Ligand: 3E8 (Tepotinib)

Total number of chains: 6
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 6 100.0% 4R1VA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
TYR MET MET_HUMAN 8AU3A 2.26 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_nnoai APEdist_aaao 3E8 Type1 1052 - 1349 0 None Y1234E,Y1235E Hepatocyte growth factor receptor
TYR MET MET_HUMAN 8AU3B 2.26 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_nnoai APEdist_aaao 3E8 Type1 1056 - 1349 0 None Y1234E,Y1235E Hepatocyte growth factor receptor
TYR MET MET_HUMAN 8AU5A 2.72 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai 3E8 Type1 1067 - 1346 0 None F1200I Hepatocyte growth factor receptor
TYR MET MET_HUMAN 8AW1A 2.14 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_niiai APEdist_aaai 3E8 Type1 1066 - 1345 0 None Y1235D Hepatocyte growth factor receptor
TYR MET MET_HUMAN 8AW1B 2.14 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai 3E8 Type1 1064 - 1345 0 None Y1235D Hepatocyte growth factor receptor
TYR MET MET_HUMAN 4R1VA 1.2 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai 3E8 Type1 1055 - 1345 0 None None Hepatocyte growth factor receptor

Ligand: 3E8 (Tepotinib)

Total number of chains: 6
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 6 100.0% 4R1VA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
TYR MET MET_HUMAN 8AU3A 2.26 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_nnoai APEdist_aaao 3E8 Type1 1052 - 1349 0 None Y1234E,Y1235E Hepatocyte growth factor receptor Homo sapiens
TYR MET MET_HUMAN 8AU3B 2.26 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_nnoai APEdist_aaao 3E8 Type1 1056 - 1349 0 None Y1234E,Y1235E Hepatocyte growth factor receptor Homo sapiens
TYR MET MET_HUMAN 8AU5A 2.72 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai 3E8 Type1 1067 - 1346 0 None F1200I Hepatocyte growth factor receptor Homo sapiens
TYR MET MET_HUMAN 8AW1A 2.14 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_niiai APEdist_aaai 3E8 Type1 1066 - 1345 0 None Y1235D Hepatocyte growth factor receptor Homo sapiens
TYR MET MET_HUMAN 8AW1B 2.14 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai 3E8 Type1 1064 - 1345 0 None Y1235D Hepatocyte growth factor receptor Homo sapiens
TYR MET MET_HUMAN 4R1VA 1.2 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai 3E8 Type1 1055 - 1345 0 None None Hepatocyte growth factor receptor Homo sapiens

Ligand: 3E8 (Tepotinib)

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism