Ligand: 8BM

Total number of chains: 2
Active chains: 1
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 1 50.0% 5UGBA
DFGout BBAminus 1 50.0% 5UGAA
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity_label Spatial_Dihedral_labels ChelixSaltbr_label ActLoopNT-ActLoopCT APEtype APEdihe_label APEdist_label Ligand Ligand_type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
TYR EGFR EGFR_HUMAN 5UGBA 2.53 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 8BM Type1 695 - 1018 0 None None Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5UGAA 1.82 Inactive DFGout‑BBAminus out-out in-in TYR APEdihe_iiiai APEdist_aaai 8BM Type1 703 - 985 0 None T790M,L858R,V948R Epidermal growth factor receptor

Ligand: 8BM

Total number of chains: 2
Active chains: 1
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 1 50.0% 5UGBA
DFGout BBAminus 1 50.0% 5UGAA
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity_label Spatial_Dihedral_labels ChelixSaltbr_label ActLoopNT-ActLoopCT APEtype APEdihe_label APEdist_label Ligand Ligand_type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
TYR EGFR EGFR_HUMAN 5UGBA 2.53 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 8BM Type1 695 - 1018 0 None None Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 5UGAA 1.82 Inactive DFGout‑BBAminus out-out in-in TYR APEdihe_iiiai APEdist_aaai 8BM Type1 703 - 985 0 None T790M,L858R,V948R Epidermal growth factor receptor Homo sapiens

Ligand: 8BM

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains - renumbered by
Uniprot PDB Alignment
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Hover over column headers for tooltip help

Family Gene UniprotID PDB Resolution Activity_label Spatial_Dihedral_labels ChelixSaltbr_label ActLoopNT-ActLoopCT APEtype APEdihe_label APEdist_label Ligand Ligand_type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism