PDB: 9FMR — CMGC CDK12_HUMAN

Total number of chains: 3
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 2 66.7% 9FMRE
DFGin None 1 33.3% 9FMRB
All chains - renumbered by
Uniprot PDB Alignment

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Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CDK12 CDK12_HUMAN 9FMRE Q9NYV4 714 1042 1490.0 RMF:61101 Type1 Inactive DFGin 6.793 14.64 ABAminus -113.83, -79.52 -84.15, 118.47 -115.27, 16.16 293.54, 100.02 -64.02, -34.33 in-out in 9.633 Saltbr-out 3.612 HRD-out -79.17, 82.22 -59.96, 8.89 out-in-out SNCoio in-out ActLoopNT-in 3.026 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -148.14, -27.51 APE9-dihe-na -104.44, 148.12 APE8-dihe-in -51.45, 137.55 APE8-rot-in 306.02 APE67-dihe-in -70.5, -21.3 -54.61, -36.19 APE12-dist-out 14.298 APE11-dist-in 12.211 APE10-dist-in 7.469 APE9-dist-in 3.767 None TPO893 TPO893 XRAY 3.9 0.209 0.25 E 351 329 0 0 0 0 [[727, 1020]] 1.0 9fmr CMGC_CDK12_HUMAN CMGC 2.9e-84 288.8 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 9FMRH Q9NYV4 714 1044 1490.0 RMF:61101 Type1 Inactive DFGin 6.801 14.603 ABAminus -113.95, -78.4 -84.85, 124.02 -118.87, 17.95 291.29, 89.7 -63.88, -35.4 in-in in 8.592 Saltbr-in 3.552 HRD-in -72.47, -40.65 59.82, 5.57 in-in-in SNCiii in-in ActLoopNT-in 2.944 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -147.74, -27.71 APE9-dihe-na -103.25, 148.34 APE8-dihe-in -51.07, 136.63 APE8-rot-in 306.14 APE67-dihe-in -69.99, -21.15 -54.39, -34.8 APE12-dist-in 13.823 APE11-dist-in 12.098 APE10-dist-in 7.255 APE9-dist-in 3.608 None TPO893 TPO893 XRAY 3.9 0.209 0.25 H 351 331 0 0 0 0 [[727, 1020]] 1.0 9fmr CMGC_CDK12_HUMAN CMGC 2.9e-84 288.8 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 9FMRB Q9NYV4 714 1047 1490.0 RMF:61101 Type1 Inactive DFGin 7.124 15.031 None -111.49, -74.26 -77.99, -72.15 68.85, 12.84 296.16, 89.8 -66.22, -36.51 in-out in 8.332 Saltbr-out 4.45 HRD-in -70.8, -35.56 62.81, 1.22 out-in-in SNCoii in-in ActLoopNT-in 3.072 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.03, -25.75 APE9-dihe-na -103.56, 146.88 APE8-dihe-in -51.72, 138.27 APE8-rot-in 305.58 APE67-dihe-in -69.51, -21.36 -53.61, -35.19 APE12-dist-in 13.987 APE11-dist-in 12.27 APE10-dist-in 7.331 APE9-dist-in 3.865 None TPO893 TPO893 XRAY 3.9 0.209 0.25 B 351 334 0 0 0 0 [[727, 1020]] 1.0 9fmr CMGC_CDK12_HUMAN CMGC 2.9e-84 288.8 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12

PDB: 9FMR — CMGC CDK12_HUMAN

Total number of chains: 3
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 2 66.7% 9FMRE
DFGin None 1 33.3% 9FMRB
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CDK12 CDK12_HUMAN 9FMRE Q9NYV4 714 1042 1490.0 RMF:61101 Type1 Inactive DFGin 6.793 14.64 ABAminus -113.83, -79.52 -84.15, 118.47 -115.27, 16.16 293.54, 100.02 -64.02, -34.33 in-out in 9.633 Saltbr-out 3.612 HRD-out -79.17, 82.22 -59.96, 8.89 out-in-out SNCoio in-out ActLoopNT-in 3.026 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -148.14, -27.51 APE9-dihe-na -104.44, 148.12 APE8-dihe-in -51.45, 137.55 APE8-rot-in 306.02 APE67-dihe-in -70.5, -21.3 -54.61, -36.19 APE12-dist-out 14.298 APE11-dist-in 12.211 APE10-dist-in 7.469 APE9-dist-in 3.767 None TPO893 TPO893 XRAY 3.9 0.209 0.25 E 351 329 0 0 0 0 [[727, 1020]] 1.0 9fmr Homo sapiens CMGC_CDK12_HUMAN CMGC 2.9e-84 288.8 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 9FMRH Q9NYV4 714 1044 1490.0 RMF:61101 Type1 Inactive DFGin 6.801 14.603 ABAminus -113.95, -78.4 -84.85, 124.02 -118.87, 17.95 291.29, 89.7 -63.88, -35.4 in-in in 8.592 Saltbr-in 3.552 HRD-in -72.47, -40.65 59.82, 5.57 in-in-in SNCiii in-in ActLoopNT-in 2.944 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -147.74, -27.71 APE9-dihe-na -103.25, 148.34 APE8-dihe-in -51.07, 136.63 APE8-rot-in 306.14 APE67-dihe-in -69.99, -21.15 -54.39, -34.8 APE12-dist-in 13.823 APE11-dist-in 12.098 APE10-dist-in 7.255 APE9-dist-in 3.608 None TPO893 TPO893 XRAY 3.9 0.209 0.25 H 351 331 0 0 0 0 [[727, 1020]] 1.0 9fmr Homo sapiens CMGC_CDK12_HUMAN CMGC 2.9e-84 288.8 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 9FMRB Q9NYV4 714 1047 1490.0 RMF:61101 Type1 Inactive DFGin 7.124 15.031 None -111.49, -74.26 -77.99, -72.15 68.85, 12.84 296.16, 89.8 -66.22, -36.51 in-out in 8.332 Saltbr-out 4.45 HRD-in -70.8, -35.56 62.81, 1.22 out-in-in SNCoii in-in ActLoopNT-in 3.072 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.03, -25.75 APE9-dihe-na -103.56, 146.88 APE8-dihe-in -51.72, 138.27 APE8-rot-in 305.58 APE67-dihe-in -69.51, -21.36 -53.61, -35.19 APE12-dist-in 13.987 APE11-dist-in 12.27 APE10-dist-in 7.331 APE9-dist-in 3.865 None TPO893 TPO893 XRAY 3.9 0.209 0.25 B 351 334 0 0 0 0 [[727, 1020]] 1.0 9fmr Homo sapiens CMGC_CDK12_HUMAN CMGC 2.9e-84 288.8 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12

PDB: 9FMR — CMGC CDK12_HUMAN

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name