Ligand: OV0

Total number of chains: 2
Active chains: 0
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 1 50.0% 7UYWA
DFGin BLAminus 1 50.0% 7UYUA
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR JAK2-2 JAK2_HUMAN 7UYWA O60674 842 1131 1132.0 OV0:1201 Type1 Inactive DFGin 6.162 13.552 ABAminus -102.13, -65.77 -97.61, 118.73 -112.34, 34.06 302.3, 86.62 -68.86, -35.74 in-in in 8.446 Saltbr-in 3.127 HRD-in -63.99, -43.03 64.14, 10.59 in-in-in SNCiii in-in ActLoopNT-in 2.857 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -67.32, 131.93 APE9-dihe-in -128.43, 132.61 APE8-dihe-in -78.21, 78.3 APE8-rot-na 32.14 APE67-dihe-in -77.48, -5.27 -63.06, -29.41 APE12-dist-na 10.281 APE11-dist-na 9.748 APE10-dist-na 10.244 APE9-dist-in 6.83 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.51 0.21 0.26 A 291 290 0 31 31 0 [[545, 807], [849, 1125]] 2.0 7uyw TYR_JAK2-2_HUMAN TYR 2.3e-87 298.5 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
TYR TYK2-2 TYK2_HUMAN 7UYUA P29597 889 1177 1187.0 OV0:1201 Type1 None DFGin 6.732 13.693 BLAminus -116.0, -173.86 46.69, 88.81 -102.3, 31.38 294.59, 76.31 -71.39, -32.91 in-in in 7.837 Saltbr-in 3.038 HRD-in -86.52, -53.34 77.94, 2.86 in-in-none SNCiin in-none ActLoopNT-in 2.911 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 117.29 APE8-dihe-in -82.32, 79.72 APE8-rot-na 31.91 APE67-dihe-in -72.66, -7.56 -62.66, -28.85 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.58 None PTR1054,PTR1055 PTR1054,PTR1055 XRAY 2.05 0.227 0.257 A 289 269 20 31 24 7 [[589, 868], [897, 1171]] 2.0 7uyu TYR_TYK2-2_HUMAN TYR 1.1e-81 279.9 2 260 259 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2

Ligand: OV0

Total number of chains: 2
Active chains: 0
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 1 50.0% 7UYWA
DFGin BLAminus 1 50.0% 7UYUA
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR JAK2-2 JAK2_HUMAN 7UYWA O60674 842 1131 1132.0 OV0:1201 Type1 Inactive DFGin 6.162 13.552 ABAminus -102.13, -65.77 -97.61, 118.73 -112.34, 34.06 302.3, 86.62 -68.86, -35.74 in-in in 8.446 Saltbr-in 3.127 HRD-in -63.99, -43.03 64.14, 10.59 in-in-in SNCiii in-in ActLoopNT-in 2.857 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -67.32, 131.93 APE9-dihe-in -128.43, 132.61 APE8-dihe-in -78.21, 78.3 APE8-rot-na 32.14 APE67-dihe-in -77.48, -5.27 -63.06, -29.41 APE12-dist-na 10.281 APE11-dist-na 9.748 APE10-dist-na 10.244 APE9-dist-in 6.83 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.51 0.21 0.26 A 291 290 0 31 31 0 [[545, 807], [849, 1125]] 2.0 7uyw Homo sapiens TYR_JAK2-2_HUMAN TYR 2.3e-87 298.5 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
TYR TYK2-2 TYK2_HUMAN 7UYUA P29597 889 1177 1187.0 OV0:1201 Type1 None DFGin 6.732 13.693 BLAminus -116.0, -173.86 46.69, 88.81 -102.3, 31.38 294.59, 76.31 -71.39, -32.91 in-in in 7.837 Saltbr-in 3.038 HRD-in -86.52, -53.34 77.94, 2.86 in-in-none SNCiin in-none ActLoopNT-in 2.911 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 117.29 APE8-dihe-in -82.32, 79.72 APE8-rot-na 31.91 APE67-dihe-in -72.66, -7.56 -62.66, -28.85 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.58 None PTR1054,PTR1055 PTR1054,PTR1055 XRAY 2.05 0.227 0.257 A 289 269 20 31 24 7 [[589, 868], [897, 1171]] 2.0 7uyu Homo sapiens TYR_TYK2-2_HUMAN TYR 1.1e-81 279.9 2 260 259 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2

Ligand: OV0

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name