Ligand: 5X4

Total number of chains: 2
Active chains: 1
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 1 50.0% 5FEDA
DFGin BLBplus 1 50.0% 5FEEA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
TYR EGFR EGFR_HUMAN 5FEDA 2.651 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 5X4 Type1 697 - 1017 0 None None Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5FEEA 2.7 Inactive DFGin‑BLBplus in-in in-out TYR APEdihe_iioao APEdist_aaai 5X4 Type1 697 - 1018 0 None T790M Epidermal growth factor receptor

Ligand: 5X4

Total number of chains: 2
Active chains: 1
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 1 50.0% 5FEDA
DFGin BLBplus 1 50.0% 5FEEA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
TYR EGFR EGFR_HUMAN 5FEDA 2.651 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 5X4 Type1 697 - 1017 0 None None Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 5FEEA 2.7 Inactive DFGin‑BLBplus in-in in-out TYR APEdihe_iioao APEdist_aaai 5X4 Type1 697 - 1018 0 None T790M Epidermal growth factor receptor Homo sapiens

Ligand: 5X4

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism