Ligand: AQ4 (Erlotinib)

Total number of chains: 3
Active chains: 0
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 1 33.3% 1M17A
DFGin BLBtrans 1 33.3% 4HJOA
DFGinter None 1 33.3% 9D5PA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
TKL ILK ILK_HUMAN 9D5PA 1.5 Pseudo DFGinter‑None out-out out-out nonTYR APEdihe_aaini APEdist_oioo AQ4 Type1 182 - 452 0 None C346S,C422S Scaffold protein ILK
TYR EGFR EGFR_HUMAN 1M17A 2.6 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai AQ4 Type1 696 - 1019 0 None None Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4HJOA 2.75 Inactive DFGin‑BLBtrans out-out out-out TYR APEdihe_iiiai APEdist_aaao AQ4 Type1 703 - 984 0 None V948R Epidermal growth factor receptor

Ligand: AQ4 (Erlotinib)

Total number of chains: 3
Active chains: 0
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 1 33.3% 1M17A
DFGin BLBtrans 1 33.3% 4HJOA
DFGinter None 1 33.3% 9D5PA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
TKL ILK ILK_HUMAN 9D5PA 1.5 Pseudo DFGinter‑None out-out out-out nonTYR APEdihe_aaini APEdist_oioo AQ4 Type1 182 - 452 0 None C346S,C422S Scaffold protein ILK Homo sapiens
TYR EGFR EGFR_HUMAN 1M17A 2.6 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai AQ4 Type1 696 - 1019 0 None None Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 4HJOA 2.75 Inactive DFGin‑BLBtrans out-out out-out TYR APEdihe_iiiai APEdist_aaao AQ4 Type1 703 - 984 0 None V948R Epidermal growth factor receptor Homo sapiens

Ligand: AQ4 (Erlotinib)

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism