Ligand: 37O

Total number of chains: 2
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAplus 1 50.0% 4QQCA
DFGout BBAminus 1 50.0% 4QQ5A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR FGFR4 FGFR4_HUMAN 4QQCA P22455 445 750 802.0 37O:60801 Type1.5_Back Inactive DFGin 5.3786 13.2944 BLAplus -105.5, 167.64 62.41, 26.27 -78.09, -25.76 56.21, 83.69 -101.85, 145.28 in-in in 8.0664 Saltbr-in 3.2123 HRD-in -73.92, -52.23 79.6, -15.21 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 116.52 APE8-dihe-out -46.45, -18.28 APE8-rot-na 329.31 APE67-dihe-in -73.13, -9.32 -59.41, -33.7 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 10.649 R664E None None XRAY 2.4 0.163 0.214 A 323.0 271.0 35 30 13 17 [[467, 745]] 1.0 4qqc TYR_FGFR4_HUMAN TYR 2.2e-100 341.2 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
TYR FGFR4 FGFR4_HUMAN 4QQ5A P22455 445 750 802.0 37O:60801 Type1.5_Back Inactive DFGout 13.8248 11.1354 BBAminus -99.0, 166.33 -153.32, 109.28 -96.97, 16.74 304.57, 104.6 -130.76, 29.26 in-in in 7.8461 Saltbr-in 2.9055 HRD-in -72.86, -56.2 82.96, -11.73 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 137.0 APE8-dihe-out -47.81, -19.48 APE8-rot-na 326.35 APE67-dihe-in -66.59, -10.5 -64.2, -38.91 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 10.2578 V550L,R664E None None XRAY 2.203 0.197 0.234 A 323.0 272.0 34 30 14 16 [[467, 745]] 1.0 4qq5 TYR_FGFR4_HUMAN TYR 3.3e-100 340.6 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4

Ligand: 37O

Total number of chains: 4
Active chains: 0
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGout BBAminus 2 50.0% 7D57A
DFGin BLAminus 1 25.0% 7D57B
DFGin BLAplus 1 25.0% 4QQCA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR SRC SRC_CHICK 7D57B P00523 257 533 533.0 37O:601 Type1.5_Back Inactive DFGin 6.3302 15.0257 BLAminus -127.74, 176.93 47.65, 65.96 -60.08, -70.51 292.09, 83.95 21.91, 999.0 in-out in 8.9052 Saltbr-out 3.8195 HRD-in -81.22, -54.0 84.65, -4.16 out-in-out SNCoio in-out ActLoopNT-in 3.0911 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -54.1 APE8-dihe-in -72.3, 58.7 APE8-rot-na 32.5 APE67-dihe-in -70.86, -19.4 -65.21, -16.73 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.6587 None None None XRAY 2.104 0.187 0.222 B 286.0 253.0 24 29 15 14 [[267, 518]] 1.0 7d57 Gallus gallus TYR_SRC_CHICK TYR 3.4e-94 320.9 1.0 260.0 260.0 403 404 405 407 409 295 310 314 383 385 384 386.0 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 7D57A P00523 258 533 533.0 37O:601 Type1 Inactive DFGout 12.5914 10.0667 BBAminus -100.01, 155.27 -129.92, 106.6 -99.38, 31.54 297.46, 95.62 -57.6, -30.69 out-out out 12.4675 Saltbr-out 15.2582 HRD-out -112.06, 89.16 -72.24, 8.08 out-out-none SNCoon out-none ActLoopNT-out 11.6899 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 36.47 APE8-rot-na 18.46 APE67-dihe-in -70.63, -17.45 -55.48, -37.92 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.104 0.187 0.222 A 286.0 261.0 15 29 14 15 [[267, 518]] 1.0 7d57 Gallus gallus TYR_SRC_CHICK TYR 3.4e-94 320.9 1.0 260.0 260.0 403 404 405 407 409 295 310 314 383 385 384 386.0 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR FGFR4 FGFR4_HUMAN 4QQCA P22455 445 750 802.0 37O:60801 Type1.5_Back Inactive DFGin 5.3786 13.2944 BLAplus -105.5, 167.64 62.41, 26.27 -78.09, -25.76 56.21, 83.69 -101.85, 145.28 in-in in 8.0664 Saltbr-in 3.2123 HRD-in -73.92, -52.23 79.6, -15.21 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 116.52 APE8-dihe-out -46.45, -18.28 APE8-rot-na 329.31 APE67-dihe-in -73.13, -9.32 -59.41, -33.7 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 10.649 R664E None None XRAY 2.4 0.163 0.214 A 323.0 271.0 35 30 13 17 [[467, 745]] 1.0 4qqc Homo sapiens TYR_FGFR4_HUMAN TYR 2.2e-100 341.2 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
TYR FGFR4 FGFR4_HUMAN 4QQ5A P22455 445 750 802.0 37O:60801 Type1.5_Back Inactive DFGout 13.8248 11.1354 BBAminus -99.0, 166.33 -153.32, 109.28 -96.97, 16.74 304.57, 104.6 -130.76, 29.26 in-in in 7.8461 Saltbr-in 2.9055 HRD-in -72.86, -56.2 82.96, -11.73 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 137.0 APE8-dihe-out -47.81, -19.48 APE8-rot-na 326.35 APE67-dihe-in -66.59, -10.5 -64.2, -38.91 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 10.2578 V550L,R664E None None XRAY 2.203 0.197 0.234 A 323.0 272.0 34 30 14 16 [[467, 745]] 1.0 4qq5 Homo sapiens TYR_FGFR4_HUMAN TYR 3.3e-100 340.6 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4

Ligand: 37O

Total number of chains: 2
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 1 50.0% 7D57B
DFGout BBAminus 1 50.0% 7D57A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR SRC SRC_CHICK 7D57B P00523 257 533 533.0 37O:601 Type1.5_Back Inactive DFGin 6.3302 15.0257 BLAminus -127.74, 176.93 47.65, 65.96 -60.08, -70.51 292.09, 83.95 21.91, 999.0 in-out in 8.9052 Saltbr-out 3.8195 HRD-in -81.22, -54.0 84.65, -4.16 out-in-out SNCoio in-out ActLoopNT-in 3.0911 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -54.1 APE8-dihe-in -72.3, 58.7 APE8-rot-na 32.5 APE67-dihe-in -70.86, -19.4 -65.21, -16.73 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.6587 None None None XRAY 2.104 0.187 0.222 B 286.0 253.0 24 29 15 14 [[267, 518]] 1.0 7d57 Gallus gallus TYR_SRC_CHICK TYR 3.4e-94 320.9 1.0 260.0 260.0 403 404 405 407 409 295 310 314 383 385 384 386.0 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 7D57A P00523 258 533 533.0 37O:601 Type1 Inactive DFGout 12.5914 10.0667 BBAminus -100.01, 155.27 -129.92, 106.6 -99.38, 31.54 297.46, 95.62 -57.6, -30.69 out-out out 12.4675 Saltbr-out 15.2582 HRD-out -112.06, 89.16 -72.24, 8.08 out-out-none SNCoon out-none ActLoopNT-out 11.6899 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 36.47 APE8-rot-na 18.46 APE67-dihe-in -70.63, -17.45 -55.48, -37.92 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.104 0.187 0.222 A 286.0 261.0 15 29 14 15 [[267, 518]] 1.0 7d57 Gallus gallus TYR_SRC_CHICK TYR 3.4e-94 320.9 1.0 260.0 260.0 403 404 405 407 409 295 310 314 383 385 384 386.0 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src