Ligand: GVD

Total number of chains: 7
Active chains: 3
Total number of genes: 4
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 5 71.4% 3SOCA
DFGin None 2 28.6% 3GGFA
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CAMK CAMK2D KCC2D_HUMAN 2VN9A Q13557 10 309 499.0 GVD:61314 Type1 Active DFGin 6.59 14.614 BLAminus -124.96, 171.71 55.2, 92.42 -101.83, 28.41 288.28, 77.94 -66.41, -20.24 in-in in 9.242 Saltbr-in 2.843 HRD-in -68.47, -47.2 70.33, 2.64 in-in-in SNCiii in-in ActLoopNT-in 2.873 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.47, 140.91 APE9-dihe-na 137.94, -158.39 APE8-dihe-in -117.81, 127.62 APE8-rot-in 304.33 APE67-dihe-in -59.63, -25.55 -44.23, -52.64 APE12-dist-in 10.261 APE11-dist-in 11.912 APE10-dist-in 6.197 APE9-dist-in 3.798 None None None XRAY 2.3 0.213 0.248 A 301 300 0 0 0 0 [[14, 272]] 1.0 2vn9 CAMK_CAMK2D_HUMAN CAMK 3.2e-97 330.9 1 256 256 156 157 158 160 162 43 61 65 133 135 134 136 196 184 179 178 177 176 175 174 173 91 Calcium/calmodulin-dependent protein kinase type II subunit delta
CAMK CAMK2D KCC2D_HUMAN 2VN9B Q13557 10 309 499.0 GVD:61310 Type1 Active DFGin 6.551 14.602 BLAminus -127.37, 171.91 57.38, 92.45 -101.92, 22.76 286.58, 76.44 -61.0, -20.5 in-in in 9.266 Saltbr-in 2.869 HRD-in -69.29, -46.65 68.24, 3.32 in-in-in SNCiii in-in ActLoopNT-in 2.8 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.29, 141.49 APE9-dihe-na 142.44, -161.34 APE8-dihe-in -114.21, 127.94 APE8-rot-in 302.01 APE67-dihe-in -63.28, -20.34 -43.86, -50.83 APE12-dist-in 10.34 APE11-dist-in 11.874 APE10-dist-in 6.184 APE9-dist-in 3.738 None None None XRAY 2.3 0.213 0.248 B 301 300 0 0 0 0 [[14, 272]] 1.0 2vn9 CAMK_CAMK2D_HUMAN CAMK 3.2e-97 330.9 1 256 256 156 157 158 160 162 43 61 65 133 135 134 136 196 184 179 178 177 176 175 174 173 91 Calcium/calmodulin-dependent protein kinase type II subunit delta
STE SLK SLK_HUMAN 2UV2A Q9H2G2 21 308 1235.0 GVD:1316 Type1 Inactive DFGin 6.392 14.668 BLAminus -137.63, 176.53 65.09, 88.86 -105.79, 29.31 299.3, 89.13 -57.8, -30.07 in-in in 9.266 Saltbr-in 3.009 HRD-in -63.28, -54.67 77.02, -4.58 in-in-out SNCiio in-out ActLoopNT-in 2.842 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oooo APE10-dihe-na -136.25, 151.49 APE9-dihe-na 68.24, 176.61 APE8-dihe-in -84.97, 119.74 APE8-rot-in 310.47 APE67-dihe-out -66.38, -23.85 -91.33, 75.21 APE12-dist-out 25.746 APE11-dist-out 29.909 APE10-dist-out 33.383 APE9-dist-out 38.719 K25T None None XRAY 2.3 0.199 0.234 A 325 286 2 0 0 0 [[34, 292]] 1.0 2uv2 STE_SLK_HUMAN STE 1.1e-96 329.1 1 257 257 172 173 174 176 178 63 79 83 152 154 153 155 217 200 195 194 193 192 191 190 189 109 STE20-like serine/threonine-protein kinase
