Ligand: DL1

Total number of chains: 4
Active chains: 3
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 6EGED
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TKL IRAK1 IRAK1_HUMAN 6BFNA P51617 194 526 712.0 DL1:60601 Type1 Active DFGin 6.4728 15.0069 BLAminus -110.63, -164.34 53.57, 66.04 -89.98, 6.39 276.1, 69.05 -60.37, -23.25 in-in in 8.5837 Saltbr-in 2.8934 HRD-in -63.56, -57.45 82.57, -20.38 in-in-in SNCiii in-in ActLoopNT-in 2.6791 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.15, 120.12 APE9-dihe-na 147.8, -171.52 APE8-dihe-in -97.13, 117.07 APE8-rot-in 305.84 APE67-dihe-in -59.67, -35.36 -56.27, -25.11 APE12-dist-in 11.7031 APE11-dist-in 11.5338 APE10-dist-in 6.1498 APE9-dist-in 5.0432 None None None XRAY 2.26 0.186 0.227 A 342.0 300.0 33 37 21 16 [[211, 520]] 1.0 6bfn TKL_IRAK1_HUMAN TKL 3.3e-84 288.5 4.0 267.0 264.0 357 358 359 361 363 239 259 263 337 339 338 340.0 406 394 389 388 387 386 385 384 383 289 Interleukin-1 receptor-associated kinase 1
TKL IRAK1 IRAK1_HUMAN 6BFNB P51617 194 526 712.0 DL1:60601 Type1 Active DFGin 6.3066 14.9365 BLAminus -109.87, -162.2 55.1, 63.78 -90.57, 8.87 274.01, 68.59 -61.57, -25.0 in-in in 8.5865 Saltbr-in 3.0341 HRD-in -64.2, -59.54 86.78, -23.84 in-in-in SNCiii in-in ActLoopNT-in 2.7254 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.09, 160.52 APE9-dihe-na 107.57, -176.31 APE8-dihe-in -92.98, 122.19 APE8-rot-in 303.15 APE67-dihe-in -66.3, -30.72 -60.6, -25.29 APE12-dist-in 11.3679 APE11-dist-in 11.2313 APE10-dist-in 6.3049 APE9-dist-in 4.9528 None None None XRAY 2.26 0.186 0.227 B 342.0 294.0 39 37 21 16 [[211, 520]] 1.0 6bfn TKL_IRAK1_HUMAN TKL 3.3e-84 288.5 4.0 267.0 264.0 357 358 359 361 363 239 259 263 337 339 338 340.0 406 394 389 388 387 386 385 384 383 289 Interleukin-1 receptor-associated kinase 1
TKL IRAK4 IRAK4_HUMAN 6EGEA Q9NWZ3 165 459 460.0 DL1:60501 Type1 Active DFGin 6.9399 14.5554 BLAminus -135.12, -165.28 63.61, 72.4 -102.34, 15.54 280.06, 84.72 -58.95, -24.98 in-in in 8.8526 Saltbr-in 2.8056 HRD-in -77.76, -48.68 75.86, 2.37 in-in-in SNCiii in-in ActLoopNT-in 2.7403 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.44, 145.15 APE9-dihe-na 161.1, -176.09 APE8-dihe-in -100.19, 114.19 APE8-rot-in 298.83 APE67-dihe-in -69.58, -10.0 -51.22, -43.25 APE12-dist-in 10.1892 APE11-dist-in 11.5967 APE10-dist-in 6.6726 APE9-dist-in 4.0972 None None None XRAY 1.401 0.179 0.201 A 302.0 270.0 25 30 19 11 [[183, 456]] 1.0 6ege TKL_IRAK4_HUMAN TKL 2.6e-83 285.5 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 6EGED Q9NWZ3 164 457 460.0 DL1:60501 Type1 None DFGin 6.4849 13.7691 BLAminus -131.26, -173.55 62.72, 71.71 -99.41, 12.5 304.64, 98.46 -67.05, -20.52 in-in in 8.9822 Saltbr-in 2.9789 HRD-in -74.07, -47.83 71.86, 0.89 in-in-none SNCiin in-none ActLoopNT-in 2.6901 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -66.83, -16.12 999.0, -13.22 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.401 0.179 0.201 D 302.0 282.0 12 30 25 5 [[183, 456]] 1.0 6ege TKL_IRAK4_HUMAN TKL 2.6e-83 285.5 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4

Ligand: DL1

Total number of chains: 4
Active chains: 3
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 6EGED
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TKL IRAK1 IRAK1_HUMAN 6BFNA P51617 194 526 712.0 DL1:60601 Type1 Active DFGin 6.4728 15.0069 BLAminus -110.63, -164.34 53.57, 66.04 -89.98, 6.39 276.1, 69.05 -60.37, -23.25 in-in in 8.5837 Saltbr-in 2.8934 HRD-in -63.56, -57.45 82.57, -20.38 in-in-in SNCiii in-in ActLoopNT-in 2.6791 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.15, 120.12 APE9-dihe-na 147.8, -171.52 APE8-dihe-in -97.13, 117.07 APE8-rot-in 305.84 APE67-dihe-in -59.67, -35.36 -56.27, -25.11 APE12-dist-in 11.7031 APE11-dist-in 11.5338 APE10-dist-in 6.1498 APE9-dist-in 5.0432 None None None XRAY 2.26 0.186 0.227 A 342.0 300.0 33 37 21 16 [[211, 520]] 1.0 6bfn Homo sapiens TKL_IRAK1_HUMAN TKL 3.3e-84 288.5 4.0 267.0 264.0 357 358 359 361 363 239 259 263 337 339 338 340.0 406 394 389 388 387 386 385 384 383 289 Interleukin-1 receptor-associated kinase 1
TKL IRAK1 IRAK1_HUMAN 6BFNB P51617 194 526 712.0 DL1:60601 Type1 Active DFGin 6.3066 14.9365 BLAminus -109.87, -162.2 55.1, 63.78 -90.57, 8.87 274.01, 68.59 -61.57, -25.0 in-in in 8.5865 Saltbr-in 3.0341 HRD-in -64.2, -59.54 86.78, -23.84 in-in-in SNCiii in-in ActLoopNT-in 2.7254 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.09, 160.52 APE9-dihe-na 107.57, -176.31 APE8-dihe-in -92.98, 122.19 APE8-rot-in 303.15 APE67-dihe-in -66.3, -30.72 -60.6, -25.29 APE12-dist-in 11.3679 APE11-dist-in 11.2313 APE10-dist-in 6.3049 APE9-dist-in 4.9528 None None None XRAY 2.26 0.186 0.227 B 342.0 294.0 39 37 21 16 [[211, 520]] 1.0 6bfn Homo sapiens TKL_IRAK1_HUMAN TKL 3.3e-84 288.5 4.0 267.0 264.0 357 358 359 361 363 239 259 263 337 339 338 340.0 406 394 389 388 387 386 385 384 383 289 Interleukin-1 receptor-associated kinase 1
TKL IRAK4 IRAK4_HUMAN 6EGEA Q9NWZ3 165 459 460.0 DL1:60501 Type1 Active DFGin 6.9399 14.5554 BLAminus -135.12, -165.28 63.61, 72.4 -102.34, 15.54 280.06, 84.72 -58.95, -24.98 in-in in 8.8526 Saltbr-in 2.8056 HRD-in -77.76, -48.68 75.86, 2.37 in-in-in SNCiii in-in ActLoopNT-in 2.7403 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.44, 145.15 APE9-dihe-na 161.1, -176.09 APE8-dihe-in -100.19, 114.19 APE8-rot-in 298.83 APE67-dihe-in -69.58, -10.0 -51.22, -43.25 APE12-dist-in 10.1892 APE11-dist-in 11.5967 APE10-dist-in 6.6726 APE9-dist-in 4.0972 None None None XRAY 1.401 0.179 0.201 A 302.0 270.0 25 30 19 11 [[183, 456]] 1.0 6ege Homo sapiens TKL_IRAK4_HUMAN TKL 2.6e-83 285.5 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 6EGED Q9NWZ3 164 457 460.0 DL1:60501 Type1 None DFGin 6.4849 13.7691 BLAminus -131.26, -173.55 62.72, 71.71 -99.41, 12.5 304.64, 98.46 -67.05, -20.52 in-in in 8.9822 Saltbr-in 2.9789 HRD-in -74.07, -47.83 71.86, 0.89 in-in-none SNCiin in-none ActLoopNT-in 2.6901 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -66.83, -16.12 999.0, -13.22 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.401 0.179 0.201 D 302.0 282.0 12 30 25 5 [[183, 456]] 1.0 6ege Homo sapiens TKL_IRAK4_HUMAN TKL 2.6e-83 285.5 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4

Ligand: DL1

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name