Ligand: 5X4

Total number of chains: 2
Active chains: 1
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 1 50.0% 5FEDA
DFGin BLBplus 1 50.0% 5FEEA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR EGFR EGFR_HUMAN 5FEDA P00533 697 1017 1210.0 5X4:1101 Type1 Active DFGin 6.1889 14.6874 BLAminus -132.06, 176.3 73.46, 78.92 -101.41, 14.2 298.37, 98.14 -61.64, -39.27 in-in in 8.5912 Saltbr-in 2.9507 HRD-in -71.77, -46.99 67.31, -1.0 in-in-in SNCiii in-in ActLoopNT-in 3.0377 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -81.35, 141.07 APE9-dihe-in -143.22, 147.19 APE8-dihe-in -79.09, 97.45 APE8-rot-na 29.19 APE67-dihe-in -72.55, -20.06 -64.96, -33.09 APE12-dist-na 12.4592 APE11-dist-na 9.8772 APE10-dist-na 10.9316 APE9-dist-in 6.7676 None None None XRAY 2.651 0.186 0.217 A 328.0 288.0 12 30 26 4 [[712, 970]] 1.0 5fed TYR_EGFR_HUMAN TYR 1.1e-87 299.8 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5FEEA P00533 697 1018 1210.0 5X4:1101 Type1 Inactive DFGin 4.5196 13.7486 BLBplus -148.22, -167.33 40.92, 69.1 -115.76, 70.34 31.37, 65.2 -71.51, -22.89 in-in in 8.7907 Saltbr-in 3.3177 HRD-in -72.57, -51.63 72.54, -3.53 in-in-out SNCiio in-out ActLoopNT-in 3.0438 ActLoopCT-out TYR APEdihe_iioao APEdist_aaai APE10-dihe-in -61.11, 145.12 APE9-dihe-in -133.91, 152.17 APE8-dihe-out -65.95, -32.07 APE8-rot-na 335.9 APE67-dihe-out -78.14, -18.7 66.26, -53.45 APE12-dist-na 11.2098 APE11-dist-na 8.3848 APE10-dist-na 10.2005 APE9-dist-in 6.9669 T790M None None XRAY 2.7 0.192 0.229 A 328.0 287.0 14 30 25 5 [[712, 970]] 1.0 5fee TYR_EGFR_HUMAN TYR 8.1e-88 300.1 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor

Ligand: 5X4

Total number of chains: 2
Active chains: 1
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 1 50.0% 5FEDA
DFGin BLBplus 1 50.0% 5FEEA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR EGFR EGFR_HUMAN 5FEDA P00533 697 1017 1210.0 5X4:1101 Type1 Active DFGin 6.1889 14.6874 BLAminus -132.06, 176.3 73.46, 78.92 -101.41, 14.2 298.37, 98.14 -61.64, -39.27 in-in in 8.5912 Saltbr-in 2.9507 HRD-in -71.77, -46.99 67.31, -1.0 in-in-in SNCiii in-in ActLoopNT-in 3.0377 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -81.35, 141.07 APE9-dihe-in -143.22, 147.19 APE8-dihe-in -79.09, 97.45 APE8-rot-na 29.19 APE67-dihe-in -72.55, -20.06 -64.96, -33.09 APE12-dist-na 12.4592 APE11-dist-na 9.8772 APE10-dist-na 10.9316 APE9-dist-in 6.7676 None None None XRAY 2.651 0.186 0.217 A 328.0 288.0 12 30 26 4 [[712, 970]] 1.0 5fed Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-87 299.8 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5FEEA P00533 697 1018 1210.0 5X4:1101 Type1 Inactive DFGin 4.5196 13.7486 BLBplus -148.22, -167.33 40.92, 69.1 -115.76, 70.34 31.37, 65.2 -71.51, -22.89 in-in in 8.7907 Saltbr-in 3.3177 HRD-in -72.57, -51.63 72.54, -3.53 in-in-out SNCiio in-out ActLoopNT-in 3.0438 ActLoopCT-out TYR APEdihe_iioao APEdist_aaai APE10-dihe-in -61.11, 145.12 APE9-dihe-in -133.91, 152.17 APE8-dihe-out -65.95, -32.07 APE8-rot-na 335.9 APE67-dihe-out -78.14, -18.7 66.26, -53.45 APE12-dist-na 11.2098 APE11-dist-na 8.3848 APE10-dist-na 10.2005 APE9-dist-in 6.9669 T790M None None XRAY 2.7 0.192 0.229 A 328.0 287.0 14 30 25 5 [[712, 970]] 1.0 5fee Homo sapiens TYR_EGFR_HUMAN TYR 8.1e-88 300.1 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor

Ligand: 5X4

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name