PDB: 6TD3 — CMGC CDK12_HUMAN

Total number of chains: 3
Active chains: 1
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 3 100.0% 6TD3B
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CDK12 CDK12_HUMAN 6TD3B Q9NYV4 715 1047 1490.0 RC8:1101 Type1 Inactive DFGin 7.0715 15.3763 BLAminus -144.85, 177.87 66.18, 66.81 -86.27, 29.11 284.0, 81.86 -68.57, -26.95 in-in in 7.9403 Saltbr-in 3.0983 HRD-in -75.0, -46.5 66.33, 3.67 in-in-out SNCiio in-out ActLoopNT-in 2.9625 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -130.74, 152.33 APE9-dihe-na 70.44, 153.31 APE8-dihe-in -72.7, 152.08 APE8-rot-out 190.09 APE67-dihe-in -62.32, -35.85 -49.81, -38.44 APE12-dist-in 13.58 APE11-dist-in 10.9935 APE10-dist-in 7.1532 APE9-dist-in 3.6429 K965R TPO893 TPO893 XRAY 3.46 0.195 0.22 B 344.0 333.0 0 29 29 0 [[727, 1020]] 1.0 6td3 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 6TD3E Q9NYV4 715 1047 1490.0 RC8:1101 Type1 Active DFGin 7.044 15.1934 BLAminus -147.32, 173.39 63.76, 65.42 -84.24, 25.56 288.49, 76.82 -64.44, -36.48 in-in in 7.9743 Saltbr-in 3.1673 HRD-in -75.19, -47.55 67.28, 2.07 in-in-in SNCiii in-in ActLoopNT-in 2.9532 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -75.91, -39.12 APE9-dihe-na -86.17, 150.74 APE8-dihe-in -63.73, 141.42 APE8-rot-in 305.37 APE67-dihe-in -59.47, -32.88 -40.08, -54.92 APE12-dist-in 13.1756 APE11-dist-in 11.9025 APE10-dist-in 6.8549 APE9-dist-in 3.4348 K965R TPO893 TPO893 XRAY 3.46 0.195 0.22 E 344.0 333.0 0 29 29 0 [[727, 1020]] 1.0 6td3 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 6TD3H Q9NYV4 715 1047 1490.0 RC8:1101 Type1 Inactive DFGin 7.0079 15.0671 BLAminus -125.85, 165.87 77.73, 76.18 -92.06, 29.13 290.22, 73.9 -71.24, -38.15 in-in in 7.8983 Saltbr-in 3.0731 HRD-in -75.01, -45.87 63.18, 11.24 in-in-out SNCiio in-out ActLoopNT-in 2.959 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iiii APE10-dihe-na -152.2, 169.13 APE9-dihe-na 75.43, 19.72 APE8-dihe-out 60.33, 162.48 APE8-rot-out 98.13 APE67-dihe-in -64.24, -27.06 -78.21, -44.67 APE12-dist-in 13.9046 APE11-dist-in 11.9021 APE10-dist-in 7.407 APE9-dist-in 3.189 K965R TPO893 TPO893 XRAY 3.46 0.195 0.22 H 344.0 333.0 0 29 29 0 [[727, 1020]] 1.0 6td3 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12

PDB: 6TD3 — CMGC CDK12_HUMAN

Total number of chains: 3
Active chains: 1
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 3 100.0% 6TD3B
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CDK12 CDK12_HUMAN 6TD3B Q9NYV4 715 1047 1490.0 RC8:1101 Type1 Inactive DFGin 7.0715 15.3763 BLAminus -144.85, 177.87 66.18, 66.81 -86.27, 29.11 284.0, 81.86 -68.57, -26.95 in-in in 7.9403 Saltbr-in 3.0983 HRD-in -75.0, -46.5 66.33, 3.67 in-in-out SNCiio in-out ActLoopNT-in 2.9625 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -130.74, 152.33 APE9-dihe-na 70.44, 153.31 APE8-dihe-in -72.7, 152.08 APE8-rot-out 190.09 APE67-dihe-in -62.32, -35.85 -49.81, -38.44 APE12-dist-in 13.58 APE11-dist-in 10.9935 APE10-dist-in 7.1532 APE9-dist-in 3.6429 K965R TPO893 TPO893 XRAY 3.46 0.195 0.22 B 344.0 333.0 0 29 29 0 [[727, 1020]] 1.0 6td3 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 6TD3E Q9NYV4 715 1047 1490.0 RC8:1101 Type1 Active DFGin 7.044 15.1934 BLAminus -147.32, 173.39 63.76, 65.42 -84.24, 25.56 288.49, 76.82 -64.44, -36.48 in-in in 7.9743 Saltbr-in 3.1673 HRD-in -75.19, -47.55 67.28, 2.07 in-in-in SNCiii in-in ActLoopNT-in 2.9532 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -75.91, -39.12 APE9-dihe-na -86.17, 150.74 APE8-dihe-in -63.73, 141.42 APE8-rot-in 305.37 APE67-dihe-in -59.47, -32.88 -40.08, -54.92 APE12-dist-in 13.1756 APE11-dist-in 11.9025 APE10-dist-in 6.8549 APE9-dist-in 3.4348 K965R TPO893 TPO893 XRAY 3.46 0.195 0.22 E 344.0 333.0 0 29 29 0 [[727, 1020]] 1.0 6td3 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 6TD3H Q9NYV4 715 1047 1490.0 RC8:1101 Type1 Inactive DFGin 7.0079 15.0671 BLAminus -125.85, 165.87 77.73, 76.18 -92.06, 29.13 290.22, 73.9 -71.24, -38.15 in-in in 7.8983 Saltbr-in 3.0731 HRD-in -75.01, -45.87 63.18, 11.24 in-in-out SNCiio in-out ActLoopNT-in 2.959 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iiii APE10-dihe-na -152.2, 169.13 APE9-dihe-na 75.43, 19.72 APE8-dihe-out 60.33, 162.48 APE8-rot-out 98.13 APE67-dihe-in -64.24, -27.06 -78.21, -44.67 APE12-dist-in 13.9046 APE11-dist-in 11.9021 APE10-dist-in 7.407 APE9-dist-in 3.189 K965R TPO893 TPO893 XRAY 3.46 0.195 0.22 H 344.0 333.0 0 29 29 0 [[727, 1020]] 1.0 6td3 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12

PDB: 6TD3 — CMGC CDK12_HUMAN

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name