KinCore

Ligand: 37O

Total number of chains: 2

Active chains: 0

Total number of genes: 1

Spatial label	Dihedral label	Number of Chains	Percent	Representative
DFGin	BLAplus	1	50.0%	4QQCA
DFGout	BBAminus	1	50.0%	4QQ5A

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Group	Gene	SwissprotID	PDB	UniprotID	First_obs_res	Last_obs_res	Length_Unp	Ligand	Ligand_type	Activity_label	Spatial_label	Phe_Glu4_dis	Phe_Lys_dis	Dihedral_label	XDFG φ,ψ	DFG-Asp φ,ψ	DFG-Phe φ,ψ	DFG-Phe χ1,χ2	DFG-Gly φ,ψ	ChelixSaltbr_label	Chelix_label	Lys_Glu_dis	Saltbr_label	LysNZ_GluOE_dis	HRD_label	His φ,ψ	Arg φ,ψ	SNC_label	SNCpymol_label	ActLoop_label	ActLoopNT_label	DFG6_XHRD_dis	ActLoopCT_label	APEtype	APEdihe_label	APEdist_label	APE10_dihe_label	APE10 φ,ψ	APE9_dihe_label	APE9 φ,ψ	APE8_dihe_label	APE8 φ,ψ	APE8_rotamer_label	APE8 χ1	APE67_label	APE6 φ,ψ	APE7 φ,ψ	APE12_dist_label	APE12_DFG4_dis	APE11_dist_label	APE11_DFG4_dis	APE10_dist_label	APE10_DFG4_dis	APE9_dist_label	APE9_Arg_dis	Chain_mut	Chain_phos	Modified_aa	Method	Resolution	Rvalue	FreeRvalue	Chain_id	ChainLen	Ordered_residues	DomainBreak	ActLoopLength	ActLoopResolvedResidues	ActLoopDisorderedResidues	Kinase_domains_Unp	N_Kinase_domains_Unp	pdb	Kincore_name	hmm	Evalue	Score	hmmbeg	hmmend	hmmlen	XDFGnum	DFGnum	PHEnum	DFG4num	DFG6num	LYSnum	GLUnum	GLU4num	XHRDnum	ARGnum	HRDnum	HRDaspnum	aFaspnum	APEnum	APE6num	APE7num	APE8num	APE9num	APE10num	APE11num	APE12num	Hinge1num	Protein_name
TYR	FGFR4	FGFR4_HUMAN	4QQCA	P22455	445	750	802.0	37O:60801	Type1.5_Back	Inactive	DFGin	5.379	13.294	BLAplus	-105.5, 167.64	62.41, 26.27	-78.09, -25.76	56.21, 83.69	-101.85, 145.28	in-in	in	8.066	Saltbr-in	3.212	HRD-in	-73.92, -52.23	79.6, -15.21	in-none-out	SNCino	none-out	ActLoopNT-none	999.0	ActLoopCT-out	TYR	APEdihe_nnoai	APEdist_aaao	APE10-dihe-none	999.0, 999.0	APE9-dihe-none	999.0, 116.52	APE8-dihe-out	-46.45, -18.28	APE8-rot-na	329.31	APE67-dihe-in	-73.13, -9.32	-59.41, -33.7	APE12-dist-na	999.0	APE11-dist-na	999.0	APE10-dist-na	999.0	APE9-dist-out	10.649	R664E	None	None	XRAY	2.4	0.163	0.214	A	323	271	35	0	0	17	[[467, 745]]	1.0	4qqc	TYR_FGFR4_HUMAN	TYR	2.2e-100	341.2	1	261	261	629	630	631	633	635	503	520	524	609	611	610	612	671	659	654	653	652	651	650	649	648	551	Fibroblast growth factor receptor 4
TYR	FGFR4	FGFR4_HUMAN	4QQ5A	P22455	445	750	802.0	37O:60801	Type1.5_Back	Inactive	DFGout	13.825	11.135	BBAminus	-99.0, 166.33	-153.32, 109.28	-96.97, 16.74	304.57, 104.6	-130.76, 29.26	in-in	in	7.846	Saltbr-in	2.905	HRD-in	-72.86, -56.2	82.96, -11.73	in-none-out	SNCino	none-out	ActLoopNT-none	999.0	ActLoopCT-out	TYR	APEdihe_nnoai	APEdist_aaao	APE10-dihe-none	999.0, 999.0	APE9-dihe-none	999.0, 137.0	APE8-dihe-out	-47.81, -19.48	APE8-rot-na	326.35	APE67-dihe-in	-66.59, -10.5	-64.2, -38.91	APE12-dist-na	999.0	APE11-dist-na	999.0	APE10-dist-na	999.0	APE9-dist-out	10.258	V550L,R664E	None	None	XRAY	2.203	0.197	0.234	A	323	272	34	0	0	16	[[467, 745]]	1.0	4qq5	TYR_FGFR4_HUMAN	TYR	3.3e-100	340.6	1	261	261	629	630	631	633	635	503	520	524	609	611	610	612	671	659	654	653	652	651	650	649	648	551	Fibroblast growth factor receptor 4

