Ligand: OV0

Total number of chains: 2
Active chains: 0
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 1 50.0% 7UYWA
DFGin BLAminus 1 50.0% 7UYUA
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
TYR JAK2-2 JAK2_HUMAN 7UYWA 2.51 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai OV0 Type1 842 - 1131 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2
TYR TYK2-2 TYK2_HUMAN 7UYUA 2.05 None DFGin‑BLAminus in-in in-none TYR APEdihe_nniai APEdist_aaai OV0 Type1 889 - 1177 0 PTR1054,PTR1055 None Non-receptor tyrosine-protein kinase TYK2

Ligand: OV0

Total number of chains: 2
Active chains: 0
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 1 50.0% 7UYWA
DFGin BLAminus 1 50.0% 7UYUA
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
TYR JAK2-2 JAK2_HUMAN 7UYWA 2.51 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai OV0 Type1 842 - 1131 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Homo sapiens
TYR TYK2-2 TYK2_HUMAN 7UYUA 2.05 None DFGin‑BLAminus in-in in-none TYR APEdihe_nniai APEdist_aaai OV0 Type1 889 - 1177 0 PTR1054,PTR1055 None Non-receptor tyrosine-protein kinase TYK2 Homo sapiens

Ligand: OV0

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Advanced page
Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism