PDB: 8BU5 — CMGC CDK12_HUMAN

Total number of chains: 3
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 2 66.7% 8BU5B
DFGin None 1 33.3% 8BU5E
All chains - renumbered by
Uniprot PDB Alignment

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Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CDK12 CDK12_HUMAN 8BU5B Q9NYV4 713 1044 1490.0 RMF:1101 Type1 Inactive DFGin 6.801 14.701 ABAminus -126.95, -66.04 -93.95, 105.24 -102.41, 30.18 293.69, 100.66 -84.84, -22.58 in-out in 8.305 Saltbr-out 3.933 HRD-out -78.59, 106.12 -94.17, 5.74 out-in-out SNCoio in-out ActLoopNT-in 2.828 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -136.91, -22.25 APE9-dihe-na -109.89, 157.52 APE8-dihe-in -56.01, 131.78 APE8-rot-in 308.02 APE67-dihe-in -60.99, -26.61 -52.03, -40.26 APE12-dist-out 14.28 APE11-dist-in 11.941 APE10-dist-in 7.36 APE9-dist-in 3.767 K965R TPO893 TPO893 XRAY 3.134 0.2 0.22 B 344 332 0 0 0 0 [[727, 1020]] 1.0 8bu5 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BU5H Q9NYV4 713 1043 1490.0 RMF:1101 Type1 Inactive DFGin 7.015 14.978 ABAminus -128.46, -54.53 -90.71, 103.12 -97.22, 31.8 290.43, 81.59 -85.33, -25.69 in-in in 8.479 Saltbr-in 3.527 HRD-in -73.55, -49.58 63.85, -4.76 in-in-in SNCiii in-in ActLoopNT-in 2.629 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.5, -28.02 APE9-dihe-na -97.36, 153.71 APE8-dihe-in -57.72, 135.61 APE8-rot-in 311.07 APE67-dihe-in -63.38, -27.52 -50.57, -39.59 APE12-dist-in 13.941 APE11-dist-in 12.128 APE10-dist-in 7.258 APE9-dist-in 3.497 K965R TPO893 TPO893 XRAY 3.134 0.2 0.22 H 344 331 0 0 0 0 [[727, 1020]] 1.0 8bu5 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BU5E Q9NYV4 713 1043 1490.0 RMF:1101 Type1 Inactive DFGin 6.942 15.122 None -123.64, -63.66 -81.97, -51.09 56.28, 22.54 292.49, 98.9 -91.33, -28.22 in-out in 8.371 Saltbr-out 3.622 HRD-in -72.77, -54.57 74.45, -4.91 out-in-out SNCoio in-out ActLoopNT-in 2.759 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -134.16, -27.33 APE9-dihe-na -98.05, 157.33 APE8-dihe-in -51.55, 136.25 APE8-rot-in 308.17 APE67-dihe-in -63.16, -26.85 -49.17, -41.17 APE12-dist-out 14.125 APE11-dist-in 12.168 APE10-dist-in 7.286 APE9-dist-in 3.726 K965R TPO893 TPO893 XRAY 3.134 0.2 0.22 E 344 331 0 0 0 0 [[727, 1020]] 1.0 8bu5 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12

PDB: 8BU5 — CMGC CDK12_HUMAN

Total number of chains: 3
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 2 66.7% 8BU5B
DFGin None 1 33.3% 8BU5E
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CDK12 CDK12_HUMAN 8BU5B Q9NYV4 713 1044 1490.0 RMF:1101 Type1 Inactive DFGin 6.801 14.701 ABAminus -126.95, -66.04 -93.95, 105.24 -102.41, 30.18 293.69, 100.66 -84.84, -22.58 in-out in 8.305 Saltbr-out 3.933 HRD-out -78.59, 106.12 -94.17, 5.74 out-in-out SNCoio in-out ActLoopNT-in 2.828 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -136.91, -22.25 APE9-dihe-na -109.89, 157.52 APE8-dihe-in -56.01, 131.78 APE8-rot-in 308.02 APE67-dihe-in -60.99, -26.61 -52.03, -40.26 APE12-dist-out 14.28 APE11-dist-in 11.941 APE10-dist-in 7.36 APE9-dist-in 3.767 K965R TPO893 TPO893 XRAY 3.134 0.2 0.22 B 344 332 0 0 0 0 [[727, 1020]] 1.0 8bu5 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BU5H Q9NYV4 713 1043 1490.0 RMF:1101 Type1 Inactive DFGin 7.015 14.978 ABAminus -128.46, -54.53 -90.71, 103.12 -97.22, 31.8 290.43, 81.59 -85.33, -25.69 in-in in 8.479 Saltbr-in 3.527 HRD-in -73.55, -49.58 63.85, -4.76 in-in-in SNCiii in-in ActLoopNT-in 2.629 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.5, -28.02 APE9-dihe-na -97.36, 153.71 APE8-dihe-in -57.72, 135.61 APE8-rot-in 311.07 APE67-dihe-in -63.38, -27.52 -50.57, -39.59 APE12-dist-in 13.941 APE11-dist-in 12.128 APE10-dist-in 7.258 APE9-dist-in 3.497 K965R TPO893 TPO893 XRAY 3.134 0.2 0.22 H 344 331 0 0 0 0 [[727, 1020]] 1.0 8bu5 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BU5E Q9NYV4 713 1043 1490.0 RMF:1101 Type1 Inactive DFGin 6.942 15.122 None -123.64, -63.66 -81.97, -51.09 56.28, 22.54 292.49, 98.9 -91.33, -28.22 in-out in 8.371 Saltbr-out 3.622 HRD-in -72.77, -54.57 74.45, -4.91 out-in-out SNCoio in-out ActLoopNT-in 2.759 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -134.16, -27.33 APE9-dihe-na -98.05, 157.33 APE8-dihe-in -51.55, 136.25 APE8-rot-in 308.17 APE67-dihe-in -63.16, -26.85 -49.17, -41.17 APE12-dist-out 14.125 APE11-dist-in 12.168 APE10-dist-in 7.286 APE9-dist-in 3.726 K965R TPO893 TPO893 XRAY 3.134 0.2 0.22 E 344 331 0 0 0 0 [[727, 1020]] 1.0 8bu5 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12

PDB: 8BU5 — CMGC CDK12_HUMAN

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name