Ligand: DL1

Total number of chains: 4
Active chains: 3
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 6EGED

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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
TKL IRAK1 IRAK1_HUMAN 6BFNA 2.26 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii DL1 Type1 194 - 526 0 None None Interleukin-1 receptor-associated kinase 1
TKL IRAK1 IRAK1_HUMAN 6BFNB 2.26 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii DL1 Type1 194 - 526 0 None None Interleukin-1 receptor-associated kinase 1
TKL IRAK4 IRAK4_HUMAN 6EGEA 1.401 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii DL1 Type1 165 - 459 0 None None Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 6EGED 1.401 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aannn APEdist_nnnn DL1 Type1 164 - 457 0 None None Interleukin-1 receptor-associated kinase 4

Ligand: DL1

Total number of chains: 4
Active chains: 3
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 6EGED

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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
TKL IRAK1 IRAK1_HUMAN 6BFNA 2.26 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii DL1 Type1 194 - 526 0 None None Interleukin-1 receptor-associated kinase 1 Homo sapiens
TKL IRAK1 IRAK1_HUMAN 6BFNB 2.26 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii DL1 Type1 194 - 526 0 None None Interleukin-1 receptor-associated kinase 1 Homo sapiens
TKL IRAK4 IRAK4_HUMAN 6EGEA 1.401 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii DL1 Type1 165 - 459 0 None None Interleukin-1 receptor-associated kinase 4 Homo sapiens
TKL IRAK4 IRAK4_HUMAN 6EGED 1.401 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aannn APEdist_nnnn DL1 Type1 164 - 457 0 None None Interleukin-1 receptor-associated kinase 4 Homo sapiens

Ligand: DL1

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative

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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism