| Group | Gene | SwissprotID | PDB | UniprotID | First_obs_res | Last_obs_res | Length_Unp | Ligand | Ligand_type | Activity_label | Spatial_label | Phe_Glu4_dis | Phe_Lys_dis | Dihedral_label | XDFG φ,ψ |
DFG-Asp φ,ψ |
DFG-Phe φ,ψ |
DFG-Phe χ1,χ2 |
DFG-Gly φ,ψ |
ChelixSaltbr_label | Chelix_label | Lys_Glu_dis | Saltbr_label | LysNZ_GluOE_dis | HRD_label | His φ,ψ | Arg φ,ψ | SNC_label | SNCpymol_label | ActLoop_label | ActLoopNT_label | DFG6_XHRD_dis | ActLoopCT_label | APEtype | APEdihe_label | APEdist_label | APE10_dihe_label | APE10 φ,ψ | APE9_dihe_label | APE9 φ,ψ | APE8_dihe_label | APE8 φ,ψ | APE8_rotamer_label | APE8 χ1 | APE67_label | APE6 φ,ψ | APE7 φ,ψ | APE12_dist_label | APE12_DFG4_dis | APE11_dist_label | APE11_DFG4_dis | APE10_dist_label | APE10_DFG4_dis | APE9_dist_label | APE9_Arg_dis | Chain_mut | Chain_phos | Modified_aa | Method | Resolution | Rvalue | FreeRvalue | Chain_id | ChainLen | Ordered_residues | DomainBreak | ActLoopLength | ActLoopResolvedResidues | ActLoopDisorderedResidues | Kinase_domains_Unp | N_Kinase_domains_Unp | pdb | Kincore_name | hmm | Evalue | Score | hmmbeg | hmmend | hmmlen | XDFGnum | DFGnum | PHEnum | DFG4num | DFG6num | LYSnum | GLUnum | GLU4num | XHRDnum | ARGnum | HRDnum | HRDaspnum | aFaspnum | APEnum | APE6num | APE7num | APE8num | APE9num | APE10num | APE11num | APE12num | Hinge1num | Protein_name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| STE | TNIK | TNIK_HUMAN | 2X7FA | Q9UKE5 | 15 | 313 | 1360.0 | 824:500 | Type1 | Inactive | DFGin | 6.7876 | 14.6427 | BLAminus | -125.93, 176.2 | 60.97, 100.67 | -114.36, 23.27 | 288.61, 85.46 | -68.11, -48.66 | in-none | in | 9.2041 | Saltbr-none | 999.0 | HRD-in | -65.92, -41.18 | 69.14, -4.02 | none-out-out | SNCnoo | out-out | ActLoopNT-out | 6.167 | ActLoopCT-out | nonTYR | APEdihe_aaini | APEdist_nnno | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, -150.84 | APE8-dihe-in | -101.28, 96.29 | APE8-rot-none | 999.0 | APE67-dihe-in | -52.7, -32.64 | -83.9, 2.97 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-out | 10.9208 | None | None | None | XRAY | 2.8 | 0.21 | 0.229 | A | 326.0 | 276.0 | 23 | 28 | 15 | 13 | [[25, 289]] | 1.0 | 2x7f | STE_TNIK_HUMAN | STE | 3.7e-105 | 356.8 | 1.0 | 257.0 | 257.0 | 170 | 171 | 172 | 174 | 176 | 54 | 69 | 73 | 150 | 152 | 151 | 153.0 | 215 | 198 | 193 | 192 | 191 | 190 | 189 | 188 | 187 | 106 | TRAF2 and NCK-interacting protein kinase |
| STE | TNIK | TNIK_HUMAN | 2X7FB | Q9UKE5 | 13 | 313 | 1360.0 | 824:500 | Type1 | Inactive | DFGin | 6.759 | 14.6163 | BLAminus | -125.8, 175.96 | 61.22, 100.42 | -113.19, 24.28 | 288.37, 86.39 | -68.54, -48.18 | in-none | in | 9.1073 | Saltbr-none | 999.0 | HRD-in | -67.06, -42.58 | 70.38, -4.99 | none-out-out | SNCnoo | out-out | ActLoopNT-out | 6.1902 | ActLoopCT-out | nonTYR | APEdihe_aaioi | APEdist_nnno | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 154.09 | APE8-dihe-in | -121.12, 111.62 | APE8-rot-out | 48.12 | APE67-dihe-in | -53.26, -31.37 | -96.48, 3.58 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-out | 11.5142 | None | None | None | XRAY | 2.8 | 0.21 | 0.229 | B | 326.0 | 288.0 | 13 | 28 | 16 | 12 | [[25, 289]] | 1.0 | 2x7f | STE_TNIK_HUMAN | STE | 3.7e-105 | 356.8 | 1.0 | 257.0 | 257.0 | 170 | 171 | 172 | 174 | 176 | 54 | 69 | 73 | 150 | 152 | 151 | 153.0 | 215 | 198 | 193 | 192 | 191 | 190 | 189 | 188 | 187 | 106 | TRAF2 and NCK-interacting protein kinase |
| STE | TNIK | TNIK_HUMAN | 2X7FC | Q9UKE5 | 14 | 313 | 1360.0 | 824:500 | Type1 | Inactive | DFGin | 6.7637 | 14.765 | BLAminus | -124.84, 175.84 | 60.69, 100.51 | -112.75, 22.89 | 287.95, 85.81 | -67.51, -48.09 | in-none | in | 9.1407 | Saltbr-none | 999.0 | HRD-in | -67.07, -40.49 | 68.23, -3.68 | none-out-none | SNCnon | out-none | ActLoopNT-out | 6.1705 | ActLoopCT-none | nonTYR | APEdihe_aanni | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 118.77 | APE8-rot-none | 999.0 | APE67-dihe-in | -54.15, -31.45 | -96.1, 4.16 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | None | None | None | XRAY | 2.8 | 0.21 | 0.229 | C | 326.0 | 285.0 | 15 | 28 | 14 | 14 | [[25, 289]] | 1.0 | 2x7f | STE_TNIK_HUMAN | STE | 3.7e-105 | 356.8 | 1.0 | 257.0 | 257.0 | 170 | 171 | 172 | 174 | 176 | 54 | 69 | 73 | 150 | 152 | 151 | 153.0 | 215 | 198 | 193 | 192 | 191 | 190 | 189 | 188 | 187 | 106 | TRAF2 and NCK-interacting protein kinase |
| STE | TNIK | TNIK_HUMAN | 2X7FD | Q9UKE5 | 17 | 306 | 1360.0 | 824:500 | Type1 | None | DFGin | 6.6469 | 15.0461 | BLAminus | -124.52, 178.85 | 56.71, 102.04 | -114.11, 22.87 | 287.2, 83.98 | -65.42, -48.91 | in-none | in | 9.4441 | Saltbr-none | 999.0 | HRD-in | -66.67, -40.26 | 66.21, -2.06 | none-none-none | SNCnnn | none-none | ActLoopNT-none | 999.0 | ActLoopCT-none | nonTYR | APEdihe_aanni | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 119.49 | APE8-rot-none | 999.0 | APE67-dihe-in | -52.92, -32.7 | -93.58, 2.88 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | None | None | None | XRAY | 2.8 | 0.21 | 0.229 | D | 326.0 | 236.0 | 51 | 28 | 13 | 15 | [[25, 289]] | 1.0 | 2x7f | STE_TNIK_HUMAN | STE | 3.7e-105 | 356.8 | 1.0 | 257.0 | 257.0 | 170 | 171 | 172 | 174 | 176 | 54 | 69 | 73 | 150 | 152 | 151 | 153.0 | 215 | 198 | 193 | 192 | 191 | 190 | 189 | 188 | 187 | 106 | TRAF2 and NCK-interacting protein kinase |
| STE | TNIK | TNIK_HUMAN | 2X7FE | Q9UKE5 | 14 | 309 | 1360.0 | 824:500 | Type1 | Inactive | DFGin | 6.6596 | 14.7942 | None | -124.38, 176.52 | 58.71, 103.53 | -115.64, 999.0 | 286.98, 84.26 | 999.0, 999.0 | in-none | in | 9.525 | Saltbr-none | 999.0 | HRD-in | -65.29, -41.79 | 67.65, -3.62 | none-none-none | SNCnnn | none-none | ActLoopNT-none | 999.0 | ActLoopCT-none | nonTYR | APEdihe_aanni | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 128.45 | APE8-rot-none | 999.0 | APE67-dihe-in | -51.92, -33.29 | -95.18, 3.25 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | None | None | None | XRAY | 2.8 | 0.21 | 0.229 | E | 326.0 | 251.0 | 45 | 28 | 10 | 18 | [[25, 289]] | 1.0 | 2x7f | STE_TNIK_HUMAN | STE | 3.7e-105 | 356.8 | 1.0 | 257.0 | 257.0 | 170 | 171 | 172 | 174 | 176 | 54 | 69 | 73 | 150 | 152 | 151 | 153.0 | 215 | 198 | 193 | 192 | 191 | 190 | 189 | 188 | 187 | 106 | TRAF2 and NCK-interacting protein kinase |
| Group | Gene | SwissprotID | PDB | UniprotID | First_obs_res | Last_obs_res | Length_Unp | Ligand | Ligand_type | Activity_label | Spatial_label | Phe_Glu4_dis | Phe_Lys_dis | Dihedral_label | XDFG φ,ψ |
DFG-Asp φ,ψ |
DFG-Phe φ,ψ |
DFG-Phe χ1,χ2 |
DFG-Gly φ,ψ |
ChelixSaltbr_label | Chelix_label | Lys_Glu_dis | Saltbr_label | LysNZ_GluOE_dis | HRD_label | His φ,ψ | Arg φ,ψ | SNC_label | SNCpymol_label | ActLoop_label | ActLoopNT_label | DFG6_XHRD_dis | ActLoopCT_label | APEtype | APEdihe_label | APEdist_label | APE10_dihe_label | APE10 φ,ψ | APE9_dihe_label | APE9 φ,ψ | APE8_dihe_label | APE8 φ,ψ | APE8_rotamer_label | APE8 χ1 | APE67_label | APE6 φ,ψ | APE7 φ,ψ | APE12_dist_label | APE12_DFG4_dis | APE11_dist_label | APE11_DFG4_dis | APE10_dist_label | APE10_DFG4_dis | APE9_dist_label | APE9_Arg_dis | Chain_mut | Chain_phos | Modified_aa | Method | Resolution | Rvalue | FreeRvalue | Chain_id | ChainLen | Ordered_residues | DomainBreak | ActLoopLength | ActLoopResolvedResidues | ActLoopDisorderedResidues | Kinase_domains_Unp | N_Kinase_domains_Unp | pdb | Species | Kincore_name | hmm | Evalue | Score | hmmbeg | hmmend | hmmlen | XDFGnum | DFGnum | PHEnum | DFG4num | DFG6num | LYSnum | GLUnum | GLU4num | XHRDnum | ARGnum | HRDnum | HRDaspnum | aFaspnum | APEnum | APE6num | APE7num | APE8num | APE9num | APE10num | APE11num | APE12num | Hinge1num | Protein_name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| STE | TNIK | TNIK_HUMAN | 2X7FA | Q9UKE5 | 15 | 313 | 1360.0 | 824:500 | Type1 | Inactive | DFGin | 6.7876 | 14.6427 | BLAminus | -125.93, 176.2 | 60.97, 100.67 | -114.36, 23.27 | 288.61, 85.46 | -68.11, -48.66 | in-none | in | 9.2041 | Saltbr-none | 999.0 | HRD-in | -65.92, -41.18 | 69.14, -4.02 | none-out-out | SNCnoo | out-out | ActLoopNT-out | 6.167 | ActLoopCT-out | nonTYR | APEdihe_aaini | APEdist_nnno | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, -150.84 | APE8-dihe-in | -101.28, 96.29 | APE8-rot-none | 999.0 | APE67-dihe-in | -52.7, -32.64 | -83.9, 2.97 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-out | 10.9208 | None | None | None | XRAY | 2.8 | 0.21 | 0.229 | A | 326.0 | 276.0 | 23 | 28 | 15 | 13 | [[25, 289]] | 1.0 | 2x7f | Homo sapiens | STE_TNIK_HUMAN | STE | 3.7e-105 | 356.8 | 1.0 | 257.0 | 257.0 | 170 | 171 | 172 | 174 | 176 | 54 | 69 | 73 | 150 | 152 | 151 | 153.0 | 215 | 198 | 193 | 192 | 191 | 190 | 189 | 188 | 187 | 106 | TRAF2 and NCK-interacting protein kinase |
| STE | TNIK | TNIK_HUMAN | 2X7FB | Q9UKE5 | 13 | 313 | 1360.0 | 824:500 | Type1 | Inactive | DFGin | 6.759 | 14.6163 | BLAminus | -125.8, 175.96 | 61.22, 100.42 | -113.19, 24.28 | 288.37, 86.39 | -68.54, -48.18 | in-none | in | 9.1073 | Saltbr-none | 999.0 | HRD-in | -67.06, -42.58 | 70.38, -4.99 | none-out-out | SNCnoo | out-out | ActLoopNT-out | 6.1902 | ActLoopCT-out | nonTYR | APEdihe_aaioi | APEdist_nnno | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 154.09 | APE8-dihe-in | -121.12, 111.62 | APE8-rot-out | 48.12 | APE67-dihe-in | -53.26, -31.37 | -96.48, 3.58 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-out | 11.5142 | None | None | None | XRAY | 2.8 | 0.21 | 0.229 | B | 326.0 | 288.0 | 13 | 28 | 16 | 12 | [[25, 289]] | 1.0 | 2x7f | Homo sapiens | STE_TNIK_HUMAN | STE | 3.7e-105 | 356.8 | 1.0 | 257.0 | 257.0 | 170 | 171 | 172 | 174 | 176 | 54 | 69 | 73 | 150 | 152 | 151 | 153.0 | 215 | 198 | 193 | 192 | 191 | 190 | 189 | 188 | 187 | 106 | TRAF2 and NCK-interacting protein kinase |
| STE | TNIK | TNIK_HUMAN | 2X7FC | Q9UKE5 | 14 | 313 | 1360.0 | 824:500 | Type1 | Inactive | DFGin | 6.7637 | 14.765 | BLAminus | -124.84, 175.84 | 60.69, 100.51 | -112.75, 22.89 | 287.95, 85.81 | -67.51, -48.09 | in-none | in | 9.1407 | Saltbr-none | 999.0 | HRD-in | -67.07, -40.49 | 68.23, -3.68 | none-out-none | SNCnon | out-none | ActLoopNT-out | 6.1705 | ActLoopCT-none | nonTYR | APEdihe_aanni | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 118.77 | APE8-rot-none | 999.0 | APE67-dihe-in | -54.15, -31.45 | -96.1, 4.16 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | None | None | None | XRAY | 2.8 | 0.21 | 0.229 | C | 326.0 | 285.0 | 15 | 28 | 14 | 14 | [[25, 289]] | 1.0 | 2x7f | Homo sapiens | STE_TNIK_HUMAN | STE | 3.7e-105 | 356.8 | 1.0 | 257.0 | 257.0 | 170 | 171 | 172 | 174 | 176 | 54 | 69 | 73 | 150 | 152 | 151 | 153.0 | 215 | 198 | 193 | 192 | 191 | 190 | 189 | 188 | 187 | 106 | TRAF2 and NCK-interacting protein kinase |
| STE | TNIK | TNIK_HUMAN | 2X7FD | Q9UKE5 | 17 | 306 | 1360.0 | 824:500 | Type1 | None | DFGin | 6.6469 | 15.0461 | BLAminus | -124.52, 178.85 | 56.71, 102.04 | -114.11, 22.87 | 287.2, 83.98 | -65.42, -48.91 | in-none | in | 9.4441 | Saltbr-none | 999.0 | HRD-in | -66.67, -40.26 | 66.21, -2.06 | none-none-none | SNCnnn | none-none | ActLoopNT-none | 999.0 | ActLoopCT-none | nonTYR | APEdihe_aanni | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 119.49 | APE8-rot-none | 999.0 | APE67-dihe-in | -52.92, -32.7 | -93.58, 2.88 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | None | None | None | XRAY | 2.8 | 0.21 | 0.229 | D | 326.0 | 236.0 | 51 | 28 | 13 | 15 | [[25, 289]] | 1.0 | 2x7f | Homo sapiens | STE_TNIK_HUMAN | STE | 3.7e-105 | 356.8 | 1.0 | 257.0 | 257.0 | 170 | 171 | 172 | 174 | 176 | 54 | 69 | 73 | 150 | 152 | 151 | 153.0 | 215 | 198 | 193 | 192 | 191 | 190 | 189 | 188 | 187 | 106 | TRAF2 and NCK-interacting protein kinase |
| STE | TNIK | TNIK_HUMAN | 2X7FE | Q9UKE5 | 14 | 309 | 1360.0 | 824:500 | Type1 | Inactive | DFGin | 6.6596 | 14.7942 | None | -124.38, 176.52 | 58.71, 103.53 | -115.64, 999.0 | 286.98, 84.26 | 999.0, 999.0 | in-none | in | 9.525 | Saltbr-none | 999.0 | HRD-in | -65.29, -41.79 | 67.65, -3.62 | none-none-none | SNCnnn | none-none | ActLoopNT-none | 999.0 | ActLoopCT-none | nonTYR | APEdihe_aanni | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 128.45 | APE8-rot-none | 999.0 | APE67-dihe-in | -51.92, -33.29 | -95.18, 3.25 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | None | None | None | XRAY | 2.8 | 0.21 | 0.229 | E | 326.0 | 251.0 | 45 | 28 | 10 | 18 | [[25, 289]] | 1.0 | 2x7f | Homo sapiens | STE_TNIK_HUMAN | STE | 3.7e-105 | 356.8 | 1.0 | 257.0 | 257.0 | 170 | 171 | 172 | 174 | 176 | 54 | 69 | 73 | 150 | 152 | 151 | 153.0 | 215 | 198 | 193 | 192 | 191 | 190 | 189 | 188 | 187 | 106 | TRAF2 and NCK-interacting protein kinase |
| Spatial label | Dihedral label | Number of Chains | Percent | Representative |
|---|
| Group | Gene | SwissprotID | PDB | UniprotID | First_obs_res | Last_obs_res | Length_Unp | Ligand | Ligand_type | Activity_label | Spatial_label | Phe_Glu4_dis | Phe_Lys_dis | Dihedral_label | XDFG φ,ψ |
DFG-Asp φ,ψ |
DFG-Phe φ,ψ |
DFG-Phe χ1,χ2 |
DFG-Gly φ,ψ |
ChelixSaltbr_label | Chelix_label | Lys_Glu_dis | Saltbr_label | LysNZ_GluOE_dis | HRD_label | His φ,ψ | Arg φ,ψ | SNC_label | SNCpymol_label | ActLoop_label | ActLoopNT_label | DFG6_XHRD_dis | ActLoopCT_label | APEtype | APEdihe_label | APEdist_label | APE10_dihe_label | APE10 φ,ψ | APE9_dihe_label | APE9 φ,ψ | APE8_dihe_label | APE8 φ,ψ | APE8_rotamer_label | APE8 χ1 | APE67_label | APE6 φ,ψ | APE7 φ,ψ | APE12_dist_label | APE12_DFG4_dis | APE11_dist_label | APE11_DFG4_dis | APE10_dist_label | APE10_DFG4_dis | APE9_dist_label | APE9_Arg_dis | Chain_mut | Chain_phos | Modified_aa | Method | Resolution | Rvalue | FreeRvalue | Chain_id | ChainLen | Ordered_residues | DomainBreak | ActLoopLength | ActLoopResolvedResidues | ActLoopDisorderedResidues | Kinase_domains_Unp | N_Kinase_domains_Unp | pdb | Species | Kincore_name | hmm | Evalue | Score | hmmbeg | hmmend | hmmlen | XDFGnum | DFGnum | PHEnum | DFG4num | DFG6num | LYSnum | GLUnum | GLU4num | XHRDnum | ARGnum | HRDnum | HRDaspnum | aFaspnum | APEnum | APE6num | APE7num | APE8num | APE9num | APE10num | APE11num | APE12num | Hinge1num | Protein_name |
|---|