Ligand: C6O

Total number of chains: 2
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 1 50.0% 6JRKA
DFGin BLAplus 1 50.0% 6JRJA

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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
TYR EGFR EGFR_HUMAN 6JRKA 2.796 Inactive DFGin‑BLAminus in-out in-none TYR APEdihe_nniai APEdist_aaai C6O Type1 696 - 1018 0 None E865A,E866A,K867A Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6JRJA 2.943 Inactive DFGin‑BLAplus in-out in-none TYR APEdihe_nnnai APEdist_aaan C6O Type1 696 - 1018 0 None T790M,C797S,E865A,E866A,K867A Epidermal growth factor receptor

Ligand: C6O

Total number of chains: 2
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 1 50.0% 6JRKA
DFGin BLAplus 1 50.0% 6JRJA

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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
TYR EGFR EGFR_HUMAN 6JRKA 2.796 Inactive DFGin‑BLAminus in-out in-none TYR APEdihe_nniai APEdist_aaai C6O Type1 696 - 1018 0 None E865A,E866A,K867A Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 6JRJA 2.943 Inactive DFGin‑BLAplus in-out in-none TYR APEdihe_nnnai APEdist_aaan C6O Type1 696 - 1018 0 None T790M,C797S,E865A,E866A,K867A Epidermal growth factor receptor Homo sapiens

Ligand: C6O

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative

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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism