Ligand: O44

Total number of chains: 1
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGout BBAminus 1 100.0% 5U8LA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR EGFR EGFR_HUMAN 5U8LA P00533 702 990 1210.0 O44:9001 Type1 Inactive DFGout 14.8147 9.3608 BBAminus -121.7, 139.9 -99.4, 120.55 -99.31, -4.66 285.11, 109.75 141.82, -0.88 out-out out 13.6537 Saltbr-out 12.5613 HRD-in -70.65, -49.86 74.9, -3.35 out-in-in SNCoii in-in ActLoopNT-in 2.8467 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -78.83, 129.47 APE9-dihe-in -131.89, 148.97 APE8-dihe-in -77.16, 74.14 APE8-rot-na 29.74 APE67-dihe-in -76.4, -4.1 -48.81, -42.77 APE12-dist-na 12.1819 APE11-dist-na 11.655 APE10-dist-na 11.4632 APE9-dist-in 7.1133 None None None XRAY 1.6 0.19 0.202 A 329.0 289.0 0 30 30 0 [[712, 970]] 1.0 5u8l TYR_EGFR_HUMAN TYR 6.4e-87 297.2 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor

Ligand: O44

Total number of chains: 3
Active chains: 0
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 1 33.3% 5K9IA
DFGout BBAminus 1 33.3% 5U8LA
DFGout None 1 33.3% 5K9IB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR SRC SRC_CHICK 5K9IA P00523 259 533 533.0 O44:601 Type1 Inactive DFGin 5.9689 14.1797 BLAminus -133.21, -168.64 64.22, 109.0 -130.28, 25.21 285.84, 84.24 -70.57, 999.0 out-out out 13.6392 Saltbr-out 13.0168 HRD-in -86.14, -53.86 87.5, -21.23 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 166.99 APE8-dihe-in -98.32, 93.95 APE8-rot-na 32.78 APE67-dihe-in -67.02, -22.02 -63.74, -29.16 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.6358 None None None XRAY 2.5 0.193 0.249 A 286.0 258.0 17 29 12 17 [[267, 518]] 1.0 5k9i Gallus gallus TYR_SRC_CHICK TYR 3.4e-94 320.9 1.0 260.0 260.0 403 404 405 407 409 295 310 314 383 385 384 386.0 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 5K9IB P00523 259 533 533.0 O44:601 Type1 Inactive DFGout 12.9542 9.8287 None -121.35, 142.56 -124.4, 101.06 -147.18, 78.53 44.24, 9.31 -166.52, 83.44 out-out out 12.5314 Saltbr-out 9.7847 HRD-in -80.24, -51.42 80.93, -6.53 out-in-none SNCoin in-none ActLoopNT-in 2.7307 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 162.79 APE8-dihe-in -76.16, 101.05 APE8-rot-na 27.35 APE67-dihe-in -63.95, -19.6 -50.93, -39.16 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.6741 None None None XRAY 2.5 0.193 0.249 B 286.0 262.0 13 29 16 13 [[267, 518]] 1.0 5k9i Gallus gallus TYR_SRC_CHICK TYR 3.4e-94 320.9 1.0 260.0 260.0 403 404 405 407 409 295 310 314 383 385 384 386.0 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR EGFR EGFR_HUMAN 5U8LA P00533 702 990 1210.0 O44:9001 Type1 Inactive DFGout 14.8147 9.3608 BBAminus -121.7, 139.9 -99.4, 120.55 -99.31, -4.66 285.11, 109.75 141.82, -0.88 out-out out 13.6537 Saltbr-out 12.5613 HRD-in -70.65, -49.86 74.9, -3.35 out-in-in SNCoii in-in ActLoopNT-in 2.8467 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -78.83, 129.47 APE9-dihe-in -131.89, 148.97 APE8-dihe-in -77.16, 74.14 APE8-rot-na 29.74 APE67-dihe-in -76.4, -4.1 -48.81, -42.77 APE12-dist-na 12.1819 APE11-dist-na 11.655 APE10-dist-na 11.4632 APE9-dist-in 7.1133 None None None XRAY 1.6 0.19 0.202 A 329.0 289.0 0 30 30 0 [[712, 970]] 1.0 5u8l Homo sapiens TYR_EGFR_HUMAN TYR 6.4e-87 297.2 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor

Ligand: O44

Total number of chains: 2
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 1 50.0% 5K9IA
DFGout None 1 50.0% 5K9IB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR SRC SRC_CHICK 5K9IA P00523 259 533 533.0 O44:601 Type1 Inactive DFGin 5.9689 14.1797 BLAminus -133.21, -168.64 64.22, 109.0 -130.28, 25.21 285.84, 84.24 -70.57, 999.0 out-out out 13.6392 Saltbr-out 13.0168 HRD-in -86.14, -53.86 87.5, -21.23 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 166.99 APE8-dihe-in -98.32, 93.95 APE8-rot-na 32.78 APE67-dihe-in -67.02, -22.02 -63.74, -29.16 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.6358 None None None XRAY 2.5 0.193 0.249 A 286.0 258.0 17 29 12 17 [[267, 518]] 1.0 5k9i Gallus gallus TYR_SRC_CHICK TYR 3.4e-94 320.9 1.0 260.0 260.0 403 404 405 407 409 295 310 314 383 385 384 386.0 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 5K9IB P00523 259 533 533.0 O44:601 Type1 Inactive DFGout 12.9542 9.8287 None -121.35, 142.56 -124.4, 101.06 -147.18, 78.53 44.24, 9.31 -166.52, 83.44 out-out out 12.5314 Saltbr-out 9.7847 HRD-in -80.24, -51.42 80.93, -6.53 out-in-none SNCoin in-none ActLoopNT-in 2.7307 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 162.79 APE8-dihe-in -76.16, 101.05 APE8-rot-na 27.35 APE67-dihe-in -63.95, -19.6 -50.93, -39.16 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.6741 None None None XRAY 2.5 0.193 0.249 B 286.0 262.0 13 29 16 13 [[267, 518]] 1.0 5k9i Gallus gallus TYR_SRC_CHICK TYR 3.4e-94 320.9 1.0 260.0 260.0 403 404 405 407 409 295 310 314 383 385 384 386.0 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src