PDB: 9AXX — 2 kinases

Total number of chains: 4
Active chains: 0
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 50.0% 9AXXD
DFGin BLBplus 2 50.0% 9AXXA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
STE MAP2K1 MP2K1_HUMAN 9AXXA Q02750 41 382 393.0 A1AHE:60401,ANP:60402 Type1,ATPlike Inactive DFGin 6.1565 14.4729 BLBplus -142.21, 167.57 61.94, 40.19 -92.82, 170.58 38.95, 89.02 -82.21, 74.48 out-out out 15.9248 Saltbr-out 15.6608 HRD-in -77.34, -56.94 85.02, -11.71 out-out-out SNCooo out-out ActLoopNT-out 9.6225 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -70.01, 140.02 APE9-dihe-na -107.63, 178.58 APE8-dihe-out -103.64, -13.88 APE8-rot-out 56.98 APE67-dihe-out -152.18, 145.48 -132.34, 175.09 APE12-dist-out 18.633 APE11-dist-out 16.0857 APE10-dist-out 21.091 APE9-dist-out 12.7711 S218A,S222A None None XRAY 2.07 0.215 0.248 A 310.0 298.0 0 26 26 0 [[68, 361]] 1.0 9axx STE_MAP2K1_HUMAN STE 6.5e-98 333.1 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9AXXC Q02750 37 378 393.0 A1AHE:60401,ANP:60402 Type1,ATPlike Inactive DFGin 6.0661 14.2508 BLBplus -153.34, 165.37 62.85, 41.08 -93.54, 164.6 44.67, 86.41 -75.31, 71.49 out-out out 15.5167 Saltbr-out 15.0221 HRD-in -80.68, -38.87 53.15, 7.3 out-out-out SNCooo out-out ActLoopNT-out 9.6912 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -68.91, 127.09 APE9-dihe-na -100.27, 169.31 APE8-dihe-out -98.12, -23.61 APE8-rot-out 61.42 APE67-dihe-out -153.77, 146.66 -125.41, 178.29 APE12-dist-out 18.4501 APE11-dist-out 16.1193 APE10-dist-out 21.5812 APE9-dist-out 12.7488 S218A,S222A None None XRAY 2.07 0.215 0.248 C 310.0 297.0 1 26 26 0 [[68, 361]] 1.0 9axx STE_MAP2K1_HUMAN STE 6.5e-98 333.1 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
TKL BRAF BRAF_HUMAN 9AXXB P15056 449 721 766.0 ANP:60801 ATPlike Inactive DFGin 6.2724 14.156 BLAminus -118.96, -160.68 44.13, 79.21 -91.3, 29.71 285.28, 70.2 -64.85, -24.03 in-out in 8.9679 Saltbr-out 6.0423 HRD-in -74.42, -44.59 66.93, 5.21 out-in-in SNCoii in-in ActLoopNT-in 2.911 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.1, 120.32 APE9-dihe-na 137.74, -165.97 APE8-dihe-in -102.01, 122.38 APE8-rot-in 304.65 APE67-dihe-in -63.13, -30.61 -66.04, -26.1 APE12-dist-in 13.0987 APE11-dist-in 12.6277 APE10-dist-in 7.4721 APE9-dist-in 5.708 None None None XRAY 2.07 0.215 0.248 B 280.0 261.0 12 30 24 6 [[457, 716]] 1.0 9axx TKL_BRAF_HUMAN TKL 7.8e-82 280.7 4.0 266.0 263.0 593 594 595 597 599 483 501 505 573 575 574 576.0 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 9AXXD P15056 449 720 766.0 No_ligand No_ligand Inactive DFGin 6.3836 14.1977 BLAminus -129.89, -173.73 62.98, 88.51 -109.58, 28.81 291.63, 88.61 -59.73, -40.17 in-in in 8.1758 Saltbr-in 2.7448 HRD-in -72.62, -47.14 70.14, -3.87 in-in-out SNCiio in-out ActLoopNT-in 2.8476 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -147.43, 156.79 APE9-dihe-na -104.74, -133.5 APE8-dihe-in -87.21, 139.54 APE8-rot-in 302.48 APE67-dihe-in -63.49, -37.11 -65.97, -35.07 APE12-dist-in 10.4009 APE11-dist-out 6.0235 APE10-dist-out 9.1006 APE9-dist-in 4.67 None None None XRAY 2.07 0.215 0.248 D 280.0 272.0 0 30 30 0 [[457, 716]] 1.0 9axx TKL_BRAF_HUMAN TKL 7.8e-82 280.7 4.0 266.0 263.0 593 594 595 597 599 483 501 505 573 575 574 576.0 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf

PDB: 9AXX — 2 kinases

Total number of chains: 4
Active chains: 0
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 50.0% 9AXXD
DFGin BLBplus 2 50.0% 9AXXA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
STE MAP2K1 MP2K1_HUMAN 9AXXA Q02750 41 382 393.0 A1AHE:60401,ANP:60402 Type1,ATPlike Inactive DFGin 6.1565 14.4729 BLBplus -142.21, 167.57 61.94, 40.19 -92.82, 170.58 38.95, 89.02 -82.21, 74.48 out-out out 15.9248 Saltbr-out 15.6608 HRD-in -77.34, -56.94 85.02, -11.71 out-out-out SNCooo out-out ActLoopNT-out 9.6225 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -70.01, 140.02 APE9-dihe-na -107.63, 178.58 APE8-dihe-out -103.64, -13.88 APE8-rot-out 56.98 APE67-dihe-out -152.18, 145.48 -132.34, 175.09 APE12-dist-out 18.633 APE11-dist-out 16.0857 APE10-dist-out 21.091 APE9-dist-out 12.7711 S218A,S222A None None XRAY 2.07 0.215 0.248 A 310.0 298.0 0 26 26 0 [[68, 361]] 1.0 9axx Homo sapiens STE_MAP2K1_HUMAN STE 6.5e-98 333.1 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9AXXC Q02750 37 378 393.0 A1AHE:60401,ANP:60402 Type1,ATPlike Inactive DFGin 6.0661 14.2508 BLBplus -153.34, 165.37 62.85, 41.08 -93.54, 164.6 44.67, 86.41 -75.31, 71.49 out-out out 15.5167 Saltbr-out 15.0221 HRD-in -80.68, -38.87 53.15, 7.3 out-out-out SNCooo out-out ActLoopNT-out 9.6912 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -68.91, 127.09 APE9-dihe-na -100.27, 169.31 APE8-dihe-out -98.12, -23.61 APE8-rot-out 61.42 APE67-dihe-out -153.77, 146.66 -125.41, 178.29 APE12-dist-out 18.4501 APE11-dist-out 16.1193 APE10-dist-out 21.5812 APE9-dist-out 12.7488 S218A,S222A None None XRAY 2.07 0.215 0.248 C 310.0 297.0 1 26 26 0 [[68, 361]] 1.0 9axx Homo sapiens STE_MAP2K1_HUMAN STE 6.5e-98 333.1 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
TKL BRAF BRAF_HUMAN 9AXXB P15056 449 721 766.0 ANP:60801 ATPlike Inactive DFGin 6.2724 14.156 BLAminus -118.96, -160.68 44.13, 79.21 -91.3, 29.71 285.28, 70.2 -64.85, -24.03 in-out in 8.9679 Saltbr-out 6.0423 HRD-in -74.42, -44.59 66.93, 5.21 out-in-in SNCoii in-in ActLoopNT-in 2.911 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.1, 120.32 APE9-dihe-na 137.74, -165.97 APE8-dihe-in -102.01, 122.38 APE8-rot-in 304.65 APE67-dihe-in -63.13, -30.61 -66.04, -26.1 APE12-dist-in 13.0987 APE11-dist-in 12.6277 APE10-dist-in 7.4721 APE9-dist-in 5.708 None None None XRAY 2.07 0.215 0.248 B 280.0 261.0 12 30 24 6 [[457, 716]] 1.0 9axx Homo sapiens TKL_BRAF_HUMAN TKL 7.8e-82 280.7 4.0 266.0 263.0 593 594 595 597 599 483 501 505 573 575 574 576.0 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 9AXXD P15056 449 720 766.0 No_ligand No_ligand Inactive DFGin 6.3836 14.1977 BLAminus -129.89, -173.73 62.98, 88.51 -109.58, 28.81 291.63, 88.61 -59.73, -40.17 in-in in 8.1758 Saltbr-in 2.7448 HRD-in -72.62, -47.14 70.14, -3.87 in-in-out SNCiio in-out ActLoopNT-in 2.8476 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -147.43, 156.79 APE9-dihe-na -104.74, -133.5 APE8-dihe-in -87.21, 139.54 APE8-rot-in 302.48 APE67-dihe-in -63.49, -37.11 -65.97, -35.07 APE12-dist-in 10.4009 APE11-dist-out 6.0235 APE10-dist-out 9.1006 APE9-dist-in 4.67 None None None XRAY 2.07 0.215 0.248 D 280.0 272.0 0 30 30 0 [[457, 716]] 1.0 9axx Homo sapiens TKL_BRAF_HUMAN TKL 7.8e-82 280.7 4.0 266.0 263.0 593 594 595 597 599 483 501 505 573 575 574 576.0 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf

PDB: 9AXX — 2 kinases

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name