Ligand: 046

Total number of chains: 2
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGout BBAminus 2 100.0% 3UGCA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
TYR JAK2-2 JAK2_HUMAN 7RN6A 1.5 Inactive DFGout‑BBAminus in-in none-out TYR APEdihe_nioai APEdist_aaao 046 Type2 839 - 1130 0 PTR1007 None Tyrosine-protein kinase JAK2
TYR JAK2-2 JAK2_HUMAN 3UGCA 1.34 Inactive DFGout‑BBAminus in-in out-out TYR APEdihe_oioai APEdist_aaao 046 Type2 843 - 1129 0 None Y1007F,Y1008F Tyrosine-protein kinase JAK2

Ligand: 046

Total number of chains: 3
Active chains: 0
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGout BBAminus 2 66.7% 3UGCA
DFGout None 1 33.3% 4O2ZA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
TYR JAK2-2 JAK2_HUMAN 7RN6A 1.5 Inactive DFGout‑BBAminus in-in none-out TYR APEdihe_nioai APEdist_aaao 046 Type2 839 - 1130 0 PTR1007 None Tyrosine-protein kinase JAK2 Homo sapiens
TYR JAK2-2 JAK2_HUMAN 3UGCA 1.34 Inactive DFGout‑BBAminus in-in out-out TYR APEdihe_oioai APEdist_aaao 046 Type2 843 - 1129 0 None Y1007F,Y1008F Tyrosine-protein kinase JAK2 Homo sapiens
CMGC MPK3 A0A3S7WR45_LEIDO 4O2ZA 2.71 Inactive DFGout‑None in-in out-out nonTYR APEdihe_aaoii APEdist_oioo 046 Type2 5 - 363 0 None None Mitogen-activated protein kinase Leishmania donovani

Ligand: 046

Total number of chains: 1
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGout None 1 100.0% 4O2ZA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
CMGC MPK3 A0A3S7WR45_LEIDO 4O2ZA 2.71 Inactive DFGout‑None in-in out-out nonTYR APEdihe_aaoii APEdist_oioo 046 Type2 5 - 363 0 None None Mitogen-activated protein kinase Leishmania donovani