLAminus in-in in-in 3O0 Type1 6 - 288 D144N None 0

CDK5 (Cyclin-dependent kinase 5)

No non-human structures known.