Ligand: 6H3

Total number of chains: 5
Active chains: 1
Total number of genes: 4
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 80.0% 6G54A
DFGout None 1 20.0% 5J7SA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC MAPK1 MK01_HUMAN 6G54A P28482 10 356 360.0 6H3:403 Type1 Active DFGin 6.8714 16.2079 BLAminus -132.88, -179.11 65.87, 69.62 -92.42, 26.13 283.45, 69.74 -65.96, -27.02 out-in out 10.1983 Saltbr-in 2.7797 HRD-in -75.15, -46.62 69.02, 1.28 in-in-in SNCiii in-in ActLoopNT-in 2.7772 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -95.74, -31.04 APE9-dihe-na -74.65, 165.75 APE8-dihe-in -65.58, 131.17 APE8-rot-in 305.71 APE67-dihe-in -65.73, -17.41 -55.69, -47.01 APE12-dist-in 13.6771 APE11-dist-in 10.778 APE10-dist-in 6.6196 APE9-dist-in 4.3477 None None None XRAY 2.05 0.185 0.221 A 361.0 347.0 0 31 31 0 [[25, 313]] 1.0 6g54 CMGC_MAPK1_HUMAN CMGC 9.2e-86 293.7 1.0 301.0 301.0 166 167 168 170 172 54 71 75 146 148 147 149.0 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK3 MK03_HUMAN 6GESB P27361 25 374 379.0 6H3:401 Type1 Inactive DFGin 6.894 15.4972 BLAminus -138.79, 174.04 68.33, 84.06 -104.81, 19.96 280.63, 68.61 -61.52, -24.52 in-in in 9.3661 Saltbr-in 2.9312 HRD-in -74.27, -56.06 78.37, 3.28 in-in-out SNCiio in-out ActLoopNT-in 2.7841 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -97.48, -39.89 APE9-dihe-na -63.16, 160.66 APE8-dihe-in -55.88, 126.17 APE8-rot-in 317.05 APE67-dihe-in -63.74, -19.63 -50.02, -51.48 APE12-dist-out 14.3289 APE11-dist-in 10.9522 APE10-dist-in 6.917 APE9-dist-in 4.4242 None None None XRAY 2.07 0.172 0.213 B 380.0 350.0 0 31 31 0 [[42, 330]] 1.0 6ges CMGC_MAPK3_HUMAN CMGC 3.2e-87 298.5 1.0 301.0 301.0 183 184 185 187 189 71 88 92 163 165 164 166.0 227 214 209 208 207 206 205 204 203 123 Mitogen-activated protein kinase 3
CMGC MAPK3 MK03_HUMAN 6GESA P27361 25 374 379.0 6H3:401,EWH:402 Type1,Allosteric Inactive DFGin 6.9525 15.557 BLAminus -139.32, 176.86 65.58, 87.64 -106.07, 21.81 281.49, 72.32 -67.67, -20.97 in-in in 9.4645 Saltbr-in 2.8664 HRD-in -74.62, -54.83 79.01, 3.71 in-in-out SNCiio in-out ActLoopNT-in 2.7498 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -96.37, -37.93 APE9-dihe-na -66.29, 158.31 APE8-dihe-in -54.71, 127.96 APE8-rot-in 319.22 APE67-dihe-in -62.74, -20.38 -53.12, -50.26 APE12-dist-out 14.2267 APE11-dist-in 11.0263 APE10-dist-in 6.9344 APE9-dist-in 4.4094 None None None XRAY 2.07 0.172 0.213 A 380.0 350.0 0 31 31 0 [[42, 330]] 1.0 6ges CMGC_MAPK3_HUMAN CMGC 3.2e-87 298.5 1.0 301.0 301.0 183 184 185 187 189 71 88 92 163 165 164 166.0 227 214 209 208 207 206 205 204 203 123 Mitogen-activated protein kinase 3
TKL MAP3K7 M3K7_HUMAN 5J7SA O43318 31 496 606.0 6H3:60601 Type1 Inactive DFGout 13.0487 9.156 None -101.18, 92.1 -53.74, 146.51 -177.4, 999.0 243.66, 99.72 999.0, 999.0 out-out out 14.9272 Saltbr-out 13.3956 HRD-in -77.38, -39.09 74.94, -52.96 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 69.2 APE8-dihe-out -89.42, 6.68 APE8-rot-in 299.62 APE67-dihe-in -65.9, -22.13 -58.4, -37.8 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.1933 None None None XRAY 2.368 0.229 0.24 A 314.0 246.0 27 25 11 14 [[36, 286]] 1.0 5j7s TKL_MAP3K7_HUMAN TKL 4e-74 255.4 2.0 266.0 265.0 174 175 176 178 180 63 77 81 153 155 154 156.0 211 199 194 193 192 191 190 189 188 105 Mitogen-activated protein kinase kinase kinase 7
TYR SRC SRC_HUMAN 6ATEA P12931 260 536 536.0 6H3:601 Type1 None DFGin 7.0407 15.1686 BLAminus -135.65, -168.07 66.14, 79.15 -116.32, 24.48 292.22, 93.52 -64.92, -24.87 in-in in 7.6792 Saltbr-in 3.3998 HRD-in -88.24, -48.16 78.13, -11.21 in-in-none SNCiin in-none ActLoopNT-in 2.938 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 49.92 APE8-rot-na 24.35 APE67-dihe-in -67.09, -18.78 -61.23, -36.71 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.402 0.195 0.228 A 286.0 255.0 22 29 15 14 [[270, 521]] 1.0 6ate TYR_SRC_HUMAN TYR 1.6e-94 322.0 1.0 260.0 260.0 406 407 408 410 412 298 313 317 386 388 387 389.0 447 435 430 429 428 427 426 425 424 342 Proto-oncogene tyrosine-protein kinase Src

Ligand: 6H3

Total number of chains: 5
Active chains: 1
Total number of genes: 4
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 80.0% 6G54A
DFGout None 1 20.0% 5J7SA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC MAPK1 MK01_HUMAN 6G54A P28482 10 356 360.0 6H3:403 Type1 Active DFGin 6.8714 16.2079 BLAminus -132.88, -179.11 65.87, 69.62 -92.42, 26.13 283.45, 69.74 -65.96, -27.02 out-in out 10.1983 Saltbr-in 2.7797 HRD-in -75.15, -46.62 69.02, 1.28 in-in-in SNCiii in-in ActLoopNT-in 2.7772 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -95.74, -31.04 APE9-dihe-na -74.65, 165.75 APE8-dihe-in -65.58, 131.17 APE8-rot-in 305.71 APE67-dihe-in -65.73, -17.41 -55.69, -47.01 APE12-dist-in 13.6771 APE11-dist-in 10.778 APE10-dist-in 6.6196 APE9-dist-in 4.3477 None None None XRAY 2.05 0.185 0.221 A 361.0 347.0 0 31 31 0 [[25, 313]] 1.0 6g54 Homo sapiens CMGC_MAPK1_HUMAN CMGC 9.2e-86 293.7 1.0 301.0 301.0 166 167 168 170 172 54 71 75 146 148 147 149.0 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK3 MK03_HUMAN 6GESB P27361 25 374 379.0 6H3:401 Type1 Inactive DFGin 6.894 15.4972 BLAminus -138.79, 174.04 68.33, 84.06 -104.81, 19.96 280.63, 68.61 -61.52, -24.52 in-in in 9.3661 Saltbr-in 2.9312 HRD-in -74.27, -56.06 78.37, 3.28 in-in-out SNCiio in-out ActLoopNT-in 2.7841 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -97.48, -39.89 APE9-dihe-na -63.16, 160.66 APE8-dihe-in -55.88, 126.17 APE8-rot-in 317.05 APE67-dihe-in -63.74, -19.63 -50.02, -51.48 APE12-dist-out 14.3289 APE11-dist-in 10.9522 APE10-dist-in 6.917 APE9-dist-in 4.4242 None None None XRAY 2.07 0.172 0.213 B 380.0 350.0 0 31 31 0 [[42, 330]] 1.0 6ges Homo sapiens CMGC_MAPK3_HUMAN CMGC 3.2e-87 298.5 1.0 301.0 301.0 183 184 185 187 189 71 88 92 163 165 164 166.0 227 214 209 208 207 206 205 204 203 123 Mitogen-activated protein kinase 3
