PDB: 9AXC — 2 kinases

Total number of chains: 4
Active chains: 0
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 50.0% 9AXCC
DFGin BLBplus 2 50.0% 9AXCD
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
STE MAP2K1 MP2K1_HUMAN 9AXCB Q02750 52 380 393.0 A1AHE:401 Type3 Inactive DFGin 5.9787 13.8572 BLBplus -156.34, 159.86 58.05, 51.28 -90.68, 168.57 45.43, 79.18 -80.79, 77.37 out-out out 15.5246 Saltbr-out 16.4826 HRD-in -82.47, -42.11 70.94, -10.4 out-out-out SNCooo out-out ActLoopNT-out 9.4447 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -71.13, -44.57 APE9-dihe-na 100.23, 100.79 APE8-dihe-out -96.55, -49.37 APE8-rot-out 61.77 APE67-dihe-out -125.36, 134.49 -112.13, 139.3 APE12-dist-out 16.7317 APE11-dist-out 18.0625 APE10-dist-out 22.9269 APE9-dist-out 12.6232 S218A,S222A None None EM 4.16 999.0 999.0 B 394.0 278.0 51 26 26 0 [[68, 361]] 1.0 9axc STE_MAP2K1_HUMAN STE 1.1e-96 329.3 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9AXCD Q02750 59 383 393.0 A1AHE:401 Type3 Inactive DFGin 5.9443 14.9428 BLBplus -155.71, -173.77 60.85, 40.35 -100.84, 165.38 63.0, 90.55 -83.19, 80.54 out-out out 17.464 Saltbr-out 19.8823 HRD-in -94.68, -47.55 72.62, -11.59 out-out-out SNCooo out-out ActLoopNT-out 9.3746 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oooo APE10-dihe-na 51.94, -88.31 APE9-dihe-na 51.11, 70.23 APE8-dihe-out -66.0, -35.69 APE8-rot-in 292.49 APE67-dihe-out -158.48, 126.03 -105.47, -179.54 APE12-dist-out 18.7745 APE11-dist-out 17.0622 APE10-dist-out 21.141 APE9-dist-out 12.4403 S218A,S222A None None EM 4.16 999.0 999.0 D 394.0 275.0 50 26 26 0 [[68, 361]] 1.0 9axc STE_MAP2K1_HUMAN STE 1.1e-96 329.3 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
TKL RAF1 RAF1_HUMAN 9AXCA P04049 342 614 648.0 No_ligand No_ligand Inactive DFGin 7.1921 14.4156 BLAminus -138.33, -166.81 57.53, 66.49 -89.8, 33.05 291.57, 76.32 -64.02, -29.91 in-out in 9.5136 Saltbr-out 7.6297 HRD-in -72.6, -42.02 72.95, -10.85 out-in-out SNCoio in-out ActLoopNT-in 3.1646 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -134.52, -16.63 APE9-dihe-na -73.85, -175.48 APE8-dihe-in -71.62, 149.24 APE8-rot-in 297.36 APE67-dihe-in -71.32, -46.0 -82.78, -6.02 APE12-dist-in 12.2652 APE11-dist-in 10.7655 APE10-dist-out 9.0117 APE9-dist-out 7.1409 Y340D,Y341D None None EM 4.16 999.0 999.0 A 563.0 262.0 11 30 25 5 [[349, 608]] 1.0 9axc TKL_RAF1_HUMAN TKL 2.2e-80 276.1 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase
TKL RAF1 RAF1_HUMAN 9AXCC P04049 341 614 648.0 No_ligand No_ligand Inactive DFGin 7.0993 14.2941 BLAminus -140.87, -159.63 58.35, 65.16 -89.93, 32.3 288.78, 78.02 -61.68, -35.06 in-out in 8.1468 Saltbr-out 3.9477 HRD-in -77.54, -28.87 66.49, -1.91 out-in-out SNCoio in-out ActLoopNT-in 2.6755 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na 42.59, 31.87 APE9-dihe-na -96.68, -133.02 APE8-dihe-in -109.92, 127.09 APE8-rot-out 177.26 APE67-dihe-in -75.55, -23.65 -73.76, -3.99 APE12-dist-in 11.8637 APE11-dist-in 8.5952 APE10-dist-out 11.1083 APE9-dist-out 8.7613 Y340D,Y341D None None EM 4.16 999.0 999.0 C 563.0 264.0 10 30 30 0 [[349, 608]] 1.0 9axc TKL_RAF1_HUMAN TKL 2.2e-80 276.1 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase

PDB: 9AXC — 2 kinases

Total number of chains: 4
Active chains: 0
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 50.0% 9AXCC
DFGin BLBplus 2 50.0% 9AXCD
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
STE MAP2K1 MP2K1_HUMAN 9AXCB Q02750 52 380 393.0 A1AHE:401 Type3 Inactive DFGin 5.9787 13.8572 BLBplus -156.34, 159.86 58.05, 51.28 -90.68, 168.57 45.43, 79.18 -80.79, 77.37 out-out out 15.5246 Saltbr-out 16.4826 HRD-in -82.47, -42.11 70.94, -10.4 out-out-out SNCooo out-out ActLoopNT-out 9.4447 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -71.13, -44.57 APE9-dihe-na 100.23, 100.79 APE8-dihe-out -96.55, -49.37 APE8-rot-out 61.77 APE67-dihe-out -125.36, 134.49 -112.13, 139.3 APE12-dist-out 16.7317 APE11-dist-out 18.0625 APE10-dist-out 22.9269 APE9-dist-out 12.6232 S218A,S222A None None EM 4.16 999.0 999.0 B 394.0 278.0 51 26 26 0 [[68, 361]] 1.0 9axc Homo sapiens STE_MAP2K1_HUMAN STE 1.1e-96 329.3 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9AXCD Q02750 59 383 393.0 A1AHE:401 Type3 Inactive DFGin 5.9443 14.9428 BLBplus -155.71, -173.77 60.85, 40.35 -100.84, 165.38 63.0, 90.55 -83.19, 80.54 out-out out 17.464 Saltbr-out 19.8823 HRD-in -94.68, -47.55 72.62, -11.59 out-out-out SNCooo out-out ActLoopNT-out 9.3746 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oooo APE10-dihe-na 51.94, -88.31 APE9-dihe-na 51.11, 70.23 APE8-dihe-out -66.0, -35.69 APE8-rot-in 292.49 APE67-dihe-out -158.48, 126.03 -105.47, -179.54 APE12-dist-out 18.7745 APE11-dist-out 17.0622 APE10-dist-out 21.141 APE9-dist-out 12.4403 S218A,S222A None None EM 4.16 999.0 999.0 D 394.0 275.0 50 26 26 0 [[68, 361]] 1.0 9axc Homo sapiens STE_MAP2K1_HUMAN STE 1.1e-96 329.3 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
TKL RAF1 RAF1_HUMAN 9AXCA P04049 342 614 648.0 No_ligand No_ligand Inactive DFGin 7.1921 14.4156 BLAminus -138.33, -166.81 57.53, 66.49 -89.8, 33.05 291.57, 76.32 -64.02, -29.91 in-out in 9.5136 Saltbr-out 7.6297 HRD-in -72.6, -42.02 72.95, -10.85 out-in-out SNCoio in-out ActLoopNT-in 3.1646 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -134.52, -16.63 APE9-dihe-na -73.85, -175.48 APE8-dihe-in -71.62, 149.24 APE8-rot-in 297.36 APE67-dihe-in -71.32, -46.0 -82.78, -6.02 APE12-dist-in 12.2652 APE11-dist-in 10.7655 APE10-dist-out 9.0117 APE9-dist-out 7.1409 Y340D,Y341D None None EM 4.16 999.0 999.0 A 563.0 262.0 11 30 25 5 [[349, 608]] 1.0 9axc Homo sapiens TKL_RAF1_HUMAN TKL 2.2e-80 276.1 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase
TKL RAF1 RAF1_HUMAN 9AXCC P04049 341 614 648.0 No_ligand No_ligand Inactive DFGin 7.0993 14.2941 BLAminus -140.87, -159.63 58.35, 65.16 -89.93, 32.3 288.78, 78.02 -61.68, -35.06 in-out in 8.1468 Saltbr-out 3.9477 HRD-in -77.54, -28.87 66.49, -1.91 out-in-out SNCoio in-out ActLoopNT-in 2.6755 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na 42.59, 31.87 APE9-dihe-na -96.68, -133.02 APE8-dihe-in -109.92, 127.09 APE8-rot-out 177.26 APE67-dihe-in -75.55, -23.65 -73.76, -3.99 APE12-dist-in 11.8637 APE11-dist-in 8.5952 APE10-dist-out 11.1083 APE9-dist-out 8.7613 Y340D,Y341D None None EM 4.16 999.0 999.0 C 563.0 264.0 10 30 30 0 [[349, 608]] 1.0 9axc Homo sapiens TKL_RAF1_HUMAN TKL 2.2e-80 276.1 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase

PDB: 9AXC — 2 kinases

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name