Ligand: W4A

Total number of chains: 5
Active chains: 5
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 5 100.0% 5MYVA
All chains - renumbered by
Uniprot PDB Alignment

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Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC SRPK1 SRPK1_HUMAN 5MXXA Q96SB4 56 655 655.0 W4A:701 Type1 Active DFGin 5.977 14.189 BLAminus -117.74, -175.37 55.98, 72.09 -86.99, 11.79 273.83, 86.12 -60.63, -21.63 in-in in 9.209 Saltbr-in 2.975 HRD-in -71.08, -46.72 78.08, -5.05 in-in-in SNCiii in-in ActLoopNT-in 2.863 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -118.86, 168.59 APE9-dihe-na 76.28, 126.73 APE8-dihe-in -50.41, 144.32 APE8-rot-in 293.68 APE67-dihe-in -70.94, -15.39 -51.89, -47.56 APE12-dist-in 12.738 APE11-dist-in 10.148 APE10-dist-in 7.396 APE9-dist-in 3.163 None None None XRAY 1.75 0.175 0.205 A 399 361 22 0 0 0 [[80, 653]] 1.0 5mxx CMGC_SRPK1_HUMAN CMGC 9.4e-139 467.6 1 301 301 496 497 498 500 502 109 124 128 210 212 211 213 533 521 516 515 514 513 512 511 510 166 SRSF protein kinase 1
CMGC SRPK2 SRPK2_HUMAN 5MYVA P78362 68 688 688.0 W4A:60716 Type1 Active DFGin 6.331 13.797 BLAminus -133.46, -174.64 58.65, 65.32 -91.15, 13.08 272.47, 67.35 -64.26, -23.28 in-in in 9.357 Saltbr-in 3.083 HRD-in -70.14, -43.35 74.24, -2.44 in-in-in SNCiii in-in ActLoopNT-in 2.864 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -119.85, 167.12 APE9-dihe-na 72.17, 138.55 APE8-dihe-in -70.17, 145.46 APE8-rot-in 301.36 APE67-dihe-in -69.9, -15.95 -41.31, -56.88 APE12-dist-in 12.619 APE11-dist-in 10.613 APE10-dist-in 7.87 APE9-dist-in 3.275 None None None XRAY 2.9 0.2 0.217 A 389 352 18 0 0 0 [[81, 686]] 1.0 5myv CMGC_SRPK2_HUMAN CMGC 1.4e-144 486.7 1 301 301 529 530 531 533 535 110 125 129 211 213 212 214 566 554 549 548 547 546 545 544 543 167 SRSF protein kinase 2
CMGC SRPK2 SRPK2_HUMAN 5MYVB P78362 68 688 688.0 W4A:60715 Type1 Active DFGin 6.352 13.655 BLAminus -132.14, -175.28 57.36, 67.15 -90.74, 14.57 272.3, 66.38 -64.24, -22.8 in-in in 9.241 Saltbr-in 3.095 HRD-in -69.52, -44.04 73.41, -1.98 in-in-in SNCiii in-in ActLoopNT-in 2.864 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -118.88, 167.32 APE9-dihe-na 72.34, 139.4 APE8-dihe-in -70.2, 145.35 APE8-rot-in 302.58 APE67-dihe-in -69.24, -15.62 -41.36, -56.93 APE12-dist-in 12.619 APE11-dist-in 10.572 APE10-dist-in 7.745 APE9-dist-in 3.263 None None None XRAY 2.9 0.2 0.217 B 389 349 21 0 0 0 [[81, 686]] 1.0 5myv CMGC_SRPK2_HUMAN CMGC 1.4e-144 486.7 1 301 301 529 530 531 533 535 110 125 129 211 213 212 214 566 554 549 548 547 546 545 544 543 167 SRSF protein kinase 2
CMGC SRPK2 SRPK2_HUMAN 5MYVC P78362 68 688 688.0 W4A:60711 Type1 Active DFGin 6.359 13.639 BLAminus -132.33, -176.42 57.94, 66.74 -90.66, 15.47 272.12, 68.19 -64.19, -23.57 in-in in 9.197 Saltbr-in 3.092 HRD-in -69.62, -44.12 73.53, -2.08 in-in-in SNCiii in-in ActLoopNT-in 2.863 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -119.53, 167.9 APE9-dihe-na 72.74, 138.77 APE8-dihe-in -70.13, 144.97 APE8-rot-in 302.67 APE67-dihe-in -69.14, -16.02 -41.1, -56.52 APE12-dist-in 12.588 APE11-dist-in 10.558 APE10-dist-in 7.697 APE9-dist-in 3.261 None None None XRAY 2.9 0.2 0.217 C 389 348 22 0 0 0 [[81, 686]] 1.0 5myv CMGC_SRPK2_HUMAN CMGC 1.4e-144 486.7 1 301 301 529 530 531 533 535 110 125 129 211 213 212 214 566 554 549 548 547 546 545 544 543 167 SRSF protein kinase 2
CMGC SRPK2 SRPK2_HUMAN 5MYVD P78362 68 688 688.0 W4A:60710 Type1 Active DFGin 6.223 14.174 BLAminus -133.23, -174.98 56.82, 67.21 -92.06, 16.8 272.08, 71.69 -66.01, -21.98 in-in in 9.444 Saltbr-in 3.099 HRD-in -69.59, -43.92 73.56, -1.28 in-in-in SNCiii in-in ActLoopNT-in 2.869 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.31, 167.24 APE9-dihe-na 72.07, 138.65 APE8-dihe-in -70.56, 145.29 APE8-rot-in 303.66 APE67-dihe-in -69.61, -15.98 -41.64, -56.92 APE12-dist-in 12.619 APE11-dist-in 10.392 APE10-dist-in 7.716 APE9-dist-in 3.267 None None None XRAY 2.9 0.2 0.217 D 389 351 19 0 0 0 [[81, 686]] 1.0 5myv CMGC_SRPK2_HUMAN CMGC 1.4e-144 486.7 1 301 301 529 530 531 533 535 110 125 129 211 213 212 214 566 554 549 548 547 546 545 544 543 167 SRSF protein kinase 2

Ligand: W4A

Total number of chains: 5
Active chains: 5
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 5 100.0% 5MYVA
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC SRPK1 SRPK1_HUMAN 5MXXA Q96SB4 56 655 655.0 W4A:701 Type1 Active DFGin 5.977 14.189 BLAminus -117.74, -175.37 55.98, 72.09 -86.99, 11.79 273.83, 86.12 -60.63, -21.63 in-in in 9.209 Saltbr-in 2.975 HRD-in -71.08, -46.72 78.08, -5.05 in-in-in SNCiii in-in ActLoopNT-in 2.863 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -118.86, 168.59 APE9-dihe-na 76.28, 126.73 APE8-dihe-in -50.41, 144.32 APE8-rot-in 293.68 APE67-dihe-in -70.94, -15.39 -51.89, -47.56 APE12-dist-in 12.738 APE11-dist-in 10.148 APE10-dist-in 7.396 APE9-dist-in 3.163 None None None XRAY 1.75 0.175 0.205 A 399 361 22 0 0 0 [[80, 653]] 1.0 5mxx Homo sapiens CMGC_SRPK1_HUMAN CMGC 9.4e-139 467.6 1 301 301 496 497 498 500 502 109 124 128 210 212 211 213 533 521 516 515 514 513 512 511 510 166 SRSF protein kinase 1
CMGC SRPK2 SRPK2_HUMAN 5MYVA P78362 68 688 688.0 W4A:60716 Type1 Active DFGin 6.331 13.797 BLAminus -133.46, -174.64 58.65, 65.32 -91.15, 13.08 272.47, 67.35 -64.26, -23.28 in-in in 9.357 Saltbr-in 3.083 HRD-in -70.14, -43.35 74.24, -2.44 in-in-in SNCiii in-in ActLoopNT-in 2.864 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -119.85, 167.12 APE9-dihe-na 72.17, 138.55 APE8-dihe-in -70.17, 145.46 APE8-rot-in 301.36 APE67-dihe-in -69.9, -15.95 -41.31, -56.88 APE12-dist-in 12.619 APE11-dist-in 10.613 APE10-dist-in 7.87 APE9-dist-in 3.275 None None None XRAY 2.9 0.2 0.217 A 389 352 18 0 0 0 [[81, 686]] 1.0 5myv Homo sapiens CMGC_SRPK2_HUMAN CMGC 1.4e-144 486.7 1 301 301 529 530 531 533 535 110 125 129 211 213 212 214 566 554 549 548 547 546 545 544 543 167 SRSF protein kinase 2
CMGC SRPK2 SRPK2_HUMAN 5MYVB P78362 68 688 688.0 W4A:60715 Type1 Active DFGin 6.352 13.655 BLAminus -132.14, -175.28 57.36, 67.15 -90.74, 14.57 272.3, 66.38 -64.24, -22.8 in-in in 9.241 Saltbr-in 3.095 HRD-in -69.52, -44.04 73.41, -1.98 in-in-in SNCiii in-in ActLoopNT-in 2.864 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -118.88, 167.32 APE9-dihe-na 72.34, 139.4 APE8-dihe-in -70.2, 145.35 APE8-rot-in 302.58 APE67-dihe-in -69.24, -15.62 -41.36, -56.93 APE12-dist-in 12.619 APE11-dist-in 10.572 APE10-dist-in 7.745 APE9-dist-in 3.263 None None None XRAY 2.9 0.2 0.217 B 389 349 21 0 0 0 [[81, 686]] 1.0 5myv Homo sapiens CMGC_SRPK2_HUMAN CMGC 1.4e-144 486.7 1 301 301 529 530 531 533 535 110 125 129 211 213 212 214 566 554 549 548 547 546 545 544 543 167 SRSF protein kinase 2
CMGC SRPK2 SRPK2_HUMAN 5MYVC P78362 68 688 688.0 W4A:60711 Type1 Active DFGin 6.359 13.639 BLAminus -132.33, -176.42 57.94, 66.74 -90.66, 15.47 272.12, 68.19 -64.19, -23.57 in-in in 9.197 Saltbr-in 3.092 HRD-in -69.62, -44.12 73.53, -2.08 in-in-in SNCiii in-in ActLoopNT-in 2.863 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -119.53, 167.9 APE9-dihe-na 72.74, 138.77 APE8-dihe-in -70.13, 144.97 APE8-rot-in 302.67 APE67-dihe-in -69.14, -16.02 -41.1, -56.52 APE12-dist-in 12.588 APE11-dist-in 10.558 APE10-dist-in 7.697 APE9-dist-in 3.261 None None None XRAY 2.9 0.2 0.217 C 389 348 22 0 0 0 [[81, 686]] 1.0 5myv Homo sapiens CMGC_SRPK2_HUMAN CMGC 1.4e-144 486.7 1 301 301 529 530 531 533 535 110 125 129 211 213 212 214 566 554 549 548 547 546 545 544 543 167 SRSF protein kinase 2
CMGC SRPK2 SRPK2_HUMAN 5MYVD P78362 68 688 688.0 W4A:60710 Type1 Active DFGin 6.223 14.174 BLAminus -133.23, -174.98 56.82, 67.21 -92.06, 16.8 272.08, 71.69 -66.01, -21.98 in-in in 9.444 Saltbr-in 3.099 HRD-in -69.59, -43.92 73.56, -1.28 in-in-in SNCiii in-in ActLoopNT-in 2.869 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.31, 167.24 APE9-dihe-na 72.07, 138.65 APE8-dihe-in -70.56, 145.29 APE8-rot-in 303.66 APE67-dihe-in -69.61, -15.98 -41.64, -56.92 APE12-dist-in 12.619 APE11-dist-in 10.392 APE10-dist-in 7.716 APE9-dist-in 3.267 None None None XRAY 2.9 0.2 0.217 D 389 351 19 0 0 0 [[81, 686]] 1.0 5myv Homo sapiens CMGC_SRPK2_HUMAN CMGC 1.4e-144 486.7 1 301 301 529 530 531 533 535 110 125 129 211 213 212 214 566 554 549 548 547 546 545 544 543 167 SRSF protein kinase 2

Ligand: W4A

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name