PDB: 6TD3 — CMGC CDK12_HUMAN

Total number of chains: 3
Active chains: 1
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 3 100.0% 6TD3B

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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
CMGC CDK12 CDK12_HUMAN 6TD3B 3.46 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RC8 Type1 715 - 1047 0 TPO893 K965R Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 6TD3E 3.46 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RC8 Type1 715 - 1047 0 TPO893 K965R Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 6TD3H 3.46 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaooi APEdist_iiii RC8 Type1 715 - 1047 0 TPO893 K965R Cyclin-dependent kinase 12

PDB: 6TD3 — CMGC CDK12_HUMAN

Total number of chains: 3
Active chains: 1
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 3 100.0% 6TD3B

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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
CMGC CDK12 CDK12_HUMAN 6TD3B 3.46 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RC8 Type1 715 - 1047 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CMGC CDK12 CDK12_HUMAN 6TD3E 3.46 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RC8 Type1 715 - 1047 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CMGC CDK12 CDK12_HUMAN 6TD3H 3.46 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaooi APEdist_iiii RC8 Type1 715 - 1047 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens

PDB: 6TD3 — CMGC CDK12_HUMAN

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative

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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism