Ligand: TXV

Total number of chains: 4
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGout BBAminus 4 100.0% 8C7YA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TKL BRAF BRAF_HUMAN 8C7YA P15056 448 721 766.0 TXV:60819 Type2 Inactive DFGout 12.4076 11.7259 BBAminus -137.73, -175.36 -123.6, 90.82 -84.7, -1.49 298.01, 93.91 -135.43, 40.89 in-in in 8.3869 Saltbr-in 2.85 HRD-in -66.11, -47.81 81.15, -13.03 in-out-out SNCioo out-out ActLoopNT-out 14.6571 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iioo APE10-dihe-na -57.81, -31.54 APE9-dihe-na -75.2, -3.67 APE8-dihe-out -121.03, -1.94 APE8-rot-in 304.31 APE67-dihe-in -66.09, -22.26 -55.41, -37.84 APE12-dist-in 10.5802 APE11-dist-in 10.6089 APE10-dist-out 14.1458 APE9-dist-out 10.8656 V600E None None XRAY 1.65 0.153 0.175 A 282.0 274.0 0 30 30 0 [[457, 716]] 1.0 8c7y TKL_BRAF_HUMAN TKL 4.8e-84 288.0 4.0 267.0 264.0 593 594 595 597 599 483 501 505 573 575 574 576.0 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 8C7YB P15056 449 721 766.0 TXV:60803 Type2 Inactive DFGout 12.2037 11.7186 BBAminus -146.3, -168.52 -130.63, 88.27 -86.35, -12.6 298.57, 95.44 49.99, -135.3 in-in in 8.3789 Saltbr-in 2.7751 HRD-in -71.56, -48.93 77.75, -10.34 in-out-out SNCioo out-out ActLoopNT-out 18.0616 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 5.82 APE8-dihe-out -125.92, 1.76 APE8-rot-in 306.06 APE67-dihe-in -66.57, -23.27 -61.15, -28.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.7589 V600E None None XRAY 1.65 0.153 0.175 B 282.0 258.0 15 30 15 15 [[457, 716]] 1.0 8c7y TKL_BRAF_HUMAN TKL 4.8e-84 288.0 4.0 267.0 264.0 593 594 595 597 599 483 501 505 573 575 574 576.0 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 8C7XA P15056 449 721 766.0 TXV:60819 Type2 Inactive DFGout 12.4433 11.7323 BBAminus -135.27, -175.23 -125.31, 91.5 -84.77, 1.35 298.16, 96.35 -135.3, 38.11 in-in in 8.4984 Saltbr-in 2.8645 HRD-in -69.83, -48.66 82.13, -14.5 in-out-out SNCioo out-out ActLoopNT-out 14.6842 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iioo APE10-dihe-na -57.54, -34.33 APE9-dihe-na -66.65, -4.24 APE8-dihe-out -124.33, -3.25 APE8-rot-in 302.06 APE67-dihe-in -65.06, -18.56 -51.42, -40.3 APE12-dist-in 10.5167 APE11-dist-in 10.208 APE10-dist-out 14.0359 APE9-dist-out 10.8165 None None None XRAY 1.65 0.154 0.171 A 284.0 273.0 0 30 30 0 [[457, 716]] 1.0 8c7x TKL_BRAF_HUMAN TKL 4.8e-84 288.0 4.0 267.0 264.0 593 594 595 597 599 483 501 505 573 575 574 576.0 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 8C7XB P15056 448 721 766.0 TXV:60803 Type2 Inactive DFGout 12.3193 11.7433 BBAminus -141.6, -169.03 -129.23, 87.73 -87.17, -9.74 297.6, 98.29 46.23, -133.22 in-in in 8.4671 Saltbr-in 2.726 HRD-in -71.23, -49.45 77.51, -13.46 in-out-out SNCioo out-out ActLoopNT-out 18.1173 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, -73.7 APE9-dihe-na -64.9, -3.59 APE8-dihe-out -123.65, 0.9 APE8-rot-in 304.25 APE67-dihe-in -68.19, -19.78 -53.41, -37.43 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.2505 APE9-dist-out 10.7314 None None None XRAY 1.65 0.154 0.171 B 284.0 261.0 13 30 17 13 [[457, 716]] 1.0 8c7x TKL_BRAF_HUMAN TKL 4.8e-84 288.0 4.0 267.0 264.0 593 594 595 597 599 483 501 505 573 575 574 576.0 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf

Ligand: TXV

Total number of chains: 4
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGout BBAminus 4 100.0% 8C7YA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TKL BRAF BRAF_HUMAN 8C7YA P15056 448 721 766.0 TXV:60819 Type2 Inactive DFGout 12.4076 11.7259 BBAminus -137.73, -175.36 -123.6, 90.82 -84.7, -1.49 298.01, 93.91 -135.43, 40.89 in-in in 8.3869 Saltbr-in 2.85 HRD-in -66.11, -47.81 81.15, -13.03 in-out-out SNCioo out-out ActLoopNT-out 14.6571 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iioo APE10-dihe-na -57.81, -31.54 APE9-dihe-na -75.2, -3.67 APE8-dihe-out -121.03, -1.94 APE8-rot-in 304.31 APE67-dihe-in -66.09, -22.26 -55.41, -37.84 APE12-dist-in 10.5802 APE11-dist-in 10.6089 APE10-dist-out 14.1458 APE9-dist-out 10.8656 V600E None None XRAY 1.65 0.153 0.175 A 282.0 274.0 0 30 30 0 [[457, 716]] 1.0 8c7y Homo sapiens TKL_BRAF_HUMAN TKL 4.8e-84 288.0 4.0 267.0 264.0 593 594 595 597 599 483 501 505 573 575 574 576.0 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 8C7YB P15056 449 721 766.0 TXV:60803 Type2 Inactive DFGout 12.2037 11.7186 BBAminus -146.3, -168.52 -130.63, 88.27 -86.35, -12.6 298.57, 95.44 49.99, -135.3 in-in in 8.3789 Saltbr-in 2.7751 HRD-in -71.56, -48.93 77.75, -10.34 in-out-out SNCioo out-out ActLoopNT-out 18.0616 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 5.82 APE8-dihe-out -125.92, 1.76 APE8-rot-in 306.06 APE67-dihe-in -66.57, -23.27 -61.15, -28.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.7589 V600E None None XRAY 1.65 0.153 0.175 B 282.0 258.0 15 30 15 15 [[457, 716]] 1.0 8c7y Homo sapiens TKL_BRAF_HUMAN TKL 4.8e-84 288.0 4.0 267.0 264.0 593 594 595 597 599 483 501 505 573 575 574 576.0 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 8C7XA P15056 449 721 766.0 TXV:60819 Type2 Inactive DFGout 12.4433 11.7323 BBAminus -135.27, -175.23 -125.31, 91.5 -84.77, 1.35 298.16, 96.35 -135.3, 38.11 in-in in 8.4984 Saltbr-in 2.8645 HRD-in -69.83, -48.66 82.13, -14.5 in-out-out SNCioo out-out ActLoopNT-out 14.6842 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iioo APE10-dihe-na -57.54, -34.33 APE9-dihe-na -66.65, -4.24 APE8-dihe-out -124.33, -3.25 APE8-rot-in 302.06 APE67-dihe-in -65.06, -18.56 -51.42, -40.3 APE12-dist-in 10.5167 APE11-dist-in 10.208 APE10-dist-out 14.0359 APE9-dist-out 10.8165 None None None XRAY 1.65 0.154 0.171 A 284.0 273.0 0 30 30 0 [[457, 716]] 1.0 8c7x Homo sapiens TKL_BRAF_HUMAN TKL 4.8e-84 288.0 4.0 267.0 264.0 593 594 595 597 599 483 501 505 573 575 574 576.0 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 8C7XB P15056 448 721 766.0 TXV:60803 Type2 Inactive DFGout 12.3193 11.7433 BBAminus -141.6, -169.03 -129.23, 87.73 -87.17, -9.74 297.6, 98.29 46.23, -133.22 in-in in 8.4671 Saltbr-in 2.726 HRD-in -71.23, -49.45 77.51, -13.46 in-out-out SNCioo out-out ActLoopNT-out 18.1173 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, -73.7 APE9-dihe-na -64.9, -3.59 APE8-dihe-out -123.65, 0.9 APE8-rot-in 304.25 APE67-dihe-in -68.19, -19.78 -53.41, -37.43 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.2505 APE9-dist-out 10.7314 None None None XRAY 1.65 0.154 0.171 B 284.0 261.0 13 30 17 13 [[457, 716]] 1.0 8c7x Homo sapiens TKL_BRAF_HUMAN TKL 4.8e-84 288.0 4.0 267.0 264.0 593 594 595 597 599 483 501 505 573 575 574 576.0 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf

Ligand: TXV

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name