Ligand: WIQ

Total number of chains: 5
Active chains: 1
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAplus 3 60.0% 8UDVA
DFGin BLAminus 1 20.0% 8UDUB
DFGin BLBplus 1 20.0% 8UDUA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR FGFR3 FGFR3_HUMAN 8UDUB P22607 459 755 806.0 WIQ:61002 Type1.5_Front Active DFGin 6.4209 14.4148 BLAminus -138.69, 176.26 64.2, 86.01 -100.28, 24.84 287.71, 79.66 -57.6, -41.09 in-in in 8.1853 Saltbr-in 2.9464 HRD-in -71.69, -47.92 71.62, 0.22 in-in-in SNCiii in-in ActLoopNT-in 2.9471 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -67.88, 155.75 APE9-dihe-in -122.51, 89.95 APE8-dihe-in -81.37, 70.05 APE8-rot-na 30.61 APE67-dihe-in -66.22, -12.9 -45.0, -50.18 APE12-dist-na 999.0 APE11-dist-na 7.6606 APE10-dist-na 8.4893 APE9-dist-in 7.717 P572S,P573G None None XRAY 1.737 0.231 0.256 B 297.0 276.0 9 30 29 1 [[472, 750]] 1.0 8udu TYR_FGFR3_HUMAN TYR 8.4e-105 355.7 1.0 260.0 260.0 634 635 636 638 640 508 525 529 614 616 615 617.0 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
TYR FGFR3 FGFR3_HUMAN 8UDVA P22607 458 755 806.0 WIQ:1003 Type1.5_Back Inactive DFGin 6.0012 13.4764 BLAplus -124.26, 161.29 66.5, 36.68 -91.33, -43.75 46.96, 90.73 -84.73, 13.25 in-in in 7.6609 Saltbr-in 2.9402 HRD-in -66.26, -46.33 75.0, -11.55 in-out-out SNCioo out-out ActLoopNT-out 8.16 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -144.63, 151.27 APE9-dihe-in -107.88, 92.32 APE8-dihe-out -54.6, -21.22 APE8-rot-na 338.66 APE67-dihe-in -68.84, -8.83 -57.22, -29.15 APE12-dist-na 15.9556 APE11-dist-na 19.9983 APE10-dist-na 17.2851 APE9-dist-out 11.6116 V555M None None XRAY 2.348 0.237 0.261 A 297.0 279.0 7 30 23 7 [[472, 750]] 1.0 8udv TYR_FGFR3_HUMAN TYR 4.5e-105 356.6 1.0 260.0 260.0 634 635 636 638 640 508 525 529 614 616 615 617.0 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
TYR FGFR3 FGFR3_HUMAN 8UDVB P22607 455 755 806.0 WIQ:803 Type1.5_Back Inactive DFGin 5.4813 13.2542 BLAplus -124.6, 164.38 63.05, 27.71 -82.13, -38.21 55.85, 89.15 -91.32, 13.57 in-in in 7.68 Saltbr-in 2.9036 HRD-in -63.59, -46.44 79.4, -13.95 in-out-out SNCioo out-out ActLoopNT-out 8.9067 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -136.87, 152.88 APE9-dihe-in -110.79, 96.93 APE8-dihe-out -58.89, -20.81 APE8-rot-na 338.74 APE67-dihe-in -70.46, -8.74 -52.69, -32.19 APE12-dist-na 15.4794 APE11-dist-na 19.3858 APE10-dist-na 16.7032 APE9-dist-out 11.4241 V555M None None XRAY 2.348 0.237 0.261 B 297.0 281.0 8 30 22 8 [[472, 750]] 1.0 8udv TYR_FGFR3_HUMAN TYR 4.5e-105 356.6 1.0 260.0 260.0 634 635 636 638 640 508 525 529 614 616 615 617.0 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
TYR FGFR3 FGFR3_HUMAN 8UDVC P22607 458 755 806.0 WIQ:1004 Type1.5_Back Inactive DFGin 6.071 13.4313 BLAplus -124.65, 164.21 70.39, 38.16 -109.8, -21.91 57.41, 87.59 -78.9, -34.05 in-in in 7.6549 Saltbr-in 2.8879 HRD-in -64.72, -49.48 77.07, -10.54 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 91.25 APE8-dihe-out -54.32, -20.59 APE8-rot-na 338.75 APE67-dihe-in -71.87, -8.91 -59.36, -26.12 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.6264 V555M None None XRAY 2.348 0.237 0.261 C 297.0 269.0 17 30 14 16 [[472, 750]] 1.0 8udv TYR_FGFR3_HUMAN TYR 4.5e-105 356.6 1.0 260.0 260.0 634 635 636 638 640 508 525 529 614 616 615 617.0 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
TYR FGFR3 FGFR3_HUMAN 8UDUA P22607 460 756 806.0 WIQ:61002 Type1.5_Back Inactive DFGin 5.7614 13.5292 BLBplus -121.3, 171.32 71.72, 21.7 -99.77, 166.76 66.11, 93.34 95.58, -59.45 in-in in 7.9172 Saltbr-in 2.7343 HRD-in -77.2, -48.45 77.61, -12.83 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -71.65, 162.44 APE9-dihe-in -54.1, 129.25 APE8-dihe-in -83.64, 61.19 APE8-rot-na 34.62 APE67-dihe-in -73.43, -8.03 -52.16, -35.97 APE12-dist-na 999.0 APE11-dist-na 14.2323 APE10-dist-na 17.7469 APE9-dist-out 8.253 P572S,P573G None None XRAY 1.737 0.231 0.256 A 297.0 277.0 8 30 22 8 [[472, 750]] 1.0 8udu TYR_FGFR3_HUMAN TYR 8.4e-105 355.7 1.0 260.0 260.0 634 635 636 638 640 508 525 529 614 616 615 617.0 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3

Ligand: WIQ

Total number of chains: 5
Active chains: 1
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAplus 3 60.0% 8UDVA
DFGin BLAminus 1 20.0% 8UDUB
DFGin BLBplus 1 20.0% 8UDUA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR FGFR3 FGFR3_HUMAN 8UDUB P22607 459 755 806.0 WIQ:61002 Type1.5_Front Active DFGin 6.4209 14.4148 BLAminus -138.69, 176.26 64.2, 86.01 -100.28, 24.84 287.71, 79.66 -57.6, -41.09 in-in in 8.1853 Saltbr-in 2.9464 HRD-in -71.69, -47.92 71.62, 0.22 in-in-in SNCiii in-in ActLoopNT-in 2.9471 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -67.88, 155.75 APE9-dihe-in -122.51, 89.95 APE8-dihe-in -81.37, 70.05 APE8-rot-na 30.61 APE67-dihe-in -66.22, -12.9 -45.0, -50.18 APE12-dist-na 999.0 APE11-dist-na 7.6606 APE10-dist-na 8.4893 APE9-dist-in 7.717 P572S,P573G None None XRAY 1.737 0.231 0.256 B 297.0 276.0 9 30 29 1 [[472, 750]] 1.0 8udu Homo sapiens TYR_FGFR3_HUMAN TYR 8.4e-105 355.7 1.0 260.0 260.0 634 635 636 638 640 508 525 529 614 616 615 617.0 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
TYR FGFR3 FGFR3_HUMAN 8UDVA P22607 458 755 806.0 WIQ:1003 Type1.5_Back Inactive DFGin 6.0012 13.4764 BLAplus -124.26, 161.29 66.5, 36.68 -91.33, -43.75 46.96, 90.73 -84.73, 13.25 in-in in 7.6609 Saltbr-in 2.9402 HRD-in -66.26, -46.33 75.0, -11.55 in-out-out SNCioo out-out ActLoopNT-out 8.16 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -144.63, 151.27 APE9-dihe-in -107.88, 92.32 APE8-dihe-out -54.6, -21.22 APE8-rot-na 338.66 APE67-dihe-in -68.84, -8.83 -57.22, -29.15 APE12-dist-na 15.9556 APE11-dist-na 19.9983 APE10-dist-na 17.2851 APE9-dist-out 11.6116 V555M None None XRAY 2.348 0.237 0.261 A 297.0 279.0 7 30 23 7 [[472, 750]] 1.0 8udv Homo sapiens TYR_FGFR3_HUMAN TYR 4.5e-105 356.6 1.0 260.0 260.0 634 635 636 638 640 508 525 529 614 616 615 617.0 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
TYR FGFR3 FGFR3_HUMAN 8UDVB P22607 455 755 806.0 WIQ:803 Type1.5_Back Inactive DFGin 5.4813 13.2542 BLAplus -124.6, 164.38 63.05, 27.71 -82.13, -38.21 55.85, 89.15 -91.32, 13.57 in-in in 7.68 Saltbr-in 2.9036 HRD-in -63.59, -46.44 79.4, -13.95 in-out-out SNCioo out-out ActLoopNT-out 8.9067 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -136.87, 152.88 APE9-dihe-in -110.79, 96.93 APE8-dihe-out -58.89, -20.81 APE8-rot-na 338.74 APE67-dihe-in -70.46, -8.74 -52.69, -32.19 APE12-dist-na 15.4794 APE11-dist-na 19.3858 APE10-dist-na 16.7032 APE9-dist-out 11.4241 V555M None None XRAY 2.348 0.237 0.261 B 297.0 281.0 8 30 22 8 [[472, 750]] 1.0 8udv Homo sapiens TYR_FGFR3_HUMAN TYR 4.5e-105 356.6 1.0 260.0 260.0 634 635 636 638 640 508 525 529 614 616 615 617.0 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
TYR FGFR3 FGFR3_HUMAN 8UDVC P22607 458 755 806.0 WIQ:1004 Type1.5_Back Inactive DFGin 6.071 13.4313 BLAplus -124.65, 164.21 70.39, 38.16 -109.8, -21.91 57.41, 87.59 -78.9, -34.05 in-in in 7.6549 Saltbr-in 2.8879 HRD-in -64.72, -49.48 77.07, -10.54 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 91.25 APE8-dihe-out -54.32, -20.59 APE8-rot-na 338.75 APE67-dihe-in -71.87, -8.91 -59.36, -26.12 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.6264 V555M None None XRAY 2.348 0.237 0.261 C 297.0 269.0 17 30 14 16 [[472, 750]] 1.0 8udv Homo sapiens TYR_FGFR3_HUMAN TYR 4.5e-105 356.6 1.0 260.0 260.0 634 635 636 638 640 508 525 529 614 616 615 617.0 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
TYR FGFR3 FGFR3_HUMAN 8UDUA P22607 460 756 806.0 WIQ:61002 Type1.5_Back Inactive DFGin 5.7614 13.5292 BLBplus -121.3, 171.32 71.72, 21.7 -99.77, 166.76 66.11, 93.34 95.58, -59.45 in-in in 7.9172 Saltbr-in 2.7343 HRD-in -77.2, -48.45 77.61, -12.83 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -71.65, 162.44 APE9-dihe-in -54.1, 129.25 APE8-dihe-in -83.64, 61.19 APE8-rot-na 34.62 APE67-dihe-in -73.43, -8.03 -52.16, -35.97 APE12-dist-na 999.0 APE11-dist-na 14.2323 APE10-dist-na 17.7469 APE9-dist-out 8.253 P572S,P573G None None XRAY 1.737 0.231 0.256 A 297.0 277.0 8 30 22 8 [[472, 750]] 1.0 8udu Homo sapiens TYR_FGFR3_HUMAN TYR 8.4e-105 355.7 1.0 260.0 260.0 634 635 636 638 640 508 525 529 614 616 615 617.0 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3

Ligand: WIQ

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name