PDB: 6N8G — TKL IRAK4_HUMAN

Total number of chains: 4
Active chains: 3
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 6N8GC
All chains - renumbered by
Uniprot PDB Alignment

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Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TKL IRAK4 IRAK4_HUMAN 6N8GA Q9NWZ3 164 459 460.0 KFD:501 Type1 Active DFGin 6.857 13.85 BLAminus -131.56, 170.5 74.43, 93.31 -112.82, 5.9 310.67, 99.35 -50.67, -35.36 in-in in 8.703 Saltbr-in 3.4 HRD-in -74.01, -49.56 80.73, -4.62 in-in-in SNCiii in-in ActLoopNT-in 2.789 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.5, 156.4 APE9-dihe-na 134.1, -163.0 APE8-dihe-in -125.24, 115.56 APE8-rot-in 300.55 APE67-dihe-in -58.51, -21.49 -57.72, -36.7 APE12-dist-in 9.881 APE11-dist-in 11.989 APE10-dist-in 6.469 APE9-dist-in 3.541 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.0 0.177 0.22 A 297 288 8 0 0 4 [[183, 456]] 1.0 6n8g TKL_IRAK4_HUMAN TKL 3.9e-84 288.3 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 6N8GB Q9NWZ3 164 459 460.0 KFD:501 Type1 Inactive DFGin 6.628 14.11 BLAminus -131.69, 166.82 75.96, 91.11 -108.83, 12.45 307.58, 107.24 -56.0, -36.28 in-out in 8.795 Saltbr-out 3.655 HRD-in -73.96, -48.59 79.13, -6.97 out-in-in SNCoii in-in ActLoopNT-in 2.885 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.24, 163.81 APE9-dihe-na 129.93, -172.68 APE8-dihe-in -114.06, 121.63 APE8-rot-in 306.03 APE67-dihe-in -58.98, -19.75 -56.52, -43.04 APE12-dist-in 9.869 APE11-dist-in 12.008 APE10-dist-in 6.451 APE9-dist-in 3.611 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.0 0.177 0.22 B 297 286 10 0 0 5 [[183, 456]] 1.0 6n8g TKL_IRAK4_HUMAN TKL 3.9e-84 288.3 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 6N8GC Q9NWZ3 164 459 460.0 KFD:501 Type1 Active DFGin 6.674 13.767 BLAminus -132.63, 173.5 73.5, 89.42 -109.51, 12.57 307.44, 107.33 -58.55, -28.35 in-in in 8.81 Saltbr-in 3.347 HRD-in -80.2, -52.37 80.38, -6.83 in-in-in SNCiii in-in ActLoopNT-in 2.802 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.29, 155.42 APE9-dihe-na 139.08, -169.18 APE8-dihe-in -120.47, 120.87 APE8-rot-in 299.74 APE67-dihe-in -68.05, -14.89 -52.69, -42.94 APE12-dist-in 10.023 APE11-dist-in 11.95 APE10-dist-in 6.353 APE9-dist-in 3.661 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.0 0.177 0.22 C 297 289 7 0 0 4 [[183, 456]] 1.0 6n8g TKL_IRAK4_HUMAN TKL 3.9e-84 288.3 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 6N8GD Q9NWZ3 164 459 460.0 KFD:501 Type1 Active DFGin 6.849 14.037 BLAminus -133.11, 174.94 69.68, 87.35 -112.0, 19.02 309.42, 96.14 -69.47, -26.65 in-in in 8.466 Saltbr-in 3.063 HRD-in -74.85, -48.34 77.85, -6.98 in-in-in SNCiii in-in ActLoopNT-in 2.943 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.26, 155.15 APE9-dihe-na 138.35, -169.27 APE8-dihe-in -119.34, 119.24 APE8-rot-in 303.95 APE67-dihe-in -65.64, -14.54 -58.36, -38.59 APE12-dist-in 9.773 APE11-dist-in 11.899 APE10-dist-in 6.41 APE9-dist-in 3.799 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.0 0.177 0.22 D 297 280 16 0 0 5 [[183, 456]] 1.0 6n8g TKL_IRAK4_HUMAN TKL 3.9e-84 288.3 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4

PDB: 6N8G — TKL IRAK4_HUMAN

Total number of chains: 4
Active chains: 3
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 6N8GC
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TKL IRAK4 IRAK4_HUMAN 6N8GA Q9NWZ3 164 459 460.0 KFD:501 Type1 Active DFGin 6.857 13.85 BLAminus -131.56, 170.5 74.43, 93.31 -112.82, 5.9 310.67, 99.35 -50.67, -35.36 in-in in 8.703 Saltbr-in 3.4 HRD-in -74.01, -49.56 80.73, -4.62 in-in-in SNCiii in-in ActLoopNT-in 2.789 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.5, 156.4 APE9-dihe-na 134.1, -163.0 APE8-dihe-in -125.24, 115.56 APE8-rot-in 300.55 APE67-dihe-in -58.51, -21.49 -57.72, -36.7 APE12-dist-in 9.881 APE11-dist-in 11.989 APE10-dist-in 6.469 APE9-dist-in 3.541 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.0 0.177 0.22 A 297 288 8 0 0 4 [[183, 456]] 1.0 6n8g Homo sapiens TKL_IRAK4_HUMAN TKL 3.9e-84 288.3 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 6N8GB Q9NWZ3 164 459 460.0 KFD:501 Type1 Inactive DFGin 6.628 14.11 BLAminus -131.69, 166.82 75.96, 91.11 -108.83, 12.45 307.58, 107.24 -56.0, -36.28 in-out in 8.795 Saltbr-out 3.655 HRD-in -73.96, -48.59 79.13, -6.97 out-in-in SNCoii in-in ActLoopNT-in 2.885 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.24, 163.81 APE9-dihe-na 129.93, -172.68 APE8-dihe-in -114.06, 121.63 APE8-rot-in 306.03 APE67-dihe-in -58.98, -19.75 -56.52, -43.04 APE12-dist-in 9.869 APE11-dist-in 12.008 APE10-dist-in 6.451 APE9-dist-in 3.611 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.0 0.177 0.22 B 297 286 10 0 0 5 [[183, 456]] 1.0 6n8g Homo sapiens TKL_IRAK4_HUMAN TKL 3.9e-84 288.3 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 6N8GC Q9NWZ3 164 459 460.0 KFD:501 Type1 Active DFGin 6.674 13.767 BLAminus -132.63, 173.5 73.5, 89.42 -109.51, 12.57 307.44, 107.33 -58.55, -28.35 in-in in 8.81 Saltbr-in 3.347 HRD-in -80.2, -52.37 80.38, -6.83 in-in-in SNCiii in-in ActLoopNT-in 2.802 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.29, 155.42 APE9-dihe-na 139.08, -169.18 APE8-dihe-in -120.47, 120.87 APE8-rot-in 299.74 APE67-dihe-in -68.05, -14.89 -52.69, -42.94 APE12-dist-in 10.023 APE11-dist-in 11.95 APE10-dist-in 6.353 APE9-dist-in 3.661 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.0 0.177 0.22 C 297 289 7 0 0 4 [[183, 456]] 1.0 6n8g Homo sapiens TKL_IRAK4_HUMAN TKL 3.9e-84 288.3 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 6N8GD Q9NWZ3 164 459 460.0 KFD:501 Type1 Active DFGin 6.849 14.037 BLAminus -133.11, 174.94 69.68, 87.35 -112.0, 19.02 309.42, 96.14 -69.47, -26.65 in-in in 8.466 Saltbr-in 3.063 HRD-in -74.85, -48.34 77.85, -6.98 in-in-in SNCiii in-in ActLoopNT-in 2.943 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.26, 155.15 APE9-dihe-na 138.35, -169.27 APE8-dihe-in -119.34, 119.24 APE8-rot-in 303.95 APE67-dihe-in -65.64, -14.54 -58.36, -38.59 APE12-dist-in 9.773 APE11-dist-in 11.899 APE10-dist-in 6.41 APE9-dist-in 3.799 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.0 0.177 0.22 D 297 280 16 0 0 5 [[183, 456]] 1.0 6n8g Homo sapiens TKL_IRAK4_HUMAN TKL 3.9e-84 288.3 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4

PDB: 6N8G — TKL IRAK4_HUMAN

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name