Ligand: RKO

Total number of chains: 3
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 1 33.3% 8BUCB
DFGin BLAminus 1 33.3% 8BUCE
DFGin None 1 33.3% 8BUCH
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CDK12 CDK12_HUMAN 8BUCB Q9NYV4 715 1041 1490.0 RKO:61101 Type1 Inactive DFGin 6.835 15.495 ABAminus -130.47, -49.88 -100.7, 87.88 -87.1, 28.61 287.17, 76.07 -67.87, -32.97 in-in in 8.127 Saltbr-in 2.928 HRD-in -72.49, -52.56 71.47, 1.89 in-in-out SNCiio in-out ActLoopNT-in 2.827 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -120.68, -53.4 APE9-dihe-na -81.9, 152.03 APE8-dihe-in -63.34, 145.38 APE8-rot-out 183.29 APE67-dihe-in -65.1, -32.1 -54.44, -34.81 APE12-dist-in 13.234 APE11-dist-in 11.425 APE10-dist-in 6.56 APE9-dist-in 3.613 K965R TPO893 TPO893 XRAY 3.85 0.183 0.224 B 344 327 0 0 0 0 [[727, 1020]] 1.0 8buc CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUCE Q9NYV4 715 1039 1490.0 RKO:61101 Type1 Inactive DFGin 7.236 15.335 BLAminus -141.04, 176.79 52.98, 78.31 -91.94, 30.22 286.84, 76.41 -65.41, -31.19 in-in in 7.961 Saltbr-in 2.908 HRD-in -69.25, -49.18 71.49, 1.27 in-in-out SNCiio in-out ActLoopNT-in 2.87 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -94.07, -41.15 APE9-dihe-na -76.31, 151.65 APE8-dihe-in -63.11, 145.53 APE8-rot-out 179.86 APE67-dihe-in -66.95, -27.99 -55.33, -37.54 APE12-dist-in 12.996 APE11-dist-in 12.54 APE10-dist-in 6.8 APE9-dist-in 3.464 K965R TPO893 TPO893 XRAY 3.85 0.183 0.224 E 344 325 0 0 0 0 [[727, 1020]] 1.0 8buc CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUCH Q9NYV4 715 1044 1490.0 RKO:61101 Type1 Inactive DFGin 6.938 15.242 None -126.85, -64.01 -88.43, 98.06 -96.23, 24.88 287.21, 69.27 -75.34, -9.66 in-in in 7.946 Saltbr-in 3.3 HRD-in -84.47, -51.91 75.61, -7.74 in-in-in SNCiii in-in ActLoopNT-in 2.979 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.44, -52.72 APE9-dihe-na -81.82, 150.47 APE8-dihe-in -58.85, 136.79 APE8-rot-in 300.83 APE67-dihe-in -60.33, -38.14 -49.32, -40.23 APE12-dist-in 13.762 APE11-dist-in 11.782 APE10-dist-in 6.973 APE9-dist-in 3.26 K965R TPO893 TPO893 XRAY 3.85 0.183 0.224 H 344 330 0 0 0 0 [[727, 1020]] 1.0 8buc CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12

Ligand: RKO

Total number of chains: 3
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 1 33.3% 8BUCB
DFGin BLAminus 1 33.3% 8BUCE
DFGin None 1 33.3% 8BUCH
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CDK12 CDK12_HUMAN 8BUCB Q9NYV4 715 1041 1490.0 RKO:61101 Type1 Inactive DFGin 6.835 15.495 ABAminus -130.47, -49.88 -100.7, 87.88 -87.1, 28.61 287.17, 76.07 -67.87, -32.97 in-in in 8.127 Saltbr-in 2.928 HRD-in -72.49, -52.56 71.47, 1.89 in-in-out SNCiio in-out ActLoopNT-in 2.827 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -120.68, -53.4 APE9-dihe-na -81.9, 152.03 APE8-dihe-in -63.34, 145.38 APE8-rot-out 183.29 APE67-dihe-in -65.1, -32.1 -54.44, -34.81 APE12-dist-in 13.234 APE11-dist-in 11.425 APE10-dist-in 6.56 APE9-dist-in 3.613 K965R TPO893 TPO893 XRAY 3.85 0.183 0.224 B 344 327 0 0 0 0 [[727, 1020]] 1.0 8buc Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUCE Q9NYV4 715 1039 1490.0 RKO:61101 Type1 Inactive DFGin 7.236 15.335 BLAminus -141.04, 176.79 52.98, 78.31 -91.94, 30.22 286.84, 76.41 -65.41, -31.19 in-in in 7.961 Saltbr-in 2.908 HRD-in -69.25, -49.18 71.49, 1.27 in-in-out SNCiio in-out ActLoopNT-in 2.87 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -94.07, -41.15 APE9-dihe-na -76.31, 151.65 APE8-dihe-in -63.11, 145.53 APE8-rot-out 179.86 APE67-dihe-in -66.95, -27.99 -55.33, -37.54 APE12-dist-in 12.996 APE11-dist-in 12.54 APE10-dist-in 6.8 APE9-dist-in 3.464 K965R TPO893 TPO893 XRAY 3.85 0.183 0.224 E 344 325 0 0 0 0 [[727, 1020]] 1.0 8buc Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUCH Q9NYV4 715 1044 1490.0 RKO:61101 Type1 Inactive DFGin 6.938 15.242 None -126.85, -64.01 -88.43, 98.06 -96.23, 24.88 287.21, 69.27 -75.34, -9.66 in-in in 7.946 Saltbr-in 3.3 HRD-in -84.47, -51.91 75.61, -7.74 in-in-in SNCiii in-in ActLoopNT-in 2.979 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.44, -52.72 APE9-dihe-na -81.82, 150.47 APE8-dihe-in -58.85, 136.79 APE8-rot-in 300.83 APE67-dihe-in -60.33, -38.14 -49.32, -40.23 APE12-dist-in 13.762 APE11-dist-in 11.782 APE10-dist-in 6.973 APE9-dist-in 3.26 K965R TPO893 TPO893 XRAY 3.85 0.183 0.224 H 344 330 0 0 0 0 [[727, 1020]] 1.0 8buc Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12

Ligand: RKO

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name