STE STK26 STK26_HUMAN 3GGFA Q9P289 17 300 416.0 GVD:305 Type1 Inactive DFGin 6.513 17.533 None -107.18, 8.32 -96.74, 1.83 -77.63, 129.12 182.23, 74.2 -169.36, -175.42 out-out out 13.268 Saltbr-out 11.913 HRD-out -112.33, 146.97 -132.0, 153.35 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -59.52, -49.61 APE9-dihe-na 109.3, -174.5 APE8-dihe-in -89.03, 130.3 APE8-rot-out 188.7 APE67-dihe-in -59.01, -28.43 -93.03, -11.97 APE12-dist-out 20.726 APE11-dist-out 20.075 APE10-dist-out 20.472 APE9-dist-out 12.368 None None None XRAY 2.35 0.222 0.277 A 301 275 9 0 0 9 [[24, 274]] 1.0 3ggf STE_STK26_HUMAN STE 3.5e-100 340.6 1 257 257 161 162 163 165 167 53 70 74 141 143 142 144 201 189 184 183 182 181 180 179 178 100 Serine/threonine-protein kinase 26
STE STK26 STK26_HUMAN 3GGFB Q9P289 18 297 416.0 GVD:304 Type1 Inactive DFGin 6.381 17.715 None -107.34, 9.0 -94.45, -5.79 -73.15, 129.62 180.07, 74.63 -158.4, -173.99 out-out out 13.248 Saltbr-out 12.17 HRD-out -111.96, 147.3 -128.45, 152.94 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -61.97, -49.3 APE9-dihe-na 108.76, -176.86 APE8-dihe-in -86.01, 129.64 APE8-rot-out 192.14 APE67-dihe-in -66.2, -27.4 -96.0, -3.24 APE12-dist-out 20.151 APE11-dist-out 19.528 APE10-dist-out 20.068 APE9-dist-out 11.872 None None None XRAY 2.35 0.222 0.277 B 301 270 10 0 0 10 [[24, 274]] 1.0 3ggf STE_STK26_HUMAN STE 3.5e-100 340.6 1 257 257 161 162 163 165 167 53 70 74 141 143 142 144 201 189 184 183 182 181 180 179 178 100 Serine/threonine-protein kinase 26
TKL ACVR2A AVR2A_HUMAN 3SOCA P27037 191 486 513.0 GVD:60001 Type1 Inactive DFGin 7.627 14.12 BLAminus -129.53, 162.94 71.26, 89.98 -103.8, 24.98 302.16, 98.96 -63.88, -23.66 in-in in 8.11 Saltbr-in 2.662 HRD-in -79.15, -50.46 79.66, 5.28 in-in-out SNCiio in-out ActLoopNT-in 2.904 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -135.71, 167.82 APE9-dihe-na -85.17, -168.04 APE8-dihe-in -72.04, 119.11 APE8-rot-in 310.28 APE67-dihe-in -43.46, -38.05 -39.83, -55.04 APE12-dist-in 9.982 APE11-dist-out 5.797 APE10-dist-out 8.94 APE9-dist-in 3.591 None None None XRAY 1.95 0.165 0.211 A 322 296 0 0 0 0 [[192, 481]] 1.0 3soc TKL_ACVR2A_HUMAN TKL 3.5e-83 285.1 2 266 265 339 340 341 343 345 219 232 236 319 321 320 322 386 369 364 363 362 361 360 359 358 268 Activin receptor type-2A
TKL ACVR2A AVR2A_HUMAN 3SOCB P27037 191 486 513.0 GVD:60001 Type1 Active DFGin 7.582 13.883 BLAminus -125.19, 161.27 74.66, 92.72 -105.52, 25.82 308.76, 104.61 -59.88, -27.57 in-in in 7.987 Saltbr-in 2.681 HRD-in -86.72, -48.71 80.27, -0.88 in-in-in SNCiii in-in ActLoopNT-in 2.882 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -95.59, -20.99 APE9-dihe-na -82.69, -168.74 APE8-dihe-in -77.8, 127.48 APE8-rot-in 301.33 APE67-dihe-in -68.64, -19.61 -61.12, -39.03 APE12-dist-in 10.99 APE11-dist-in 12.401 APE10-dist-in 6.373 APE9-dist-in 3.368 None None None XRAY 1.95 0.165 0.211 B 322 294 2 0 0 2 [[192, 481]] 1.0 3soc TKL_ACVR2A_HUMAN TKL 3.5e-83 285.1 2 266 265 339 340 341 343 345 219 232 236 319 321 320 322 386 369 364 363 362 361 360 359 358 268 Activin receptor type-2A

Ligand: GVD

Total number of chains: 7
Active chains: 3
Total number of genes: 4
