Ligand: 3E8 (Tepotinib)

Total number of chains: 6
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 6 100.0% 4R1VA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR MET MET_HUMAN 8AU3A P08581 1052 1349 1390.0 3E8:1401 Type1 Inactive DFGin 5.6836 14.2897 BLBplus -124.89, -160.9 56.91, 51.79 -144.24, 164.35 65.96, 84.2 62.67, -127.3 out-out out 12.1068 Saltbr-out 10.7283 HRD-in -74.56, -50.99 74.86, 1.96 out-out-out SNCooo out-out ActLoopNT-out 10.7586 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -67.06 APE8-dihe-out -64.75, -14.77 APE8-rot-na 35.69 APE67-dihe-in -73.18, -9.04 -40.0, -46.69 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 10.2708 Y1234E,Y1235E None None XRAY 2.26 0.198 0.24 A 299.0 285.0 13 32 19 13 [[1078, 1339]] 1.0 8au3 TYR_MET_HUMAN TYR 4.5e-91 310.8 2.0 260.0 259.0 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204.0 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR MET MET_HUMAN 8AU3B P08581 1056 1349 1390.0 3E8:1401 Type1 Inactive DFGin 5.4962 14.4728 BLBplus -125.67, -163.77 56.96, 51.67 -147.0, 169.32 67.61, 95.69 59.55, -126.73 out-out out 15.3906 Saltbr-out 16.7854 HRD-in -71.6, -51.19 76.55, 0.05 out-out-out SNCooo out-out ActLoopNT-out 10.966 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -66.77 APE8-dihe-out -65.4, -13.15 APE8-rot-na 35.16 APE67-dihe-in -76.94, -3.51 -35.23, -49.22 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 10.3309 Y1234E,Y1235E None None XRAY 2.26 0.198 0.24 B 299.0 281.0 13 32 19 13 [[1078, 1339]] 1.0 8au3 TYR_MET_HUMAN TYR 4.5e-91 310.8 2.0 260.0 259.0 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204.0 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR MET MET_HUMAN 8AU5A P08581 1067 1346 1390.0 3E8:1401 Type1 Inactive DFGin 5.707 14.3738 BLBplus -119.33, -165.19 60.98, 56.2 -152.49, 146.81 74.85, 101.87 68.18, -123.4 out-out out 15.3357 Saltbr-out 11.5365 HRD-in -65.68, -49.98 78.74, -13.11 out-out-in SNCooi out-in ActLoopNT-out 10.7998 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -77.2, 134.11 APE9-dihe-in -112.02, 144.15 APE8-dihe-in -87.51, 76.24 APE8-rot-na 34.54 APE67-dihe-in -68.65, -16.74 -55.51, -46.08 APE12-dist-na 20.9168 APE11-dist-na 16.4449 APE10-dist-na 17.7727 APE9-dist-in 7.409 F1200I None None XRAY 2.72 0.239 0.278 A 299.0 265.0 15 32 30 2 [[1078, 1339]] 1.0 8au5 TYR_MET_HUMAN TYR 1.6e-91 312.3 2.0 260.0 259.0 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204.0 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR MET MET_HUMAN 8AW1A P08581 1066 1345 1390.0 3E8:1401 Type1 Inactive DFGin 5.2954 13.9327 BLBplus -124.71, -163.84 60.77, 51.89 -150.77, 158.45 69.7, 88.83 60.72, -129.97 out-out out 14.4136 Saltbr-out 12.1899 HRD-in -71.16, -55.41 80.21, -13.77 out-out-none SNCoon out-none ActLoopNT-out 10.7712 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 138.91 APE9-dihe-in -126.21, 148.9 APE8-dihe-in -85.84, 71.21 APE8-rot-na 27.14 APE67-dihe-in -72.93, -13.12 -55.01, -33.46 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 18.2332 APE9-dist-in 7.2085 Y1235D None None XRAY 2.14 0.218 0.241 A 299.0 263.0 17 32 24 8 [[1078, 1339]] 1.0 8aw1 TYR_MET_HUMAN TYR 3.4e-91 311.1 2.0 260.0 259.0 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204.0 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR MET MET_HUMAN 8AW1B P08581 1064 1345 1390.0 3E8:1401 Type1 Inactive DFGin 5.302 14.1499 BLBplus -123.92, -163.21 58.0, 49.54 -149.17, 156.39 75.23, 94.55 65.41, -133.45 out-out out 14.8977 Saltbr-out 12.5072 HRD-in -69.21, -52.41 76.89, -7.96 out-out-in SNCooi out-in ActLoopNT-out 10.5347 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -97.96, 136.97 APE9-dihe-in -126.46, 148.09 APE8-dihe-in -85.21, 69.6 APE8-rot-na 28.63 APE67-dihe-in -72.96, -12.49 -53.88, -33.35 APE12-dist-na 999.0 APE11-dist-na 18.0632 APE10-dist-na 18.1359 APE9-dist-in 7.2607 Y1235D None None XRAY 2.14 0.218 0.241 B 299.0 264.0 18 32 24 8 [[1078, 1339]] 1.0 8aw1 TYR_MET_HUMAN TYR 3.4e-91 311.1 2.0 260.0 259.0 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204.0 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR MET MET_HUMAN 4R1VA P08581 1055 1345 1390.0 3E8:1401 Type1 Inactive DFGin 6.8506 15.1308 BLBplus -128.85, -160.46 55.61, 46.43 -145.43, 164.26 73.06, 94.72 59.68, -132.26 out-out out 13.9143 Saltbr-out 11.0746 HRD-in -72.84, -48.56 75.96, -10.9 out-out-in SNCooi out-in ActLoopNT-out 10.4489 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -95.25, 114.51 APE9-dihe-in -113.76, 127.94 APE8-dihe-in -81.67, 70.95 APE8-rot-na 30.91 APE67-dihe-in -76.37, -2.92 -53.11, -41.22 APE12-dist-na 20.0982 APE11-dist-na 17.6961 APE10-dist-na 15.8636 APE9-dist-in 7.0884 None None None XRAY 1.2 0.146 0.176 A 291.0 289.0 2 32 32 0 [[1078, 1339]] 1.0 4r1v TYR_MET_HUMAN TYR 5.6e-92 313.7 2.0 260.0 259.0 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204.0 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor

Ligand: 3E8 (Tepotinib)

Total number of chains: 6
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 6 100.0% 4R1VA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR MET MET_HUMAN 8AU3A P08581 1052 1349 1390.0 3E8:1401 Type1 Inactive DFGin 5.6836 14.2897 BLBplus -124.89, -160.9 56.91, 51.79 -144.24, 164.35 65.96, 84.2 62.67, -127.3 out-out out 12.1068 Saltbr-out 10.7283 HRD-in -74.56, -50.99 74.86, 1.96 out-out-out SNCooo out-out ActLoopNT-out 10.7586 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -67.06 APE8-dihe-out -64.75, -14.77 APE8-rot-na 35.69 APE67-dihe-in -73.18, -9.04 -40.0, -46.69 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 10.2708 Y1234E,Y1235E None None XRAY 2.26 0.198 0.24 A 299.0 285.0 13 32 19 13 [[1078, 1339]] 1.0 8au3 Homo sapiens TYR_MET_HUMAN TYR 4.5e-91 310.8 2.0 260.0 259.0 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204.0 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR MET MET_HUMAN 8AU3B P08581 1056 1349 1390.0 3E8:1401 Type1 Inactive DFGin 5.4962 14.4728 BLBplus -125.67, -163.77 56.96, 51.67 -147.0, 169.32 67.61, 95.69 59.55, -126.73 out-out out 15.3906 Saltbr-out 16.7854 HRD-in -71.6, -51.19 76.55, 0.05 out-out-out SNCooo out-out ActLoopNT-out 10.966 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -66.77 APE8-dihe-out -65.4, -13.15 APE8-rot-na 35.16 APE67-dihe-in -76.94, -3.51 -35.23, -49.22 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 10.3309 Y1234E,Y1235E None None XRAY 2.26 0.198 0.24 B 299.0 281.0 13 32 19 13 [[1078, 1339]] 1.0 8au3 Homo sapiens TYR_MET_HUMAN TYR 4.5e-91 310.8 2.0 260.0 259.0 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204.0 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR MET MET_HUMAN 8AU5A P08581 1067 1346 1390.0 3E8:1401 Type1 Inactive DFGin 5.707 14.3738 BLBplus -119.33, -165.19 60.98, 56.2 -152.49, 146.81 74.85, 101.87 68.18, -123.4 out-out out 15.3357 Saltbr-out 11.5365 HRD-in -65.68, -49.98 78.74, -13.11 out-out-in SNCooi out-in ActLoopNT-out 10.7998 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -77.2, 134.11 APE9-dihe-in -112.02, 144.15 APE8-dihe-in -87.51, 76.24 APE8-rot-na 34.54 APE67-dihe-in -68.65, -16.74 -55.51, -46.08 APE12-dist-na 20.9168 APE11-dist-na 16.4449 APE10-dist-na 17.7727 APE9-dist-in 7.409 F1200I None None XRAY 2.72 0.239 0.278 A 299.0 265.0 15 32 30 2 [[1078, 1339]] 1.0 8au5 Homo sapiens TYR_MET_HUMAN TYR 1.6e-91 312.3 2.0 260.0 259.0 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204.0 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR MET MET_HUMAN 8AW1A P08581 1066 1345 1390.0 3E8:1401 Type1 Inactive DFGin 5.2954 13.9327 BLBplus -124.71, -163.84 60.77, 51.89 -150.77, 158.45 69.7, 88.83 60.72, -129.97 out-out out 14.4136 Saltbr-out 12.1899 HRD-in -71.16, -55.41 80.21, -13.77 out-out-none SNCoon out-none ActLoopNT-out 10.7712 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 138.91 APE9-dihe-in -126.21, 148.9 APE8-dihe-in -85.84, 71.21 APE8-rot-na 27.14 APE67-dihe-in -72.93, -13.12 -55.01, -33.46 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 18.2332 APE9-dist-in 7.2085 Y1235D None None XRAY 2.14 0.218 0.241 A 299.0 263.0 17 32 24 8 [[1078, 1339]] 1.0 8aw1 Homo sapiens TYR_MET_HUMAN TYR 3.4e-91 311.1 2.0 260.0 259.0 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204.0 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR MET MET_HUMAN 8AW1B P08581 1064 1345 1390.0 3E8:1401 Type1 Inactive DFGin 5.302 14.1499 BLBplus -123.92, -163.21 58.0, 49.54 -149.17, 156.39 75.23, 94.55 65.41, -133.45 out-out out 14.8977 Saltbr-out 12.5072 HRD-in -69.21, -52.41 76.89, -7.96 out-out-in SNCooi out-in ActLoopNT-out 10.5347 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -97.96, 136.97 APE9-dihe-in -126.46, 148.09 APE8-dihe-in -85.21, 69.6 APE8-rot-na 28.63 APE67-dihe-in -72.96, -12.49 -53.88, -33.35 APE12-dist-na 999.0 APE11-dist-na 18.0632 APE10-dist-na 18.1359 APE9-dist-in 7.2607 Y1235D None None XRAY 2.14 0.218 0.241 B 299.0 264.0 18 32 24 8 [[1078, 1339]] 1.0 8aw1 Homo sapiens TYR_MET_HUMAN TYR 3.4e-91 311.1 2.0 260.0 259.0 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204.0 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR MET MET_HUMAN 4R1VA P08581 1055 1345 1390.0 3E8:1401 Type1 Inactive DFGin 6.8506 15.1308 BLBplus -128.85, -160.46 55.61, 46.43 -145.43, 164.26 73.06, 94.72 59.68, -132.26 out-out out 13.9143 Saltbr-out 11.0746 HRD-in -72.84, -48.56 75.96, -10.9 out-out-in SNCooi out-in ActLoopNT-out 10.4489 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -95.25, 114.51 APE9-dihe-in -113.76, 127.94 APE8-dihe-in -81.67, 70.95 APE8-rot-na 30.91 APE67-dihe-in -76.37, -2.92 -53.11, -41.22 APE12-dist-na 20.0982 APE11-dist-na 17.6961 APE10-dist-na 15.8636 APE9-dist-in 7.0884 None None None XRAY 1.2 0.146 0.176 A 291.0 289.0 2 32 32 0 [[1078, 1339]] 1.0 4r1v Homo sapiens TYR_MET_HUMAN TYR 5.6e-92 313.7 2.0 260.0 259.0 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204.0 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor

Ligand: 3E8 (Tepotinib)

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name