Ligand: 37O

Total number of chains: 4

Active chains: 0

Total number of genes: 2

Spatial label	Dihedral label	Number of Chains	Percent	Representative
DFGout	BBAminus	2	50.0%	7D57A
DFGin	BLAminus	1	25.0%	7D57B
DFGin	BLAplus	1	25.0%	4QQCA

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Group	Gene	SwissprotID	PDB	UniprotID	First_obs_res	Last_obs_res	Length_Unp	Ligand	Ligand_type	Activity_label	Spatial_label	Phe_Glu4_dis	Phe_Lys_dis	Dihedral_label	XDFG φ,ψ	DFG-Asp φ,ψ	DFG-Phe φ,ψ	DFG-Phe χ1,χ2	DFG-Gly φ,ψ	ChelixSaltbr_label	Chelix_label	Lys_Glu_dis	Saltbr_label	LysNZ_GluOE_dis	HRD_label	His φ,ψ	Arg φ,ψ	SNC_label	SNCpymol_label	ActLoop_label	ActLoopNT_label	DFG6_XHRD_dis	ActLoopCT_label	APEtype	APEdihe_label	APEdist_label	APE10_dihe_label	APE10 φ,ψ	APE9_dihe_label	APE9 φ,ψ	APE8_dihe_label	APE8 φ,ψ	APE8_rotamer_label	APE8 χ1	APE67_label	APE6 φ,ψ	APE7 φ,ψ	APE12_dist_label	APE12_DFG4_dis	APE11_dist_label	APE11_DFG4_dis	APE10_dist_label	APE10_DFG4_dis	APE9_dist_label	APE9_Arg_dis	Chain_mut	Chain_phos	Modified_aa	Method	Resolution	Rvalue	FreeRvalue	Chain_id	ChainLen	Ordered_residues	DomainBreak	ActLoopLength	ActLoopResolvedResidues	ActLoopDisorderedResidues	Kinase_domains_Unp	N_Kinase_domains_Unp	pdb	Species	Kincore_name	hmm	Evalue	Score	hmmbeg	hmmend	hmmlen	XDFGnum	DFGnum	PHEnum	DFG4num	DFG6num	LYSnum	GLUnum	GLU4num	XHRDnum	ARGnum	HRDnum	HRDaspnum	aFaspnum	APEnum	APE6num	APE7num	APE8num	APE9num	APE10num	APE11num	APE12num	Hinge1num	Protein_name
TYR	SRC	SRC_CHICK	7D57B	P00523	257	533	533.0	37O:601	Type1.5_Back	Inactive	DFGin	6.33	15.026	BLAminus	-127.74, 176.93	47.65, 65.96	-60.08, -70.51	292.09, 83.95	21.91, 999.0	in-out	in	8.905	Saltbr-out	3.82	HRD-in	-81.22, -54.0	84.65, -4.16	out-in-out	SNCoio	in-out	ActLoopNT-in	3.091	ActLoopCT-out	TYR	APEdihe_nniai	APEdist_aaao	APE10-dihe-none	999.0, 999.0	APE9-dihe-none	999.0, -54.1	APE8-dihe-in	-72.3, 58.7	APE8-rot-na	32.5	APE67-dihe-in	-70.86, -19.4	-65.21, -16.73	APE12-dist-na	999.0	APE11-dist-na	999.0	APE10-dist-na	999.0	APE9-dist-out	9.659	None	None	None	XRAY	2.104	0.187	0.222	B	286	253	24	0	0	14	[[267, 518]]	1.0	7d57	Gallus gallus	TYR_SRC_CHICK	TYR	3.4e-94	320.9	1	260	260	403	404	405	407	409	295	310	314	383	385	384	386	444	432	427	426	425	424	423	422	421	339	Proto-oncogene tyrosine-protein kinase Src
