Ligand: IHH

Total number of chains: 1
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGout None 1 100.0% 6YG5A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
STE MAP2K7 MP2K7_HUMAN 6YG5A O14733 101 403 419.0 IHH:60501 Type1 Inactive DFGout 14.6243 12.5001 None -82.13, 150.25 -82.61, 0.2 -71.2, 148.66 192.27, 49.92 16.39, 43.73 in-na in 9.0934 Saltbr-na 999.0 HRD-in -91.88, -54.83 65.15, 26.24 na-out-none SNCaon out-none ActLoopNT-out 3.7145 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None CSO202,CSO260 XRAY 2.4 0.233 0.281 A 307.0 262.0 41 27 6 21 [[120, 380]] 1.0 6yg5 STE_MAP2K7_HUMAN STE 2.4e-80 275.5 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7

Ligand: IHH

Total number of chains: 5
Active chains: 0
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 80.0% 3F6XD
DFGout None 1 20.0% 6YG5A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR SRC SRC_CHICK 3F6XA P00523 255 533 533.0 IHH:1 Type1 None DFGin 6.4551 14.0682 BLAminus -145.58, -171.22 50.93, 84.46 -103.71, 27.02 296.31, 84.62 -56.44, -32.19 in-in in 7.7753 Saltbr-in 2.7918 HRD-in -87.12, -53.49 80.13, -9.7 in-in-none SNCiin in-none ActLoopNT-in 2.9472 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 137.19 APE9-dihe-in -75.66, 152.05 APE8-dihe-in -49.31, 94.84 APE8-rot-na 28.47 APE67-dihe-in -60.1, -19.69 -50.76, -42.02 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.6763 APE9-dist-in 6.2478 None None None XRAY 2.35 0.234 0.266 A 286.0 264.0 15 29 19 10 [[267, 518]] 1.0 3f6x Gallus gallus TYR_SRC_CHICK TYR 3.4e-94 320.9 1.0 260.0 260.0 403 404 405 407 409 295 310 314 383 385 384 386.0 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 3F6XB P00523 255 533 533.0 IHH:1 Type1 None DFGin 6.3671 14.7068 BLAminus -143.73, 176.33 66.16, 82.35 -104.26, 21.94 300.66, 109.17 -54.23, -26.39 in-in in 8.5247 Saltbr-in 2.6425 HRD-in -95.38, -53.98 79.7, -5.11 in-in-none SNCiin in-none ActLoopNT-in 3.071 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -24.89 APE9-dihe-in -77.49, 138.69 APE8-dihe-in -55.05, 102.57 APE8-rot-na 30.78 APE67-dihe-in -55.84, -20.36 -50.35, -41.87 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.0406 APE9-dist-in 6.1022 None None None XRAY 2.35 0.234 0.266 B 286.0 267.0 12 29 18 11 [[267, 518]] 1.0 3f6x Gallus gallus TYR_SRC_CHICK TYR 3.4e-94 320.9 1.0 260.0 260.0 403 404 405 407 409 295 310 314 383 385 384 386.0 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 3F6XC P00523 255 533 533.0 IHH:1 Type1 Inactive DFGin 6.4027 13.9037 BLAminus -138.36, -176.92 55.35, 93.48 -110.67, 31.48 295.19, 88.75 -62.88, -22.84 in-out in 7.2638 Saltbr-out 4.3256 HRD-in -83.92, -48.68 77.13, -3.85 out-in-none SNCoin in-none ActLoopNT-in 2.7685 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 109.16 APE9-dihe-in -52.73, 156.53 APE8-dihe-in -54.14, 101.8 APE8-rot-na 25.69 APE67-dihe-in -69.39, -17.52 -53.55, -31.82 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.745 APE9-dist-in 6.2841 None None None XRAY 2.35 0.234 0.266 C 286.0 265.0 14 29 19 10 [[267, 518]] 1.0 3f6x Gallus gallus TYR_SRC_CHICK TYR 3.4e-94 320.9 1.0 260.0 260.0 403 404 405 407 409 295 310 314 383 385 384 386.0 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 3F6XD P00523 257 533 533.0 IHH:1 Type1 None DFGin 6.3909 14.7718 BLAminus -139.04, 173.47 61.43, 85.17 -101.0, 30.99 295.99, 108.16 -61.08, -19.89 in-in in 8.6017 Saltbr-in 2.8719 HRD-in -82.85, -51.65 79.89, -0.15 in-in-none SNCiin in-none ActLoopNT-in 2.9657 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 70.66 APE9-dihe-in -69.9, 165.23 APE8-dihe-in -59.79, 102.15 APE8-rot-na 28.02 APE67-dihe-in -64.62, -18.4 -51.92, -37.08 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.7722 APE9-dist-in 6.3012 None None None XRAY 2.35 0.234 0.266 D 286.0 267.0 10 29 19 10 [[267, 518]] 1.0 3f6x Gallus gallus TYR_SRC_CHICK TYR 3.4e-94 320.9 1.0 260.0 260.0 403 404 405 407 409 295 310 314 383 385 384 386.0 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
STE MAP2K7 MP2K7_HUMAN 6YG5A O14733 101 403 419.0 IHH:60501 Type1 Inactive DFGout 14.6243 12.5001 None -82.13, 150.25 -82.61, 0.2 -71.2, 148.66 192.27, 49.92 16.39, 43.73 in-na in 9.0934 Saltbr-na 999.0 HRD-in -91.88, -54.83 65.15, 26.24 na-out-none SNCaon out-none ActLoopNT-out 3.7145 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None CSO202,CSO260 XRAY 2.4 0.233 0.281 A 307.0 262.0 41 27 6 21 [[120, 380]] 1.0 6yg5 Homo sapiens STE_MAP2K7_HUMAN STE 2.4e-80 275.5 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7

Ligand: IHH

Total number of chains: 4
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 3F6XD
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR SRC SRC_CHICK 3F6XA P00523 255 533 533.0 IHH:1 Type1 None DFGin 6.4551 14.0682 BLAminus -145.58, -171.22 50.93, 84.46 -103.71, 27.02 296.31, 84.62 -56.44, -32.19 in-in in 7.7753 Saltbr-in 2.7918 HRD-in -87.12, -53.49 80.13, -9.7 in-in-none SNCiin in-none ActLoopNT-in 2.9472 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 137.19 APE9-dihe-in -75.66, 152.05 APE8-dihe-in -49.31, 94.84 APE8-rot-na 28.47 APE67-dihe-in -60.1, -19.69 -50.76, -42.02 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.6763 APE9-dist-in 6.2478 None None None XRAY 2.35 0.234 0.266 A 286.0 264.0 15 29 19 10 [[267, 518]] 1.0 3f6x Gallus gallus TYR_SRC_CHICK TYR 3.4e-94 320.9 1.0 260.0 260.0 403 404 405 407 409 295 310 314 383 385 384 386.0 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 3F6XB P00523 255 533 533.0 IHH:1 Type1 None DFGin 6.3671 14.7068 BLAminus -143.73, 176.33 66.16, 82.35 -104.26, 21.94 300.66, 109.17 -54.23, -26.39 in-in in 8.5247 Saltbr-in 2.6425 HRD-in -95.38, -53.98 79.7, -5.11 in-in-none SNCiin in-none ActLoopNT-in 3.071 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -24.89 APE9-dihe-in -77.49, 138.69 APE8-dihe-in -55.05, 102.57 APE8-rot-na 30.78 APE67-dihe-in -55.84, -20.36 -50.35, -41.87 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.0406 APE9-dist-in 6.1022 None None None XRAY 2.35 0.234 0.266 B 286.0 267.0 12 29 18 11 [[267, 518]] 1.0 3f6x Gallus gallus TYR_SRC_CHICK TYR 3.4e-94 320.9 1.0 260.0 260.0 403 404 405 407 409 295 310 314 383 385 384 386.0 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 3F6XC P00523 255 533 533.0 IHH:1 Type1 Inactive DFGin 6.4027 13.9037 BLAminus -138.36, -176.92 55.35, 93.48 -110.67, 31.48 295.19, 88.75 -62.88, -22.84 in-out in 7.2638 Saltbr-out 4.3256 HRD-in -83.92, -48.68 77.13, -3.85 out-in-none SNCoin in-none ActLoopNT-in 2.7685 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 109.16 APE9-dihe-in -52.73, 156.53 APE8-dihe-in -54.14, 101.8 APE8-rot-na 25.69 APE67-dihe-in -69.39, -17.52 -53.55, -31.82 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.745 APE9-dist-in 6.2841 None None None XRAY 2.35 0.234 0.266 C 286.0 265.0 14 29 19 10 [[267, 518]] 1.0 3f6x Gallus gallus TYR_SRC_CHICK TYR 3.4e-94 320.9 1.0 260.0 260.0 403 404 405 407 409 295 310 314 383 385 384 386.0 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 3F6XD P00523 257 533 533.0 IHH:1 Type1 None DFGin 6.3909 14.7718 BLAminus -139.04, 173.47 61.43, 85.17 -101.0, 30.99 295.99, 108.16 -61.08, -19.89 in-in in 8.6017 Saltbr-in 2.8719 HRD-in -82.85, -51.65 79.89, -0.15 in-in-none SNCiin in-none ActLoopNT-in 2.9657 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 70.66 APE9-dihe-in -69.9, 165.23 APE8-dihe-in -59.79, 102.15 APE8-rot-na 28.02 APE67-dihe-in -64.62, -18.4 -51.92, -37.08 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.7722 APE9-dist-in 6.3012 None None None XRAY 2.35 0.234 0.266 D 286.0 267.0 10 29 19 10 [[267, 518]] 1.0 3f6x Gallus gallus TYR_SRC_CHICK TYR 3.4e-94 320.9 1.0 260.0 260.0 403 404 405 407 409 295 310 314 383 385 384 386.0 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src