PDB: 8BUO — CMGC CDK12_HUMAN

Total number of chains: 3
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 1 33.3% 8BUOB
DFGin BLAminus 1 33.3% 8BUOE
DFGin None 1 33.3% 8BUOH
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CDK12 CDK12_HUMAN 8BUOB Q9NYV4 715 1040 1490.0 RLC:1101 Type1 Inactive DFGin 6.577 15.6443 ABAminus -146.64, 39.95 -136.73, 75.69 -99.12, 16.92 290.75, 79.72 -67.9, -33.68 in-in in 8.2125 Saltbr-in 2.831 HRD-in -67.45, -41.41 63.58, -11.91 in-in-in SNCiii in-in ActLoopNT-in 2.9789 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -115.89, -24.96 APE9-dihe-na -114.96, 153.64 APE8-dihe-in -59.59, 137.04 APE8-rot-in 298.26 APE67-dihe-in -58.73, -33.95 -50.83, -38.96 APE12-dist-in 13.2777 APE11-dist-in 11.4095 APE10-dist-in 7.0434 APE9-dist-in 3.9158 K965R TPO893 TPO893 XRAY 3.58 0.179 0.219 B 344.0 326.0 0 29 29 0 [[727, 1020]] 1.0 8buo CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUOE Q9NYV4 715 1040 1490.0 RLC:1101 Type1 Inactive DFGin 6.9418 15.6202 BLAminus -143.37, -172.35 44.48, 74.17 -91.23, 22.68 280.06, 81.2 -62.03, -28.06 in-in in 8.0683 Saltbr-in 3.0558 HRD-out -76.67, 113.14 -91.39, -21.48 in-in-in SNCiii in-in ActLoopNT-in 2.8935 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -97.19, -25.24 APE9-dihe-na -90.88, 153.8 APE8-dihe-in -61.01, 138.91 APE8-rot-in 296.79 APE67-dihe-in -57.07, -33.65 -55.69, -42.2 APE12-dist-in 12.5157 APE11-dist-in 12.5542 APE10-dist-in 6.8393 APE9-dist-in 3.7348 K965R TPO893 TPO893 XRAY 3.58 0.179 0.219 E 344.0 326.0 0 29 29 0 [[727, 1020]] 1.0 8buo CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUOH Q9NYV4 715 1044 1490.0 RLC:1101 Type1 Inactive DFGin 6.9531 15.2665 None -133.0, -52.84 -89.06, 92.6 -92.03, 19.54 286.01, 76.31 -65.14, -29.67 in-in in 8.1958 Saltbr-in 3.2893 HRD-in -68.8, -55.72 77.31, -13.16 in-in-in SNCiii in-in ActLoopNT-in 2.885 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.5, -30.39 APE9-dihe-na -96.1, 151.94 APE8-dihe-in -61.51, 140.45 APE8-rot-in 333.9 APE67-dihe-in -58.03, -34.02 -53.9, -41.38 APE12-dist-in 13.5492 APE11-dist-in 11.7907 APE10-dist-in 6.7655 APE9-dist-in 3.3578 K965R TPO893 TPO893 XRAY 3.58 0.179 0.219 H 344.0 330.0 0 29 29 0 [[727, 1020]] 1.0 8buo CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12

PDB: 8BUO — CMGC CDK12_HUMAN

Total number of chains: 3
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 1 33.3% 8BUOB
DFGin BLAminus 1 33.3% 8BUOE
DFGin None 1 33.3% 8BUOH
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CDK12 CDK12_HUMAN 8BUOB Q9NYV4 715 1040 1490.0 RLC:1101 Type1 Inactive DFGin 6.577 15.6443 ABAminus -146.64, 39.95 -136.73, 75.69 -99.12, 16.92 290.75, 79.72 -67.9, -33.68 in-in in 8.2125 Saltbr-in 2.831 HRD-in -67.45, -41.41 63.58, -11.91 in-in-in SNCiii in-in ActLoopNT-in 2.9789 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -115.89, -24.96 APE9-dihe-na -114.96, 153.64 APE8-dihe-in -59.59, 137.04 APE8-rot-in 298.26 APE67-dihe-in -58.73, -33.95 -50.83, -38.96 APE12-dist-in 13.2777 APE11-dist-in 11.4095 APE10-dist-in 7.0434 APE9-dist-in 3.9158 K965R TPO893 TPO893 XRAY 3.58 0.179 0.219 B 344.0 326.0 0 29 29 0 [[727, 1020]] 1.0 8buo Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUOE Q9NYV4 715 1040 1490.0 RLC:1101 Type1 Inactive DFGin 6.9418 15.6202 BLAminus -143.37, -172.35 44.48, 74.17 -91.23, 22.68 280.06, 81.2 -62.03, -28.06 in-in in 8.0683 Saltbr-in 3.0558 HRD-out -76.67, 113.14 -91.39, -21.48 in-in-in SNCiii in-in ActLoopNT-in 2.8935 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -97.19, -25.24 APE9-dihe-na -90.88, 153.8 APE8-dihe-in -61.01, 138.91 APE8-rot-in 296.79 APE67-dihe-in -57.07, -33.65 -55.69, -42.2 APE12-dist-in 12.5157 APE11-dist-in 12.5542 APE10-dist-in 6.8393 APE9-dist-in 3.7348 K965R TPO893 TPO893 XRAY 3.58 0.179 0.219 E 344.0 326.0 0 29 29 0 [[727, 1020]] 1.0 8buo Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUOH Q9NYV4 715 1044 1490.0 RLC:1101 Type1 Inactive DFGin 6.9531 15.2665 None -133.0, -52.84 -89.06, 92.6 -92.03, 19.54 286.01, 76.31 -65.14, -29.67 in-in in 8.1958 Saltbr-in 3.2893 HRD-in -68.8, -55.72 77.31, -13.16 in-in-in SNCiii in-in ActLoopNT-in 2.885 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.5, -30.39 APE9-dihe-na -96.1, 151.94 APE8-dihe-in -61.51, 140.45 APE8-rot-in 333.9 APE67-dihe-in -58.03, -34.02 -53.9, -41.38 APE12-dist-in 13.5492 APE11-dist-in 11.7907 APE10-dist-in 6.7655 APE9-dist-in 3.3578 K965R TPO893 TPO893 XRAY 3.58 0.179 0.219 H 344.0 330.0 0 29 29 0 [[727, 1020]] 1.0 8buo Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12

PDB: 8BUO — CMGC CDK12_HUMAN

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name