CMGC MAPK3 MK03_HUMAN 6GESA P27361 25 374 379.0 6H3:401,EWH:402 Type1,Allosteric Inactive DFGin 6.9525 15.557 BLAminus -139.32, 176.86 65.58, 87.64 -106.07, 21.81 281.49, 72.32 -67.67, -20.97 in-in in 9.4645 Saltbr-in 2.8664 HRD-in -74.62, -54.83 79.01, 3.71 in-in-out SNCiio in-out ActLoopNT-in 2.7498 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -96.37, -37.93 APE9-dihe-na -66.29, 158.31 APE8-dihe-in -54.71, 127.96 APE8-rot-in 319.22 APE67-dihe-in -62.74, -20.38 -53.12, -50.26 APE12-dist-out 14.2267 APE11-dist-in 11.0263 APE10-dist-in 6.9344 APE9-dist-in 4.4094 None None None XRAY 2.07 0.172 0.213 A 380.0 350.0 0 31 31 0 [[42, 330]] 1.0 6ges Homo sapiens CMGC_MAPK3_HUMAN CMGC 3.2e-87 298.5 1.0 301.0 301.0 183 184 185 187 189 71 88 92 163 165 164 166.0 227 214 209 208 207 206 205 204 203 123 Mitogen-activated protein kinase 3
TKL MAP3K7 M3K7_HUMAN 5J7SA O43318 31 496 606.0 6H3:60601 Type1 Inactive DFGout 13.0487 9.156 None -101.18, 92.1 -53.74, 146.51 -177.4, 999.0 243.66, 99.72 999.0, 999.0 out-out out 14.9272 Saltbr-out 13.3956 HRD-in -77.38, -39.09 74.94, -52.96 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 69.2 APE8-dihe-out -89.42, 6.68 APE8-rot-in 299.62 APE67-dihe-in -65.9, -22.13 -58.4, -37.8 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.1933 None None None XRAY 2.368 0.229 0.24 A 314.0 246.0 27 25 11 14 [[36, 286]] 1.0 5j7s Homo sapiens TKL_MAP3K7_HUMAN TKL 4e-74 255.4 2.0 266.0 265.0 174 175 176 178 180 63 77 81 153 155 154 156.0 211 199 194 193 192 191 190 189 188 105 Mitogen-activated protein kinase kinase kinase 7
TYR SRC SRC_HUMAN 6ATEA P12931 260 536 536.0 6H3:601 Type1 None DFGin 7.0407 15.1686 BLAminus -135.65, -168.07 66.14, 79.15 -116.32, 24.48 292.22, 93.52 -64.92, -24.87 in-in in 7.6792 Saltbr-in 3.3998 HRD-in -88.24, -48.16 78.13, -11.21 in-in-none SNCiin in-none ActLoopNT-in 2.938 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 49.92 APE8-rot-na 24.35 APE67-dihe-in -67.09, -18.78 -61.23, -36.71 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.402 0.195 0.228 A 286.0 255.0 22 29 15 14 [[270, 521]] 1.0 6ate Homo sapiens TYR_SRC_HUMAN TYR 1.6e-94 322.0 1.0 260.0 260.0 406 407 408 410 412 298 313 317 386 388 387 389.0 447 435 430 429 428 427 426 425 424 342 Proto-oncogene tyrosine-protein kinase Src

Ligand: 6H3

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name