Ligand: J2V

Total number of chains: 2
Active chains: 1
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 100.0% 5QILA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TKL TGFBR1 TGFR1_HUMAN 5QILA P36897 200 499 503.0 J2V:60601 Type1 Active DFGin 6.1235 12.8928 BLAminus -133.55, -173.28 54.13, 68.92 -94.29, 10.19 306.15, 4.81 -59.56, -26.12 in-in in 7.7817 Saltbr-in 3.0119 HRD-in -72.26, -48.55 71.72, 0.05 in-in-in SNCiii in-in ActLoopNT-in 2.9767 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -84.42, -32.81 APE9-dihe-na -79.5, -152.05 APE8-dihe-in -86.88, 119.67 APE8-rot-in 305.45 APE67-dihe-in -55.45, -33.57 -52.15, -44.93 APE12-dist-in 12.8387 APE11-dist-in 12.2774 APE10-dist-in 6.1526 APE9-dist-in 3.7916 T204D None None XRAY 1.98 0.171 0.21 A 307.0 300.0 0 32 32 0 [[205, 494]] 1.0 5qil TKL_TGFBR1_HUMAN TKL 3.3e-85 291.7 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TKL TGFBR2 TGFR2_HUMAN 5QINA P37173 240 541 567.0 J2V:601 Type1 None DFGin 7.4322 13.6924 BLAminus -160.38, -171.51 70.13, 63.56 -97.31, 22.31 300.17, 115.61 -64.51, -28.45 in-in in 7.7525 Saltbr-in 2.968 HRD-in -64.72, -51.48 70.07, 3.51 in-in-none SNCiin in-none ActLoopNT-in 2.9449 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_niii APE10-dihe-na -105.98, 157.24 APE9-dihe-na 110.69, -170.54 APE8-dihe-in -92.43, 119.77 APE8-rot-in 303.14 APE67-dihe-in -57.21, -32.74 -53.66, -41.1 APE12-dist-none 999.0 APE11-dist-in 12.1938 APE10-dist-in 6.0999 APE9-dist-in 3.9176 E431A,R433A,E485A,K488A,R493A,R495A None None XRAY 1.57 0.188 0.203 A 316.0 295.0 7 32 30 2 [[244, 540]] 1.0 5qin TKL_TGFBR2_HUMAN TKL 1.9e-77 266.3 2.0 266.0 265.0 396 397 398 400 402 277 290 294 376 378 377 379.0 446 428 423 422 421 420 419 418 417 326 TGF-beta receptor type-2

Ligand: J2V

Total number of chains: 2
Active chains: 1
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 100.0% 5QILA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TKL TGFBR1 TGFR1_HUMAN 5QILA P36897 200 499 503.0 J2V:60601 Type1 Active DFGin 6.1235 12.8928 BLAminus -133.55, -173.28 54.13, 68.92 -94.29, 10.19 306.15, 4.81 -59.56, -26.12 in-in in 7.7817 Saltbr-in 3.0119 HRD-in -72.26, -48.55 71.72, 0.05 in-in-in SNCiii in-in ActLoopNT-in 2.9767 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -84.42, -32.81 APE9-dihe-na -79.5, -152.05 APE8-dihe-in -86.88, 119.67 APE8-rot-in 305.45 APE67-dihe-in -55.45, -33.57 -52.15, -44.93 APE12-dist-in 12.8387 APE11-dist-in 12.2774 APE10-dist-in 6.1526 APE9-dist-in 3.7916 T204D None None XRAY 1.98 0.171 0.21 A 307.0 300.0 0 32 32 0 [[205, 494]] 1.0 5qil Homo sapiens TKL_TGFBR1_HUMAN TKL 3.3e-85 291.7 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TKL TGFBR2 TGFR2_HUMAN 5QINA P37173 240 541 567.0 J2V:601 Type1 None DFGin 7.4322 13.6924 BLAminus -160.38, -171.51 70.13, 63.56 -97.31, 22.31 300.17, 115.61 -64.51, -28.45 in-in in 7.7525 Saltbr-in 2.968 HRD-in -64.72, -51.48 70.07, 3.51 in-in-none SNCiin in-none ActLoopNT-in 2.9449 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_niii APE10-dihe-na -105.98, 157.24 APE9-dihe-na 110.69, -170.54 APE8-dihe-in -92.43, 119.77 APE8-rot-in 303.14 APE67-dihe-in -57.21, -32.74 -53.66, -41.1 APE12-dist-none 999.0 APE11-dist-in 12.1938 APE10-dist-in 6.0999 APE9-dist-in 3.9176 E431A,R433A,E485A,K488A,R493A,R495A None None XRAY 1.57 0.188 0.203 A 316.0 295.0 7 32 30 2 [[244, 540]] 1.0 5qin Homo sapiens TKL_TGFBR2_HUMAN TKL 1.9e-77 266.3 2.0 266.0 265.0 396 397 398 400 402 277 290 294 376 378 377 379.0 446 428 423 422 421 420 419 418 417 326 TGF-beta receptor type-2

Ligand: J2V

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name