Ligand: RK8

Total number of chains: 3
Active chains: 1
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 3 100.0% 7AKHA
All chains - renumbered by
Uniprot PDB Alignment

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Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC DYRK1A DYR1A_HUMAN 7AKEA Q13627 148 481 763.0 RK8:60501 Type1 Inactive DFGin 6.963 14.696 BLAminus -124.29, 171.29 66.05, 88.52 -103.72, 32.03 286.65, 86.84 -69.65, -28.4 in-in in 8.657 Saltbr-in 2.74 HRD-in -55.46, -52.04 76.49, -6.74 in-in-out SNCiio in-out ActLoopNT-in 2.82 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -139.97, 172.85 APE9-dihe-na 70.76, 139.43 APE8-dihe-in -62.48, 134.14 APE8-rot-out 223.94 APE67-dihe-in -56.1, -32.56 -47.63, -48.41 APE12-dist-in 12.591 APE11-dist-in 10.85 APE10-dist-in 6.827 APE9-dist-in 3.233 None PTR321 PTR321 XRAY 2.3 0.23 0.284 A 359 326 8 0 0 0 [[159, 479]] 1.0 7ake CMGC_DYRK1A_HUMAN CMGC 8.2e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 7AKEB Q13627 148 481 763.0 RK8:60501 Type1 Inactive DFGin 6.962 14.536 BLAminus -123.67, 174.51 70.81, 90.54 -105.83, 23.0 281.74, 93.32 -67.08, -29.7 in-in in 8.426 Saltbr-in 2.881 HRD-in -57.75, -50.61 73.65, -0.98 in-in-out SNCiio in-out ActLoopNT-in 2.878 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -134.84, 158.68 APE9-dihe-na 73.04, 138.35 APE8-dihe-in -54.72, 130.03 APE8-rot-out 183.62 APE67-dihe-in -61.07, -29.87 -52.21, -41.09 APE12-dist-in 11.72 APE11-dist-in 10.621 APE10-dist-in 6.908 APE9-dist-in 2.993 None PTR321 PTR321 XRAY 2.3 0.23 0.284 B 359 329 5 0 0 0 [[159, 479]] 1.0 7ake CMGC_DYRK1A_HUMAN CMGC 8.2e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK2 DYRK2_HUMAN 7AKHA Q92630 146 535 601.0 RK8:60601 Type1 Active DFGin 6.926 15.074 BLAminus -121.6, -171.14 52.21, 81.66 -96.01, 25.36 287.39, 72.64 -67.66, -23.05 in-in in 9.121 Saltbr-in 2.705 HRD-in -56.66, -58.54 81.07, -0.93 in-in-in SNCiii in-in ActLoopNT-in 2.821 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.43, 168.94 APE9-dihe-na 72.6, 150.47 APE8-dihe-in -61.43, 140.56 APE8-rot-in 278.26 APE67-dihe-in -62.31, -24.44 -52.56, -49.45 APE12-dist-in 12.815 APE11-dist-in 11.442 APE10-dist-in 6.914 APE9-dist-in 3.229 None SEP232,PTR382,SEP458 SEP232,PTR382,SEP458 XRAY 2.85 0.188 0.245 A 429 390 0 0 0 0 [[222, 535]] 1.0 7akh CMGC_DYRK2_HUMAN CMGC 1.5e-98 335.8 1 301 301 367 368 369 371 373 251 266 270 345 347 346 348 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2

Ligand: RK8

Total number of chains: 3
Active chains: 1
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 3 100.0% 7AKHA
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC DYRK1A DYR1A_HUMAN 7AKEA Q13627 148 481 763.0 RK8:60501 Type1 Inactive DFGin 6.963 14.696 BLAminus -124.29, 171.29 66.05, 88.52 -103.72, 32.03 286.65, 86.84 -69.65, -28.4 in-in in 8.657 Saltbr-in 2.74 HRD-in -55.46, -52.04 76.49, -6.74 in-in-out SNCiio in-out ActLoopNT-in 2.82 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -139.97, 172.85 APE9-dihe-na 70.76, 139.43 APE8-dihe-in -62.48, 134.14 APE8-rot-out 223.94 APE67-dihe-in -56.1, -32.56 -47.63, -48.41 APE12-dist-in 12.591 APE11-dist-in 10.85 APE10-dist-in 6.827 APE9-dist-in 3.233 None PTR321 PTR321 XRAY 2.3 0.23 0.284 A 359 326 8 0 0 0 [[159, 479]] 1.0 7ake Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.2e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 7AKEB Q13627 148 481 763.0 RK8:60501 Type1 Inactive DFGin 6.962 14.536 BLAminus -123.67, 174.51 70.81, 90.54 -105.83, 23.0 281.74, 93.32 -67.08, -29.7 in-in in 8.426 Saltbr-in 2.881 HRD-in -57.75, -50.61 73.65, -0.98 in-in-out SNCiio in-out ActLoopNT-in 2.878 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -134.84, 158.68 APE9-dihe-na 73.04, 138.35 APE8-dihe-in -54.72, 130.03 APE8-rot-out 183.62 APE67-dihe-in -61.07, -29.87 -52.21, -41.09 APE12-dist-in 11.72 APE11-dist-in 10.621 APE10-dist-in 6.908 APE9-dist-in 2.993 None PTR321 PTR321 XRAY 2.3 0.23 0.284 B 359 329 5 0 0 0 [[159, 479]] 1.0 7ake Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.2e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK2 DYRK2_HUMAN 7AKHA Q92630 146 535 601.0 RK8:60601 Type1 Active DFGin 6.926 15.074 BLAminus -121.6, -171.14 52.21, 81.66 -96.01, 25.36 287.39, 72.64 -67.66, -23.05 in-in in 9.121 Saltbr-in 2.705 HRD-in -56.66, -58.54 81.07, -0.93 in-in-in SNCiii in-in ActLoopNT-in 2.821 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.43, 168.94 APE9-dihe-na 72.6, 150.47 APE8-dihe-in -61.43, 140.56 APE8-rot-in 278.26 APE67-dihe-in -62.31, -24.44 -52.56, -49.45 APE12-dist-in 12.815 APE11-dist-in 11.442 APE10-dist-in 6.914 APE9-dist-in 3.229 None SEP232,PTR382,SEP458 SEP232,PTR382,SEP458 XRAY 2.85 0.188 0.245 A 429 390 0 0 0 0 [[222, 535]] 1.0 7akh Homo sapiens CMGC_DYRK2_HUMAN CMGC 1.5e-98 335.8 1 301 301 367 368 369 371 373 251 266 270 345 347 346 348 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2

Ligand: RK8

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name