Ligand: M77 (Fasudil)

Total number of chains: 5
Active chains: 4
Total number of genes: 3
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 5 100.0% 5VEFA
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AGC CDC42BPB MRCKB_HUMAN 3TKUA Q9Y5S2 2 415 1711.0 M77:418,M77:419 Type1,Allosteric Active DFGin 6.602 13.355 BLAminus -143.03, 175.94 52.02, 80.01 -94.23, 18.83 305.33, 99.72 -66.85, -0.48 in-in in 8.858 Saltbr-in 2.916 HRD-in -68.08, -55.01 75.95, 5.48 in-in-in SNCiii in-in ActLoopNT-in 3.044 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.43, 163.82 APE9-dihe-na 93.99, -165.51 APE8-dihe-in -114.48, 131.1 APE8-rot-in 310.89 APE67-dihe-in -54.25, -25.55 -45.59, -49.4 APE12-dist-in 11.04 APE11-dist-in 11.04 APE10-dist-in 5.176 APE9-dist-in 3.762 None None None XRAY 2.15 0.223 0.273 A 433 395 0 0 0 0 [[76, 342]] 1.0 3tku AGC_CDC42BPB_HUMAN AGC 7.2e-96 326.3 1 260 260 217 218 219 221 223 105 124 128 197 199 198 200 263 246 241 240 239 238 237 236 235 154 Serine/threonine-protein kinase MRCK beta
AGC CDC42BPB MRCKB_HUMAN 3TKUB Q9Y5S2 2 415 1711.0 M77:418,M77:419 Type1,Allosteric Active DFGin 6.7 13.42 BLAminus -146.47, 178.95 50.88, 78.82 -93.25, 17.64 304.13, 100.62 -66.46, -1.59 in-in in 8.934 Saltbr-in 2.849 HRD-in -79.08, -52.56 75.39, 5.44 in-in-in SNCiii in-in ActLoopNT-in 3.022 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.41, 166.49 APE9-dihe-na 89.07, -163.52 APE8-dihe-in -118.0, 134.6 APE8-rot-in 310.18 APE67-dihe-in -54.07, -25.9 -51.37, -47.08 APE12-dist-in 11.06 APE11-dist-in 11.053 APE10-dist-in 5.192 APE9-dist-in 3.746 None None None XRAY 2.15 0.223 0.273 B 433 395 0 0 0 0 [[76, 342]] 1.0 3tku AGC_CDC42BPB_HUMAN AGC 7.2e-96 326.3 1 260 260 217 218 219 221 223 105 124 128 197 199 198 200 263 246 241 240 239 238 237 236 235 154 Serine/threonine-protein kinase MRCK beta
AGC ROCK1 ROCK1_HUMAN 2ESMA Q13464 6 405 1354.0 M77:60416 Type1 Active DFGin 6.105 13.688 BLAminus -120.74, 175.27 52.57, 92.93 -113.78, 23.07 302.86, 94.18 -55.5, -15.7 in-in in 8.584 Saltbr-in 2.762 HRD-in -64.55, -47.39 72.73, -12.37 in-in-in SNCiii in-in ActLoopNT-in 3.313 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.11, 156.73 APE9-dihe-na 129.25, -151.41 APE8-dihe-in -127.71, 135.99 APE8-rot-in 310.98 APE67-dihe-in -65.34, -28.12 -39.62, -57.01 APE12-dist-in 11.724 APE11-dist-in 11.453 APE10-dist-in 5.777 APE9-dist-in 3.535 None None None XRAY 3.2 0.245 0.269 A 415 400 0 0 0 0 [[76, 338]] 1.0 2esm AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 2ESMB Q13464 6 402 1354.0 M77:60416 Type1 Inactive DFGin 6.061 13.637 BLAminus -120.7, -179.63 48.01, 93.78 -115.66, 13.56 300.62, 93.21 -64.59, 23.21 in-in in 8.7 Saltbr-in 2.809 HRD-in -64.68, -48.55 75.56, -17.87 in-in-out SNCiio in-out ActLoopNT-in 3.202 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iioo APE10-dihe-na -120.49, 130.15 APE9-dihe-na -108.34, 137.67 APE8-dihe-out 42.68, 79.42 APE8-rot-out 61.99 APE67-dihe-in -35.68, -40.73 -70.2, -8.79 APE12-dist-in 8.402 APE11-dist-in 12.146 APE10-dist-out 11.118 APE9-dist-out 9.349 None None None XRAY 3.2 0.245 0.269 B 415 397 0 0 0 0 [[76, 338]] 1.0 2esm AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
STE PAK4 PAK4_HUMAN 5VEFA O96013 300 589 591.0 M77:601 Type1 Active DFGin 9.346 14.591 BLAminus -136.52, -176.88 59.47, 65.15 -89.64, 13.99 283.23, 80.94 -61.13, -20.52 in-in in 7.74 Saltbr-in 3.421 HRD-in -69.98, -53.91 75.95, 7.79 in-in-in SNCiii in-in ActLoopNT-in 2.864 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.13, 146.51 APE9-dihe-na 127.95, -160.54 APE8-dihe-in -118.96, 120.95 APE8-rot-in 302.31 APE67-dihe-in -69.34, -18.53 -36.63, -52.05 APE12-dist-in 8.781 APE11-dist-in 11.284 APE10-dist-in 5.646 APE9-dist-in 3.383 None SEP474 SEP474 XRAY 1.752 0.202 0.239 A 319 290 0 0 0 0 [[321, 572]] 1.0 5vef STE_PAK4_HUMAN STE 2.4e-88 301.8 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4

Ligand: M77 (Fasudil)

Total number of chains: 18
Active chains: 7
Total number of genes: 5
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 9 50.0% 5LCPA
DFGin BLAminus 9 50.0% 6EM2A
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AGC PRKACA KAPCA_BOVIN 2GNIA P00517 11 351 351.0 M77:60601 Type1 Inactive DFGin 6.122 13.339 ABAminus -125.47, 13.51 -148.05, 120.42 -113.28, 22.31 295.85, 71.04 -57.43, -24.9 in-in in 9.251 Saltbr-in 2.862 HRD-in -97.25, -49.49 72.22, 6.42 in-in-in SNCiii in-in ActLoopNT-in 2.99 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.86, 164.06 APE9-dihe-na 122.41, -161.87 APE8-dihe-in -119.99, 136.29 APE8-rot-in 295.68 APE67-dihe-in -63.27, -25.72 -47.9, -45.46 APE12-dist-in 8.141 APE11-dist-in 11.265 APE10-dist-in 5.779 APE9-dist-in 3.376 L50I,V124M,E128D,Q182K,T184A SEP11,TPO198,SEP339 SEP11,TPO198,SEP339 XRAY 2.27 0.192 0.268 A 350 341 0 0 0 0 [[44, 298]] 1.0 2gni Bos taurus AGC_PRKACA_BOVIN AGC 2.1e-95 324.8 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 1Q8WA P00517 15 351 351.0 M77:60960 Type1 Active DFGin 6.516 14.691 BLAminus -127.81, 164.07 85.37, 88.74 -113.2, 23.58 288.03, 80.25 -50.72, -40.77 in-in in 8.864 Saltbr-in 2.788 HRD-in -88.09, -59.12 85.64, -3.61 in-in-in SNCiii in-in ActLoopNT-in 3.125 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.12, 157.94 APE9-dihe-na 118.72, -168.38 APE8-dihe-in -118.75, 133.72 APE8-rot-in 300.62 APE67-dihe-in -62.19, -20.35 -49.36, -50.33 APE12-dist-in 8.427 APE11-dist-in 11.788 APE10-dist-in 6.4 APE9-dist-in 4.06 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.2 0.22 0.295 A 350 337 0 0 0 0 [[44, 298]] 1.0 1q8w Bos taurus AGC_PRKACA_BOVIN AGC 1.3e-94 322.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC ROCK2 ROCK2_BOVIN 2F2UA Q28021 27 417 1388.0 M77:501 Type1 Inactive DFGin 6.154 13.964 ABAminus -125.36, 20.74 -155.97, 132.58 -140.63, 28.66 305.18, 93.77 -61.1, -20.63 in-in in 9.201 Saltbr-in 2.848 HRD-in -71.0, -56.95 70.45, 14.05 in-in-out SNCiio in-out ActLoopNT-in 3.1 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -125.24, 160.08 APE9-dihe-na 106.51, 163.99 APE8-dihe-in -75.45, 135.55 APE8-rot-out 188.78 APE67-dihe-in -58.72, -25.7 -36.99, -50.18 APE12-dist-in 9.876 APE11-dist-in 11.655 APE10-dist-in 5.753 APE9-dist-in 3.774 None None None XRAY 2.4 0.197 0.235 A 402 386 0 0 0 0 [[92, 354]] 1.0 2f2u Bos taurus AGC_ROCK2_BOVIN AGC 2.6e-93 317.9 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_BOVIN 2F2UB Q28021 27 417 1388.0 M77:1501 Type1 Inactive DFGin 6.161 13.252 BLAminus -137.47, 174.34 55.62, 88.13 -108.95, 28.93 305.37, 102.14 -67.94, -16.5 in-in in 8.356 Saltbr-in 3.031 HRD-in -77.45, -48.84 68.99, 13.39 in-in-out SNCiio in-out ActLoopNT-in 2.944 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioo APE10-dihe-na -93.52, 138.42 APE9-dihe-na -106.28, -104.32 APE8-dihe-in -64.29, 128.15 APE8-rot-in 304.0 APE67-dihe-in -52.28, -37.75 -95.33, 10.69 APE12-dist-out 5.164 APE11-dist-in 9.625 APE10-dist-out 10.117 APE9-dist-out 9.097 None None None XRAY 2.4 0.197 0.235 B 402 383 0 0 0 0 [[92, 354]] 1.0 2f2u Bos taurus AGC_ROCK2_BOVIN AGC 2.6e-93 317.9 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC PRKACA KAPCA_CRIGR 5NW8A P25321 12 351 351.0 M77:60402 Type1 Inactive DFGin 6.336 14.386 ABAminus -118.68, -32.42 -99.03, 121.53 -122.45, 23.74 290.12, 82.65 -65.48, -23.88 in-in in 8.884 Saltbr-in 2.705 HRD-in -87.46, -57.12 74.8, 8.43 in-in-in SNCiii in-in ActLoopNT-in 2.909 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.41, 158.53 APE9-dihe-na 124.11, -167.34 APE8-dihe-in -113.09, 136.58 APE8-rot-in 301.73 APE67-dihe-in -53.51, -29.49 -47.53, -53.31 APE12-dist-in 8.204 APE11-dist-in 11.556 APE10-dist-in 5.922 APE9-dist-in 3.772 None SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 2.086 0.178 0.212 A 351 340 0 0 0 0 [[44, 298]] 1.0 5nw8 Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.5e-95 323.3 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_CRIGR 5LCPA P25321 1 351 351.0 M77:60401 Type1 Inactive DFGin 6.513 14.567 ABAminus -121.65, -30.45 -98.92, 119.1 -122.07, 18.29 284.17, 84.65 -65.16, -27.53 in-in in 8.899 Saltbr-in 2.759 HRD-in -92.61, -56.98 71.24, 5.31 in-in-in SNCiii in-in ActLoopNT-in 2.916 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.37, 152.55 APE9-dihe-na 132.49, -162.49 APE8-dihe-in -118.01, 135.22 APE8-rot-in 296.96 APE67-dihe-in -61.44, -24.53 -48.46, -49.38 APE12-dist-in 8.187 APE11-dist-in 11.476 APE10-dist-in 5.922 APE9-dist-in 3.949 None SEP11,TPO198,SEP339 SEP11,TPO198,SEP339 XRAY 1.433 0.134 0.166 A 353 351 0 0 0 0 [[44, 298]] 1.0 5lcp Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.6e-95 323.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_CRIGR 5O0EA P25321 1 351 351.0 M77:60401 Type1 Inactive DFGin 6.523 14.455 ABAminus -120.87, -28.54 -98.9, 119.84 -125.0, 19.69 283.23, 84.18 -67.0, -26.17 in-in in 8.861 Saltbr-in 2.786 HRD-in -91.49, -57.65 74.16, -1.91 in-in-in SNCiii in-in ActLoopNT-in 2.926 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.49, 154.58 APE9-dihe-na 133.99, -164.02 APE8-dihe-in -122.83, 136.35 APE8-rot-in 298.08 APE67-dihe-in -61.85, -22.28 -48.99, -49.98 APE12-dist-in 8.187 APE11-dist-in 11.413 APE10-dist-in 5.874 APE9-dist-in 4.06 None SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 1.5 0.133 0.17 A 353 351 0 0 0 0 [[44, 298]] 1.0 5o0e Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.6e-95 323.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_CRIGR 5OK3A P25321 1 351 351.0 M77:60401 Type1 Inactive DFGin 6.615 14.415 ABAminus -120.44, -31.18 -98.89, 117.63 -123.6, 23.39 284.71, 82.73 -69.59, -23.81 in-in in 8.934 Saltbr-in 2.739 HRD-in -95.2, -57.86 72.09, 2.44 in-in-in SNCiii in-in ActLoopNT-in 2.925 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.84, 153.6 APE9-dihe-na 133.87, -163.65 APE8-dihe-in -122.15, 135.18 APE8-rot-in 299.79 APE67-dihe-in -60.82, -23.36 -49.17, -49.56 APE12-dist-in 8.219 APE11-dist-in 11.466 APE10-dist-in 5.878 APE9-dist-in 4.055 None SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 1.588 0.141 0.172 A 353 351 0 0 0 0 [[44, 298]] 1.0 5ok3 Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.6e-95 323.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_CRIGR 6ERWA P25321 1 351 351.0 M77:60401 Type1 Inactive DFGin 6.401 14.47 ABAminus -121.15, -34.81 -95.55, 109.86 -114.31, 21.73 291.27, 86.69 -64.06, -18.67 in-in in 8.902 Saltbr-in 2.874 HRD-in -86.55, -59.04 70.6, 12.67 in-in-in SNCiii in-in ActLoopNT-in 2.896 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.31, 155.57 APE9-dihe-na 122.97, -167.43 APE8-dihe-in -109.73, 134.74 APE8-rot-in 295.31 APE67-dihe-in -57.25, -24.48 -52.2, -50.35 APE12-dist-in 8.161 APE11-dist-in 11.455 APE10-dist-in 5.864 APE9-dist-in 3.846 None SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 1.89 0.195 0.229 A 353 348 3 0 0 0 [[44, 298]] 1.0 6erw Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.6e-95 323.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_CRIGR 6I2AA P25321 1 351 351.0 M77:60401 Type1 Inactive DFGin 6.628 14.635 ABAminus -122.01, -33.61 -93.89, 119.82 -124.65, 22.24 282.35, 82.22 -67.92, -23.48 in-in in 9.193 Saltbr-in 2.561 HRD-in -101.03, -58.68 69.95, -0.61 in-in-in SNCiii in-in ActLoopNT-in 2.941 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.26, 150.72 APE9-dihe-na 137.51, -163.36 APE8-dihe-in -120.26, 133.94 APE8-rot-in 301.03 APE67-dihe-in -62.45, -25.53 -48.16, -48.1 APE12-dist-in 8.121 APE11-dist-in 11.44 APE10-dist-in 5.894 APE9-dist-in 4.154 None SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 1.75 0.175 0.207 A 353 351 0 0 0 0 [[44, 298]] 1.0 6i2a Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.6e-95 323.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_CRIGR 6I2CA P25321 12 351 351.0 M77:60401 Type1 Inactive DFGin 6.5 14.606 ABAminus -115.95, -34.45 -102.09, 116.9 -120.62, 23.53 285.01, 87.65 -68.52, -23.98 in-in in 8.846 Saltbr-in 2.92 HRD-in -86.43, -55.89 76.54, -1.15 in-in-in SNCiii in-in ActLoopNT-in 2.944 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.94, 153.26 APE9-dihe-na 129.65, -163.32 APE8-dihe-in -118.65, 136.78 APE8-rot-in 299.53 APE67-dihe-in -56.88, -28.13 -49.75, -50.61 APE12-dist-in 8.304 APE11-dist-in 11.519 APE10-dist-in 5.897 APE9-dist-in 3.716 None SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 1.82 0.187 0.221 A 353 338 2 0 0 0 [[44, 298]] 1.0 6i2c Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.6e-95 323.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_CRIGR 6EM2A P25321 12 351 351.0 M77:60401 Type1 Active DFGin 6.098 14.514 BLAminus -119.73, 168.43 71.45, 87.62 -96.71, 20.34 273.03, 58.25 -60.57, -24.08 in-in in 8.84 Saltbr-in 2.67 HRD-in -89.33, -54.43 71.02, 10.57 in-in-in SNCiii in-in ActLoopNT-in 2.944 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.33, 158.5 APE9-dihe-na 116.31, 173.93 APE8-dihe-in -92.1, 134.84 APE8-rot-in 313.8 APE67-dihe-in -63.32, -22.08 -46.46, -47.85 APE12-dist-in 8.065 APE11-dist-in 11.281 APE10-dist-in 5.803 APE9-dist-in 4.039 None SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 1.3 0.133 0.152 A 353 340 0 0 0 0 [[44, 298]] 1.0 6em2 Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.6e-95 323.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_CRIGR 6YNAA P25321 1 351 351.0 M77:60402 Type1 Active DFGin 6.202 14.334 BLAminus -119.96, 179.81 63.19, 78.66 -92.28, 22.25 273.96, 61.01 -60.67, -22.0 in-in in 8.696 Saltbr-in 2.64 HRD-in -90.85, -54.18 73.93, 11.37 in-in-in SNCiii in-in ActLoopNT-in 2.923 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.28, 159.25 APE9-dihe-na 133.12, -164.07 APE8-dihe-in -114.68, 130.03 APE8-rot-in 297.53 APE67-dihe-in -61.88, -21.65 -45.58, -51.04 APE12-dist-in 8.276 APE11-dist-in 11.637 APE10-dist-in 6.136 APE9-dist-in 3.765 None SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 1.47 0.165 0.189 A 353 351 0 0 0 0 [[44, 298]] 1.0 6yna Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.6e-95 323.