Ligand: R2E

Total number of chains: 7
Active chains: 1
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBtrans 5 71.4% 8F1WA
DFGin BLAminus 1 14.3% 8F1YA
DFGin BLBplus 1 14.3% 7A6JB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
TYR EGFR EGFR_HUMAN 8F1YA 2.75 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai R2E Type1 696 - 1019 0 None None Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7A6JB 2.0 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_nniai APEdist_aaao R2E Type1 699 - 984 0 None T790M,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8F1WA 3.2 Inactive DFGin‑BLBtrans out-out out-out TYR APEdihe_oiiai APEdist_aaai R2E Type1 701 - 1007 0 None T790M,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8F1WB 3.2 Inactive DFGin‑BLBtrans out-out out-none TYR APEdihe_nniai APEdist_aaai R2E Type1 700 - 1007 0 None T790M,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8F1WC 3.2 Inactive DFGin‑BLBtrans out-out out-none TYR APEdihe_nniai APEdist_aaai R2E Type1 700 - 1007 0 None T790M,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8F1WD 3.2 Inactive DFGin‑BLBtrans out-out out-out TYR APEdihe_oiiai APEdist_aaai R2E Type1 700 - 1007 0 None T790M,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7A6JA 2.0 Inactive DFGin‑BLBtrans out-out out-out TYR APEdihe_nniai APEdist_aaao R2E Type1 699 - 982 0 None T790M,V948R Epidermal growth factor receptor

Ligand: R2E

Total number of chains: 7
Active chains: 1
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBtrans 5 71.4% 8F1WA
DFGin BLAminus 1 14.3% 8F1YA
DFGin BLBplus 1 14.3% 7A6JB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
TYR EGFR EGFR_HUMAN 8F1YA 2.75 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai R2E Type1 696 - 1019 0 None None Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 7A6JB 2.0 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_nniai APEdist_aaao R2E Type1 699 - 984 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 8F1WA 3.2 Inactive DFGin‑BLBtrans out-out out-out TYR APEdihe_oiiai APEdist_aaai R2E Type1 701 - 1007 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 8F1WB 3.2 Inactive DFGin‑BLBtrans out-out out-none TYR APEdihe_nniai APEdist_aaai R2E Type1 700 - 1007 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 8F1WC 3.2 Inactive DFGin‑BLBtrans out-out out-none TYR APEdihe_nniai APEdist_aaai R2E Type1 700 - 1007 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 8F1WD 3.2 Inactive DFGin‑BLBtrans out-out out-out TYR APEdihe_oiiai APEdist_aaai R2E Type1 700 - 1007 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 7A6JA 2.0 Inactive DFGin‑BLBtrans out-out out-out TYR APEdihe_nniai APEdist_aaao R2E Type1 699 - 982 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens

Ligand: R2E

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism