Ligand: B8Z

Total number of chains: 2
Active chains: 0
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 1 50.0% 7XC1A
DFGin None 1 50.0% 8X3MA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC MAPK1 MK01_HUMAN 7XC1A P28482 10 360 360.0 5ID:401,B8Z:405 Type1,Allosteric Inactive DFGin 6.7078 15.976 BLAminus -137.71, -179.56 58.01, 78.42 -93.4, 30.18 285.99, 69.28 -65.81, -34.24 in-in in 9.5275 Saltbr-in 2.9997 HRD-in -74.95, -51.9 73.0, -2.02 in-in-out SNCiio in-out ActLoopNT-in 2.7443 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_ioii APE10-dihe-na -122.62, 101.42 APE9-dihe-na 74.74, 135.42 APE8-dihe-in -55.35, 136.96 APE8-rot-in 306.98 APE67-dihe-in -57.04, -22.83 -48.83, -53.13 APE12-dist-in 8.7119 APE11-dist-out 7.512 APE10-dist-in 7.787 APE9-dist-in 3.0162 None None NEP125 XRAY 2.09 0.232 0.271 A 368.0 351.0 0 31 31 0 [[25, 313]] 1.0 7xc1 CMGC_MAPK1_HUMAN CMGC 9.9e-86 293.6 1.0 301.0 301.0 166 167 168 170 172 54 71 75 146 148 147 149.0 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK14 MK14_HUMAN 8X3MA Q16539 4 353 360.0 B8Z:401 Allosteric Inactive DFGin 7.7119 16.8556 None -115.94, 168.03 71.62, -88.99 88.0, 131.81 286.06, 88.99 -70.61, 105.76 in-in in 9.6027 Saltbr-in 3.0578 HRD-in -66.17, -53.58 79.95, -8.82 in-out-out SNCioo out-out ActLoopNT-out 10.5579 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -137.62, 133.04 APE9-dihe-na -62.46, -10.4 APE8-dihe-out -67.81, -17.48 APE8-rot-out 51.83 APE67-dihe-in -60.97, -25.8 -116.4, -18.75 APE12-dist-out 22.0398 APE11-dist-out 24.1061 APE10-dist-out 18.4386 APE9-dist-out 11.7912 None None None XRAY 1.85 0.183 0.226 A 365.0 350.0 0 25 25 0 [[24, 308]] 1.0 8x3m CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14

Ligand: B8Z

Total number of chains: 2
Active chains: 0
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 1 50.0% 7XC1A
DFGin None 1 50.0% 8X3MA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC MAPK1 MK01_HUMAN 7XC1A P28482 10 360 360.0 5ID:401,B8Z:405 Type1,Allosteric Inactive DFGin 6.7078 15.976 BLAminus -137.71, -179.56 58.01, 78.42 -93.4, 30.18 285.99, 69.28 -65.81, -34.24 in-in in 9.5275 Saltbr-in 2.9997 HRD-in -74.95, -51.9 73.0, -2.02 in-in-out SNCiio in-out ActLoopNT-in 2.7443 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_ioii APE10-dihe-na -122.62, 101.42 APE9-dihe-na 74.74, 135.42 APE8-dihe-in -55.35, 136.96 APE8-rot-in 306.98 APE67-dihe-in -57.04, -22.83 -48.83, -53.13 APE12-dist-in 8.7119 APE11-dist-out 7.512 APE10-dist-in 7.787 APE9-dist-in 3.0162 None None NEP125 XRAY 2.09 0.232 0.271 A 368.0 351.0 0 31 31 0 [[25, 313]] 1.0 7xc1 Homo sapiens CMGC_MAPK1_HUMAN CMGC 9.9e-86 293.6 1.0 301.0 301.0 166 167 168 170 172 54 71 75 146 148 147 149.0 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK14 MK14_HUMAN 8X3MA Q16539 4 353 360.0 B8Z:401 Allosteric Inactive DFGin 7.7119 16.8556 None -115.94, 168.03 71.62, -88.99 88.0, 131.81 286.06, 88.99 -70.61, 105.76 in-in in 9.6027 Saltbr-in 3.0578 HRD-in -66.17, -53.58 79.95, -8.82 in-out-out SNCioo out-out ActLoopNT-out 10.5579 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -137.62, 133.04 APE9-dihe-na -62.46, -10.4 APE8-dihe-out -67.81, -17.48 APE8-rot-out 51.83 APE67-dihe-in -60.97, -25.8 -116.4, -18.75 APE12-dist-out 22.0398 APE11-dist-out 24.1061 APE10-dist-out 18.4386 APE9-dist-out 11.7912 None None None XRAY 1.85 0.183 0.226 A 365.0 350.0 0 25 25 0 [[24, 308]] 1.0 8x3m Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14

Ligand: B8Z

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name