PDB: 8CHF — 2 kinases

Total number of chains: 4
Active chains: 0
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBminus 2 50.0% 8CHFE
DFGin None 2 50.0% 8CHFA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
STE MAP2K1 MP2K1_HUMAN 8CHFE Q02750 62 379 393.0 No_ligand No_ligand Inactive DFGin 8.7484 15.2997 BLBminus -137.77, -175.22 48.59, 66.74 -80.75, 172.08 303.75, 164.33 -88.09, 43.03 out-out out 15.1413 Saltbr-out 14.1559 HRD-in -63.69, -43.07 70.86, -8.01 out-out-out SNCooo out-out ActLoopNT-out 9.061 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -100.97, 134.92 APE9-dihe-na -78.84, 122.16 APE8-dihe-out -62.21, -40.86 APE8-rot-out 69.52 APE67-dihe-out -84.12, 93.44 -141.68, 94.92 APE12-dist-out 16.2177 APE11-dist-out 19.9204 APE10-dist-out 22.4925 APE9-dist-out 12.4155 S218A,S222A None None EM 4.25 0.445 999.0 E 393.0 278.0 40 26 26 0 [[68, 361]] 1.0 8chf STE_MAP2K1_HUMAN STE 1.1e-96 329.3 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 8CHFF Q02750 62 379 393.0 No_ligand No_ligand Inactive DFGin 8.7485 15.2989 BLBminus -137.78, -175.27 48.68, 66.76 -80.77, 172.08 303.82, 164.27 -88.11, 43.03 out-out out 15.1413 Saltbr-out 14.1562 HRD-in -63.7, -43.05 70.8, -7.98 out-out-out SNCooo out-out ActLoopNT-out 9.0612 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -100.94, 134.91 APE9-dihe-na -78.8, 122.14 APE8-dihe-out -62.21, -40.91 APE8-rot-out 69.52 APE67-dihe-out -84.11, 93.44 -141.62, 94.91 APE12-dist-out 16.2176 APE11-dist-out 19.9205 APE10-dist-out 22.4925 APE9-dist-out 12.4151 S218A,S222A None None EM 4.25 0.445 999.0 F 393.0 278.0 40 26 26 0 [[68, 361]] 1.0 8chf STE_MAP2K1_HUMAN STE 1.1e-96 329.3 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
TKL RAF1 RAF1_HUMAN 8CHFA P04049 341 626 648.0 29L:60701 Type1 Inactive DFGin 6.9193 13.7979 None -77.69, -137.87 -62.1, 150.83 -123.34, 43.11 304.09, 90.48 -53.76, -47.63 in-out in 8.5922 Saltbr-out 6.6899 HRD-in -62.51, -43.32 69.96, -9.45 out-in-out SNCoio in-out ActLoopNT-in 2.8262 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na 55.74, 2.9 APE9-dihe-na 55.92, 40.68 APE8-dihe-in -131.33, 94.1 APE8-rot-out 59.25 APE67-dihe-inflip 81.42, -0.92 -97.97, 165.62 APE12-dist-in 7.3494 APE11-dist-in 11.6311 APE10-dist-in 6.9434 APE9-dist-out 10.1571 Y341D SEP621 SEP621 EM 4.25 0.445 999.0 A 648.0 280.0 6 30 24 6 [[349, 608]] 1.0 8chf TKL_RAF1_HUMAN TKL 3e-80 275.8 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase
TKL RAF1 RAF1_HUMAN 8CHFB P04049 341 626 648.0 29L:60701 Type1 Inactive DFGin 6.9191 13.7979 None -77.67, -137.85 -62.16, 150.83 -123.29, 43.03 304.08, 90.5 -53.73, -47.64 in-out in 8.5922 Saltbr-out 6.6905 HRD-in -62.53, -43.31 69.92, -9.4 out-in-out SNCoio in-out ActLoopNT-in 2.8268 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na 55.74, 2.9 APE9-dihe-na 55.89, 40.65 APE8-dihe-in -131.28, 94.15 APE8-rot-out 59.25 APE67-dihe-inflip 81.39, -0.89 -98.01, 165.61 APE12-dist-in 7.3494 APE11-dist-in 11.631 APE10-dist-in 6.9423 APE9-dist-out 10.1569 Y341D SEP621 SEP621 EM 4.25 0.445 999.0 B 648.0 280.0 6 30 24 6 [[349, 608]] 1.0 8chf TKL_RAF1_HUMAN TKL 3e-80 275.8 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase

PDB: 8CHF — 2 kinases

Total number of chains: 4
Active chains: 0
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBminus 2 50.0% 8CHFE
DFGin None 2 50.0% 8CHFA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
STE MAP2K1 MP2K1_HUMAN 8CHFE Q02750 62 379 393.0 No_ligand No_ligand Inactive DFGin 8.7484 15.2997 BLBminus -137.77, -175.22 48.59, 66.74 -80.75, 172.08 303.75, 164.33 -88.09, 43.03 out-out out 15.1413 Saltbr-out 14.1559 HRD-in -63.69, -43.07 70.86, -8.01 out-out-out SNCooo out-out ActLoopNT-out 9.061 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -100.97, 134.92 APE9-dihe-na -78.84, 122.16 APE8-dihe-out -62.21, -40.86 APE8-rot-out 69.52 APE67-dihe-out -84.12, 93.44 -141.68, 94.92 APE12-dist-out 16.2177 APE11-dist-out 19.9204 APE10-dist-out 22.4925 APE9-dist-out 12.4155 S218A,S222A None None EM 4.25 0.445 999.0 E 393.0 278.0 40 26 26 0 [[68, 361]] 1.0 8chf Homo sapiens STE_MAP2K1_HUMAN STE 1.1e-96 329.3 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 8CHFF Q02750 62 379 393.0 No_ligand No_ligand Inactive DFGin 8.7485 15.2989 BLBminus -137.78, -175.27 48.68, 66.76 -80.77, 172.08 303.82, 164.27 -88.11, 43.03 out-out out 15.1413 Saltbr-out 14.1562 HRD-in -63.7, -43.05 70.8, -7.98 out-out-out SNCooo out-out ActLoopNT-out 9.0612 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -100.94, 134.91 APE9-dihe-na -78.8, 122.14 APE8-dihe-out -62.21, -40.91 APE8-rot-out 69.52 APE67-dihe-out -84.11, 93.44 -141.62, 94.91 APE12-dist-out 16.2176 APE11-dist-out 19.9205 APE10-dist-out 22.4925 APE9-dist-out 12.4151 S218A,S222A None None EM 4.25 0.445 999.0 F 393.0 278.0 40 26 26 0 [[68, 361]] 1.0 8chf Homo sapiens STE_MAP2K1_HUMAN STE 1.1e-96 329.3 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
TKL RAF1 RAF1_HUMAN 8CHFA P04049 341 626 648.0 29L:60701 Type1 Inactive DFGin 6.9193 13.7979 None -77.69, -137.87 -62.1, 150.83 -123.34, 43.11 304.09, 90.48 -53.76, -47.63 in-out in 8.5922 Saltbr-out 6.6899 HRD-in -62.51, -43.32 69.96, -9.45 out-in-out SNCoio in-out ActLoopNT-in 2.8262 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na 55.74, 2.9 APE9-dihe-na 55.92, 40.68 APE8-dihe-in -131.33, 94.1 APE8-rot-out 59.25 APE67-dihe-inflip 81.42, -0.92 -97.97, 165.62 APE12-dist-in 7.3494 APE11-dist-in 11.6311 APE10-dist-in 6.9434 APE9-dist-out 10.1571 Y341D SEP621 SEP621 EM 4.25 0.445 999.0 A 648.0 280.0 6 30 24 6 [[349, 608]] 1.0 8chf Homo sapiens TKL_RAF1_HUMAN TKL 3e-80 275.8 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase
TKL RAF1 RAF1_HUMAN 8CHFB P04049 341 626 648.0 29L:60701 Type1 Inactive DFGin 6.9191 13.7979 None -77.67, -137.85 -62.16, 150.83 -123.29, 43.03 304.08, 90.5 -53.73, -47.64 in-out in 8.5922 Saltbr-out 6.6905 HRD-in -62.53, -43.31 69.92, -9.4 out-in-out SNCoio in-out ActLoopNT-in 2.8268 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na 55.74, 2.9 APE9-dihe-na 55.89, 40.65 APE8-dihe-in -131.28, 94.15 APE8-rot-out 59.25 APE67-dihe-inflip 81.39, -0.89 -98.01, 165.61 APE12-dist-in 7.3494 APE11-dist-in 11.631 APE10-dist-in 6.9423 APE9-dist-out 10.1569 Y341D SEP621 SEP621 EM 4.25 0.445 999.0 B 648.0 280.0 6 30 24 6 [[349, 608]] 1.0 8chf Homo sapiens TKL_RAF1_HUMAN TKL 3e-80 275.8 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase

PDB: 8CHF — 2 kinases

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name