Ligand: AV9 (Tivozanib)

Total number of chains: 5
Active chains: 0
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGout BBAminus 5 100.0% 4ASEA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
STE SLK SLK_HUMAN 8BEMD Q9H2G2 19 310 1235.0 AV9:60401 Type1 Inactive DFGout 15.609 9.9932 BBAminus -129.69, -171.85 -147.29, 95.2 -67.37, -14.53 272.02, 82.73 97.97, 999.0 out-none out 11.5707 Saltbr-none 999.0 HRD-in -73.63, -51.69 82.34, -9.81 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na -107.2, 146.53 APE9-dihe-na -108.51, -140.02 APE8-dihe-in -73.06, 128.87 APE8-rot-out 206.21 APE67-dihe-in -57.91, -29.99 -86.03, -11.51 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.7505 None None None XRAY 2.6 0.224 0.255 D 303.0 273.0 19 28 15 13 [[34, 292]] 1.0 8bem STE_SLK_HUMAN STE 8.6e-97 329.4 1.0 257.0 257.0 172 173 174 176 178 63 79 83 152 154 153 155.0 217 200 195 194 193 192 191 190 189 109 STE20-like serine/threonine-protein kinase
STE SLK SLK_HUMAN 8BEMG Q9H2G2 19 309 1235.0 AV9:60401 Type1 Inactive DFGout 15.3561 9.9535 BBAminus -127.42, -170.65 -149.27, 90.59 -63.76, -33.71 272.3, 85.55 107.87, 999.0 out-none out 11.5692 Saltbr-none 999.0 HRD-in -73.12, -53.95 82.08, -10.44 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na -90.9, -30.32 APE9-dihe-na 83.56, -160.87 APE8-dihe-in -88.82, 133.57 APE8-rot-out 56.86 APE67-dihe-in -57.37, -30.65 -86.38, -11.59 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.8172 None None None XRAY 2.6 0.224 0.255 G 303.0 270.0 21 28 14 14 [[34, 292]] 1.0 8bem STE_SLK_HUMAN STE 8.6e-97 329.4 1.0 257.0 257.0 172 173 174 176 178 63 79 83 152 154 153 155.0 217 200 195 194 193 192 191 190 189 109 STE20-like serine/threonine-protein kinase
STE SLK SLK_HUMAN 8BEMA Q9H2G2 19 309 1235.0 AV9:60401 Type1.5_Front Inactive DFGout 15.3204 10.3427 BBAminus -126.87, -173.24 -145.98, 95.31 -71.29, -11.44 274.39, 85.56 92.57, 999.0 out-none out 11.248 Saltbr-none 999.0 HRD-in -73.36, -54.08 82.06, -7.69 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na -86.71, -31.34 APE9-dihe-na 83.07, -163.39 APE8-dihe-in -88.8, 134.74 APE8-rot-out 59.81 APE67-dihe-in -58.75, -30.61 -85.18, -13.04 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.336 None None None XRAY 2.6 0.224 0.255 A 303.0 272.0 19 28 15 13 [[34, 292]] 1.0 8bem STE_SLK_HUMAN STE 8.6e-97 329.4 1.0 257.0 257.0 172 173 174 176 178 63 79 83 152 154 153 155.0 217 200 195 194 193 192 191 190 189 109 STE20-like serine/threonine-protein kinase
STE SLK SLK_HUMAN 8BEMB Q9H2G2 19 310 1235.0 AV9:60401 Type1.5_Front Inactive DFGout 15.3625 10.3862 BBAminus -130.09, -171.07 -147.42, 95.57 -73.15, -8.63 276.71, 86.66 100.89, 999.0 out-out out 11.371 Saltbr-out 8.7129 HRD-in -73.46, -53.46 83.25, -10.95 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na -84.78, -30.24 APE9-dihe-na 85.62, -163.37 APE8-dihe-in -89.09, 132.42 APE8-rot-out 195.94 APE67-dihe-in -58.26, -30.88 -85.95, -14.97 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.4036 None None None XRAY 2.6 0.224 0.255 B 303.0 275.0 17 28 15 13 [[34, 292]] 1.0 8bem STE_SLK_HUMAN STE 8.6e-97 329.4 1.0 257.0 257.0 172 173 174 176 178 63 79 83 152 154 153 155.0 217 200 195 194 193 192 191 190 189 109 STE20-like serine/threonine-protein kinase
TYR KDR VGFR2_HUMAN 4ASEA P35968 807 1169 1356.0 AV9:3169 Type2 Inactive DFGout 15.5083 9.6214 BBAminus -131.22, 172.65 -143.22, 109.66 -69.47, -29.54 275.37, 90.83 50.61, -120.83 in-in in 7.6836 Saltbr-in 3.0518 HRD-in -82.51, -52.61 76.99, -4.03 in-out-in SNCioi out-in ActLoopNT-out 16.4515 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -117.53, 119.23 APE9-dihe-in -120.88, 143.86 APE8-dihe-in -75.11, 65.17 APE8-rot-na 28.66 APE67-dihe-in -64.27, -9.66 -54.44, -43.05 APE12-dist-na 16.1551 APE11-dist-na 13.7976 APE10-dist-na 11.6525 APE9-dist-in 7.9754 E990V None None XRAY 1.83 0.207 0.231 A 353.0 307.0 6 30 30 0 [[834, 1162]] 1.0 4ase TYR_KDR_HUMAN TYR 6e-100 339.8 1.0 260.0 260.0 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028.0 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2

Ligand: AV9 (Tivozanib)

Total number of chains: 5
Active chains: 0
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGout BBAminus 5 100.0% 4ASEA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
STE SLK SLK_HUMAN 8BEMD Q9H2G2 19 310 1235.0 AV9:60401 Type1 Inactive DFGout 15.609 9.9932 BBAminus -129.69, -171.85 -147.29, 95.2 -67.37, -14.53 272.02, 82.73 97.97, 999.0 out-none out 11.5707 Saltbr-none 999.0 HRD-in -73.63, -51.69 82.34, -9.81 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na -107.2, 146.53 APE9-dihe-na -108.51, -140.02 APE8-dihe-in -73.06, 128.87 APE8-rot-out 206.21 APE67-dihe-in -57.91, -29.99 -86.03, -11.51 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.7505 None None None XRAY 2.6 0.224 0.255 D 303.0 273.0 19 28 15 13 [[34, 292]] 1.0 8bem Homo sapiens STE_SLK_HUMAN STE 8.6e-97 329.4 1.0 257.0 257.0 172 173 174 176 178 63 79 83 152 154 153 155.0 217 200 195 194 193 192 191 190 189 109 STE20-like serine/threonine-protein kinase
STE SLK SLK_HUMAN 8BEMG Q9H2G2 19 309 1235.0 AV9:60401 Type1 Inactive DFGout 15.3561 9.9535 BBAminus -127.42, -170.65 -149.27, 90.59 -63.76, -33.71 272.3, 85.55 107.87, 999.0 out-none out 11.5692 Saltbr-none 999.0 HRD-in -73.12, -53.95 82.08, -10.44 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na -90.9, -30.32 APE9-dihe-na 83.56, -160.87 APE8-dihe-in -88.82, 133.57 APE8-rot-out 56.86 APE67-dihe-in -57.37, -30.65 -86.38, -11.59 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.8172 None None None XRAY 2.6 0.224 0.255 G 303.0 270.0 21 28 14 14 [[34, 292]] 1.0 8bem Homo sapiens STE_SLK_HUMAN STE 8.6e-97 329.4 1.0 257.0 257.0 172 173 174 176 178 63 79 83 152 154 153 155.0 217 200 195 194 193 192 191 190 189 109 STE20-like serine/threonine-protein kinase
STE SLK SLK_HUMAN 8BEMA Q9H2G2 19 309 1235.0 AV9:60401 Type1.5_Front Inactive DFGout 15.3204 10.3427 BBAminus -126.87, -173.24 -145.98, 95.31 -71.29, -11.44 274.39, 85.56 92.57, 999.0 out-none out 11.248 Saltbr-none 999.0 HRD-in -73.36, -54.08 82.06, -7.69 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na -86.71, -31.34 APE9-dihe-na 83.07, -163.39 APE8-dihe-in -88.8, 134.74 APE8-rot-out 59.81 APE67-dihe-in -58.75, -30.61 -85.18, -13.04 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.336 None None None XRAY 2.6 0.224 0.255 A 303.0 272.0 19 28 15 13 [[34, 292]] 1.0 8bem Homo sapiens STE_SLK_HUMAN STE 8.6e-97 329.4 1.0 257.0 257.0 172 173 174 176 178 63 79 83 152 154 153 155.0 217 200 195 194 193 192 191 190 189 109 STE20-like serine/threonine-protein kinase
STE SLK SLK_HUMAN 8BEMB Q9H2G2 19 310 1235.0 AV9:60401 Type1.5_Front Inactive DFGout 15.3625 10.3862 BBAminus -130.09, -171.07 -147.42, 95.57 -73.15, -8.63 276.71, 86.66 100.89, 999.0 out-out out 11.371 Saltbr-out 8.7129 HRD-in -73.46, -53.46 83.25, -10.95 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na -84.78, -30.24 APE9-dihe-na 85.62, -163.37 APE8-dihe-in -89.09, 132.42 APE8-rot-out 195.94 APE67-dihe-in -58.26, -30.88 -85.95, -14.97 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.4036 None None None XRAY 2.6 0.224 0.255 B 303.0 275.0 17 28 15 13 [[34, 292]] 1.0 8bem Homo sapiens STE_SLK_HUMAN STE 8.6e-97 329.4 1.0 257.0 257.0 172 173 174 176 178 63 79 83 152 154 153 155.0 217 200 195 194 193 192 191 190 189 109 STE20-like serine/threonine-protein kinase
TYR KDR VGFR2_HUMAN 4ASEA P35968 807 1169 1356.0 AV9:3169 Type2 Inactive DFGout 15.5083 9.6214 BBAminus -131.22, 172.65 -143.22, 109.66 -69.47, -29.54 275.37, 90.83 50.61, -120.83 in-in in 7.6836 Saltbr-in 3.0518 HRD-in -82.51, -52.61 76.99, -4.03 in-out-in SNCioi out-in ActLoopNT-out 16.4515 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -117.53, 119.23 APE9-dihe-in -120.88, 143.86 APE8-dihe-in -75.11, 65.17 APE8-rot-na 28.66 APE67-dihe-in -64.27, -9.66 -54.44, -43.05 APE12-dist-na 16.1551 APE11-dist-na 13.7976 APE10-dist-na 11.6525 APE9-dist-in 7.9754 E990V None None XRAY 1.83 0.207 0.231 A 353.0 307.0 6 30 30 0 [[834, 1162]] 1.0 4ase Homo sapiens TYR_KDR_HUMAN TYR 6e-100 339.8 1.0 260.0 260.0 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028.0 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2

Ligand: AV9 (Tivozanib)

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name