Ligand: KY9

Total number of chains: 3
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAplus 2 66.7% 8A2AA
DFGin BLBplus 1 33.3% 8A2BA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR EGFR EGFR_HUMAN 8A27A P00533 701 985 1210.0 KY9:1102 Type3 Inactive DFGin 5.6719 14.3813 BLAplus -145.52, -178.77 57.22, 42.47 -100.42, -1.68 47.88, 94.3 -89.32, 20.08 out-out out 13.2375 Saltbr-out 11.7141 HRD-in -70.42, -54.97 75.01, -8.44 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 122.04 APE8-dihe-in -81.29, 59.61 APE8-rot-na 35.43 APE67-dihe-in -73.27, -7.01 -50.89, -40.08 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.4843 None None None XRAY 1.07 0.126 0.16 A 326.0 269.0 16 30 14 16 [[712, 970]] 1.0 8a27 TYR_EGFR_HUMAN TYR 1e-87 299.8 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8A2AA P00533 700 1019 1210.0 KY9:1101 Type3 Inactive DFGin 5.1166 14.3564 BLAplus -139.34, 175.57 57.42, 45.45 -97.33, -2.42 49.8, 85.36 -104.26, 24.72 out-out out 13.6372 Saltbr-out 12.2545 HRD-in -68.19, -54.53 72.52, -7.02 out-out-out SNCooo out-out ActLoopNT-out 6.6205 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 117.68 APE8-dihe-in -79.56, 62.59 APE8-rot-na 33.47 APE67-dihe-in -77.17, -2.3 -52.5, -40.39 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.0375 None None None XRAY 1.43 0.19 0.223 A 326.0 306.0 8 30 22 8 [[712, 970]] 1.0 8a2a TYR_EGFR_HUMAN TYR 1e-87 299.8 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8A2BA P00533 702 990 1210.0 KY9:1101 Type3 Inactive DFGin 5.4256 14.4349 BLBplus -143.53, -174.33 44.34, 37.79 -92.75, 167.36 44.38, 91.12 110.41, -145.91 out-out out 13.2465 Saltbr-out 12.2604 HRD-in -75.49, -60.69 77.7, -7.21 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 108.84 APE8-dihe-in -84.13, 67.89 APE8-rot-na 33.21 APE67-dihe-in -76.37, -2.66 -52.66, -40.29 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.0656 L858R,V948R None None XRAY 1.69 0.212 0.258 A 326.0 272.0 17 30 13 17 [[712, 970]] 1.0 8a2b TYR_EGFR_HUMAN TYR 8.1e-87 296.9 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor

Ligand: KY9

Total number of chains: 3
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAplus 2 66.7% 8A2AA
DFGin BLBplus 1 33.3% 8A2BA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR EGFR EGFR_HUMAN 8A27A P00533 701 985 1210.0 KY9:1102 Type3 Inactive DFGin 5.6719 14.3813 BLAplus -145.52, -178.77 57.22, 42.47 -100.42, -1.68 47.88, 94.3 -89.32, 20.08 out-out out 13.2375 Saltbr-out 11.7141 HRD-in -70.42, -54.97 75.01, -8.44 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 122.04 APE8-dihe-in -81.29, 59.61 APE8-rot-na 35.43 APE67-dihe-in -73.27, -7.01 -50.89, -40.08 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.4843 None None None XRAY 1.07 0.126 0.16 A 326.0 269.0 16 30 14 16 [[712, 970]] 1.0 8a27 Homo sapiens TYR_EGFR_HUMAN TYR 1e-87 299.8 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8A2AA P00533 700 1019 1210.0 KY9:1101 Type3 Inactive DFGin 5.1166 14.3564 BLAplus -139.34, 175.57 57.42, 45.45 -97.33, -2.42 49.8, 85.36 -104.26, 24.72 out-out out 13.6372 Saltbr-out 12.2545 HRD-in -68.19, -54.53 72.52, -7.02 out-out-out SNCooo out-out ActLoopNT-out 6.6205 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 117.68 APE8-dihe-in -79.56, 62.59 APE8-rot-na 33.47 APE67-dihe-in -77.17, -2.3 -52.5, -40.39 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.0375 None None None XRAY 1.43 0.19 0.223 A 326.0 306.0 8 30 22 8 [[712, 970]] 1.0 8a2a Homo sapiens TYR_EGFR_HUMAN TYR 1e-87 299.8 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8A2BA P00533 702 990 1210.0 KY9:1101 Type3 Inactive DFGin 5.4256 14.4349 BLBplus -143.53, -174.33 44.34, 37.79 -92.75, 167.36 44.38, 91.12 110.41, -145.91 out-out out 13.2465 Saltbr-out 12.2604 HRD-in -75.49, -60.69 77.7, -7.21 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 108.84 APE8-dihe-in -84.13, 67.89 APE8-rot-na 33.21 APE67-dihe-in -76.37, -2.66 -52.66, -40.29 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.0656 L858R,V948R None None XRAY 1.69 0.212 0.258 A 326.0 272.0 17 30 13 17 [[712, 970]] 1.0 8a2b Homo sapiens TYR_EGFR_HUMAN TYR 8.1e-87 296.9 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor

Ligand: KY9

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name