Ligand: 3E8 (Tepotinib, Tepmetko)

Total number of chains: 6
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 6 100.0% 4R1VA
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR MET MET_HUMAN 8AU3A P08581 1052 1349 1390.0 3E8:1401 Type1 Inactive DFGin 5.684 14.29 BLBplus -124.89, -160.9 56.91, 51.79 -144.24, 164.35 65.96, 84.2 62.67, -127.3 out-out out 12.107 Saltbr-out 10.728 HRD-in -74.56, -50.99 74.86, 1.96 out-out-out SNCooo out-out ActLoopNT-out 10.759 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -67.06 APE8-dihe-out -64.75, -14.77 APE8-rot-na 35.69 APE67-dihe-in -73.18, -9.04 -40.0, -46.69 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 10.271 Y1234E,Y1235E None None XRAY 2.26 0.198 0.24 A 299 285 13 0 0 13 [[1078, 1339]] 1.0 8au3 TYR_MET_HUMAN TYR 4.5e-91 310.8 2 260 259 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR MET MET_HUMAN 8AU3B P08581 1056 1349 1390.0 3E8:1401 Type1 Inactive DFGin 5.496 14.473 BLBplus -125.67, -163.77 56.96, 51.67 -147.0, 169.32 67.61, 95.69 59.55, -126.73 out-out out 15.391 Saltbr-out 16.785 HRD-in -71.6, -51.19 76.55, 0.05 out-out-out SNCooo out-out ActLoopNT-out 10.966 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -66.77 APE8-dihe-out -65.4, -13.15 APE8-rot-na 35.16 APE67-dihe-in -76.94, -3.51 -35.23, -49.22 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 10.331 Y1234E,Y1235E None None XRAY 2.26 0.198 0.24 B 299 281 13 0 0 13 [[1078, 1339]] 1.0 8au3 TYR_MET_HUMAN TYR 4.5e-91 310.8 2 260 259 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR MET MET_HUMAN 8AU5A P08581 1067 1346 1390.0 3E8:1401 Type1 Inactive DFGin 5.707 14.374 BLBplus -119.33, -165.19 60.98, 56.2 -152.49, 146.81 74.85, 101.87 68.18, -123.4 out-out out 15.336 Saltbr-out 11.537 HRD-in -65.68, -49.98 78.74, -13.11 out-out-in SNCooi out-in ActLoopNT-out 10.8 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -77.2, 134.11 APE9-dihe-in -112.02, 144.15 APE8-dihe-in -87.51, 76.24 APE8-rot-na 34.54 APE67-dihe-in -68.65, -16.74 -55.51, -46.08 APE12-dist-na 20.917 APE11-dist-na 16.445 APE10-dist-na 17.773 APE9-dist-in 7.409 F1200I None None XRAY 2.72 0.239 0.278 A 299 265 15 0 0 2 [[1078, 1339]] 1.0 8au5 TYR_MET_HUMAN TYR 1.6e-91 312.3 2 260 259 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR MET MET_HUMAN 8AW1A P08581 1066 1345 1390.0 3E8:1401 Type1 Inactive DFGin 5.295 13.933 BLBplus -124.71, -163.84 60.77, 51.89 -150.77, 158.45 69.7, 88.83 60.72, -129.97 out-out out 14.414 Saltbr-out 12.19 HRD-in -71.16, -55.41 80.21, -13.77 out-out-none SNCoon out-none ActLoopNT-out 10.771 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 138.91 APE9-dihe-in -126.21, 148.9 APE8-dihe-in -85.84, 71.21 APE8-rot-na 27.14 APE67-dihe-in -72.93, -13.12 -55.01, -33.46 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 18.233 APE9-dist-in 7.208 Y1235D None None XRAY 2.14 0.218 0.241 A 299 263 17 0 0 8 [[1078, 1339]] 1.0 8aw1 TYR_MET_HUMAN TYR 3.4e-91 311.1 2 260 259 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR MET MET_HUMAN 8AW1B P08581 1064 1345 1390.0 3E8:1401 Type1 Inactive DFGin 5.302 14.15 BLBplus -123.92, -163.21 58.0, 49.54 -149.17, 156.39 75.23, 94.55 65.41, -133.45 out-out out 14.898 Saltbr-out 12.507 HRD-in -69.21, -52.41 76.89, -7.96 out-out-in SNCooi out-in ActLoopNT-out 10.535 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -97.96, 136.97 APE9-dihe-in -126.46, 148.09 APE8-dihe-in -85.21, 69.6 APE8-rot-na 28.63 APE67-dihe-in -72.96, -12.49 -53.88, -33.35 APE12-dist-na 999.0 APE11-dist-na 18.063 APE10-dist-na 18.136 APE9-dist-in 7.261 Y1235D None None XRAY 2.14 0.218 0.241 B 299 264 18 0 0 8 [[1078, 1339]] 1.0 8aw1 TYR_MET_HUMAN TYR 3.4e-91 311.1 2 260 259 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR MET MET_HUMAN 4R1VA P08581 1055 1345 1390.0 3E8:1401 Type1 Inactive DFGin 6.851 15.131 BLBplus -128.85, -160.46 55.61, 46.43 -145.43, 164.26 73.06, 94.72 59.68, -132.26 out-out out 13.914 Saltbr-out 11.075 HRD-in -72.84, -48.56 75.96, -10.9 out-out-in SNCooi out-in ActLoopNT-out 10.449 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -95.25, 114.51 APE9-dihe-in -113.76, 127.94 APE8-dihe-in -81.67, 70.95 APE8-rot-na 30.91 APE67-dihe-in -76.37, -2.92 -53.11, -41.22 APE12-dist-na 20.098 APE11-dist-na 17.696 APE10-dist-na 15.864 APE9-dist-in 7.088 None None None XRAY 1.2 0.146 0.176 A 291 289 2 0 0 0 [[1078, 1339]] 1.0 4r1v TYR_MET_HUMAN TYR 5.6e-92 313.7 2 260 259 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor

Ligand: 3E8 (Tepotinib, Tepmetko)

Total number of chains: 6
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 6 100.0% 4R1VA
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR MET MET_HUMAN 8AU3A P08581 1052 1349 1390.0 3E8:1401 Type1 Inactive DFGin 5.684 14.29 BLBplus -124.89, -160.9 56.91, 51.79 -144.24, 164.35 65.96, 84.2 62.67, -127.3 out-out out 12.107 Saltbr-out 10.728 HRD-in -74.56, -50.99 74.86, 1.96 out-out-out SNCooo out-out ActLoopNT-out 10.759 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -67.06 APE8-dihe-out -64.75, -14.77 APE8-rot-na 35.69 APE67-dihe-in -73.18, -9.04 -40.0, -46.69 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 10.271 Y1234E,Y1235E None None XRAY 2.26 0.198 0.24 A 299 285 13 0 0 13 [[1078, 1339]] 1.0 8au3 Homo sapiens TYR_MET_HUMAN TYR 4.5e-91 310.8 2 260 259 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR MET MET_HUMAN 8AU3B P08581 1056 1349 1390.0 3E8:1401 Type1 Inactive DFGin 5.496 14.473 BLBplus -125.67, -163.77 56.96, 51.67 -147.0, 169.32 67.61, 95.69 59.55, -126.73 out-out out 15.391 Saltbr-out 16.785 HRD-in -71.6, -51.19 76.55, 0.05 out-out-out SNCooo out-out ActLoopNT-out 10.966 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -66.77 APE8-dihe-out -65.4, -13.15 APE8-rot-na 35.16 APE67-dihe-in -76.94, -3.51 -35.23, -49.22 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 10.331 Y1234E,Y1235E None None XRAY 2.26 0.198 0.24 B 299 281 13 0 0 13 [[1078, 1339]] 1.0 8au3 Homo sapiens TYR_MET_HUMAN TYR 4.5e-91 310.8 2 260 259 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR MET MET_HUMAN 8AU5A P08581 1067 1346 1390.0 3E8:1401 Type1 Inactive DFGin 5.707 14.374 BLBplus -119.33, -165.19 60.98, 56.2 -152.49, 146.81 74.85, 101.87 68.18, -123.4 out-out out 15.336 Saltbr-out 11.537 HRD-in -65.68, -49.98 78.74, -13.11 out-out-in SNCooi out-in ActLoopNT-out 10.8 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -77.2, 134.11 APE9-dihe-in -112.02, 144.15 APE8-dihe-in -87.51, 76.24 APE8-rot-na 34.54 APE67-dihe-in -68.65, -16.74 -55.51, -46.08 APE12-dist-na 20.917 APE11-dist-na 16.445 APE10-dist-na 17.773 APE9-dist-in 7.409 F1200I None None XRAY 2.72 0.239 0.278 A 299 265 15 0 0 2 [[1078, 1339]] 1.0 8au5 Homo sapiens TYR_MET_HUMAN TYR 1.6e-91 312.3 2 260 259 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR MET MET_HUMAN 8AW1A P08581 1066 1345 1390.0 3E8:1401 Type1 Inactive DFGin 5.295 13.933 BLBplus -124.71, -163.84 60.77, 51.89 -150.77, 158.45 69.7, 88.83 60.72, -129.97 out-out out 14.414 Saltbr-out 12.19 HRD-in -71.16, -55.41 80.21, -13.77 out-out-none SNCoon out-none ActLoopNT-out 10.771 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 138.91 APE9-dihe-in -126.21, 148.9 APE8-dihe-in -85.84, 71.21 APE8-rot-na 27.14 APE67-dihe-in -72.93, -13.12 -55.01, -33.46 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 18.233 APE9-dist-in 7.208 Y1235D None None XRAY 2.14 0.218 0.241 A 299 263 17 0 0 8 [[1078, 1339]] 1.0 8aw1 Homo sapiens TYR_MET_HUMAN TYR 3.4e-91 311.1 2 260 259 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR MET MET_HUMAN 8AW1B P08581 1064 1345 1390.0 3E8:1401 Type1 Inactive DFGin 5.302 14.15 BLBplus -123.92, -163.21 58.0, 49.54 -149.17, 156.39 75.23, 94.55 65.41, -133.45 out-out out 14.898 Saltbr-out 12.507 HRD-in -69.21, -52.41 76.89, -7.96 out-out-in SNCooi out-in ActLoopNT-out 10.535 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -97.96, 136.97 APE9-dihe-in -126.46, 148.09 APE8-dihe-in -85.21, 69.6 APE8-rot-na 28.63 APE67-dihe-in -72.96, -12.49 -53.88, -33.35 APE12-dist-na 999.0 APE11-dist-na 18.063 APE10-dist-na 18.136 APE9-dist-in 7.261 Y1235D None None XRAY 2.14 0.218 0.241 B 299 264 18 0 0 8 [[1078, 1339]] 1.0 8aw1 Homo sapiens TYR_MET_HUMAN TYR 3.4e-91 311.1 2 260 259 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR MET MET_HUMAN 4R1VA P08581 1055 1345 1390.0 3E8:1401 Type1 Inactive DFGin 6.851 15.131 BLBplus -128.85, -160.46 55.61, 46.43 -145.43, 164.26 73.06, 94.72 59.68, -132.26 out-out out 13.914 Saltbr-out 11.075 HRD-in -72.84, -48.56 75.96, -10.9 out-out-in SNCooi out-in ActLoopNT-out 10.449 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -95.25, 114.51 APE9-dihe-in -113.76, 127.94 APE8-dihe-in -81.67, 70.95 APE8-rot-na 30.91 APE67-dihe-in -76.37, -2.92 -53.11, -41.22 APE12-dist-na 20.098 APE11-dist-na 17.696 APE10-dist-na 15.864 APE9-dist-in 7.088 None None None XRAY 1.2 0.146 0.176 A 291 289 2 0 0 0 [[1078, 1339]] 1.0 4r1v Homo sapiens TYR_MET_HUMAN TYR 5.6e-92 313.7 2 260 259 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor

Ligand: 3E8 (Tepotinib, Tepmetko)

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name