CK1_VRK1 (Serine/threonine-protein kinase VRK1)

Total number of chains: 78
Active chains: 1
Family: CK1
Uniprot: VRK1_HUMAN
Kinase Domain Residues: 37 - 326
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 76 97.4% AF-Q99986-K3A
DFGin None 2 2.6% 2KTYA

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PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AF-Q99986-K3A 29 334 396.0 No_ligand No_ligand Active DFGin 7.855 14.607 BLAminus -119.69, -179.59 64.74, 62.18 -76.51, 26.37 292.6, 86.66 -65.07, -24.37 in-in in 7.909 Saltbr-in 2.742 HRD-in -84.6, -47.87 78.67, -17.76 in-in-in SNCiii in-in ActLoopNT-in 2.968 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -85.29, 147.36 APE9-dihe-na 87.15, -175.44 APE8-dihe-in -81.65, 119.55 APE8-rot-in 301.17 APE67-dihe-in -65.28, -29.48 -56.82, -38.5 APE12-dist-in 12.16 APE11-dist-in 12.139 APE10-dist-in 6.381 APE9-dist-in 4.371 None None None AF2 -1.0 1.0 1.0 A 306 306 0 0 0 0 [[37, 326]] 1.0 AF-Q99986-K3 CK1_VRK1_HUMAN CK1 5e-106 359.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
6AC9A 21 342 396.0 ANP:401 ATPlike Inactive DFGin 7.921 14.706 BLAminus -114.21, 177.93 70.15, 93.84 -115.1, 19.79 299.42, 81.98 -60.26, -28.75 in-in in 7.95 Saltbr-in 2.779 HRD-in -85.24, -47.15 69.74, 5.52 in-in-out SNCiio in-out ActLoopNT-in 2.799 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -132.17, 15.24 APE9-dihe-na 79.52, -153.87 APE8-dihe-in -97.68, 119.65 APE8-rot-in 299.88 APE67-dihe-in -62.87, -27.26 -44.77, -50.87 APE12-dist-in 9.478 APE11-dist-out 5.963 APE10-dist-out 10.714 APE9-dist-in 3.851 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.07 0.187 0.223 A 370 317 5 0 0 0 [[37, 326]] 1.0 6ac9 CK1_VRK1_HUMAN CK1 8.9e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
6AC9B 21 341 396.0 ANP:401 ATPlike Inactive DFGin 7.916 14.739 BLAminus -115.54, 178.38 75.12, 91.43 -115.59, 17.29 297.69, 88.6 -57.57, -34.6 in-in in 8.093 Saltbr-in 2.77 HRD-in -83.61, -50.49 74.28, -0.88 in-in-out SNCiio in-out ActLoopNT-in 2.793 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -114.62, 8.0 APE9-dihe-na 78.71, -152.8 APE8-dihe-in -103.98, 122.42 APE8-rot-in 297.61 APE67-dihe-in -64.96, -28.03 -44.02, -51.48 APE12-dist-in 9.99 APE11-dist-out 5.433 APE10-dist-out 10.749 APE9-dist-in 3.727 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.07 0.187 0.223 B 370 316 5 0 0 0 [[37, 326]] 1.0 6ac9 CK1_VRK1_HUMAN CK1 8.9e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
6AC9C 24 341 396.0 ANP:402 ATPlike Inactive DFGin 7.927 14.325 BLAminus -121.92, 176.09 69.3, 88.62 -104.37, 22.99 293.32, 87.67 -64.92, -32.52 in-in in 7.605 Saltbr-in 2.793 HRD-in -88.58, -46.78 72.09, 4.58 in-in-out SNCiio in-out ActLoopNT-in 2.856 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -67.72, 154.65 APE9-dihe-na 94.16, -162.22 APE8-dihe-in -91.17, 117.25 APE8-rot-in 299.96 APE67-dihe-in -65.18, -24.09 -48.81, -46.56 APE12-dist-out 14.966 APE11-dist-in 13.64 APE10-dist-in 7.925 APE9-dist-in 4.153 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.07 0.187 0.223 C 370 307 11 0 0 0 [[37, 326]] 1.0 6ac9 CK1_VRK1_HUMAN CK1 8.9e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
6AC9D 23 341 396.0 ANP:402 ATPlike Inactive DFGin 7.739 14.33 BLAminus -116.24, 179.23 65.24, 86.32 -103.3, 26.16 293.03, 86.03 -64.75, -25.98 in-in in 7.722 Saltbr-in 2.797 HRD-in -87.33, -42.3 69.45, 1.55 in-in-out SNCiio in-out ActLoopNT-in 2.992 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -66.0, 154.0 APE9-dihe-na 92.71, -167.74 APE8-dihe-in -86.89, 111.15 APE8-rot-in 299.25 APE67-dihe-in -66.58, -28.49 -43.2, -46.61 APE12-dist-out 14.83 APE11-dist-in 13.447 APE10-dist-in 7.737 APE9-dist-in 4.26 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.07 0.187 0.223 D 370 306 13 0 0 0 [[37, 326]] 1.0 6ac9 CK1_VRK1_HUMAN CK1 8.9e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
AF-Q99986-K1A 29 334 396.0 No_ligand No_ligand Inactive DFGin 8.283 14.584 BLAminus -116.22, 175.16 68.86, 62.05 -78.73, 25.47 298.95, 82.4 -65.45, -25.9 in-in in 7.769 Saltbr-in 2.638 HRD-in -85.34, -48.1 75.11, 0.62 in-in-out SNCiio in-out ActLoopNT-in 2.95 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -54.35, 145.53 APE9-dihe-na 88.61, -168.93 APE8-dihe-in -80.66, 116.83 APE8-rot-in 300.65 APE67-dihe-in -69.43, -27.77 -53.52, -41.73 APE12-dist-out 15.122 APE11-dist-in 13.592 APE10-dist-in 7.908 APE9-dist-in 4.295 None None None AF2 -1.0 1.0 1.0 A 306 306 0 0 0 0 [[37, 326]] 1.0 AF-Q99986-K1 CK1_VRK1_HUMAN CK1 5e-106 359.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
2LAVA 1 361 396.0 No_ligand No_ligand Inactive DFGin 8.986 18.467 BLAminus -104.7, 164.97 58.57, 105.4 -91.24, -47.91 319.25, 98.88 52.76, 23.83 in-out in 9.155 Saltbr-out 7.864 HRD-in -68.39, -66.65 67.7, 29.87 out-in-out SNCoio in-out ActLoopNT-in 2.626 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iiio APE10-dihe-na -62.24, 124.33 APE9-dihe-na 174.92, 155.66 APE8-dihe-in -102.39, 138.01 APE8-rot-in 334.0 APE67-dihe-in -57.87, -37.94 -48.28, -25.53 APE12-dist-in 8.787 APE11-dist-in 11.079 APE10-dist-in 6.676 APE9-dist-out 7.771 None None None NMR 999.0 999.0 999.0 A 361 361 0 0 0 0 [[37, 326]] 1.0 2lav CK1_VRK1_HUMAN CK1 9.2e-106 359.0 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
6BP0A 20 341 396.0 No_ligand No_ligand Inactive DFGin 7.899 14.613 BLAminus -115.13, 179.0 70.55, 71.89 -95.8, 16.39 303.84, 78.03 -60.39, -37.23 in-in in 7.729 Saltbr-in 2.78 HRD-in -89.43, -46.42 71.54, 4.58 in-in-out SNCiio in-out ActLoopNT-in 2.898 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -119.33, 13.08 APE9-dihe-na 74.96, -159.37 APE8-dihe-in -101.74, 124.19 APE8-rot-in 297.87 APE67-dihe-in -62.96, -28.12 -54.38, -45.62 APE12-dist-in 9.528 APE11-dist-out 5.767 APE10-dist-out 10.937 APE9-dist-in 3.676 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 1.9 0.189 0.226 A 364 317 5 0 0 0 [[37, 326]] 1.0 6bp0 CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
6BP0C 21 341 396.0 No_ligand No_ligand Inactive DFGin 7.939 14.851 BLAminus -116.27, 178.65 72.76, 71.27 -96.93, 15.82 304.69, 78.55 -60.82, -36.22 in-in in 8.014 Saltbr-in 2.747 HRD-in -87.79, -47.2 71.69, 3.65 in-in-out SNCiio in-out ActLoopNT-in 2.879 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -119.41, 12.06 APE9-dihe-na 90.25, -158.01 APE8-dihe-in -101.06, 122.29 APE8-rot-in 297.48 APE67-dihe-in -69.11, -23.96 -55.18, -40.69 APE12-dist-in 9.332 APE11-dist-out 5.615 APE10-dist-out 10.959 APE9-dist-in 3.737 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 1.9 0.189 0.226 C 364 315 6 0 0 0 [[37, 326]] 1.0 6bp0 CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
6BRUA 20 341 396.0 No_ligand No_ligand Inactive DFGin 8.033 14.707 BLAminus -117.66, 174.8 73.4, 90.42 -111.17, 18.43 297.57, 83.73 -62.66, -32.45 in-in in 7.75 Saltbr-in 2.723 HRD-in -89.4, -48.02 76.76, 0.18 in-in-out SNCiio in-out ActLoopNT-in 2.909 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -112.07, 4.26 APE9-dihe-na 85.33, -161.74 APE8-dihe-in -100.33, 121.11 APE8-rot-in 296.71 APE67-dihe-in -67.79, -25.01 -53.75, -41.68 APE12-dist-in 9.256 APE11-dist-out 5.497 APE10-dist-out 10.929 APE9-dist-in 3.804 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 1.8 0.196 0.214 A 364 322 0 0 0 0 [[37, 326]] 1.0 6bru CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
6BRUC 21 341 396.0 No_ligand No_ligand Inactive DFGin 7.985 14.962 BLAminus -117.45, 175.22 72.9, 90.95 -111.5, 17.79 298.09, 83.36 -63.53, -31.92 in-in in 8.028 Saltbr-in 2.732 HRD-in -88.93, -48.21 76.94, 0.57 in-in-out SNCiio in-out ActLoopNT-in 2.87 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -112.0, 3.87 APE9-dihe-na 86.79, -161.39 APE8-dihe-in -100.72, 120.61 APE8-rot-in 298.11 APE67-dihe-in -68.1, -24.22 -53.45, -41.86 APE12-dist-in 9.195 APE11-dist-out 5.51 APE10-dist-out 10.96 APE9-dist-in 3.808 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 1.8 0.196 0.214 C 364 315 6 0 0 0 [[37, 326]] 1.0 6bru CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
6BTWC 21 341 396.0 No_ligand No_ligand Inactive DFGin 7.901 14.845 BLAminus -115.06, 173.48 78.14, 95.08 -115.95, 16.82 299.73, 84.12 -61.42, -29.78 in-in in 8.098 Saltbr-in 2.637 HRD-in -79.8, -44.78 64.46, 9.45 in-in-out SNCiio in-out ActLoopNT-in 2.897 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -116.67, 8.32 APE9-dihe-na 85.69, -157.8 APE8-dihe-in -104.89, 121.6 APE8-rot-in 294.77 APE67-dihe-in -67.83, -24.48 -53.21, -41.44 APE12-dist-in 9.309 APE11-dist-out 5.483 APE10-dist-out 10.847 APE9-dist-in 3.668 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 1.9 0.184 0.215 C 364 315 6 0 0 0 [[37, 326]] 1.0 6btw CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
6BU6C 21 341 396.0 No_ligand No_ligand Inactive DFGin 7.944 14.969 BLAminus -117.18, 175.95 73.51, 91.5 -111.82, 15.91 297.66, 83.38 -64.79, -27.67 in-in in 8.173 Saltbr-in 2.723 HRD-in -87.76, -48.87 78.25, -0.92 in-in-out SNCiio in-out ActLoopNT-in 2.853 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -109.17, 2.29 APE9-dihe-na 87.9, -161.95 APE8-dihe-in -100.19, 119.95 APE8-rot-in 298.15 APE67-dihe-in -68.79, -25.2 -52.88, -41.93 APE12-dist-in 9.091 APE11-dist-out 5.53 APE10-dist-out 10.945 APE9-dist-in 3.847 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 1.8 0.186 0.212 C 364 315 6 0 0 0 [[37, 326]] 1.0 6bu6 CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
6CFMC 21 341 396.0 No_ligand No_ligand Inactive DFGin 7.851 14.953 BLAminus -123.42, 174.01 73.65, 94.53 -118.05, 16.57 295.96, 85.64 -61.62, -32.15 in-in in 8.272 Saltbr-in 2.848 HRD-in -85.66, -49.06 72.84, 13.62 in-in-out SNCiio in-out ActLoopNT-in 2.817 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -130.41, 10.66 APE9-dihe-na 103.07, -153.01 APE8-dihe-in -105.77, 122.69 APE8-rot-in 300.58 APE67-dihe-in -64.29, -35.62 -55.74, -43.04 APE12-dist-in 9.648 APE11-dist-out 5.734 APE10-dist-out 10.691 APE9-dist-in 3.986 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.45 0.203 0.245 C 364 316 5 0 0 0 [[37, 326]] 1.0 6cfm CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
6CMMA 20 341 396.0 No_ligand No_ligand Inactive DFGin 7.939 14.853 BLAminus -118.01, 179.55 70.25, 94.14 -114.09, 19.03 296.97, 80.28 -64.11, -27.16 in-in in 7.987 Saltbr-in 2.724 HRD-in -70.61, -48.88 72.27, 0.35 in-in-out SNCiio in-out ActLoopNT-in 2.835 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -115.61, 6.25 APE9-dihe-na 83.26, -156.76 APE8-dihe-in -101.59, 132.95 APE8-rot-in 301.05 APE67-dihe-in -61.96, -26.2 -62.18, -45.9 APE12-dist-in 9.405 APE11-dist-out 5.579 APE10-dist-out 10.786 APE9-dist-in 3.796 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.1 0.192 0.222 A 364 318 4 0 0 0 [[37, 326]] 1.0 6cmm CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
6CMMC 21 341 396.0 No_ligand No_ligand Inactive DFGin 7.913 14.838 BLAminus -118.19, 172.22 77.38, 94.72 -118.56, 19.82 299.14, 81.41 -62.89, -28.04 in-in in 8.09 Saltbr-in 2.659 HRD-in -85.44, -49.56 76.52, 1.18 in-in-out SNCiio in-out ActLoopNT-in 2.817 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -126.71, 22.14 APE9-dihe-na 66.49, -154.73 APE8-dihe-in -106.73, 121.33 APE8-rot-in 297.11 APE67-dihe-in -65.73, -23.75 -52.02, -44.91 APE12-dist-in 9.357 APE11-dist-out 5.62 APE10-dist-out 10.622 APE9-dist-in 3.633 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.1 0.192 0.222 C 364 316 5 0 0 0 [[37, 326]] 1.0 6cmm CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
6CQHC 21 341 396.0 No_ligand No_ligand Inactive DFGin 7.983 14.851 BLAminus -118.07, 171.71 76.59, 94.42 -117.6, 18.62 300.15, 81.64 -66.87, -26.53 in-in in 8.206 Saltbr-in 2.634 HRD-in -92.02, -48.17 76.02, 0.45 in-in-out SNCiio in-out ActLoopNT-in 2.877 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoi APE10-dihe-na 999.0, 7.71 APE9-dihe-na 82.96, -159.08 APE8-dihe-in -106.9, 123.02 APE8-rot-in 294.19 APE67-dihe-in -67.55, -22.98 -57.09, -40.82 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 10.275 APE9-dist-in 3.617 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.15 0.203 0.239 C 364 308 13 0 0 7 [[37, 326]] 1.0 6cqh CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
6CSWA 20 341 396.0 No_ligand No_ligand Inactive DFGin 7.952 14.924 BLAminus -122.51, 173.92 71.82, 95.83 -120.18, 18.9 297.48, 79.83 -60.53, -29.57 in-in in 8.26 Saltbr-in 2.827 HRD-in -91.54, -44.14 76.02, 1.18 in-in-out SNCiio in-out ActLoopNT-in 2.902 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -111.14, 8.96 APE9-dihe-na 81.62, -159.14 APE8-dihe-in -98.32, 128.16 APE8-rot-in 303.45 APE67-dihe-in -67.96, -21.86 -52.63, -48.85 APE12-dist-in 8.932 APE11-dist-out 5.581 APE10-dist-out 10.956 APE9-dist-in 3.683 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.25 0.19 0.233 A 364 316 6 0 0 0 [[37, 326]] 1.0 6csw CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
6CSWC 20 341 396.0 No_ligand No_ligand Inactive DFGin 7.92 14.962 BLAminus -123.35, 175.87 70.95, 94.91 -118.46, 18.78 298.16, 84.07 -62.21, -28.69 in-in in 8.281 Saltbr-in 2.681 HRD-in -86.8, -47.4 74.78, 6.82 in-in-out SNCiio in-out ActLoopNT-in 2.849 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -93.09, 2.93 APE9-dihe-na 81.91, -151.33 APE8-dihe-in -107.83, 122.33 APE8-rot-in 299.96 APE67-dihe-in -62.29, -29.36 -52.62, -45.06 APE12-dist-in 8.669 APE11-dist-out 5.582 APE10-dist-out 11.169 APE9-dist-in 3.802 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.25 0.19 0.233 C 364 319 3 0 0 1 [[37, 326]] 1.0 6csw CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
6DD4A 20 341 396.0 No_ligand No_ligand Inactive DFGin 7.876 14.838 BLAminus -120.41, 173.02 75.13, 94.02 -114.1, 14.98 299.39, 83.08 -58.5, -29.65 in-in in 8.081 Saltbr-in 2.542 HRD-in -82.93, -47.61 72.82, 3.43 in-in-out SNCiio in-out ActLoopNT-in 2.84 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -111.48, 6.67 APE9-dihe-na 82.5, -163.01 APE8-dihe-in -94.17, 125.47 APE8-rot-in 297.51 APE67-dihe-in -62.9, -24.88 -50.41, -51.16 APE12-dist-in 8.931 APE11-dist-out 5.472 APE10-dist-out 11.007 APE9-dist-in 3.71 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.1 0.196 0.226 A 364 317 5 0 0 0 [[37, 326]] 1.0 6dd4 CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
6DD4C 21 341 396.0 No_ligand No_ligand Inactive DFGin 7.917 14.913 BLAminus -119.83, 175.04 73.93, 94.49 -116.65, 17.84 297.32, 82.95 -65.53, -26.45 in-in in 8.042 Saltbr-in 2.628 HRD-in -89.97, -49.3 75.88, 5.26 in-in-out SNCiio in-out ActLoopNT-in 2.817 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -120.92, 5.41 APE9-dihe-na 86.74, -156.9 APE8-dihe-in -103.04, 119.22 APE8-rot-in 302.42 APE67-dihe-in -62.83, -29.71 -48.5, -44.98 APE12-dist-in 9.609 APE11-dist-out 5.515 APE10-dist-out 10.954 APE9-dist-in 3.838 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.1 0.196 0.226 C 364 317 4 0 0 0 [[37, 326]] 1.0 6dd4 CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
6VZHA 20 341 396.0 No_ligand No_ligand Inactive DFGin 8.07 14.63 BLAminus -119.11, -165.76 57.07, 58.18 -85.56, 20.64 296.92, 77.29 -62.31, -38.38 in-none in 7.598 Saltbr-none 999.0 HRD-in -87.43, -61.36 81.37, 3.25 none-in-out SNCnio in-out ActLoopNT-in 2.894 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -96.58, -2.29 APE9-dihe-na 95.82, -158.45 APE8-dihe-in -97.53, 125.47 APE8-rot-in 301.35 APE67-dihe-in -65.35, -28.4 -59.05, -45.83 APE12-dist-in 10.054 APE11-dist-out 5.99 APE10-dist-out 11.072 APE9-dist-in 4.155 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.55 0.217 0.251 A 364 317 5 0 0 0 [[37, 326]] 1.0 6vzh CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
6VZHC 21 341 396.0 No_ligand No_ligand Inactive DFGin 8.005 14.868 BLAminus -116.13, -175.0 63.78, 73.2 -103.71, 27.78 305.13, 71.56 -64.11, -34.62 in-none in 7.835 Saltbr-none 999.0 HRD-in -87.12, -61.01 79.21, 4.12 none-in-out SNCnio in-out ActLoopNT-in 2.906 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -111.31, 3.43 APE9-dihe-na 87.47, -167.24 APE8-dihe-in -81.92, 128.85 APE8-rot-in 310.31 APE67-dihe-in -66.4, -28.62 -58.47, -46.31 APE12-dist-in 9.519 APE11-dist-out 5.672 APE10-dist-out 10.841 APE9-dist-in 3.864 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.55 0.217 0.251 C 364 315 6 0 0 0 [[37, 326]] 1.0 6vzh CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
8V42A 20 341 396.0 No_ligand No_ligand Inactive DFGin 7.853 14.81 BLAminus -121.51, 175.02 72.65, 94.71 -118.54, 19.89 299.65, 83.97 -59.01, -29.73 in-in in 8.212 Saltbr-in 2.865 HRD-in -83.99, -58.09 83.43, 6.42 in-in-out SNCiio in-out ActLoopNT-in 2.869 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -99.72, 1.75 APE9-dihe-na 88.26, -152.18 APE8-dihe-in -102.45, 129.29 APE8-rot-in 302.03 APE67-dihe-in -66.72, -27.45 -54.7, -46.25 APE12-dist-in 9.69 APE11-dist-out 5.059 APE10-dist-out 10.756 APE9-dist-in 3.725 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.3 0.199 0.231 A 364 312 10 0 0 0 [[37, 326]] 1.0 8v42 CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
8V42C 21 341 396.0 No_ligand No_ligand Inactive DFGin 7.894 14.793 BLAminus -123.1, 173.79 74.88, 93.95 -117.93, 23.53 298.38, 87.45 -66.4, -24.74 in-in in 8.15 Saltbr-in 3.1 HRD-in -85.5, -57.27 80.14, 9.55 in-in-out SNCiio in-out ActLoopNT-in 2.792 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -121.06, 1.32 APE9-dihe-na 82.38, -165.01 APE8-dihe-in -98.07, 122.8 APE8-rot-in 302.61 APE67-dihe-in -67.57, -28.21 -55.26, -41.9 APE12-dist-in 9.275 APE11-dist-out 4.841 APE10-dist-out 10.392 APE9-dist-in 3.903 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.3 0.199 0.231 C 364 315 6 0 0 0 [[37, 326]] 1.0 8v42 CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
2RSVA 1 396 396.0 No_ligand No_ligand Inactive DFGin 9.457 17.356 BLAminus -126.95, 167.12 53.65, 57.68 -59.68, -51.55 307.53, 91.34 93.81, -35.83 in-out in 8.252 Saltbr-out 6.016 HRD-out -151.68, -51.8 55.83, 53.12 out-in-out SNCoio in-out ActLoopNT-in 2.889 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na 61.47, 172.38 APE9-dihe-na 122.51, -164.12 APE8-dihe-in -87.87, 178.09 APE8-rot-out 49.7 APE67-dihe-in -51.36, -24.62 -116.16, -26.84 APE12-dist-in 9.745 APE11-dist-in 9.201 APE10-dist-in 7.485 APE9-dist-out 8.931 None None None NMR 999.0 999.0 999.0 A 403 396 0 0 0 0 [[37, 326]] 1.0 2rsv CK1_VRK1_HUMAN CK1 1.3e-105 358.6 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
5UKFA 20 341 396.0 8E1:401 Type1 Inactive DFGin 7.859 14.425 BLAminus -119.38, 173.41 75.63, 89.68 -116.06, 14.39 298.31, 90.17 -54.65, -38.06 in-out in 8.244 Saltbr-out 3.678 HRD-in -79.04, -57.54 80.31, -4.23 out-in-out SNCoio in-out ActLoopNT-in 2.831 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -63.69, -39.06 APE9-dihe-na 83.51, -147.55 APE8-dihe-in -109.2, 120.2 APE8-rot-in 298.23 APE67-dihe-in -64.41, -31.89 -42.31, -49.41 APE12-dist-in 9.511 APE11-dist-out 5.84 APE10-dist-out 9.809 APE9-dist-in 3.891 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.4 0.179 0.214 A 363 322 0 0 0 0 [[37, 326]] 1.0 5ukf CK1_VRK1_HUMAN CK1 8.3e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
5UKFB 51 341 396.0 8E1:401 Type1 Inactive DFGin 8.097 14.664 BLAminus -121.11, 172.72 70.19, 89.58 -108.13, 26.3 294.0, 86.12 -70.32, -38.73 in-none in 8.303 Saltbr-none 999.0 HRD-in -78.71, -64.95 86.46, -3.2 none-in-out SNCnio in-out ActLoopNT-in 2.912 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -75.53, 157.07 APE9-dihe-na 91.4, -169.09 APE8-dihe-in -84.62, 126.19 APE8-rot-in 289.52 APE67-dihe-in -64.84, -37.67 -57.81, -40.1 APE12-dist-out 14.838 APE11-dist-in 13.523 APE10-dist-in 7.842 APE9-dist-in 4.275 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.4 0.179 0.214 B 363 265 40 0 0 0 [[37, 326]] 1.0 5ukf CK1_VRK1_HUMAN CK1 8.3e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
5UKFC 21 341 396.0 8E1:401 Type1 Inactive DFGin 7.907 15.055 BLAminus -114.51, 177.87 73.15, 91.67 -116.1, 13.64 296.69, 91.23 -56.4, -31.52 in-none in 8.636 Saltbr-none 999.0 HRD-in -84.93, -54.46 77.79, -1.55 none-in-out SNCnio in-out ActLoopNT-in 2.855 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -63.77, -41.33 APE9-dihe-na 83.79, -153.92 APE8-dihe-in -103.66, 122.47 APE8-rot-in 295.8 APE67-dihe-in -65.42, -25.93 -48.36, -48.26 APE12-dist-in 9.325 APE11-dist-out 5.931 APE10-dist-out 9.875 APE9-dist-in 4.035 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.4 0.179 0.214 C 363 317 4 0 0 0 [[37, 326]] 1.0 5ukf CK1_VRK1_HUMAN CK1 8.3e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
5UKFD 39 341 396.0 8E1:402 Type1 Inactive DFGin 7.855 14.662 BLAminus -113.78, 177.54 70.67, 89.75 -108.82, 24.37 295.86, 87.15 -64.56, -29.83 in-in in 9.779 Saltbr-in 2.701 HRD-in -84.79, -51.24 76.1, -0.34 in-in-out SNCiio in-out ActLoopNT-in 2.979 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -75.62, 154.64 APE9-dihe-na 93.28, -169.83 APE8-dihe-in -86.2, 117.34 APE8-rot-in 297.37 APE67-dihe-in -69.56, -25.24 -47.9, -42.95 APE12-dist-out 14.976 APE11-dist-in 13.621 APE10-dist-in 7.924 APE9-dist-in 4.269 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.4 0.179 0.214 D 363 268 37 0 0 0 [[37, 326]] 1.0 5ukf CK1_VRK1_HUMAN CK1 8.3e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
3OP5A 21 341 396.0 REB:365 Type1 Inactive DFGin 7.953 14.534 BLAminus -114.82, 176.41 71.01, 96.34 -120.14, 18.32 297.72, 91.95 -64.04, -28.74 in-out in 7.905 Saltbr-out 4.41 HRD-in -81.17, -51.65 71.32, 4.58 out-in-out SNCoio in-out ActLoopNT-in 2.809 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -121.23, 18.55 APE9-dihe-na 75.48, -153.65 APE8-dihe-in -102.2, 117.44 APE8-rot-in 299.56 APE67-dihe-in -69.82, -27.08 -41.77, -48.52 APE12-dist-in 9.195 APE11-dist-out 5.48 APE10-dist-out 10.83 APE9-dist-in 3.671 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.4 0.179 0.213 A 364 320 1 0 0 0 [[37, 326]] 1.0 3op5 CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
3OP5B 21 341 396.0 REB:365 Type1 Inactive DFGin 7.958 14.643 BLAminus -113.97, 176.01 71.29, 96.02 -119.19, 18.9 297.8, 91.46 -64.52, -28.62 in-out in 8.115 Saltbr-out 4.406 HRD-in -81.96, -51.98 71.81, 3.7 out-in-out SNCoio in-out ActLoopNT-in 2.81 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -118.98, 15.13 APE9-dihe-na 73.86, -155.53 APE8-dihe-in -100.82, 117.46 APE8-rot-in 300.82 APE67-dihe-in -69.97, -26.87 -41.58, -48.34 APE12-dist-in 9.266 APE11-dist-out 5.364 APE10-dist-out 10.711 APE9-dist-in 3.729 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.4 0.179 0.213 B 364 319 2 0 0 0 [[37, 326]] 1.0 3op5 CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
3OP5C 22 341 396.0 REB:365 Type1 Inactive DFGin 7.92 14.431 BLAminus -113.54, 176.44 69.75, 97.17 -118.63, 20.05 296.44, 91.45 -64.33, -26.27 in-none in 8.334 Saltbr-none 999.0 HRD-in -81.5, -52.35 71.18, 5.09 none-in-out SNCnio in-out ActLoopNT-in 2.827 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -72.8, 159.76 APE9-dihe-na 87.63, -165.14 APE8-dihe-in -90.95, 116.06 APE8-rot-in 302.3 APE67-dihe-in -69.84, -27.29 -42.27, -48.51 APE12-dist-out 15.049 APE11-dist-in 13.784 APE10-dist-in 7.966 APE9-dist-in 4.007 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.4 0.179 0.213 C 364 308 12 0 0 0 [[37, 326]] 1.0 3op5 CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
3OP5D 25 341 396.0 REB:365 Type1 Inactive DFGin 7.969 14.453 BLAminus -112.89, 176.13 70.95, 97.27 -119.85, 19.74 297.32, 91.51 -64.31, -27.23 in-none in 7.925 Saltbr-none 999.0 HRD-in -80.63, -52.15 71.05, 5.02 none-in-out SNCnio in-out ActLoopNT-in 2.828 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooi APE10-dihe-na -69.13, 152.48 APE9-dihe-na 88.04, -168.28 APE8-dihe-in -88.02, 114.99 APE8-rot-in 302.83 APE67-dihe-in -62.29, -38.34 -40.98, -47.51 APE12-dist-out 15.304 APE11-dist-out 14.006 APE10-dist-out 8.294 APE9-dist-in 4.001 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.4 0.179 0.213 D 364 302 15 0 0 0 [[37, 326]] 1.0 3op5 CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
5UVFA 20 341 396.0 7DZ:401 Type1 Inactive DFGin 8.068 14.985 BLAminus -116.03, 174.63 69.35, 93.67 -111.58, 17.18 296.91, 82.24 -59.96, -29.3 in-none in 8.098 Saltbr-none 999.0 HRD-in -86.38, -53.2 77.43, -1.98 none-in-out SNCnio in-out ActLoopNT-in 2.799 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -119.56, 12.28 APE9-dihe-na 82.85, -155.5 APE8-dihe-in -99.21, 123.02 APE8-rot-in 299.54 APE67-dihe-in -63.69, -28.35 -46.21, -50.09 APE12-dist-in 9.398 APE11-dist-out 5.72 APE10-dist-out 10.76 APE9-dist-in 3.899 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.0 0.175 0.204 A 364 317 5 0 0 0 [[37, 326]] 1.0 5uvf CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
5UVFB 21 341 396.0 7DZ:402 Type1 Inactive DFGin 7.963 14.754 BLAminus -115.7, 176.8 71.96, 96.31 -118.35, 14.05 295.68, 88.15 -59.17, -30.58 in-out in 8.103 Saltbr-out 3.684 HRD-in -86.18, -52.27 78.12, -1.25 out-in-out SNCoio in-out ActLoopNT-in 2.826 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -115.45, -0.11 APE9-dihe-na 82.24, -156.58 APE8-dihe-in -99.4, 115.21 APE8-rot-in 299.7 APE67-dihe-in -66.33, -25.81 -39.2, -50.38 APE12-dist-in 10.347 APE11-dist-out 5.207 APE10-dist-out 10.711 APE9-dist-in 3.813 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.0 0.175 0.204 B 364 316 5 0 0 0 [[37, 326]] 1.0 5uvf CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
6BP0B 23 341 396.0 E1D:404 Type1 Inactive DFGin 8.396 14.437 BLAminus -117.24, 179.69 62.15, 74.56 -92.04, 17.43 300.07, 74.46 -60.36, -36.15 in-in in 7.779 Saltbr-in 2.655 HRD-in -91.52, -43.82 71.22, 1.27 in-in-out SNCiio in-out ActLoopNT-in 2.971 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -62.38, 155.05 APE9-dihe-na 100.06, -162.09 APE8-dihe-in -99.16, 118.44 APE8-rot-in 302.05 APE67-dihe-in -65.07, -29.6 -53.14, -44.01 APE12-dist-out 15.332 APE11-dist-in 13.848 APE10-dist-out 8.056 APE9-dist-in 4.146 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 1.9 0.189 0.226 B 364 304 15 0 0 0 [[37, 326]] 1.0 6bp0 CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
6BTWB 23 341 396.0 E8D:404 Type1 Inactive DFGin 8.576 14.566 BLAminus -111.26, 172.85 68.97, 87.06 -103.29, 23.53 295.38, 79.52 -63.81, -42.55 in-in in 7.583 Saltbr-in 2.906 HRD-in -93.84, -43.96 69.15, -0.07 in-in-out SNCiio in-out ActLoopNT-in 2.91 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -60.91, 151.83 APE9-dihe-na 100.5, -167.0 APE8-dihe-in -92.97, 119.96 APE8-rot-in 300.18 APE67-dihe-in -73.31, -24.32 -57.12, -36.39 APE12-dist-out 15.325 APE11-dist-in 13.938 APE10-dist-out 8.182 APE9-dist-in 4.123 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 1.9 0.184 0.215 B 364 301 18 0 0 0 [[37, 326]] 1.0 6btw CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
6BU6B 23 341 396.0 E8V:401 Type1 Inactive DFGin 8.268 14.621 BLAminus -116.17, 174.71 71.73, 90.61 -112.18, 20.9 296.52, 84.84 -64.88, -27.0 in-in in 8.088 Saltbr-in 2.742 HRD-in -88.46, -49.62 77.08, 1.91 in-in-out SNCiio in-out ActLoopNT-in 2.869 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooi APE10-dihe-na -61.72, 158.34 APE9-dihe-na 92.24, -163.66 APE8-dihe-in -96.91, 119.69 APE8-rot-in 300.47 APE67-dihe-in -70.15, -24.73 -54.45, -40.48 APE12-dist-out 15.523 APE11-dist-out 14.178 APE10-dist-out 8.422 APE9-dist-in 3.997 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 1.8 0.186 0.212 B 364 307 12 0 0 0 [[37, 326]] 1.0 6bu6 CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
6BU6D 22 341 396.0 E8V:401 Type1 Inactive DFGin 8.19 14.491 BLAminus -117.45, 173.99 70.17, 88.84 -106.05, 22.0 293.29, 84.87 -55.23, -29.8 in-in in 8.126 Saltbr-in 2.765 HRD-in -88.95, -48.69 76.34, 2.59 in-in-out SNCiio in-out ActLoopNT-in 2.866 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -61.65, 158.02 APE9-dihe-na 93.89, -164.33 APE8-dihe-in -97.16, 119.8 APE8-rot-in 299.52 APE67-dihe-in -70.9, -24.87 -53.15, -41.73 APE12-dist-out 15.071 APE11-dist-in 13.65 APE10-dist-in 7.879 APE9-dist-in 4.04 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 1.8 0.186 0.212 D 364 318 2 0 0 0 [[37, 326]] 1.0 6bu6 CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
6CMMB 23 341 396.0 F7D:401 Type1 Inactive DFGin 8.476 14.483 BLAminus -115.06, 177.55 64.23, 84.91 -98.08, 23.22 291.58, 82.57 -66.41, -28.16 in-in in 7.601 Saltbr-in 2.897 HRD-in -88.21, -48.16 77.0, 4.0 in-in-out SNCiio in-out ActLoopNT-in 2.959 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -59.62, 146.4 APE9-dihe-na 107.7, -170.45 APE8-dihe-in -90.13, 117.89 APE8-rot-in 302.22 APE67-dihe-in -67.83, -25.02 -51.39, -42.58 APE12-dist-out 15.037 APE11-dist-in 13.451 APE10-dist-in 7.738 APE9-dist-in 4.065 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.1 0.192 0.222 B 364 310 9 0 0 0 [[37, 326]] 1.0 6cmm CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
6CMMD 23 341 396.0 F7D:401 Type1 Inactive DFGin 8.303 14.576 BLAminus -120.35, -178.73 57.57, 80.72 -90.78, 22.63 288.79, 76.0 -64.84, -22.8 in-in in 7.794 Saltbr-in 2.995 HRD-in -88.03, -46.07 76.94, -0.28 in-in-out SNCiio in-out ActLoopNT-in 2.909 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -59.16, 154.16 APE9-dihe-na 94.99, -165.63 APE8-dihe-in -97.55, 123.52 APE8-rot-in 296.28 APE67-dihe-in -67.77, -24.35 -58.36, -42.41 APE12-dist-out 14.924 APE11-dist-in 13.193 APE10-dist-in 7.433 APE9-dist-in 4.166 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.1 0.192 0.222 D 364 315 4 0 0 0 [[37, 326]] 1.0 6cmm CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
6CNXA 20 341 396.0 F87:401 Type1 Inactive DFGin 8.07 14.968 BLAminus -118.67, 171.71 78.23, 84.24 -105.86, 18.22 298.1, 81.05 -66.18, -28.04 in-in in 8.076 Saltbr-in 2.71 HRD-in -87.45, -49.38 77.51, -6.45 in-in-out SNCiio in-out ActLoopNT-in 2.903 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -102.75, 3.42 APE9-dihe-na 88.52, -160.39 APE8-dihe-in -99.42, 119.25 APE8-rot-in 299.48 APE67-dihe-in -66.91, -26.62 -49.42, -43.65 APE12-dist-in 9.623 APE11-dist-out 5.48 APE10-dist-out 10.812 APE9-dist-in 3.837 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.0 0.188 0.211 A 364 322 0 0 0 0 [[37, 326]] 1.0 6cnx CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