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC CDC42BPB MRCKB_HUMAN 3TKUA Q9Y5S2 2 415 1711.0 M77:418,M77:419 Type1,Allosteric Active DFGin 6.602 13.355 BLAminus -143.03, 175.94 52.02, 80.01 -94.23, 18.83 305.33, 99.72 -66.85, -0.48 in-in in 8.858 Saltbr-in 2.916 HRD-in -68.08, -55.01 75.95, 5.48 in-in-in SNCiii in-in ActLoopNT-in 3.044 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.43, 163.82 APE9-dihe-na 93.99, -165.51 APE8-dihe-in -114.48, 131.1 APE8-rot-in 310.89 APE67-dihe-in -54.25, -25.55 -45.59, -49.4 APE12-dist-in 11.04 APE11-dist-in 11.04 APE10-dist-in 5.176 APE9-dist-in 3.762 None None None XRAY 2.15 0.223 0.273 A 433 395 0 0 0 0 [[76, 342]] 1.0 3tku Homo sapiens AGC_CDC42BPB_HUMAN AGC 7.2e-96 326.3 1 260 260 217 218 219 221 223 105 124 128 197 199 198 200 263 246 241 240 239 238 237 236 235 154 Serine/threonine-protein kinase MRCK beta
AGC CDC42BPB MRCKB_HUMAN 3TKUB Q9Y5S2 2 415 1711.0 M77:418,M77:419 Type1,Allosteric Active DFGin 6.7 13.42 BLAminus -146.47, 178.95 50.88, 78.82 -93.25, 17.64 304.13, 100.62 -66.46, -1.59 in-in in 8.934 Saltbr-in 2.849 HRD-in -79.08, -52.56 75.39, 5.44 in-in-in SNCiii in-in ActLoopNT-in 3.022 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.41, 166.49 APE9-dihe-na 89.07, -163.52 APE8-dihe-in -118.0, 134.6 APE8-rot-in 310.18 APE67-dihe-in -54.07, -25.9 -51.37, -47.08 APE12-dist-in 11.06 APE11-dist-in 11.053 APE10-dist-in 5.192 APE9-dist-in 3.746 None None None XRAY 2.15 0.223 0.273 B 433 395 0 0 0 0 [[76, 342]] 1.0 3tku Homo sapiens AGC_CDC42BPB_HUMAN AGC 7.2e-96 326.3 1 260 260 217 218 219 221 223 105 124 128 197 199 198 200 263 246 241 240 239 238 237 236 235 154 Serine/threonine-protein kinase MRCK beta
AGC ROCK1 ROCK1_HUMAN 2ESMA Q13464 6 405 1354.0 M77:60416 Type1 Active DFGin 6.105 13.688 BLAminus -120.74, 175.27 52.57, 92.93 -113.78, 23.07 302.86, 94.18 -55.5, -15.7 in-in in 8.584 Saltbr-in 2.762 HRD-in -64.55, -47.39 72.73, -12.37 in-in-in SNCiii in-in ActLoopNT-in 3.313 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.11, 156.73 APE9-dihe-na 129.25, -151.41 APE8-dihe-in -127.71, 135.99 APE8-rot-in 310.98 APE67-dihe-in -65.34, -28.12 -39.62, -57.01 APE12-dist-in 11.724 APE11-dist-in 11.453 APE10-dist-in 5.777 APE9-dist-in 3.535 None None None XRAY 3.2 0.245 0.269 A 415 400 0 0 0 0 [[76, 338]] 1.0 2esm Homo sapiens AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 2ESMB Q13464 6 402 1354.0 M77:60416 Type1 Inactive DFGin 6.061 13.637 BLAminus -120.7, -179.63 48.01, 93.78 -115.66, 13.56 300.62, 93.21 -64.59, 23.21 in-in in 8.7 Saltbr-in 2.809 HRD-in -64.68, -48.55 75.56, -17.87 in-in-out SNCiio in-out ActLoopNT-in 3.202 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iioo APE10-dihe-na -120.49, 130.15 APE9-dihe-na -108.34, 137.67 APE8-dihe-out 42.68, 79.42 APE8-rot-out 61.99 APE67-dihe-in -35.68, -40.73 -70.2, -8.79 APE12-dist-in 8.402 APE11-dist-in 12.146 APE10-dist-out 11.118 APE9-dist-out 9.349 None None None XRAY 3.2 0.245 0.269 B 415 397 0 0 0 0 [[76, 338]] 1.0 2esm Homo sapiens AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
STE PAK4 PAK4_HUMAN 5VEFA O96013 300 589 591.0 M77:601 Type1 Active DFGin 9.346 14.591 BLAminus -136.52, -176.88 59.47, 65.15 -89.64, 13.99 283.23, 80.94 -61.13, -20.52 in-in in 7.74 Saltbr-in 3.421 HRD-in -69.98, -53.91 75.95, 7.79 in-in-in SNCiii in-in ActLoopNT-in 2.864 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.13, 146.51 APE9-dihe-na 127.95, -160.54 APE8-dihe-in -118.96, 120.95 APE8-rot-in 302.31 APE67-dihe-in -69.34, -18.53 -36.63, -52.05 APE12-dist-in 8.781 APE11-dist-in 11.284 APE10-dist-in 5.646 APE9-dist-in 3.383 None SEP474 SEP474 XRAY 1.752 0.202 0.239 A 319 290 0 0 0 0 [[321, 572]] 1.0 5vef Homo sapiens STE_PAK4_HUMAN STE 2.4e-88 301.8 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4

Ligand: M77 (Fasudil)

Total number of chains: 13
Active chains: 3
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 9 69.2% 5LCPA
DFGin BLAminus 4 30.8% 6EM2A
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AGC PRKACA KAPCA_BOVIN 2GNIA P00517 11 351 351.0 M77:60601 Type1 Inactive DFGin 6.122 13.339 ABAminus -125.47, 13.51 -148.05, 120.42 -113.28, 22.31 295.85, 71.04 -57.43, -24.9 in-in in 9.251 Saltbr-in 2.862 HRD-in -97.25, -49.49 72.22, 6.42 in-in-in SNCiii in-in ActLoopNT-in 2.99 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.86, 164.06 APE9-dihe-na 122.41, -161.87 APE8-dihe-in -119.99, 136.29 APE8-rot-in 295.68 APE67-dihe-in -63.27, -25.72 -47.9, -45.46 APE12-dist-in 8.141 APE11-dist-in 11.265 APE10-dist-in 5.779 APE9-dist-in 3.376 L50I,V124M,E128D,Q182K,T184A SEP11,TPO198,SEP339 SEP11,TPO198,SEP339 XRAY 2.27 0.192 0.268 A 350 341 0 0 0 0 [[44, 298]] 1.0 2gni Bos taurus AGC_PRKACA_BOVIN AGC 2.1e-95 324.8 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 1Q8WA P00517 15 351 351.0 M77:60960 Type1 Active DFGin 6.516 14.691 BLAminus -127.81, 164.07 85.37, 88.74 -113.2, 23.58 288.03, 80.25 -50.72, -40.77 in-in in 8.864 Saltbr-in 2.788 HRD-in -88.09, -59.12 85.64, -3.61 in-in-in SNCiii in-in ActLoopNT-in 3.125 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.12, 157.94 APE9-dihe-na 118.72, -168.38 APE8-dihe-in -118.75, 133.72 APE8-rot-in 300.62 APE67-dihe-in -62.19, -20.35 -49.36, -50.33 APE12-dist-in 8.427 APE11-dist-in 11.788 APE10-dist-in 6.4 APE9-dist-in 4.06 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.2 0.22 0.295 A 350 337 0 0 0 0 [[44, 298]] 1.0 1q8w Bos taurus AGC_PRKACA_BOVIN AGC 1.3e-94 322.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC ROCK2 ROCK2_BOVIN 2F2UA Q28021 27 417 1388.0 M77:501 Type1 Inactive DFGin 6.154 13.964 ABAminus -125.36, 20.74 -155.97, 132.58 -140.63, 28.66 305.18, 93.77 -61.1, -20.63 in-in in 9.201 Saltbr-in 2.848 HRD-in -71.0, -56.95 70.45, 14.05 in-in-out SNCiio in-out ActLoopNT-in 3.1 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -125.24, 160.08 APE9-dihe-na 106.51, 163.99 APE8-dihe-in -75.45, 135.55 APE8-rot-out 188.78 APE67-dihe-in -58.72, -25.7 -36.99, -50.18 APE12-dist-in 9.876 APE11-dist-in 11.655 APE10-dist-in 5.753 APE9-dist-in 3.774 None None None XRAY 2.4 0.197 0.235 A 402 386 0 0 0 0 [[92, 354]] 1.0 2f2u Bos taurus AGC_ROCK2_BOVIN AGC 2.6e-93 317.9 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_BOVIN 2F2UB Q28021 27 417 1388.0 M77:1501 Type1 Inactive DFGin 6.161 13.252 BLAminus -137.47, 174.34 55.62, 88.13 -108.95, 28.93 305.37, 102.14 -67.94, -16.5 in-in in 8.356 Saltbr-in 3.031 HRD-in -77.45, -48.84 68.99, 13.39 in-in-out SNCiio in-out ActLoopNT-in 2.944 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioo APE10-dihe-na -93.52, 138.42 APE9-dihe-na -106.28, -104.32 APE8-dihe-in -64.29, 128.15 APE8-rot-in 304.0 APE67-dihe-in -52.28, -37.75 -95.33, 10.69 APE12-dist-out 5.164 APE11-dist-in 9.625 APE10-dist-out 10.117 APE9-dist-out 9.097 None None None XRAY 2.4 0.197 0.235 B 402 383 0 0 0 0 [[92, 354]] 1.0 2f2u Bos taurus AGC_ROCK2_BOVIN AGC 2.6e-93 317.9 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC PRKACA KAPCA_CRIGR 5NW8A P25321 12 351 351.0 M77:60402 Type1 Inactive DFGin 6.336 14.386 ABAminus -118.68, -32.42 -99.03, 121.53 -122.45, 23.74 290.12, 82.65 -65.48, -23.88 in-in in 8.884 Saltbr-in 2.705 HRD-in -87.46, -57.12 74.8, 8.43 in-in-in SNCiii in-in ActLoopNT-in 2.909 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.41, 158.53 APE9-dihe-na 124.11, -167.34 APE8-dihe-in -113.09, 136.58 APE8-rot-in 301.73 APE67-dihe-in -53.51, -29.49 -47.53, -53.31 APE12-dist-in 8.204 APE11-dist-in 11.556 APE10-dist-in 5.922 APE9-dist-in 3.772 None SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 2.086 0.178 0.212 A 351 340 0 0 0 0 [[44, 298]] 1.0 5nw8 Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.5e-95 323.3 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_CRIGR 5LCPA P25321 1 351 351.0 M77:60401 Type1 Inactive DFGin 6.513 14.567 ABAminus -121.65, -30.45 -98.92, 119.1 -122.07, 18.29 284.17, 84.65 -65.16, -27.53 in-in in 8.899 Saltbr-in 2.759 HRD-in -92.61, -56.98 71.24, 5.31 in-in-in SNCiii in-in ActLoopNT-in 2.916 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.37, 152.55 APE9-dihe-na 132.49, -162.49 APE8-dihe-in -118.01, 135.22 APE8-rot-in 296.96 APE67-dihe-in -61.44, -24.53 -48.46, -49.38 APE12-dist-in 8.187 APE11-dist-in 11.476 APE10-dist-in 5.922 APE9-dist-in 3.949 None SEP11,TPO198,SEP339 SEP11,TPO198,SEP339 XRAY 1.433 0.134 0.166 A 353 351 0 0 0 0 [[44, 298]] 1.0 5lcp Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.6e-95 323.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_CRIGR 5O0EA P25321 1 351 351.0 M77:60401 Type1 Inactive DFGin 6.523 14.455 ABAminus -120.87, -28.54 -98.9, 119.84 -125.0, 19.69 283.23, 84.18 -67.0, -26.17 in-in in 8.861 Saltbr-in 2.786 HRD-in -91.49, -57.65 74.16, -1.91 in-in-in SNCiii in-in ActLoopNT-in 2.926 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.49, 154.58 APE9-dihe-na 133.99, -164.02 APE8-dihe-in -122.83, 136.35 APE8-rot-in 298.08 APE67-dihe-in -61.85, -22.28 -48.99, -49.98 APE12-dist-in 8.187 APE11-dist-in 11.413 APE10-dist-in 5.874 APE9-dist-in 4.06 None SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 1.5 0.133 0.17 A 353 351 0 0 0 0 [[44, 298]] 1.0 5o0e Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.6e-95 323.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_CRIGR 5OK3A P25321 1 351 351.0 M77:60401 Type1 Inactive DFGin 6.615 14.415 ABAminus -120.44, -31.18 -98.89, 117.63 -123.6, 23.39 284.71, 82.73 -69.59, -23.81 in-in in 8.934 Saltbr-in 2.739 HRD-in -95.2, -57.86 72.09, 2.44 in-in-in SNCiii in-in ActLoopNT-in 2.925 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.84, 153.6 APE9-dihe-na 133.87, -163.65 APE8-dihe-in -122.15, 135.18 APE8-rot-in 299.79 APE67-dihe-in -60.82, -23.36 -49.17, -49.56 APE12-dist-in 8.219 APE11-dist-in 11.466 APE10-dist-in 5.878 APE9-dist-in 4.055 None SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 1.588 0.141 0.172 A 353 351 0 0 0 0 [[44, 298]] 1.0 5ok3 Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.6e-95 323.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_CRIGR 6ERWA P25321 1 351 351.0 M77:60401 Type1 Inactive DFGin 6.401 14.47 ABAminus -121.15, -34.81 -95.55, 109.86 -114.31, 21.73 291.27, 86.69 -64.06, -18.67 in-in in 8.902 Saltbr-in 2.874 HRD-in -86.55, -59.04 70.6, 12.67 in-in-in SNCiii in-in ActLoopNT-in 2.896 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.31, 155.57 APE9-dihe-na 122.97, -167.43 APE8-dihe-in -109.73, 134.74 APE8-rot-in 295.31 APE67-dihe-in -57.25, -24.48 -52.2, -50.35 APE12-dist-in 8.161 APE11-dist-in 11.455 APE10-dist-in 5.864 APE9-dist-in 3.846 None SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 1.89 0.195 0.229 A 353 348 3 0 0 0 [[44, 298]] 1.0 6erw Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.6e-95 323.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_CRIGR 6I2AA P25321 1 351 351.0 M77:60401 Type1 Inactive DFGin 6.628 14.635 ABAminus -122.01, -33.61 -93.89, 119.82 -124.65, 22.24 282.35, 82.22 -67.92, -23.48 in-in in 9.193 Saltbr-in 2.561 HRD-in -101.03, -58.68 69.95, -0.61 in-in-in SNCiii in-in ActLoopNT-in 2.941 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.26, 150.72 APE9-dihe-na 137.51, -163.36 APE8-dihe-in -120.26, 133.94 APE8-rot-in 301.03 APE67-dihe-in -62.45, -25.53 -48.16, -48.1 APE12-dist-in 8.121 APE11-dist-in 11.44 APE10-dist-in 5.894 APE9-dist-in 4.154 None SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 1.75 0.175 0.207 A 353 351 0 0 0 0 [[44, 298]] 1.0 6i2a Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.6e-95 323.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_CRIGR 6I2CA P25321 12 351 351.0 M77:60401 Type1 Inactive DFGin 6.5 14.606 ABAminus -115.95, -34.45 -102.09, 116.9 -120.62, 23.53 285.01, 87.65 -68.52, -23.98 in-in in 8.846 Saltbr-in 2.92 HRD-in -86.43, -55.89 76.54, -1.15 in-in-in SNCiii in-in ActLoopNT-in 2.944 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.94, 153.26 APE9-dihe-na 129.65, -163.32 APE8-dihe-in -118.65, 136.78 APE8-rot-in 299.53 APE67-dihe-in -56.88, -28.13 -49.75, -50.61 APE12-dist-in 8.304 APE11-dist-in 11.519 APE10-dist-in 5.897 APE9-dist-in 3.716 None SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 1.82 0.187 0.221 A 353 338 2 0 0 0 [[44, 298]] 1.0 6i2c Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.6e-95 323.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_CRIGR 6EM2A P25321 12 351 351.0 M77:60401 Type1 Active DFGin 6.098 14.514 BLAminus -119.73, 168.43 71.45, 87.62 -96.71, 20.34 273.03, 58.25 -60.57, -24.08 in-in in 8.84 Saltbr-in 2.67 HRD-in -89.33, -54.43 71.02, 10.57 in-in-in SNCiii in-in ActLoopNT-in 2.944 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.33, 158.5 APE9-dihe-na 116.31, 173.93 APE8-dihe-in -92.1, 134.84 APE8-rot-in 313.8 APE67-dihe-in -63.32, -22.08 -46.46, -47.85 APE12-dist-in 8.065 APE11-dist-in 11.281 APE10-dist-in 5.803 APE9-dist-in 4.039 None SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 1.3 0.133 0.152 A 353 340 0 0 0 0 [[44, 298]] 1.0 6em2 Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.6e-95 323.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_CRIGR 6YNAA P25321 1 351 351.0 M77:60402 Type1 Active DFGin 6.202 14.334 BLAminus -119.96, 179.81 63.19, 78.66 -92.28, 22.25 273.96, 61.01 -60.67, -22.0 in-in in 8.696 Saltbr-in 2.64 HRD-in -90.85, -54.18 73.93, 11.37 in-in-in SNCiii in-in ActLoopNT-in 2.923 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.28, 159.25 APE9-dihe-na 133.12, -164.07 APE8-dihe-in -114.68, 130.03 APE8-rot-in 297.53 APE67-dihe-in -61.88, -21.65 -45.58, -51.04 APE12-dist-in 8.276 APE11-dist-in 11.637 APE10-dist-in 6.136 APE9-dist-in 3.765 None SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 1.47 0.165 0.189 A 353 351 0 0 0 0 [[44, 298]] 1.0 6yna Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.6e-95 323.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha