Ligand: 3YT

Total number of chains: 3
Active chains: 1
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 66.7% 8X5KA
DFGin None 1 33.3% 5UT2A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR JAK2-1 JAK2_HUMAN 5UT2A O60674 536 808 1132.0 3YT:903 Type1 Pseudo DFGin 7.1266 13.3116 None -90.0, 179.18 -75.04, 157.7 -78.17, -8.03 29.61, 139.64 71.77, -178.13 in-na in 9.4878 Saltbr-na 999.0 HRD-in -87.63, -60.17 95.16, -5.73 na-out-out SNCaoo out-out ActLoopNT-out 9.8702 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.9, -38.59 APE9-dihe-out -61.51, -24.95 APE8-dihe-out -88.74, 4.33 APE8-rot-na 288.64 APE67-dihe-out -101.61, 25.26 -63.02, 138.09 APE12-dist-na 10.0143 APE11-dist-na 11.5548 APE10-dist-na 16.1573 APE9-dist-out 12.8792 W659A,W777A,F794H None None XRAY 1.75 0.163 0.201 A 289.0 273.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 5ut2 TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR SYK KSYK_HUMAN 8X5KA P43405 363 632 635.0 3YT:701 Type1 None DFGin 6.3819 14.6558 BLAminus -132.21, -172.26 63.3, 68.78 -95.24, 19.38 292.18, 89.98 -56.7, -30.78 in-in in 7.8942 Saltbr-in 2.95 HRD-in -71.77, -56.19 75.58, 0.61 in-in-none SNCiin in-none ActLoopNT-in 2.9476 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 67.95 APE8-rot-na 32.78 APE67-dihe-in -63.64, -18.99 -57.25, -32.9 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.8 0.192 0.244 A 280.0 264.0 6 31 26 5 [[370, 628]] 1.0 8x5k TYR_SYK_HUMAN TYR 4.8e-90 307.3 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
TYR SYK KSYK_HUMAN 4RX9A P43405 363 635 635.0 3YT:60702 Type1 Active DFGin 6.5363 14.4979 BLAminus -131.55, -166.02 53.8, 76.49 -95.21, 18.16 288.88, 90.96 -57.69, -29.73 in-in in 8.1675 Saltbr-in 3.1254 HRD-in -77.32, -52.67 70.66, 10.77 in-in-in SNCiii in-in ActLoopNT-in 2.9602 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -78.14, 87.16 APE9-dihe-in -107.75, 147.74 APE8-dihe-in -79.62, 70.69 APE8-rot-na 28.2 APE67-dihe-in -66.03, -15.15 -48.72, -38.82 APE12-dist-na 999.0 APE11-dist-na 11.0764 APE10-dist-na 10.7611 APE9-dist-in 6.9972 None None None XRAY 1.75 0.175 0.197 A 290.0 264.0 9 31 30 1 [[370, 628]] 1.0 4rx9 TYR_SYK_HUMAN TYR 4e-90 307.6 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK

Ligand: 3YT

Total number of chains: 4
Active chains: 1
Total number of genes: 3
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 50.0% 8X5KA
DFGin None 2 50.0% 5UT2A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR JAK2-1 JAK2_HUMAN 5UT2A O60674 536 808 1132.0 3YT:903 Type1 Pseudo DFGin 7.1266 13.3116 None -90.0, 179.18 -75.04, 157.7 -78.17, -8.03 29.61, 139.64 71.77, -178.13 in-na in 9.4878 Saltbr-na 999.0 HRD-in -87.63, -60.17 95.16, -5.73 na-out-out SNCaoo out-out ActLoopNT-out 9.8702 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.9, -38.59 APE9-dihe-out -61.51, -24.95 APE8-dihe-out -88.74, 4.33 APE8-rot-na 288.64 APE67-dihe-out -101.61, 25.26 -63.02, 138.09 APE12-dist-na 10.0143 APE11-dist-na 11.5548 APE10-dist-na 16.1573 APE9-dist-out 12.8792 W659A,W777A,F794H None None XRAY 1.75 0.163 0.201 A 289.0 273.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 5ut2 Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR SYK KSYK_HUMAN 8X5KA P43405 363 632 635.0 3YT:701 Type1 None DFGin 6.3819 14.6558 BLAminus -132.21, -172.26 63.3, 68.78 -95.24, 19.38 292.18, 89.98 -56.7, -30.78 in-in in 7.8942 Saltbr-in 2.95 HRD-in -71.77, -56.19 75.58, 0.61 in-in-none SNCiin in-none ActLoopNT-in 2.9476 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 67.95 APE8-rot-na 32.78 APE67-dihe-in -63.64, -18.99 -57.25, -32.9 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.8 0.192 0.244 A 280.0 264.0 6 31 26 5 [[370, 628]] 1.0 8x5k Homo sapiens TYR_SYK_HUMAN TYR 4.8e-90 307.3 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
TYR SYK KSYK_HUMAN 4RX9A P43405 363 635 635.0 3YT:60702 Type1 Active DFGin 6.5363 14.4979 BLAminus -131.55, -166.02 53.8, 76.49 -95.21, 18.16 288.88, 90.96 -57.69, -29.73 in-in in 8.1675 Saltbr-in 3.1254 HRD-in -77.32, -52.67 70.66, 10.77 in-in-in SNCiii in-in ActLoopNT-in 2.9602 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -78.14, 87.16 APE9-dihe-in -107.75, 147.74 APE8-dihe-in -79.62, 70.69 APE8-rot-na 28.2 APE67-dihe-in -66.03, -15.15 -48.72, -38.82 APE12-dist-na 999.0 APE11-dist-na 11.0764 APE10-dist-na 10.7611 APE9-dist-in 6.9972 None None None XRAY 1.75 0.175 0.197 A 290.0 264.0 9 31 30 1 [[370, 628]] 1.0 4rx9 Homo sapiens TYR_SYK_HUMAN TYR 4e-90 307.6 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
OTHER PINK1 PINK1_TRICA 8UCTA D6WMX4 122 566 570.0 3YT:604 Type1 Inactive DFGin 9.6675 15.5149 None -106.46, -71.46 -86.94, 98.04 -82.78, 26.92 282.15, 73.59 -69.21, -17.85 in-in in 7.7276 Saltbr-in 3.5456 HRD-in -61.61, -52.71 76.55, -7.29 in-in-in SNCiii in-in ActLoopNT-in 2.8231 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na 143.12, -153.91 APE9-dihe-na -114.43, -90.54 APE8-dihe-in -52.28, 116.57 APE8-rot-na 181.23 APE67-dihe-in -80.32, -30.67 -78.6, -18.94 APE12-dist-in 7.6852 APE11-dist-in 9.8751 APE10-dist-in 5.4884 APE9-dist-in 4.262 W131A,W142A,Y225A,Y378A,F401A,F437A None None XRAY 2.93 0.284 0.305 A 455.0 391.0 37 34 34 0 [[61, 504]] 1.0 8uct Tribolium castaneum OTHER_PINK1_TRICA PINK1 1.6e-89 306.3 5.0 367.0 363.0 358 359 360 362 364 196 217 221 334 336 335 337.0 410 392 387 386 385 384 383 382 381 295 Serine/threonine-protein kinase Pink1, mitochondrial

Ligand: 3YT

Total number of chains: 1
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin None 1 100.0% 8UCTA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
OTHER PINK1 PINK1_TRICA 8UCTA D6WMX4 122 566 570.0 3YT:604 Type1 Inactive DFGin 9.6675 15.5149 None -106.46, -71.46 -86.94, 98.04 -82.78, 26.92 282.15, 73.59 -69.21, -17.85 in-in in 7.7276 Saltbr-in 3.5456 HRD-in -61.61, -52.71 76.55, -7.29 in-in-in SNCiii in-in ActLoopNT-in 2.8231 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na 143.12, -153.91 APE9-dihe-na -114.43, -90.54 APE8-dihe-in -52.28, 116.57 APE8-rot-na 181.23 APE67-dihe-in -80.32, -30.67 -78.6, -18.94 APE12-dist-in 7.6852 APE11-dist-in 9.8751 APE10-dist-in 5.4884 APE9-dist-in 4.262 W131A,W142A,Y225A,Y378A,F401A,F437A None None XRAY 2.93 0.284 0.305 A 455.0 391.0 37 34 34 0 [[61, 504]] 1.0 8uct Tribolium castaneum OTHER_PINK1_TRICA PINK1 1.6e-89 306.3 5.0 367.0 363.0 358 359 360 362 364 196 217 221 334 336 335 337.0 410 392 387 386 385 384 383 382 381 295 Serine/threonine-protein kinase Pink1, mitochondrial