Ligand: 4Z5

Total number of chains: 3
Active chains: 0
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGout BBAminus 3 100.0% 5C9CA

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Family Gene UniprotID PDB Resolution Activity_label Spatial_Dihedral_labels ChelixSaltbr_label ActLoopNT-ActLoopCT APEtype APEdihe_label APEdist_label Ligand Ligand_type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
TKL BRAF BRAF_HUMAN 5C9CA 2.7 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aanoi APEdist_nnnn 4Z5 Type2 449 - 720 0 None V600E Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 5C9CB 2.7 Inactive DFGout‑BBAminus in-in none-none nonTYR APEdihe_aanii APEdist_nnnn 4Z5 Type2 449 - 720 0 None V600E Serine/threonine-protein kinase B-raf
TYR EPHA2 EPHA2_HUMAN 8XPVA 1.55 Inactive DFGout‑BBAminus in-in none-none TYR APEdihe_nniai APEdist_aaai 4Z5 Type2 604 - 895 0 None None Ephrin type-A receptor 2

Ligand: 4Z5

Total number of chains: 3
Active chains: 0
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGout BBAminus 3 100.0% 5C9CA

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Family Gene UniprotID PDB Resolution Activity_label Spatial_Dihedral_labels ChelixSaltbr_label ActLoopNT-ActLoopCT APEtype APEdihe_label APEdist_label Ligand Ligand_type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
TKL BRAF BRAF_HUMAN 5C9CA 2.7 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aanoi APEdist_nnnn 4Z5 Type2 449 - 720 0 None V600E Serine/threonine-protein kinase B-raf Homo sapiens
TKL BRAF BRAF_HUMAN 5C9CB 2.7 Inactive DFGout‑BBAminus in-in none-none nonTYR APEdihe_aanii APEdist_nnnn 4Z5 Type2 449 - 720 0 None V600E Serine/threonine-protein kinase B-raf Homo sapiens
TYR EPHA2 EPHA2_HUMAN 8XPVA 1.55 Inactive DFGout‑BBAminus in-in none-none TYR APEdihe_nniai APEdist_aaai 4Z5 Type2 604 - 895 0 None None Ephrin type-A receptor 2 Homo sapiens

Ligand: 4Z5

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative

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Family Gene UniprotID PDB Resolution Activity_label Spatial_Dihedral_labels ChelixSaltbr_label ActLoopNT-ActLoopCT APEtype APEdihe_label APEdist_label Ligand Ligand_type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism