KinCore

Ligand: ZRT

Total number of chains: 3

Spatial label	Dihedral label	Number of Chains	Representative
DFGin	BLAminus	1	7UKVA
DFGin	BLBtrans	2	7UKWB

Database table as tsv

Family	Gene	UniprotID	PDB	Resolution	Activity	Spatial-Dihedral	Chelix-SaltBridge	ActLoopNT-ActLoopCT	Ligand	Type	Residues in structure	Unresolved residues in A-loop	Phosphorylation	Mutation	Protein
TYR	EGFR	EGFR_HUMAN	7UKVA	2.4	None	DFGin‑BLAminus	in-in	in-none	ZRT	Type1	696 - 1018	6	None	None	Epidermal growth factor receptor
TYR	EGFR	EGFR_HUMAN	7UKWB	2.6	Inactive	DFGin‑BLBtrans	out-out	none-none	ZRT	Type1	702 - 1010	17	None	T790M,V948R	Epidermal growth factor receptor
TYR	EGFR	EGFR_HUMAN	7UKWC	2.6	Inactive	DFGin‑BLBtrans	out-out	out-none	ZRT	Type1	700 - 1005	13	None	T790M,V948R	Epidermal growth factor receptor

Ligand: ZRT

Total number of chains: 3

Spatial label	Dihedral label	Number of Chains	Representative
DFGin	BLAminus	1	7UKVA
DFGin	BLBtrans	2	7UKWB

Database table as tsv

Family	Gene	UniprotID	PDB	Resolution	Activity	Spatial-Dihedral	Chelix-SaltBridge	ActLoopNT-ActLoopCT	Ligand	Type	Residues in structure	Unresolved residues in A-loop	Phosphorylation	Mutation	Protein	Organism
TYR	EGFR	EGFR_HUMAN	7UKVA	2.4	None	DFGin‑BLAminus	in-in	in-none	ZRT	Type1	696 - 1018	6	None	None	Epidermal growth factor receptor	Homo sapiens
TYR	EGFR	EGFR_HUMAN	7UKWB	2.6	Inactive	DFGin‑BLBtrans	out-out	none-none	ZRT	Type1	702 - 1010	17	None	T790M,V948R	Epidermal growth factor receptor	Homo sapiens
TYR	EGFR	EGFR_HUMAN	7UKWC	2.6	Inactive	DFGin‑BLBtrans	out-out	out-none	ZRT	Type1	700 - 1005	13	None	T790M,V948R	Epidermal growth factor receptor	Homo sapiens

Ligand: ZRT

Total number of chains: 0

Spatial label	Dihedral label	Number of Chains	Representative

Database table as tsv

Family	Gene	UniprotID	PDB	Resolution	Activity	Spatial-Dihedral	Chelix-SaltBridge	ActLoopNT-ActLoopCT	Ligand	Type	Residues in structure	Unresolved residues in A-loop	Phosphorylation	Mutation	Protein	Organism