Ligand: R2E

Total number of chains: 7
Active chains: 1
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBtrans 5 71.4% 8F1WA
DFGin BLAminus 1 14.3% 8F1YA
DFGin BLBplus 1 14.3% 7A6JB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR EGFR EGFR_HUMAN 8F1YA P00533 696 1019 1210.0 R2E:1101 Type1 Active DFGin 5.8928 15.2152 BLAminus -140.27, -173.76 62.92, 82.37 -103.43, 34.41 296.38, 97.61 -65.28, -35.48 in-in in 8.7665 Saltbr-in 3.1035 HRD-in -72.9, -46.1 67.76, 1.27 in-in-in SNCiii in-in ActLoopNT-in 3.0771 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -54.27, 107.83 APE9-dihe-in -116.34, 152.7 APE8-dihe-in -84.23, 88.9 APE8-rot-na 19.13 APE67-dihe-in -72.32, -8.46 -55.36, -45.52 APE12-dist-na 11.7851 APE11-dist-na 9.5725 APE10-dist-na 10.3764 APE9-dist-in 6.8028 None None None XRAY 2.75 0.206 0.228 A 331.0 293.0 9 30 27 3 [[712, 970]] 1.0 8f1y TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7A6JB P00533 699 984 1210.0 R2E:1101 Type1 Inactive DFGin 5.4584 13.796 BLBplus -144.25, -179.46 65.49, 29.82 -99.51, 152.89 65.46, 98.76 73.1, -125.3 out-out out 13.4592 Saltbr-out 10.9975 HRD-in -71.08, -55.82 83.36, -14.67 out-out-out SNCooo out-out ActLoopNT-out 9.3757 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -57.31 APE8-dihe-in -78.95, 60.24 APE8-rot-na 32.73 APE67-dihe-in -71.17, -11.35 -55.28, -40.66 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.7277 T790M,V948R None None XRAY 2.0 0.192 0.216 B 333.0 271.0 15 30 15 15 [[712, 970]] 1.0 7a6j TYR_EGFR_HUMAN TYR 6.4e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8F1WA P00533 701 1007 1210.0 R2E:1101 Type1 Inactive DFGin 5.28 16.3794 BLBtrans -128.45, -172.46 54.26, 51.11 -103.7, 148.5 152.13, 74.45 76.8, -16.65 out-out out 13.4689 Saltbr-out 13.2056 HRD-in -72.99, -57.24 80.64, -5.91 out-out-out SNCooo out-out ActLoopNT-out 8.08 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -99.43, -53.06 APE9-dihe-in -72.87, 140.92 APE8-dihe-in -84.73, 81.02 APE8-rot-na 32.64 APE67-dihe-in -74.93, -2.07 -61.05, -46.98 APE12-dist-na 19.3161 APE11-dist-na 16.4946 APE10-dist-na 12.2558 APE9-dist-in 7.5564 T790M,V948R None None XRAY 3.2 0.233 0.274 A 331.0 303.0 4 30 26 4 [[712, 970]] 1.0 8f1w TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8F1WB P00533 700 1007 1210.0 R2E:1101 Type1 Inactive DFGin 4.3583 15.7338 BLBtrans -129.99, -174.05 52.25, 52.37 -111.11, 152.05 129.92, 81.6 82.17, -3.69 out-out out 13.4371 Saltbr-out 14.4631 HRD-in -72.48, -56.45 81.7, -6.34 out-out-none SNCoon out-none ActLoopNT-out 8.9129 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 140.67 APE8-dihe-in -84.49, 80.46 APE8-rot-na 32.73 APE67-dihe-in -74.43, -1.94 -61.83, -47.13 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.7267 T790M,V948R None None XRAY 3.2 0.233 0.274 B 331.0 288.0 17 30 16 14 [[712, 970]] 1.0 8f1w TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8F1WC P00533 700 1007 1210.0 R2E:1101 Type1 Inactive DFGin 5.4113 16.3302 BLBtrans -128.1, -172.08 53.52, 45.92 -101.71, 133.48 161.59, 77.0 98.24, -6.72 out-out out 13.166 Saltbr-out 13.4617 HRD-in -72.8, -56.41 81.38, -6.01 out-out-none SNCoon out-none ActLoopNT-out 8.7158 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 141.55 APE8-dihe-in -84.21, 80.52 APE8-rot-na 32.64 APE67-dihe-in -74.76, -1.9 -61.65, -47.2 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.6822 T790M,V948R None None XRAY 3.2 0.233 0.274 C 331.0 290.0 18 30 16 14 [[712, 970]] 1.0 8f1w TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8F1WD P00533 700 1007 1210.0 R2E:1101 Type1 Inactive DFGin 5.3647 16.324 BLBtrans -129.36, -171.8 54.41, 47.64 -102.11, 148.89 154.19, 76.79 83.64, -7.92 out-out out 13.8483 Saltbr-out 18.1946 HRD-in -72.16, -56.36 81.51, -6.86 out-out-out SNCooo out-out ActLoopNT-out 8.7074 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -108.09, -47.67 APE9-dihe-in -78.16, 141.77 APE8-dihe-in -84.0, 80.49 APE8-rot-na 32.67 APE67-dihe-in -74.57, -2.54 -61.13, -46.62 APE12-dist-na 18.7731 APE11-dist-na 15.9144 APE10-dist-na 11.838 APE9-dist-in 7.5846 T790M,V948R None None XRAY 3.2 0.233 0.274 D 331.0 304.0 4 30 26 4 [[712, 970]] 1.0 8f1w TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7A6JA P00533 699 982 1210.0 R2E:1101 Type1 Inactive DFGin 5.4528 16.6183 BLBtrans -120.02, 179.59 64.16, 32.38 -80.87, 139.28 157.53, 71.5 71.31, -7.23 out-out out 13.9373 Saltbr-out 13.5276 HRD-in -70.46, -55.09 81.28, -12.68 out-out-out SNCooo out-out ActLoopNT-out 8.0759 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 127.23 APE8-dihe-in -79.55, 65.7 APE8-rot-na 33.45 APE67-dihe-in -69.43, -10.33 -53.39, -41.4 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.1909 T790M,V948R None None XRAY 2.0 0.192 0.216 A 333.0 270.0 14 30 16 14 [[712, 970]] 1.0 7a6j TYR_EGFR_HUMAN TYR 6.4e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor

Ligand: R2E

Total number of chains: 7
Active chains: 1
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBtrans 5 71.4% 8F1WA
DFGin BLAminus 1 14.3% 8F1YA
DFGin BLBplus 1 14.3% 7A6JB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR EGFR EGFR_HUMAN 8F1YA P00533 696 1019 1210.0 R2E:1101 Type1 Active DFGin 5.8928 15.2152 BLAminus -140.27, -173.76 62.92, 82.37 -103.43, 34.41 296.38, 97.61 -65.28, -35.48 in-in in 8.7665 Saltbr-in 3.1035 HRD-in -72.9, -46.1 67.76, 1.27 in-in-in SNCiii in-in ActLoopNT-in 3.0771 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -54.27, 107.83 APE9-dihe-in -116.34, 152.7 APE8-dihe-in -84.23, 88.9 APE8-rot-na 19.13 APE67-dihe-in -72.32, -8.46 -55.36, -45.52 APE12-dist-na 11.7851 APE11-dist-na 9.5725 APE10-dist-na 10.3764 APE9-dist-in 6.8028 None None None XRAY 2.75 0.206 0.228 A 331.0 293.0 9 30 27 3 [[712, 970]] 1.0 8f1y Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7A6JB P00533 699 984 1210.0 R2E:1101 Type1 Inactive DFGin 5.4584 13.796 BLBplus -144.25, -179.46 65.49, 29.82 -99.51, 152.89 65.46, 98.76 73.1, -125.3 out-out out 13.4592 Saltbr-out 10.9975 HRD-in -71.08, -55.82 83.36, -14.67 out-out-out SNCooo out-out ActLoopNT-out 9.3757 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -57.31 APE8-dihe-in -78.95, 60.24 APE8-rot-na 32.73 APE67-dihe-in -71.17, -11.35 -55.28, -40.66 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.7277 T790M,V948R None None XRAY 2.0 0.192 0.216 B 333.0 271.0 15 30 15 15 [[712, 970]] 1.0 7a6j Homo sapiens TYR_EGFR_HUMAN TYR 6.4e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8F1WA P00533 701 1007 1210.0 R2E:1101 Type1 Inactive DFGin 5.28 16.3794 BLBtrans -128.45, -172.46 54.26, 51.11 -103.7, 148.5 152.13, 74.45 76.8, -16.65 out-out out 13.4689 Saltbr-out 13.2056 HRD-in -72.99, -57.24 80.64, -5.91 out-out-out SNCooo out-out ActLoopNT-out 8.08 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -99.43, -53.06 APE9-dihe-in -72.87, 140.92 APE8-dihe-in -84.73, 81.02 APE8-rot-na 32.64 APE67-dihe-in -74.93, -2.07 -61.05, -46.98 APE12-dist-na 19.3161 APE11-dist-na 16.4946 APE10-dist-na 12.2558 APE9-dist-in 7.5564 T790M,V948R None None XRAY 3.2 0.233 0.274 A 331.0 303.0 4 30 26 4 [[712, 970]] 1.0 8f1w Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8F1WB P00533 700 1007 1210.0 R2E:1101 Type1 Inactive DFGin 4.3583 15.7338 BLBtrans -129.99, -174.05 52.25, 52.37 -111.11, 152.05 129.92, 81.6 82.17, -3.69 out-out out 13.4371 Saltbr-out 14.4631 HRD-in -72.48, -56.45 81.7, -6.34 out-out-none SNCoon out-none ActLoopNT-out 8.9129 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 140.67 APE8-dihe-in -84.49, 80.46 APE8-rot-na 32.73 APE67-dihe-in -74.43, -1.94 -61.83, -47.13 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.7267 T790M,V948R None None XRAY 3.2 0.233 0.274 B 331.0 288.0 17 30 16 14 [[712, 970]] 1.0 8f1w Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8F1WC P00533 700 1007 1210.0 R2E:1101 Type1 Inactive DFGin 5.4113 16.3302 BLBtrans -128.1, -172.08 53.52, 45.92 -101.71, 133.48 161.59, 77.0 98.24, -6.72 out-out out 13.166 Saltbr-out 13.4617 HRD-in -72.8, -56.41 81.38, -6.01 out-out-none SNCoon out-none ActLoopNT-out 8.7158 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 141.55 APE8-dihe-in -84.21, 80.52 APE8-rot-na 32.64 APE67-dihe-in -74.76, -1.9 -61.65, -47.2 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.6822 T790M,V948R None None XRAY 3.2 0.233 0.274 C 331.0 290.0 18 30 16 14 [[712, 970]] 1.0 8f1w Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8F1WD P00533 700 1007 1210.0 R2E:1101 Type1 Inactive DFGin 5.3647 16.324 BLBtrans -129.36, -171.8 54.41, 47.64 -102.11, 148.89 154.19, 76.79 83.64, -7.92 out-out out 13.8483 Saltbr-out 18.1946 HRD-in -72.16, -56.36 81.51, -6.86 out-out-out SNCooo out-out ActLoopNT-out 8.7074 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -108.09, -47.67 APE9-dihe-in -78.16, 141.77 APE8-dihe-in -84.0, 80.49 APE8-rot-na 32.67 APE67-dihe-in -74.57, -2.54 -61.13, -46.62 APE12-dist-na 18.7731 APE11-dist-na 15.9144 APE10-dist-na 11.838 APE9-dist-in 7.5846 T790M,V948R None None XRAY 3.2 0.233 0.274 D 331.0 304.0 4 30 26 4 [[712, 970]] 1.0 8f1w Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7A6JA P00533 699 982 1210.0 R2E:1101 Type1 Inactive DFGin 5.4528 16.6183 BLBtrans -120.02, 179.59 64.16, 32.38 -80.87, 139.28 157.53, 71.5 71.31, -7.23 out-out out 13.9373 Saltbr-out 13.5276 HRD-in -70.46, -55.09 81.28, -12.68 out-out-out SNCooo out-out ActLoopNT-out 8.0759 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 127.23 APE8-dihe-in -79.55, 65.7 APE8-rot-na 33.45 APE67-dihe-in -69.43, -10.33 -53.39, -41.4 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.1909 T790M,V948R None None XRAY 2.0 0.192 0.216 A 333.0 270.0 14 30 16 14 [[712, 970]] 1.0 7a6j Homo sapiens TYR_EGFR_HUMAN TYR 6.4e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor

Ligand: R2E

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name