Ligand: H7O

Total number of chains: 3
Active chains: 0
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 2 66.7% 9EWTA
DFGin BLAminus 1 33.3% 7DHKA

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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
CMGC DYRK2 DYRK2_HUMAN 7DHKA 2.341 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii H7O Type1 215 - 538 0 PTR382,SEP458 None Dual specificity tyrosine-phosphorylation-regulated kinase 2
TYR EGFR EGFR_HUMAN 9EWTA 3.019 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_nniai APEdist_aaao A1H7O Type1.5_Back 703 - 984 0 None V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 9EWTB 3.019 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_nniai APEdist_aaai A1H7O Type1.5_Back 703 - 984 0 None V948R Epidermal growth factor receptor

Ligand: H7O

Total number of chains: 3
Active chains: 0
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 2 66.7% 9EWTA
DFGin BLAminus 1 33.3% 7DHKA

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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
CMGC DYRK2 DYRK2_HUMAN 7DHKA 2.341 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii H7O Type1 215 - 538 0 PTR382,SEP458 None Dual specificity tyrosine-phosphorylation-regulated kinase 2 Homo sapiens
TYR EGFR EGFR_HUMAN 9EWTA 3.019 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_nniai APEdist_aaao A1H7O Type1.5_Back 703 - 984 0 None V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 9EWTB 3.019 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_nniai APEdist_aaai A1H7O Type1.5_Back 703 - 984 0 None V948R Epidermal growth factor receptor Homo sapiens

Ligand: H7O

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative

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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism