Ligand: 3YT

Total number of chains: 3
Active chains: 1
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 66.7% 8X5KA
DFGin None 1 33.3% 5UT2A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
TYR JAK2-1 JAK2_HUMAN 5UT2A 1.75 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao 3YT Type1 536 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
TYR SYK KSYK_HUMAN 8X5KA 1.8 None DFGin‑BLAminus in-in in-none TYR APEdihe_nnnai APEdist_aaan 3YT Type1 363 - 632 0 None None Tyrosine-protein kinase SYK
TYR SYK KSYK_HUMAN 4RX9A 1.75 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 3YT Type1 363 - 635 0 None None Tyrosine-protein kinase SYK

Ligand: 3YT

Total number of chains: 4
Active chains: 1
Total number of genes: 3
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 50.0% 8X5KA
DFGin None 2 50.0% 5UT2A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
TYR JAK2-1 JAK2_HUMAN 5UT2A 1.75 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao 3YT Type1 536 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
TYR SYK KSYK_HUMAN 8X5KA 1.8 None DFGin‑BLAminus in-in in-none TYR APEdihe_nnnai APEdist_aaan 3YT Type1 363 - 632 0 None None Tyrosine-protein kinase SYK Homo sapiens
TYR SYK KSYK_HUMAN 4RX9A 1.75 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 3YT Type1 363 - 635 0 None None Tyrosine-protein kinase SYK Homo sapiens
OTHER PINK1 PINK1_TRICA 8UCTA 2.93 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiai APEdist_iiii 3YT Type1 122 - 566 0 None W131A,W142A,Y225A,Y378A,F401A,F437A Serine/threonine-protein kinase Pink1, mitochondrial Tribolium castaneum

Ligand: 3YT

Total number of chains: 1
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin None 1 100.0% 8UCTA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
OTHER PINK1 PINK1_TRICA 8UCTA 2.93 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiai APEdist_iiii 3YT Type1 122 - 566 0 None W131A,W142A,Y225A,Y378A,F401A,F437A Serine/threonine-protein kinase Pink1, mitochondrial Tribolium castaneum