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 5 71.4% 3SOCA
DFGin None 2 28.6% 3GGFA
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CAMK CAMK2D KCC2D_HUMAN 2VN9A Q13557 10 309 499.0 GVD:61314 Type1 Active DFGin 6.59 14.614 BLAminus -124.96, 171.71 55.2, 92.42 -101.83, 28.41 288.28, 77.94 -66.41, -20.24 in-in in 9.242 Saltbr-in 2.843 HRD-in -68.47, -47.2 70.33, 2.64 in-in-in SNCiii in-in ActLoopNT-in 2.873 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.47, 140.91 APE9-dihe-na 137.94, -158.39 APE8-dihe-in -117.81, 127.62 APE8-rot-in 304.33 APE67-dihe-in -59.63, -25.55 -44.23, -52.64 APE12-dist-in 10.261 APE11-dist-in 11.912 APE10-dist-in 6.197 APE9-dist-in 3.798 None None None XRAY 2.3 0.213 0.248 A 301 300 0 0 0 0 [[14, 272]] 1.0 2vn9 Homo sapiens CAMK_CAMK2D_HUMAN CAMK 3.2e-97 330.9 1 256 256 156 157 158 160 162 43 61 65 133 135 134 136 196 184 179 178 177 176 175 174 173 91 Calcium/calmodulin-dependent protein kinase type II subunit delta
CAMK CAMK2D KCC2D_HUMAN 2VN9B Q13557 10 309 499.0 GVD:61310 Type1 Active DFGin 6.551 14.602 BLAminus -127.37, 171.91 57.38, 92.45 -101.92, 22.76 286.58, 76.44 -61.0, -20.5 in-in in 9.266 Saltbr-in 2.869 HRD-in -69.29, -46.65 68.24, 3.32 in-in-in SNCiii in-in ActLoopNT-in 2.8 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.29, 141.49 APE9-dihe-na 142.44, -161.34 APE8-dihe-in -114.21, 127.94 APE8-rot-in 302.01 APE67-dihe-in -63.28, -20.34 -43.86, -50.83 APE12-dist-in 10.34 APE11-dist-in 11.874 APE10-dist-in 6.184 APE9-dist-in 3.738 None None None XRAY 2.3 0.213 0.248 B 301 300 0 0 0 0 [[14, 272]] 1.0 2vn9 Homo sapiens CAMK_CAMK2D_HUMAN CAMK 3.2e-97 330.9 1 256 256 156 157 158 160 162 43 61 65 133 135 134 136 196 184 179 178 177 176 175 174 173 91 Calcium/calmodulin-dependent protein kinase type II subunit delta
STE SLK SLK_HUMAN 2UV2A Q9H2G2 21 308 1235.0 GVD:1316 Type1 Inactive DFGin 6.392 14.668 BLAminus -137.63, 176.53 65.09, 88.86 -105.79, 29.31 299.3, 89.13 -57.8, -30.07 in-in in 9.266 Saltbr-in 3.009 HRD-in -63.28, -54.67 77.02, -4.58 in-in-out SNCiio in-out ActLoopNT-in 2.842 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oooo APE10-dihe-na -136.25, 151.49 APE9-dihe-na 68.24, 176.61 APE8-dihe-in -84.97, 119.74 APE8-rot-in 310.47 APE67-dihe-out -66.38, -23.85 -91.33, 75.21 APE12-dist-out 25.746 APE11-dist-out 29.909 APE10-dist-out 33.383 APE9-dist-out 38.719 K25T None None XRAY 2.3 0.199 0.234 A 325 286 2 0 0 0 [[34, 292]] 1.0 2uv2 Homo sapiens STE_SLK_HUMAN STE 1.1e-96 329.1 1 257 257 172 173 174 176 178 63 79 83 152 154 153 155 217 200 195 194 193 192 191 190 189 109 STE20-like serine/threonine-protein kinase
STE STK26 STK26_HUMAN 3GGFA Q9P289 17 300 416.0 GVD:305 Type1 Inactive DFGin 6.513 17.533 None -107.18, 8.32 -96.74, 1.83 -77.63, 129.12 182.23, 74.2 -169.36, -175.42 out-out out 13.268 Saltbr-out 11.913 HRD-out -112.33, 146.97 -132.0, 153.35 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -59.52, -49.61 APE9-dihe-na 109.3, -174.5 APE8-dihe-in -89.03, 130.3 APE8-rot-out 188.7 APE67-dihe-in -59.01, -28.43 -93.03, -11.97 APE12-dist-out 20.726 APE11-dist-out 20.075 APE10-dist-out 20.472 APE9-dist-out 12.368 None None None XRAY 2.35 0.222 0.277 A 301 275 9 0 0 9 [[24, 274]] 1.0 3ggf Homo sapiens STE_STK26_HUMAN STE 3.5e-100 340.6 1 257 257 161 162 163 165 167 53 70 74 141 143 142 144 201 189 184 183 182 181 180 179 178 100 Serine/threonine-protein kinase 26
STE STK26 STK26_HUMAN 3GGFB Q9P289 18 297 416.0 GVD:304 Type1 Inactive DFGin 6.381 17.715 None -107.34, 9.0 -94.45, -5.79 -73.15, 129.62 180.07, 74.63 -158.4, -173.99 out-out out 13.248 Saltbr-out 12.17 HRD-out -111.96, 147.3 -128.45, 152.94 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -61.97, -49.3 APE9-dihe-na 108.76, -176.86 APE8-dihe-in -86.01, 129.64 APE8-rot-out 192.14 APE67-dihe-in -66.2, -27.4 -96.0, -3.24 APE12-dist-out 20.151 APE11-dist-out 19.528 APE10-dist-out 20.068 APE9-dist-out 11.872 None None None XRAY 2.35 0.222 0.277 B 301 270 10 0 0 10 [[24, 274]] 1.0 3ggf Homo sapiens STE_STK26_HUMAN STE 3.5e-100 340.6 1 257 257 161 162 163 165 167 53 70 74 141 143 142 144 201 189 184 183 182 181 180 179 178 100 Serine/threonine-protein kinase 26
TKL ACVR2A AVR2A_HUMAN 3SOCA P27037 191 486 513.0 GVD:60001 Type1 Inactive DFGin 7.627 14.12 BLAminus -129.53, 162.94 71.26, 89.98 -103.8, 24.98 302.16, 98.96 -63.88, -23.66 in-in in 8.11 Saltbr-in 2.662 HRD-in -79.15, -50.46 79.66, 5.28 in-in-out SNCiio in-out ActLoopNT-in 2.904 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -135.71, 167.82 APE9-dihe-na -85.17, -168.04 APE8-dihe-in -72.04, 119.11 APE8-rot-in 310.28 APE67-dihe-in -43.46, -38.05 -39.83, -55.04 APE12-dist-in 9.982 APE11-dist-out 5.797 APE10-dist-out 8.94 APE9-dist-in 3.591 None None None XRAY 1.95 0.165 0.211 A 322 296 0 0 0 0 [[192, 481]] 1.0 3soc Homo sapiens TKL_ACVR2A_HUMAN TKL 3.5e-83 285.1 2 266 265 339 340 341 343 345 219 232 236 319 321 320 322 386 369 364 363 362 361 360 359 358 268 Activin receptor type-2A
TKL ACVR2A AVR2A_HUMAN 3SOCB P27037 191 486 513.0 GVD:60001 Type1 Active DFGin 7.582 13.883 BLAminus -125.19, 161.27 74.66, 92.72 -105.52, 25.82 308.76, 104.61 -59.88, -27.57 in-in in 7.987 Saltbr-in 2.681 HRD-in -86.72, -48.71 80.27, -0.88 in-in-in SNCiii in-in ActLoopNT-in 2.882 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -95.59, -20.99 APE9-dihe-na -82.69, -168.74 APE8-dihe-in -77.8, 127.48 APE8-rot-in 301.33 APE67-dihe-in -68.64, -19.61 -61.12, -39.03 APE12-dist-in 10.99 APE11-dist-in 12.401 APE10-dist-in 6.373 APE9-dist-in 3.368 None None None XRAY 1.95 0.165 0.211 B 322 294 2 0 0 2 [[192, 481]] 1.0 3soc Homo sapiens TKL_ACVR2A_HUMAN TKL 3.5e-83 285.1 2 266 265 339 340 341 343 345 219 232 236 319 321 320 322 386 369 364 363 362 361 360 359 358 268 Activin receptor type-2A

Ligand: GVD

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name