TYR	SRC	SRC_CHICK	7D57A	P00523	258	533	533.0	37O:601	Type1	Inactive	DFGout	12.591	10.067	BBAminus	-100.01, 155.27	-129.92, 106.6	-99.38, 31.54	297.46, 95.62	-57.6, -30.69	out-out	out	12.467	Saltbr-out	15.258	HRD-out	-112.06, 89.16	-72.24, 8.08	out-out-none	SNCoon	out-none	ActLoopNT-out	11.69	ActLoopCT-none	TYR	APEdihe_nnnai	APEdist_aaan	APE10-dihe-none	999.0, 999.0	APE9-dihe-none	999.0, 999.0	APE8-dihe-none	999.0, 36.47	APE8-rot-na	18.46	APE67-dihe-in	-70.63, -17.45	-55.48, -37.92	APE12-dist-na	999.0	APE11-dist-na	999.0	APE10-dist-na	999.0	APE9-dist-none	999.0	None	None	None	XRAY	2.104	0.187	0.222	A	286	261	15	0	0	15	[[267, 518]]	1.0	7d57	Gallus gallus	TYR_SRC_CHICK	TYR	3.4e-94	320.9	1	260	260	403	404	405	407	409	295	310	314	383	385	384	386	444	432	427	426	425	424	423	422	421	339	Proto-oncogene tyrosine-protein kinase Src
TYR	FGFR4	FGFR4_HUMAN	4QQCA	P22455	445	750	802.0	37O:60801	Type1.5_Back	Inactive	DFGin	5.379	13.294	BLAplus	-105.5, 167.64	62.41, 26.27	-78.09, -25.76	56.21, 83.69	-101.85, 145.28	in-in	in	8.066	Saltbr-in	3.212	HRD-in	-73.92, -52.23	79.6, -15.21	in-none-out	SNCino	none-out	ActLoopNT-none	999.0	ActLoopCT-out	TYR	APEdihe_nnoai	APEdist_aaao	APE10-dihe-none	999.0, 999.0	APE9-dihe-none	999.0, 116.52	APE8-dihe-out	-46.45, -18.28	APE8-rot-na	329.31	APE67-dihe-in	-73.13, -9.32	-59.41, -33.7	APE12-dist-na	999.0	APE11-dist-na	999.0	APE10-dist-na	999.0	APE9-dist-out	10.649	R664E	None	None	XRAY	2.4	0.163	0.214	A	323	271	35	0	0	17	[[467, 745]]	1.0	4qqc	Homo sapiens	TYR_FGFR4_HUMAN	TYR	2.2e-100	341.2	1	261	261	629	630	631	633	635	503	520	524	609	611	610	612	671	659	654	653	652	651	650	649	648	551	Fibroblast growth factor receptor 4
TYR	FGFR4	FGFR4_HUMAN	4QQ5A	P22455	445	750	802.0	37O:60801	Type1.5_Back	Inactive	DFGout	13.825	11.135	BBAminus	-99.0, 166.33	-153.32, 109.28	-96.97, 16.74	304.57, 104.6	-130.76, 29.26	in-in	in	7.846	Saltbr-in	2.905	HRD-in	-72.86, -56.2	82.96, -11.73	in-none-out	SNCino	none-out	ActLoopNT-none	999.0	ActLoopCT-out	TYR	APEdihe_nnoai	APEdist_aaao	APE10-dihe-none	999.0, 999.0	APE9-dihe-none	999.0, 137.0	APE8-dihe-out	-47.81, -19.48	APE8-rot-na	326.35	APE67-dihe-in	-66.59, -10.5	-64.2, -38.91	APE12-dist-na	999.0	APE11-dist-na	999.0	APE10-dist-na	999.0	APE9-dist-out	10.258	V550L,R664E	None	None	XRAY	2.203	0.197	0.234	A	323	272	34	0	0	16	[[467, 745]]	1.0	4qq5	Homo sapiens	TYR_FGFR4_HUMAN	TYR	3.3e-100	340.6	1	261	261	629	630	631	633	635	503	520	524	609	611	610	612	671	659	654	653	652	651	650	649	648	551	Fibroblast growth factor receptor 4

Ligand: 37O

Total number of chains: 2

Active chains: 0

Total number of genes: 1

Spatial label	Dihedral label	Number of Chains	Percent	Representative
DFGin	BLAminus	1	50.0%	7D57B
DFGout	BBAminus	1	50.0%	7D57A

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Group	Gene	SwissprotID	PDB	UniprotID	First_obs_res	Last_obs_res	Length_Unp	Ligand	Ligand_type	Activity_label	Spatial_label	Phe_Glu4_dis	Phe_Lys_dis	Dihedral_label	XDFG φ,ψ	DFG-Asp φ,ψ	DFG-Phe φ,ψ	DFG-Phe χ1,χ2	DFG-Gly φ,ψ	ChelixSaltbr_label	Chelix_label	Lys_Glu_dis	Saltbr_label	LysNZ_GluOE_dis	HRD_label	His φ,ψ	Arg φ,ψ	SNC_label	SNCpymol_label	ActLoop_label	ActLoopNT_label	DFG6_XHRD_dis	ActLoopCT_label	APEtype	APEdihe_label	APEdist_label	APE10_dihe_label	APE10 φ,ψ	APE9_dihe_label	APE9 φ,ψ	APE8_dihe_label	APE8 φ,ψ	APE8_rotamer_label	APE8 χ1	APE67_label	APE6 φ,ψ	APE7 φ,ψ	APE12_dist_label	APE12_DFG4_dis	APE11_dist_label	APE11_DFG4_dis	APE10_dist_label	APE10_DFG4_dis	APE9_dist_label	APE9_Arg_dis	Chain_mut	Chain_phos	Modified_aa	Method	Resolution	Rvalue	FreeRvalue	Chain_id	ChainLen	Ordered_residues	DomainBreak	ActLoopLength	ActLoopResolvedResidues	ActLoopDisorderedResidues	Kinase_domains_Unp	N_Kinase_domains_Unp	pdb	Species	Kincore_name	hmm	Evalue	Score	hmmbeg	hmmend	hmmlen	XDFGnum	DFGnum	PHEnum	DFG4num	DFG6num	LYSnum	GLUnum	GLU4num	XHRDnum	ARGnum	HRDnum	HRDaspnum	aFaspnum	APEnum	APE6num	APE7num	APE8num	APE9num	APE10num	APE11num	APE12num	Hinge1num	Protein_name
TYR	SRC	SRC_CHICK	7D57B	P00523	257	533	533.0	37O:601	Type1.5_Back	Inactive	DFGin	6.33	15.026	BLAminus	-127.74, 176.93	47.65, 65.96	-60.08, -70.51	292.09, 83.95	21.91, 999.0	in-out	in	8.905	Saltbr-out	3.82	HRD-in	-81.22, -54.0	84.65, -4.16	out-in-out	SNCoio	in-out	ActLoopNT-in	3.091	ActLoopCT-out	TYR	APEdihe_nniai	APEdist_aaao	APE10-dihe-none	999.0, 999.0	APE9-dihe-none	999.0, -54.1	APE8-dihe-in	-72.3, 58.7	APE8-rot-na	32.5	APE67-dihe-in	-70.86, -19.4	-65.21, -16.73	APE12-dist-na	999.0	APE11-dist-na	999.0	APE10-dist-na	999.0	APE9-dist-out	9.659	None	None	None	XRAY	2.104	0.187	0.222	B	286	253	24	0	0	14	[[267, 518]]	1.0	7d57	Gallus gallus	TYR_SRC_CHICK	TYR	3.4e-94	320.9	1	260	260	403	404	405	407	409	295	310	314	383	385	384	386	444	432	427	426	425	424	423	422	421	339	Proto-oncogene tyrosine-protein kinase Src
TYR	SRC	SRC_CHICK	7D57A	P00523	258	533	533.0	37O:601	Type1	Inactive	DFGout	12.591	10.067	BBAminus	-100.01, 155.27	-129.92, 106.6	-99.38, 31.54	297.46, 95.62	-57.6, -30.69	out-out	out	12.467	Saltbr-out	15.258	HRD-out	-112.06, 89.16	-72.24, 8.08	out-out-none	SNCoon	out-none	ActLoopNT-out	11.69	ActLoopCT-none	TYR	APEdihe_nnnai	APEdist_aaan	APE10-dihe-none	999.0, 999.0	APE9-dihe-none	999.0, 999.0	APE8-dihe-none	999.0, 36.47	APE8-rot-na	18.46	APE67-dihe-in	-70.63, -17.45	-55.48, -37.92	APE12-dist-na	999.0	APE11-dist-na	999.0	APE10-dist-na	999.0	APE9-dist-none	999.0	None	None	None	XRAY	2.104	0.187	0.222	A	286	261	15	0	0	15	[[267, 518]]	1.0	7d57	Gallus gallus	TYR_SRC_CHICK	TYR	3.4e-94	320.9	1	260	260	403	404	405	407	409	295	310	314	383	385	384	386	444	432	427	426	425	424	423	422	421	339	Proto-oncogene tyrosine-protein kinase Src