6CQHA 20 341 396.0 F8Y:401 Type1 Inactive DFGin 8.008 14.763 BLAminus -111.2, 177.84 71.65, 92.99 -113.5, 20.29 298.38, 81.92 -64.24, -31.74 in-in in 7.987 Saltbr-in 2.719 HRD-in -84.71, -51.53 76.7, 2.57 in-in-out SNCiio in-out ActLoopNT-in 2.845 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoi APE10-dihe-na 999.0, -17.4 APE9-dihe-na 78.26, -153.63 APE8-dihe-in -106.52, 129.33 APE8-rot-in 308.27 APE67-dihe-in -63.14, -26.0 -57.9, -46.8 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 10.171 APE9-dist-in 3.603 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.15 0.203 0.239 A 364 316 6 0 0 4 [[37, 326]] 1.0 6cqh CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
6CQHB 22 341 396.0 F8Y:401 Type1 Inactive DFGin 8.571 14.534 BLAminus -111.21, 174.84 67.29, 87.72 -103.26, 28.03 297.11, 78.79 -65.77, -35.57 in-in in 7.65 Saltbr-in 2.873 HRD-in -90.46, -48.61 81.42, 3.81 in-in-out SNCiio in-out ActLoopNT-in 3.01 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -62.89, 150.55 APE9-dihe-na 106.38, -164.1 APE8-dihe-in -95.63, 117.11 APE8-rot-in 304.03 APE67-dihe-in -69.89, -25.07 -49.92, -44.26 APE12-dist-out 15.076 APE11-dist-in 13.613 APE10-dist-in 7.836 APE9-dist-in 4.087 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.15 0.203 0.239 B 364 316 4 0 0 0 [[37, 326]] 1.0 6cqh CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
6CQHD 22 341 396.0 F8Y:401 Type1 Inactive DFGin 8.174 14.593 BLAminus -115.41, 176.27 64.66, 83.6 -96.31, 20.54 290.9, 78.1 -60.27, -27.19 in-in in 7.777 Saltbr-in 2.579 HRD-in -86.32, -49.88 80.57, -0.25 in-in-out SNCiio in-out ActLoopNT-in 3.007 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -66.57, 153.39 APE9-dihe-na 100.05, -169.76 APE8-dihe-in -95.11, 122.88 APE8-rot-in 296.22 APE67-dihe-in -70.56, -25.23 -58.65, -38.36 APE12-dist-out 14.86 APE11-dist-in 13.379 APE10-dist-in 7.56 APE9-dist-in 4.047 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.15 0.203 0.239 D 364 315 5 0 0 0 [[37, 326]] 1.0 6cqh CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
6CSWB 23 341 396.0 FBY:401 Type1 Inactive DFGin 8.303 14.321 BLAminus -118.26, 175.49 64.95, 81.85 -92.61, 26.88 291.96, 78.22 -65.95, -31.62 in-in in 7.51 Saltbr-in 2.844 HRD-in -91.33, -46.07 79.24, -2.6 in-in-out SNCiio in-out ActLoopNT-in 2.949 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -55.28, 148.38 APE9-dihe-na 97.88, -167.18 APE8-dihe-in -95.88, 117.39 APE8-rot-in 298.38 APE67-dihe-in -66.19, -30.16 -52.09, -43.33 APE12-dist-out 14.866 APE11-dist-in 13.068 APE10-dist-in 7.502 APE9-dist-in 4.109 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.25 0.19 0.233 B 364 308 11 0 0 0 [[37, 326]] 1.0 6csw CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
6CSWD 22 341 396.0 FBY:401 Type1 Inactive DFGin 8.399 14.487 BLAminus -112.07, 179.32 57.92, 82.65 -91.89, 27.3 292.89, 75.39 -64.78, -23.97 in-in in 7.731 Saltbr-in 2.678 HRD-in -97.86, -46.2 77.34, -3.78 in-in-out SNCiio in-out ActLoopNT-in 3.028 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -55.55, 148.94 APE9-dihe-na 96.23, -172.08 APE8-dihe-in -89.78, 120.86 APE8-rot-in 299.91 APE67-dihe-in -68.13, -27.53 -52.18, -41.88 APE12-dist-out 14.7 APE11-dist-in 13.049 APE10-dist-in 7.334 APE9-dist-in 4.097 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.25 0.19 0.233 D 364 312 8 0 0 0 [[37, 326]] 1.0 6csw CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
6DD4B 23 341 396.0 G6J:401 Type1 Inactive DFGin 8.493 14.573 BLAminus -116.27, 174.1 65.5, 83.71 -97.19, 25.82 292.92, 76.04 -69.31, -16.08 in-in in 7.448 Saltbr-in 2.751 HRD-in -89.8, -46.83 77.94, -2.82 in-in-out SNCiio in-out ActLoopNT-in 2.932 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -56.91, 145.7 APE9-dihe-na 104.42, -168.67 APE8-dihe-in -90.31, 119.08 APE8-rot-in 302.84 APE67-dihe-in -69.05, -22.86 -50.85, -45.39 APE12-dist-out 14.94 APE11-dist-in 13.112 APE10-dist-in 7.445 APE9-dist-in 4.15 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.1 0.196 0.226 B 364 309 10 0 0 0 [[37, 326]] 1.0 6dd4 CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
6DD4D 22 341 396.0 G6J:401 Type1 Inactive DFGin 8.319 14.452 BLAminus -110.97, 176.15 62.45, 87.29 -93.85, 25.94 291.26, 76.36 -66.64, -23.33 in-in in 7.644 Saltbr-in 2.978 HRD-in -93.42, -46.94 76.68, -1.24 in-in-out SNCiio in-out ActLoopNT-in 2.898 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -53.05, 149.42 APE9-dihe-na 99.37, -171.31 APE8-dihe-in -92.36, 120.15 APE8-rot-in 301.82 APE67-dihe-in -63.05, -32.03 -54.27, -42.37 APE12-dist-out 14.775 APE11-dist-in 13.115 APE10-dist-in 7.351 APE9-dist-in 4.05 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.1 0.196 0.226 D 364 311 9 0 0 0 [[37, 326]] 1.0 6dd4 CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
6VXUA 20 341 396.0 RTJ:401 Type1 Inactive DFGin 7.862 14.767 BLAminus -116.09, -176.76 69.03, 83.37 -108.12, 16.65 297.7, 83.13 -60.6, -33.46 in-in in 8.071 Saltbr-in 2.897 HRD-in -87.24, -50.72 76.7, 3.05 in-in-out SNCiio in-out ActLoopNT-in 2.912 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -61.86, -42.13 APE9-dihe-na 84.56, -165.24 APE8-dihe-in -100.43, 134.53 APE8-rot-in 297.58 APE67-dihe-in -64.8, -37.64 -59.95, -41.99 APE12-dist-in 8.592 APE11-dist-out 5.811 APE10-dist-out 9.275 APE9-dist-in 3.638 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.0 0.185 0.203 A 364 320 2 0 0 2 [[37, 326]] 1.0 6vxu CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
6VXUB 23 341 396.0 RTJ:401 Type1 Inactive DFGin 8.356 14.396 BLAminus -115.25, -172.58 58.96, 80.43 -102.19, 15.99 295.03, 79.35 -53.51, -31.06 in-in in 7.703 Saltbr-in 2.898 HRD-in -86.55, -50.19 77.02, 4.28 in-in-out SNCiio in-out ActLoopNT-in 2.931 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -71.01, 151.52 APE9-dihe-na 94.76, -162.04 APE8-dihe-in -95.43, 120.53 APE8-rot-in 305.49 APE67-dihe-in -66.08, -28.71 -55.22, -42.84 APE12-dist-out 15.116 APE11-dist-in 13.576 APE10-dist-in 7.901 APE9-dist-in 4.083 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.0 0.185 0.203 B 364 305 14 0 0 0 [[37, 326]] 1.0 6vxu CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
6VXUD 22 341 396.0 RTJ:401 Type1 Inactive DFGin 8.304 14.588 BLAminus -114.73, 173.56 70.79, 81.33 -98.17, 34.06 290.85, 75.87 -67.02, -28.17 in-in in 7.78 Saltbr-in 3.08 HRD-in -88.21, -50.41 77.09, 4.09 in-in-out SNCiio in-out ActLoopNT-in 2.931 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -58.15, 152.14 APE9-dihe-na 92.67, -162.03 APE8-dihe-in -95.3, 121.05 APE8-rot-in 306.93 APE67-dihe-in -66.14, -28.94 -54.64, -43.17 APE12-dist-out 14.751 APE11-dist-in 13.242 APE10-dist-in 7.44 APE9-dist-in 4.088 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.0 0.185 0.203 D 364 315 5 0 0 0 [[37, 326]] 1.0 6vxu CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
8V42B 23 341 396.0 YD9:401 Type1 Inactive DFGin 8.15 14.509 BLAminus -115.25, 173.81 70.74, 81.98 -96.57, 31.4 293.02, 83.98 -65.46, -31.88 in-in in 7.683 Saltbr-in 2.981 HRD-in -84.96, -54.37 82.65, 6.55 in-in-out SNCiio in-out ActLoopNT-in 2.975 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -56.02, 147.0 APE9-dihe-na 92.25, -161.77 APE8-dihe-in -93.24, 123.77 APE8-rot-in 302.73 APE67-dihe-in -69.68, -29.13 -58.11, -42.06 APE12-dist-out 14.95 APE11-dist-in 13.216 APE10-dist-in 7.622 APE9-dist-in 4.151 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.3 0.199 0.231 B 364 298 21 0 0 0 [[37, 326]] 1.0 8v42 CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
8V42D 22 341 396.0 YD9:503 Type1 Inactive DFGin 8.427 14.572 BLAminus -115.01, 173.66 70.13, 85.46 -98.79, 31.68 291.4, 80.12 -74.01, -24.17 in-in in 8.034 Saltbr-in 2.809 HRD-in -87.0, -55.77 90.86, -4.84 in-in-out SNCiio in-out ActLoopNT-in 2.966 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -53.59, 145.4 APE9-dihe-na 95.31, -166.28 APE8-dihe-in -89.68, 124.18 APE8-rot-in 303.57 APE67-dihe-in -70.5, -24.91 -57.98, -40.51 APE12-dist-out 14.706 APE11-dist-in 13.018 APE10-dist-in 7.355 APE9-dist-in 4.153 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.3 0.199 0.231 D 364 304 16 0 0 0 [[37, 326]] 1.0 8v42 CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
5UVFC 23 341 396.0 7DZ:402 Type1.5_Back Inactive DFGin 8.448 14.566 BLAminus -113.07, 179.96 62.11, 87.8 -103.99, 18.05 293.88, 84.68 -56.31, -38.97 in-in in 7.711 Saltbr-in 3.042 HRD-in -85.64, -52.86 76.73, -0.03 in-in-out SNCiio in-out ActLoopNT-in 2.939 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -64.51, 153.81 APE9-dihe-na 95.53, -165.02 APE8-dihe-in -90.89, 115.81 APE8-rot-in 299.18 APE67-dihe-in -65.57, -30.05 -44.66, -48.36 APE12-dist-out 15.225 APE11-dist-in 13.944 APE10-dist-out 8.092 APE9-dist-in 4.191 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.0 0.175 0.204 C 364 301 18 0 0 0 [[37, 326]] 1.0 5uvf CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
5UVFD 25 341 396.0 7DZ:403 Type1.5_Back Inactive DFGin 8.337 14.862 BLAminus -114.11, 178.74 62.44, 88.7 -103.82, 25.96 292.76, 84.97 -61.85, -39.25 in-in in 8.044 Saltbr-in 2.938 HRD-in -87.55, -52.6 78.31, -2.58 in-in-out SNCiio in-out ActLoopNT-in 2.982 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -66.42, 158.8 APE9-dihe-na 91.27, -165.7 APE8-dihe-in -91.48, 116.05 APE8-rot-in 297.62 APE67-dihe-in -68.39, -23.42 -44.65, -48.42 APE12-dist-out 15.143 APE11-dist-in 13.773 APE10-dist-in 7.936 APE9-dist-in 4.104 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.0 0.175 0.204 D 364 296 21 0 0 0 [[37, 326]] 1.0 5uvf CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
6BP0D 22 341 396.0 E1D:406 Type1.5_Back Inactive DFGin 8.189 14.475 BLAminus -115.22, -179.95 61.34, 74.16 -89.56, 23.36 297.06, 72.1 -59.99, -33.49 in-in in 7.723 Saltbr-in 2.837 HRD-in -86.99, -45.85 73.72, 1.65 in-in-out SNCiio in-out ActLoopNT-in 2.949 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -63.77, 154.43 APE9-dihe-na 102.07, -167.43 APE8-dihe-in -92.02, 120.13 APE8-rot-in 298.41 APE67-dihe-in -67.53, -26.8 -52.54, -44.24 APE12-dist-out 14.83 APE11-dist-in 13.325 APE10-dist-in 7.505 APE9-dist-in 4.075 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 1.9 0.189 0.226 D 364 311 9 0 0 0 [[37, 326]] 1.0 6bp0 CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
6BRUB 23 341 396.0 E5M:401 Type1.5_Back Inactive DFGin 8.357 14.748 BLAminus -116.05, 174.64 73.11, 90.37 -112.13, 20.06 298.39, 84.27 -63.74, -27.85 in-in in 8.077 Saltbr-in 2.728 HRD-in -90.47, -48.07 75.98, 2.3 in-in-out SNCiio in-out ActLoopNT-in 2.89 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooi APE10-dihe-na -62.64, 163.66 APE9-dihe-na 89.79, -163.11 APE8-dihe-in -97.38, 120.62 APE8-rot-in 298.71 APE67-dihe-in -69.4, -24.42 -55.79, -40.6 APE12-dist-out 15.599 APE11-dist-out 14.298 APE10-dist-out 8.575 APE9-dist-in 4.024 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 1.8 0.196 0.214 B 364 301 18 0 0 0 [[37, 326]] 1.0 6bru CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
6BRUD 22 341 396.0 E5M:401 Type1.5_Back Inactive DFGin 8.236 14.624 BLAminus -117.89, 173.75 70.48, 89.16 -108.83, 20.66 296.08, 83.19 -48.29, -34.49 in-in in 8.03 Saltbr-in 2.877 HRD-in -89.48, -48.25 74.72, 2.08 in-in-out SNCiio in-out ActLoopNT-in 2.894 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -62.24, 162.75 APE9-dihe-na 91.76, -163.66 APE8-dihe-in -96.35, 120.51 APE8-rot-in 298.54 APE67-dihe-in -70.22, -23.54 -55.93, -40.24 APE12-dist-out 15.206 APE11-dist-in 13.846 APE10-dist-out 8.105 APE9-dist-in 4.058 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 1.8 0.196 0.214 D 364 311 9 0 0 0 [[37, 326]] 1.0 6bru CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
6BTWA 20 341 396.0 E8D:403 Type1.5_Back Inactive DFGin 8.005 14.815 BLAminus -117.16, 175.11 73.45, 95.27 -117.06, 20.4 298.79, 82.53 -66.86, -30.01 in-in in 7.868 Saltbr-in 2.773 HRD-in -73.11, -44.59 64.0, 9.52 in-in-out SNCiio in-out ActLoopNT-in 2.88 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -113.05, 7.29 APE9-dihe-na 80.13, -160.42 APE8-dihe-in -101.9, 126.44 APE8-rot-in 300.22 APE67-dihe-in -67.31, -25.09 -54.89, -45.07 APE12-dist-in 9.14 APE11-dist-out 5.527 APE10-dist-out 10.908 APE9-dist-in 3.709 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 1.9 0.184 0.215 A 364 317 5 0 0 0 [[37, 326]] 1.0 6btw CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
6BTWD 23 341 396.0 E8D:404 Type1.5_Back Inactive DFGin 8.248 14.504 BLAminus -117.75, 175.12 66.85, 83.81 -95.86, 25.57 292.01, 77.59 -72.26, -17.74 in-in in 7.799 Saltbr-in 2.804 HRD-in -86.53, -47.11 77.08, -0.22 in-in-out SNCiio in-out ActLoopNT-in 2.92 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -61.17, 152.72 APE9-dihe-na 97.98, -163.64 APE8-dihe-in -97.57, 116.12 APE8-rot-in 298.57 APE67-dihe-in -73.8, -26.79 -50.44, -39.9 APE12-dist-out 14.918 APE11-dist-in 13.443 APE10-dist-in 7.658 APE9-dist-in 4.13 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 1.9 0.184 0.215 D 364 307 12 0 0 0 [[37, 326]] 1.0 6btw CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
6BU6A 20 341 396.0 E8V:401 Type1.5_Back Inactive DFGin 7.987 14.826 BLAminus -117.44, 175.64 74.32, 90.34 -110.78, 17.1 297.15, 83.38 -64.18, -29.59 in-in in 7.968 Saltbr-in 2.731 HRD-in -87.08, -49.4 78.88, -0.84 in-in-out SNCiio in-out ActLoopNT-in 2.849 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -106.87, 0.03 APE9-dihe-na 89.05, -161.62 APE8-dihe-in -100.82, 121.19 APE8-rot-in 297.64 APE67-dihe-in -68.23, -25.69 -52.81, -42.42 APE12-dist-in 9.173 APE11-dist-out 5.563 APE10-dist-out 10.943 APE9-dist-in 3.859 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 1.8 0.186 0.212 A 364 322 0 0 0 0 [[37, 326]] 1.0 6bu6 CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
6CFMA 21 341 396.0 EA7:402 Type1.5_Back Inactive DFGin 7.933 14.899 BLAminus -117.58, 176.75 72.41, 88.99 -112.73, 20.45 295.51, 81.82 -65.94, -31.03 in-in in 8.006 Saltbr-in 2.803 HRD-in -85.02, -45.25 73.38, 1.8 in-in-out SNCiio in-out ActLoopNT-in 2.856 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -91.82, -9.86 APE9-dihe-na 106.18, -160.45 APE8-dihe-in -96.34, 127.15 APE8-rot-in 301.27 APE67-dihe-in -64.83, -27.76 -58.79, -43.46 APE12-dist-in 10.352 APE11-dist-out 5.646 APE10-dist-out 11.158 APE9-dist-in 3.945 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.45 0.203 0.245 A 364 316 5 0 0 0 [[37, 326]] 1.0 6cfm CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
6CFMB 23 341 396.0 EA7:404 Type1.5_Back Inactive DFGin 8.259 14.574 BLAminus -108.91, 171.8 67.7, 85.06 -98.24, 31.31 296.73, 81.09 -74.11, -26.93 in-in in 7.846 Saltbr-in 2.911 HRD-in -82.37, -57.05 82.98, 0.57 in-in-out SNCiio in-out ActLoopNT-in 2.89 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -59.4, 149.31 APE9-dihe-na 89.85, -169.27 APE8-dihe-in -85.72, 119.65 APE8-rot-in 304.36 APE67-dihe-in -63.02, -39.12 -55.36, -40.94 APE12-dist-out 14.858 APE11-dist-in 13.191 APE10-dist-in 7.519 APE9-dist-in 4.243 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.45 0.203 0.245 B 364 297 22 0 0 0 [[37, 326]] 1.0 6cfm CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
6CFMD 22 341 396.0 EA7:404 Type1.5_Back Inactive DFGin 8.285 14.625 BLAminus -115.09, 177.32 62.35, 80.54 -92.56, 30.44 294.07, 75.4 -61.95, -31.49 in-in in 7.884 Saltbr-in 2.982 HRD-in -82.48, -51.09 79.06, -6.93 in-in-out SNCiio in-out ActLoopNT-in 3.041 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -62.33, 153.26 APE9-dihe-na 93.87, -172.4 APE8-dihe-in -86.94, 125.09 APE8-rot-in 306.96 APE67-dihe-in -67.38, -30.96 -59.67, -38.18 APE12-dist-out 14.74 APE11-dist-in 13.237 APE10-dist-in 7.387 APE9-dist-in 4.279 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.45 0.203 0.245 D 364 313 7 0 0 0 [[37, 326]] 1.0 6cfm CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
6CNXB 21 341 396.0 F87:401 Type1.5_Back Inactive DFGin 8.322 14.547 BLAminus -115.62, 174.28 70.19, 90.35 -107.48, 27.1 294.52, 82.05 -63.68, -39.02 in-in in 7.755 Saltbr-in 2.756 HRD-in -89.7, -49.47 77.79, 1.89 in-in-out SNCiio in-out ActLoopNT-in 2.901 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -57.74, 153.84 APE9-dihe-na 94.87, -163.7 APE8-dihe-in -96.72, 118.51 APE8-rot-in 300.36 APE67-dihe-in -67.9, -26.38 -50.76, -42.64 APE12-dist-out 15.242 APE11-dist-in 13.682 APE10-dist-in 7.971 APE9-dist-in 3.997 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.0 0.188 0.211 B 364 311 10 0 0 0 [[37, 326]] 1.0 6cnx CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
6CNXC 21 341 396.0 FCS:401 Type1.5_Back Inactive DFGin 7.929 14.959 BLAminus -117.97, 174.58 72.5, 95.69 -112.8, 14.63 298.18, 79.72 -53.03, -36.61 in-in in 8.27 Saltbr-in 2.698 HRD-in -80.65, -55.5 79.78, -0.52 in-in-out SNCiio in-out ActLoopNT-in 2.885 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -102.77, 2.4 APE9-dihe-na 89.21, -150.13 APE8-dihe-in -109.73, 119.46 APE8-rot-in 298.92 APE67-dihe-in -67.91, -25.71 -48.97, -43.76 APE12-dist-none 999.0 APE11-dist-out 5.569 APE10-dist-out 10.874 APE9-dist-in 3.825 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.0 0.188 0.211 C 364 311 10 0 0 4 [[37, 326]] 1.0 6cnx CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
6CNXD 24 341 396.0 F87:401 Type1.5_Back Inactive DFGin 8.268 14.59 BLAminus -116.5, 175.45 68.07, 89.66 -105.26, 24.25 293.69, 81.55 -61.01, -28.01 in-in in 8.043 Saltbr-in 2.769 HRD-in -89.35, -52.24 76.81, 0.22 in-in-out SNCiio in-out ActLoopNT-in 2.896 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -52.59, 151.44 APE9-dihe-na 93.38, -163.54 APE8-dihe-in -96.97, 118.76 APE8-rot-in 300.17 APE67-dihe-in -69.21, -25.49 -50.58, -42.99 APE12-dist-out 15.091 APE11-dist-in 13.583 APE10-dist-in 7.875 APE9-dist-in 4.121 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.0 0.188 0.211 D 364 312 6 0 0 0 [[37, 326]] 1.0 6cnx CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
6NPNA 21 341 396.0 KWJ:401 Type1.5_Back Inactive DFGin 7.873 14.245 BLAminus -119.17, 172.95 75.09, 89.59 -108.0, 18.27 295.67, 83.71 -66.44, -26.61 in-in in 7.837 Saltbr-in 2.729 HRD-in -89.24, -48.0 75.46, 0.27 in-in-out SNCiio in-out ActLoopNT-in 2.898 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -99.97, -9.36 APE9-dihe-na 90.53, -162.44 APE8-dihe-in -93.92, 118.52 APE8-rot-in 305.6 APE67-dihe-in -67.7, -25.6 -53.81, -41.89 APE12-dist-in 10.452 APE11-dist-out 5.346 APE10-dist-out 10.612 APE9-dist-in 4.063 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.2 0.188 0.218 A 364 317 4 0 0 0 [[37, 326]] 1.0 6npn CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
6NPNB 24 341 396.0 KWJ:401 Type1.5_Back Inactive DFGin 7.897 14.186 BLAminus -121.49, 173.95 72.21, 84.07 -98.86, 26.98 293.62, 82.26 -66.37, -25.96 in-in in 7.833 Saltbr-in 2.681 HRD-in -91.27, -49.34 75.97, -0.29 in-in-out SNCiio in-out ActLoopNT-in 2.909 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -71.31, 153.26 APE9-dihe-na 99.07, -164.89 APE8-dihe-in -92.69, 118.62 APE8-rot-in 305.31 APE67-dihe-in -65.91, -27.16 -54.76, -41.68 APE12-dist-out 14.899 APE11-dist-in 13.348 APE10-dist-in 7.624 APE9-dist-in 4.092 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.2 0.188 0.218 B 364 301 17 0 0 0 [[37, 326]] 1.0 6npn CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
6NPNC 21 341 396.0 KWJ:401 Type1.5_Back Inactive DFGin 7.879 14.718 BLAminus -121.46, 174.24 75.08, 92.15 -111.88, 18.29 295.79, 85.38 -65.27, -28.05 in-in in 8.198 Saltbr-in 2.706 HRD-in -89.5, -49.52 75.66, 0.96 in-in-out SNCiio in-out ActLoopNT-in 2.885 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -100.08, -10.32 APE9-dihe-na 88.39, -162.15 APE8-dihe-in -95.06, 117.85 APE8-rot-in 304.01 APE67-dihe-in -69.67, -25.31 -51.69, -41.59 APE12-dist-in 9.842 APE11-dist-out 5.125 APE10-dist-out 10.643 APE9-dist-in 3.95 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.2 0.188 0.218 C 364 315 6 0 0 0 [[37, 326]] 1.0 6npn CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
6NPND 22 341 396.0 KWJ:401 Type1.5_Back Inactive DFGin 7.902 14.421 BLAminus -122.09, 171.77 67.86, 84.63 -95.8, 28.98 292.85, 92.04 -68.32, -23.59 in-in in 7.734 Saltbr-in 2.666 HRD-in -92.96, -45.57 73.38, 2.84 in-in-out SNCiio in-out ActLoopNT-in 2.994 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -71.5, 153.29 APE9-dihe-na 101.76, -167.65 APE8-dihe-in -89.04, 117.71 APE8-rot-in 304.96 APE67-dihe-in -67.62, -26.59 -55.51, -41.06 APE12-dist-out 14.815 APE11-dist-in 13.224 APE10-dist-in 7.507 APE9-dist-in 4.142 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.2 0.188 0.218 D 364 311 9 0 0 0 [[37, 326]] 1.0 6npn CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
6VXUC 21 341 396.0 VBD:401 Type1.5_Back Inactive DFGin 7.933 14.956 BLAminus -114.75, 176.59 73.33, 87.38 -108.59, 17.26 298.01, 82.77 -60.97, -33.91 in-in in 8.173 Saltbr-in 2.685 HRD-in -87.36, -50.03 77.04, 3.64 in-in-out SNCiio in-out ActLoopNT-in 2.913 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoi APE10-dihe-na 999.0, 160.08 APE9-dihe-na 85.99, -159.26 APE8-dihe-in -100.21, 133.91 APE8-rot-in 299.72 APE67-dihe-in -64.32, -38.52 -60.23, -41.06 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.067 APE9-dist-in 3.73 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.0 0.185 0.203 C 364 311 10 0 0 4 [[37, 326]] 1.0 6vxu CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
6VZHB 23 341 396.0 RYA:404 Type1.5_Back Inactive DFGin 8.344 14.206 BLAminus -120.79, -166.8 56.33, 59.14 -80.8, 7.94 300.87, 73.38 -47.26, -36.59 in-in in 7.728 Saltbr-in 2.995 HRD-in -92.77, -55.9 80.23, -2.19 in-in-out SNCiio in-out ActLoopNT-in 2.922 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -67.94, 152.72 APE9-dihe-na 97.86, -161.39 APE8-dihe-in -95.4, 124.26 APE8-rot-in 302.76 APE67-dihe-in -65.98, -28.39 -56.72, -47.18 APE12-dist-out 15.224 APE11-dist-in 13.883 APE10-dist-out 8.106 APE9-dist-in 4.119 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.55 0.217 0.251 B 364 301 18 0 0 0 [[37, 326]] 1.0 6vzh CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
6VZHD 22 341 396.0 RYA:404 Type1.5_Back Inactive DFGin 8.247 14.618 BLAminus -109.24, -177.4 58.04, 66.78 -86.29, 48.33 296.8, 67.41 -65.77, -39.54 in-in in 7.939 Saltbr-in 2.814 HRD-in -86.23, -60.59 80.89, 1.45 in-in-out SNCiio in-out ActLoopNT-in 2.934 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -65.14, 150.01 APE9-dihe-na 97.56, -161.15 APE8-dihe-in -96.29, 124.58 APE8-rot-in 304.06 APE67-dihe-in -65.24, -28.05 -59.24, -46.64 APE12-dist-out 14.745 APE11-dist-in 13.331 APE10-dist-in 7.545 APE9-dist-in 4.161 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.55 0.217 0.251 D 364 311 9 0 0 0 [[37, 326]] 1.0 6vzh CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
2KTYA 1 360 396.0 No_ligand No_ligand Inactive DFGin 5.324 15.153 None -89.4, 48.25 -88.38, 13.56 -67.73, -15.51 318.79, 139.99 -118.73, -3.9 in-out in 9.588 Saltbr-out 4.651 HRD-out -78.42, 104.69 -109.22, 23.05 out-in-out SNCoio in-out ActLoopNT-in 3.151 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na -48.81, -30.88 APE9-dihe-na -140.12, -137.46 APE8-dihe-in -89.92, 130.62 APE8-rot-out 194.46 APE67-dihe-in -50.66, -57.74 -50.93, -21.33 APE12-dist-in 10.476 APE11-dist-in 11.356 APE10-dist-in 5.746 APE9-dist-out 7.401 None None None NMR 999.0 999.0 999.0 A 368 360 0 0 0 0 [[37, 326]] 1.0 2kty CK1_VRK1_HUMAN CK1 9.8e-106 358.9 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
2KULA 1 360 396.0 No_ligand No_ligand Inactive DFGin 6.249 13.159 None -136.39, -155.46 72.24, -78.37 55.92, -7.95 293.82, 125.62 -72.72, -31.43 in-in in 8.583 Saltbr-in 2.617 HRD-out -119.9, 103.12 -73.71, -46.93 in-in-out SNCiio in-out ActLoopNT-in 2.768 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na -76.69, -64.74 APE9-dihe-na -109.51, -104.17 APE8-dihe-in -89.82, 146.99 APE8-rot-out 38.36 APE67-dihe-in -74.0, -55.74 -68.22, -27.75 APE12-dist-in 10.539 APE11-dist-in 9.91 APE10-dist-in 4.082 APE9-dist-out 6.856 None None None NMR 999.0 999.0 999.0 A 368 360 0 0 0 0 [[37, 326]] 1.0 2kul CK1_VRK1_HUMAN CK1 9.8e-106 358.9 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1

CK1_VRK1 (Serine/threonine-protein kinase VRK1)

Total number of chains: 78
Active chains: 1
Family: CK1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 76 97.4% AF-Q99986-K3A
DFGin None 2 2.6% 2KTYA

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
VRK1_HUMAN AF-Q99986-K3A Q99986 29 334 396.0 No_ligand No_ligand Active DFGin 7.855 14.607 BLAminus -119.69, -179.59 64.74, 62.18 -76.51, 26.37 292.6, 86.66 -65.07, -24.37 in-in in 7.909 Saltbr-in 2.742 HRD-in -84.6, -47.87 78.67, -17.76 in-in-in SNCiii in-in ActLoopNT-in 2.968 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -85.29, 147.36 APE9-dihe-na 87.15, -175.44 APE8-dihe-in -81.65, 119.55 APE8-rot-in 301.17 APE67-dihe-in -65.28, -29.48 -56.82, -38.5 APE12-dist-in 12.16 APE11-dist-in 12.139 APE10-dist-in 6.381 APE9-dist-in 4.371 None None None AF2 -1.0 1.0 1.0 A 306 306 0 0 0 0 [[37, 326]] 1.0 AF-Q99986-K3 Homo sapiens CK1_VRK1_HUMAN CK1 5e-106 359.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
VRK1_HUMAN 6AC9A Q99986 21 342 396.0 ANP:401 ATPlike Inactive DFGin 7.921 14.706 BLAminus -114.21, 177.93 70.15, 93.84 -115.1, 19.79 299.42, 81.98 -60.26, -28.75 in-in in 7.95 Saltbr-in 2.779 HRD-in -85.24, -47.15 69.74, 5.52 in-in-out SNCiio in-out ActLoopNT-in 2.799 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -132.17, 15.24 APE9-dihe-na 79.52, -153.87 APE8-dihe-in -97.68, 119.65 APE8-rot-in 299.88 APE67-dihe-in -62.87, -27.26 -44.77, -50.87 APE12-dist-in 9.478 APE11-dist-out 5.963 APE10-dist-out 10.714 APE9-dist-in 3.851 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.07 0.187 0.223 A 370 317 5 0 0 0 [[37, 326]] 1.0 6ac9 Homo sapiens CK1_VRK1_HUMAN CK1 8.9e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
VRK1_HUMAN 6AC9B Q99986 21 341 396.0 ANP:401 ATPlike Inactive DFGin 7.916 14.739 BLAminus -115.54, 178.38 75.12, 91.43 -115.59, 17.29 297.69, 88.6 -57.57, -34.6 in-in in 8.093 Saltbr-in 2.77 HRD-in -83.61, -50.49 74.28, -0.88 in-in-out SNCiio in-out ActLoopNT-in 2.793 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -114.62, 8.0 APE9-dihe-na 78.71, -152.8 APE8-dihe-in -103.98, 122.42 APE8-rot-in 297.61 APE67-dihe-in -64.96, -28.03 -44.02, -51.48 APE12-dist-in 9.99 APE11-dist-out 5.433 APE10-dist-out 10.749 APE9-dist-in 3.727 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.07 0.187 0.223 B 370 316 5 0 0 0 [[37, 326]] 1.0 6ac9 Homo sapiens CK1_VRK1_HUMAN CK1 8.9e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
VRK1_HUMAN 6AC9C Q99986 24 341 396.0 ANP:402 ATPlike Inactive DFGin 7.927 14.325 BLAminus -121.92, 176.09 69.3, 88.62 -104.37, 22.99 293.32, 87.67 -64.92, -32.52 in-in in 7.605 Saltbr-in 2.793 HRD-in -88.58, -46.78 72.09, 4.58 in-in-out SNCiio in-out ActLoopNT-in 2.856 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -67.72, 154.65 APE9-dihe-na 94.16, -162.22 APE8-dihe-in -91.17, 117.25 APE8-rot-in 299.96 APE67-dihe-in -65.18, -24.09 -48.81, -46.56 APE12-dist-out 14.966 APE11-dist-in 13.64 APE10-dist-in 7.925 APE9-dist-in 4.153 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.07 0.187 0.223 C 370 307 11 0 0 0 [[37, 326]] 1.0 6ac9 Homo sapiens CK1_VRK1_HUMAN CK1 8.9e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
VRK1_HUMAN 6AC9D Q99986 23 341 396.0 ANP:402 ATPlike Inactive DFGin 7.739 14.33 BLAminus -116.24, 179.23 65.24, 86.32 -103.3, 26.16 293.03, 86.03 -64.75, -25.98 in-in in 7.722 Saltbr-in 2.797 HRD-in -87.33, -42.3 69.45, 1.55 in-in-out SNCiio in-out ActLoopNT-in 2.992 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -66.0, 154.0 APE9-dihe-na 92.71, -167.74 APE8-dihe-in -86.89, 111.15 APE8-rot-in 299.25 APE67-dihe-in -66.58, -28.49 -43.2, -46.61 APE12-dist-out 14.83 APE11-dist-in 13.447 APE10-dist-in 7.737 APE9-dist-in 4.26 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.07 0.187 0.223 D 370 306 13 0 0 0 [[37, 326]] 1.0 6ac9 Homo sapiens CK1_VRK1_HUMAN CK1 8.9e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
VRK1_HUMAN AF-Q99986-K1A Q99986 29 334 396.0 No_ligand No_ligand Inactive DFGin 8.283 14.584 BLAminus -116.22, 175.16 68.86, 62.05 -78.73, 25.47 298.95, 82.4 -65.45, -25.9 in-in in 7.769 Saltbr-in 2.638 HRD-in -85.34, -48.1 75.11, 0.62 in-in-out SNCiio in-out ActLoopNT-in 2.95 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -54.35, 145.53 APE9-dihe-na 88.61, -168.93 APE8-dihe-in -80.66, 116.83 APE8-rot-in 300.65 APE67-dihe-in -69.43, -27.77 -53.52, -41.73 APE12-dist-out 15.122 APE11-dist-in 13.592 APE10-dist-in 7.908 APE9-dist-in 4.295 None None None AF2 -1.0 1.0 1.0 A 306 306 0 0 0 0 [[37, 326]] 1.0 AF-Q99986-K1 Homo sapiens CK1_VRK1_HUMAN CK1 5e-106 359.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
VRK1_HUMAN 2LAVA Q99986 1 361 396.0 No_ligand No_ligand Inactive DFGin 8.986 18.467 BLAminus -104.7, 164.97 58.57, 105.4 -91.24, -47.91 319.25, 98.88 52.76, 23.83 in-out in 9.155 Saltbr-out 7.864 HRD-in -68.39, -66.65 67.7, 29.87 out-in-out SNCoio in-out ActLoopNT-in 2.626 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iiio APE10-dihe-na -62.24, 124.33 APE9-dihe-na 174.92, 155.66 APE8-dihe-in -102.39, 138.01 APE8-rot-in 334.0 APE67-dihe-in -57.87, -37.94 -48.28, -25.53 APE12-dist-in 8.787 APE11-dist-in 11.079 APE10-dist-in 6.676 APE9-dist-out 7.771 None None None NMR 999.0 999.0 999.0 A 361 361 0 0 0 0 [[37, 326]] 1.0 2lav Homo sapiens CK1_VRK1_HUMAN CK1 9.2e-106 359.0 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
VRK1_HUMAN 6BP0A Q99986 20 341 396.0 No_ligand No_ligand Inactive DFGin 7.899 14.613 BLAminus -115.13, 179.0 70.55, 71.89 -95.8, 16.39 303.84, 78.03 -60.39, -37.23 in-in in 7.729 Saltbr-in 2.78 HRD-in -89.43, -46.42 71.54, 4.58 in-in-out SNCiio in-out ActLoopNT-in 2.898 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -119.33, 13.08 APE9-dihe-na 74.96, -159.37 APE8-dihe-in -101.74, 124.19 APE8-rot-in 297.87 APE67-dihe-in -62.96, -28.12 -54.38, -45.62 APE12-dist-in 9.528 APE11-dist-out 5.767 APE10-dist-out 10.937 APE9-dist-in 3.676 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 1.9 0.189 0.226 A 364 317 5 0 0 0 [[37, 326]] 1.0 6bp0 Homo sapiens CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
VRK1_HUMAN 6BP0C Q99986 21 341 396.0 No_ligand No_ligand Inactive DFGin 7.939 14.851 BLAminus -116.27, 178.65 72.76, 71.27 -96.93, 15.82 304.69, 78.55 -60.82, -36.22 in-in in 8.014 Saltbr-in 2.747 HRD-in -87.79, -47.2 71.69, 3.65 in-in-out SNCiio in-out ActLoopNT-in 2.879 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -119.41, 12.06 APE9-dihe-na 90.25, -158.01 APE8-dihe-in -101.06, 122.29 APE8-rot-in 297.48 APE67-dihe-in -69.11, -23.96 -55.18, -40.69 APE12-dist-in 9.332 APE11-dist-out 5.615 APE10-dist-out 10.959 APE9-dist-in 3.737 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 1.9 0.189 0.226 C 364 315 6 0 0 0 [[37, 326]] 1.0 6bp0 Homo sapiens CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
VRK1_HUMAN 6BRUA Q99986 20 341 396.0 No_ligand No_ligand Inactive DFGin 8.033 14.707 BLAminus -117.66, 174.8 73.4, 90.42 -111.17, 18.43 297.57, 83.73 -62.66, -32.45 in-in in 7.75 Saltbr-in 2.723 HRD-in -89.4, -48.02 76.76, 0.18 in-in-out SNCiio in-out ActLoopNT-in 2.909 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -112.07, 4.26 APE9-dihe-na 85.33, -161.74 APE8-dihe-in -100.33, 121.11 APE8-rot-in 296.71 APE67-dihe-in -67.79, -25.01 -53.75, -41.68 APE12-dist-in 9.256 APE11-dist-out 5.497 APE10-dist-out 10.929 APE9-dist-in 3.804 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 1.8 0.196 0.214 A 364 322 0 0 0 0 [[37, 326]] 1.0 6bru Homo sapiens CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
VRK1_HUMAN 6BRUC Q99986 21 341 396.0 No_ligand No_ligand Inactive DFGin 7.985 14.962 BLAminus -117.45, 175.22 72.9, 90.95 -111.5, 17.79 298.09, 83.36 -63.53, -31.92 in-in in 8.028 Saltbr-in 2.732 HRD-in -88.93, -48.21 76.94, 0.57 in-in-out SNCiio in-out ActLoopNT-in 2.87 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -112.0, 3.87 APE9-dihe-na 86.79, -161.39 APE8-dihe-in -100.72, 120.61 APE8-rot-in 298.11 APE67-dihe-in -68.1, -24.22 -53.45, -41.86 APE12-dist-in 9.195 APE11-dist-out 5.51 APE10-dist-out 10.96 APE9-dist-in 3.808 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 1.8 0.196 0.214 C 364 315 6 0 0 0 [[37, 326]] 1.0 6bru Homo sapiens CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
VRK1_HUMAN 6BTWC Q99986 21 341 396.0 No_ligand No_ligand Inactive DFGin 7.901 14.845 BLAminus -115.06, 173.48 78.14, 95.08 -115.95, 16.82 299.73, 84.12 -61.42, -29.78 in-in in 8.098 Saltbr-in 2.637 HRD-in -79.8, -44.78 64.46, 9.45 in-in-out SNCiio in-out ActLoopNT-in 2.897 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -116.67, 8.32 APE9-dihe-na 85.69, -157.8 APE8-dihe-in -104.89, 121.6 APE8-rot-in 294.77 APE67-dihe-in -67.83, -24.48 -53.21, -41.44 APE12-dist-in 9.309 APE11-dist-out 5.483 APE10-dist-out 10.847 APE9-dist-in 3.668 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 1.9 0.184 0.215 C 364 315 6 0 0 0 [[37, 326]] 1.0 6btw Homo sapiens CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
VRK1_HUMAN 6BU6C Q99986 21 341 396.0 No_ligand No_ligand Inactive DFGin 7.944 14.969 BLAminus -117.18, 175.95 73.51, 91.5 -111.82, 15.91 297.66, 83.38 -64.79, -27.67 in-in in 8.173 Saltbr-in 2.723 HRD-in -87.76, -48.87 78.25, -0.92 in-in-out SNCiio in-out ActLoopNT-in 2.853 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -109.17, 2.29 APE9-dihe-na 87.9, -161.95 APE8-dihe-in -100.19, 119.95 APE8-rot-in 298.15 APE67-dihe-in -68.79, -25.2 -52.88, -41.93 APE12-dist-in 9.091 APE11-dist-out 5.53 APE10-dist-out 10.945 APE9-dist-in 3.847 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 1.8 0.186 0.212 C 364 315 6 0 0 0 [[37, 326]] 1.0 6bu6 Homo sapiens CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
VRK1_HUMAN 6CFMC Q99986 21 341 396.0 No_ligand No_ligand Inactive DFGin 7.851 14.953 BLAminus -123.42, 174.01 73.65, 94.53 -118.05, 16.57 295.96, 85.64 -61.62, -32.15 in-in in 8.272 Saltbr-in 2.848 HRD-in -85.66, -49.06 72.84, 13.62 in-in-out SNCiio in-out ActLoopNT-in 2.817 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -130.41, 10.66 APE9-dihe-na 103.07, -153.01 APE8-dihe-in -105.77, 122.69 APE8-rot-in 300.58 APE67-dihe-in -64.29, -35.62 -55.74, -43.04 APE12-dist-in 9.648 APE11-dist-out 5.734 APE10-dist-out 10.691 APE9-dist-in 3.986 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.45 0.203 0.245 C 364 316 5 0 0 0 [[37, 326]] 1.0 6cfm Homo sapiens CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
VRK1_HUMAN 6CMMA Q99986 20 341 396.0 No_ligand No_ligand Inactive DFGin 7.939 14.853 BLAminus -118.01, 179.55 70.25, 94.14 -114.09, 19.03 296.97, 80.28 -64.11, -27.16 in-in in 7.987 Saltbr-in 2.724 HRD-in -70.61, -48.88 72.27, 0.35 in-in-out SNCiio in-out ActLoopNT-in 2.835 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -115.61, 6.25 APE9-dihe-na 83.26, -156.76 APE8-dihe-in -101.59, 132.95 APE8-rot-in 301.05 APE67-dihe-in -61.96, -26.2 -62.18, -45.9 APE12-dist-in 9.405 APE11-dist-out 5.579 APE10-dist-out 10.786 APE9-dist-in 3.796 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.1 0.192 0.222 A 364 318 4 0 0 0 [[37, 326]] 1.0 6cmm Homo sapiens CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
VRK1_HUMAN 6CMMC Q99986 21 341 396.0 No_ligand No_ligand Inactive DFGin 7.913 14.838 BLAminus -118.19, 172.22 77.38, 94.72 -118.56, 19.82 299.14, 81.41 -62.89, -28.04 in-in in 8.09 Saltbr-in 2.659 HRD-in -85.44, -49.56 76.52, 1.18 in-in-out SNCiio in-out ActLoopNT-in 2.817 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -126.71, 22.14 APE9-dihe-na 66.49, -154.73 APE8-dihe-in -106.73, 121.33 APE8-rot-in 297.11 APE67-dihe-in -65.73, -23.75 -52.02, -44.91 APE12-dist-in 9.357 APE11-dist-out 5.62 APE10-dist-out 10.622 APE9-dist-in 3.633 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.1 0.192 0.222 C 364 316 5 0 0 0 [[37, 326]] 1.0 6cmm Homo sapiens CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
VRK1_HUMAN 6CQHC Q99986 21 341 396.0 No_ligand No_ligand Inactive DFGin 7.983 14.851 BLAminus -118.07, 171.71 76.59, 94.42 -117.6, 18.62 300.15, 81.64 -66.87, -26.53 in-in in 8.206 Saltbr-in 2.634 HRD-in -92.02, -48.17 76.02, 0.45 in-in-out SNCiio in-out ActLoopNT-in 2.877 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoi APE10-dihe-na 999.0, 7.71 APE9-dihe-na 82.96, -159.08 APE8-dihe-in -106.9, 123.02 APE8-rot-in 294.19 APE67-dihe-in -67.55, -22.98 -57.09, -40.82 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 10.275 APE9-dist-in 3.617 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.15 0.203 0.239 C 364 308 13 0 0 7 [[37, 326]] 1.0 6cqh Homo sapiens CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
VRK1_HUMAN 6CSWA Q99986 20 341 396.0 No_ligand No_ligand Inactive DFGin 7.952 14.924 BLAminus -122.51, 173.92 71.82, 95.83 -120.18, 18.9 297.48, 79.83 -60.53, -29.57 in-in in 8.26 Saltbr-in 2.827 HRD-in -91.54, -44.14 76.02, 1.18 in-in-out SNCiio in-out ActLoopNT-in 2.902 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -111.14, 8.96 APE9-dihe-na 81.62, -159.14 APE8-dihe-in -98.32, 128.16 APE8-rot-in 303.45 APE67-dihe-in -67.96, -21.86 -52.63, -48.85 APE12-dist-in 8.932 APE11-dist-out 5.581 APE10-dist-out 10.956 APE9-dist-in 3.683 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.25 0.19 0.233 A 364 316 6 0 0 0 [[37, 326]] 1.0 6csw Homo sapiens CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
VRK1_HUMAN 6CSWC Q99986 20 341 396.0 No_ligand No_ligand Inactive DFGin 7.92 14.962 BLAminus -123.35, 175.87 70.95, 94.91 -118.46, 18.78 298.16, 84.07 -62.21, -28.69 in-in in 8.281 Saltbr-in 2.681 HRD-in -86.8, -47.4 74.78, 6.82 in-in-out SNCiio in-out ActLoopNT-in 2.849 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -93.09, 2.93 APE9-dihe-na 81.91, -151.33 APE8-dihe-in -107.83, 122.33 APE8-rot-in 299.96 APE67-dihe-in -62.29, -29.36 -52.62, -45.06 APE12-dist-in 8.669 APE11-dist-out 5.582 APE10-dist-out 11.169 APE9-dist-in 3.802 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.25 0.19 0.233 C 364 319 3 0 0 1 [[37, 326]] 1.0 6csw Homo sapiens CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
VRK1_HUMAN 6DD4A Q99986 20 341 396.0 No_ligand No_ligand Inactive DFGin 7.876 14.838 BLAminus -120.41, 173.02 75.13, 94.02 -114.1, 14.98 299.39, 83.08 -58.5, -29.65 in-in in 8.081 Saltbr-in 2.542 HRD-in -82.93, -47.61 72.82, 3.43 in-in-out SNCiio in-out ActLoopNT-in 2.84 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -111.48, 6.67 APE9-dihe-na 82.5, -163.01 APE8-dihe-in -94.17, 125.47 APE8-rot-in 297.51 APE67-dihe-in -62.9, -24.88 -50.41, -51.16 APE12-dist-in 8.931 APE11-dist-out 5.472 APE10-dist-out 11.007 APE9-dist-in 3.71 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.1 0.196 0.226 A 364 317 5 0 0 0 [[37, 326]] 1.0 6dd4 Homo sapiens CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
VRK1_HUMAN 6DD4C Q99986 21 341 396.0 No_ligand No_ligand Inactive DFGin 7.917 14.913 BLAminus -119.83, 175.04 73.93, 94.49 -116.65, 17.84 297.32, 82.95 -65.53, -26.45 in-in in 8.042 Saltbr-in 2.628 HRD-in -89.97, -49.3 75.88, 5.26 in-in-out SNCiio in-out ActLoopNT-in 2.817 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -120.92, 5.41 APE9-dihe-na 86.74, -156.9 APE8-dihe-in -103.04, 119.22 APE8-rot-in 302.42 APE67-dihe-in -62.83, -29.71 -48.5, -44.98 APE12-dist-in 9.609 APE11-dist-out 5.515 APE10-dist-out 10.954 APE9-dist-in 3.838 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.1 0.196 0.226 C 364 317 4 0 0 0 [[37, 326]] 1.0 6dd4 Homo sapiens CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
VRK1_HUMAN 6VZHA Q99986 20 341 396.0 No_ligand No_ligand Inactive DFGin 8.07 14.63 BLAminus -119.11, -165.76 57.07, 58.18 -85.56, 20.64 296.92, 77.29 -62.31, -38.38 in-none in 7.598 Saltbr-none 999.0 HRD-in -87.43, -61.36 81.37, 3.25 none-in-out SNCnio in-out ActLoopNT-in 2.894 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -96.58, -2.29 APE9-dihe-na 95.82, -158.45 APE8-dihe-in -97.53, 125.47 APE8-rot-in 301.35 APE67-dihe-in -65.35, -28.4 -59.05, -45.83 APE12-dist-in 10.054 APE11-dist-out 5.99 APE10-dist-out 11.072 APE9-dist-in 4.155 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.55 0.217 0.251 A 364 317 5 0 0 0 [[37, 326]] 1.0 6vzh Homo sapiens CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
VRK1_HUMAN 6VZHC Q99986 21 341 396.0 No_ligand No_ligand Inactive DFGin 8.005 14.868 BLAminus -116.13, -175.0 63.78, 73.2 -103.71, 27.78 305.13, 71.56 -64.11, -34.62 in-none in 7.835 Saltbr-none 999.0 HRD-in -87.12, -61.01 79.21, 4.12 none-in-out SNCnio in-out ActLoopNT-in 2.906 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -111.31, 3.43 APE9-dihe-na 87.47, -167.24 APE8-dihe-in -81.92, 128.85 APE8-rot-in 310.31 APE67-dihe-in -66.4, -28.62 -58.47, -46.31 APE12-dist-in 9.519 APE11-dist-out 5.672 APE10-dist-out 10.841 APE9-dist-in 3.864 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.55 0.217 0.251 C 364 315 6 0 0 0 [[37, 326]] 1.0 6vzh Homo sapiens CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
VRK1_HUMAN 8V42A Q99986 20 341 396.0 No_ligand No_ligand Inactive DFGin 7.853 14.81 BLAminus -121.51, 175.02 72.65, 94.71 -118.54, 19.89 299.65, 83.97 -59.01, -29.73 in-in in 8.212 Saltbr-in 2.865 HRD-in -83.99, -58.09 83.43, 6.42 in-in-out SNCiio in-out ActLoopNT-in 2.869 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -99.72, 1.75 APE9-dihe-na 88.26, -152.18 APE8-dihe-in -102.45, 129.29 APE8-rot-in 302.03 APE67-dihe-in -66.72, -27.45 -54.7, -46.25 APE12-dist-in 9.69 APE11-dist-out 5.059 APE10-dist-out 10.756 APE9-dist-in 3.725 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.3 0.199 0.231 A 364 312 10 0 0 0 [[37, 326]] 1.0 8v42 Homo sapiens CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
VRK1_HUMAN 8V42C Q99986 21 341 396.0 No_ligand No_ligand Inactive DFGin 7.894 14.793 BLAminus -123.1, 173.79 74.88, 93.95 -117.93, 23.53 298.38, 87.45 -66.4, -24.74 in-in in 8.15 Saltbr-in 3.1 HRD-in -85.5, -57.27 80.14, 9.55 in-in-out SNCiio in-out ActLoopNT-in 2.792 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -121.06, 1.32 APE9-dihe-na 82.38, -165.01 APE8-dihe-in -98.07, 122.8 APE8-rot-in 302.61 APE67-dihe-in -67.57, -28.21 -55.26, -41.9 APE12-dist-in 9.275 APE11-dist-out 4.841 APE10-dist-out 10.392 APE9-dist-in 3.903 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.3 0.199 0.231 C 364 315 6 0 0 0 [[37, 326]] 1.0 8v42 Homo sapiens CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
VRK1_HUMAN 2RSVA Q99986 1 396 396.0 No_ligand No_ligand Inactive DFGin 9.457 17.356 BLAminus -126.95, 167.12 53.65, 57.68 -59.68, -51.55 307.53, 91.34 93.81, -35.83 in-out in 8.252 Saltbr-out 6.016 HRD-out -151.68, -51.8 55.83, 53.12 out-in-out SNCoio in-out ActLoopNT-in 2.889 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na 61.47, 172.38 APE9-dihe-na 122.51, -164.12 APE8-dihe-in -87.87, 178.09 APE8-rot-out 49.7 APE67-dihe-in -51.36, -24.62 -116.16, -26.84 APE12-dist-in 9.745 APE11-dist-in 9.201 APE10-dist-in 7.485 APE9-dist-out 8.931 None None None NMR 999.0 999.0 999.0 A 403 396 0 0 0 0 [[37, 326]] 1.0 2rsv Homo sapiens CK1_VRK1_HUMAN CK1 1.3e-105 358.6 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
VRK1_HUMAN 5UKFA Q99986 20 341 396.0 8E1:401 Type1 Inactive DFGin 7.859 14.425 BLAminus -119.38, 173.41 75.63, 89.68 -116.06, 14.39 298.31, 90.17 -54.65, -38.06 in-out in 8.244 Saltbr-out 3.678 HRD-in -79.04, -57.54 80.31, -4.23 out-in-out SNCoio in-out ActLoopNT-in 2.831 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -63.69, -39.06 APE9-dihe-na 83.51, -147.55 APE8-dihe-in -109.2, 120.2 APE8-rot-in 298.23 APE67-dihe-in -64.41, -31.89 -42.31, -49.41 APE12-dist-in 9.511 APE11-dist-out 5.84 APE10-dist-out 9.809 APE9-dist-in 3.891 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.4 0.179 0.214 A 363 322 0 0 0 0 [[37, 326]] 1.0 5ukf Homo sapiens CK1_VRK1_HUMAN CK1 8.3e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
VRK1_HUMAN 5UKFB Q99986 51 341 396.0 8E1:401 Type1 Inactive DFGin 8.097 14.664 BLAminus -121.11, 172.72 70.19, 89.58 -108.13, 26.3 294.0, 86.12 -70.32, -38.73 in-none in 8.303 Saltbr-none 999.0 HRD-in -78.71, -64.95 86.46, -3.2 none-in-out SNCnio in-out ActLoopNT-in 2.912 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -75.53, 157.07 APE9-dihe-na 91.4, -169.09 APE8-dihe-in -84.62, 126.19 APE8-rot-in 289.52 APE67-dihe-in -64.84, -37.67 -57.81, -40.1 APE12-dist-out 14.838 APE11-dist-in 13.523 APE10-dist-in 7.842 APE9-dist-in 4.275 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.4 0.179 0.214 B 363 265 40 0 0 0 [[37, 326]] 1.0 5ukf Homo sapiens CK1_VRK1_HUMAN CK1 8.3e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
VRK1_HUMAN 5UKFC Q99986 21 341 396.0 8E1:401 Type1 Inactive DFGin 7.907 15.055 BLAminus -114.51, 177.87 73.15, 91.67 -116.1, 13.64 296.69, 91.23 -56.4, -31.52 in-none in 8.636 Saltbr-none 999.0 HRD-in -84.93, -54.46 77.79, -1.55 none-in-out SNCnio in-out ActLoopNT-in 2.855 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -63.77, -41.33 APE9-dihe-na 83.79, -153.92 APE8-dihe-in -103.66, 122.47 APE8-rot-in 295.8 APE67-dihe-in -65.42, -25.93 -48.36, -48.26 APE12-dist-in 9.325 APE11-dist-out 5.931 APE10-dist-out 9.875 APE9-dist-in 4.035 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.4 0.179 0.214 C 363 317 4 0 0 0 [[37, 326]] 1.0 5ukf Homo sapiens CK1_VRK1_HUMAN CK1 8.3e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
VRK1_HUMAN 5UKFD Q99986 39 341 396.0 8E1:402 Type1 Inactive DFGin 7.855 14.662 BLAminus -113.78, 177.54 70.67, 89.75 -108.82, 24.37 295.86, 87.15 -64.56, -29.83 in-in in 9.779 Saltbr-in 2.701 HRD-in -84.79, -51.24 76.1, -0.34 in-in-out SNCiio in-out ActLoopNT-in 2.979 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -75.62, 154.64 APE9-dihe-na 93.28, -169.83 APE8-dihe-in -86.2, 117.34 APE8-rot-in 297.37 APE67-dihe-in -69.56, -25.24 -47.9, -42.95 APE12-dist-out 14.976 APE11-dist-in 13.621 APE10-dist-in 7.924 APE9-dist-in 4.269 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.4 0.179 0.214 D 363 268 37 0 0 0 [[37, 326]] 1.0 5ukf Homo sapiens CK1_VRK1_HUMAN CK1 8.3e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
VRK1_HUMAN 3OP5A Q99986 21 341 396.0 REB:365 Type1 Inactive DFGin 7.953 14.534 BLAminus -114.82, 176.41 71.01, 96.34 -120.14, 18.32 297.72, 91.95 -64.04, -28.74 in-out in 7.905 Saltbr-out 4.41 HRD-in -81.17, -51.65 71.32, 4.58 out-in-out SNCoio in-out ActLoopNT-in 2.809 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -121.23, 18.55 APE9-dihe-na 75.48, -153.65 APE8-dihe-in -102.2, 117.44 APE8-rot-in 299.56 APE67-dihe-in -69.82, -27.08 -41.77, -48.52 APE12-dist-in 9.195 APE11-dist-out 5.48 APE10-dist-out 10.83 APE9-dist-in 3.671 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.4 0.179 0.213 A 364 320 1 0 0 0 [[37, 326]] 1.0 3op5 Homo sapiens CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
VRK1_HUMAN 3OP5B Q99986 21 341 396.0 REB:365 Type1 Inactive DFGin 7.958 14.643 BLAminus -113.97, 176.01 71.29, 96.02 -119.19, 18.9 297.8, 91.46 -64.52, -28.62 in-out in 8.115 Saltbr-out 4.406 HRD-in -81.96, -51.98 71.81, 3.7 out-in-out SNCoio in-out ActLoopNT-in 2.81 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -118.98, 15.13 APE9-dihe-na 73.86, -155.53 APE8-dihe-in -100.82, 117.46 APE8-rot-in 300.82 APE67-dihe-in -69.97, -26.87 -41.58, -48.34 APE12-dist-in 9.266 APE11-dist-out 5.364 APE10-dist-out 10.711 APE9-dist-in 3.729 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.4 0.179 0.213 B 364 319 2 0 0 0 [[37, 326]] 1.0 3op5 Homo sapiens CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
VRK1_HUMAN 3OP5C Q99986 22 341 396.0 REB:365 Type1 Inactive DFGin 7.92 14.431 BLAminus -113.54, 176.44 69.75, 97.17 -118.63, 20.05 296.44, 91.45 -64.33, -26.27 in-none in 8.334 Saltbr-none 999.0 HRD-in -81.5, -52.35 71.18, 5.09 none-in-out SNCnio in-out ActLoopNT-in 2.827 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -72.8, 159.76 APE9-dihe-na 87.63, -165.14 APE8-dihe-in -90.95, 116.06 APE8-rot-in 302.3 APE67-dihe-in -69.84, -27.29 -42.27, -48.51 APE12-dist-out 15.049 APE11-dist-in 13.784 APE10-dist-in 7.966 APE9-dist-in 4.007 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.4 0.179 0.213 C 364 308 12 0 0 0 [[37, 326]] 1.0 3op5 Homo sapiens CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
VRK1_HUMAN 3OP5D Q99986 25 341 396.0 REB:365 Type1 Inactive DFGin 7.969 14.453 BLAminus -112.89, 176.13 70.95, 97.27 -119.85, 19.74 297.32, 91.51 -64.31, -27.23 in-none in 7.925 Saltbr-none 999.0 HRD-in -80.63, -52.15 71.05, 5.02 none-in-out SNCnio in-out ActLoopNT-in 2.828 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooi APE10-dihe-na -69.13, 152.48 APE9-dihe-na 88.04, -168.28 APE8-dihe-in -88.02, 114.99 APE8-rot-in 302.83 APE67-dihe-in -62.29, -38.34 -40.98, -47.51 APE12-dist-out 15.304 APE11-dist-out 14.006 APE10-dist-out 8.294 APE9-dist-in 4.001 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.4 0.179 0.213 D 364 302 15 0 0 0 [[37, 326]] 1.0 3op5 Homo sapiens CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
VRK1_HUMAN 5UVFA Q99986 20 341 396.0 7DZ:401 Type1 Inactive DFGin 8.068 14.985 BLAminus -116.03, 174.63 69.35, 93.67 -111.58, 17.18 296.91, 82.24 -59.96, -29.3 in-none in 8.098 Saltbr-none 999.0 HRD-in -86.38, -53.2 77.43, -1.98 none-in-out SNCnio in-out ActLoopNT-in 2.799 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -119.56, 12.28 APE9-dihe-na 82.85, -155.5 APE8-dihe-in -99.21, 123.02 APE8-rot-in 299.54 APE67-dihe-in -63.69, -28.35 -46.21, -50.09 APE12-dist-in 9.398 APE11-dist-out 5.72 APE10-dist-out 10.76 APE9-dist-in 3.899 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.0 0.175 0.204 A 364 317 5 0 0 0 [[37, 326]] 1.0 5uvf Homo sapiens CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
VRK1_HUMAN 5UVFB Q99986 21 341 396.0 7DZ:402 Type1 Inactive DFGin 7.963 14.754 BLAminus -115.7, 176.8 71.96, 96.31 -118.35, 14.05 295.68, 88.15 -59.17, -30.58 in-out in 8.103 Saltbr-out 3.684 HRD-in -86.18, -52.27 78.12, -1.25 out-in-out SNCoio in-out ActLoopNT-in 2.826 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -115.45, -0.11 APE9-dihe-na 82.24, -156.58 APE8-dihe-in -99.4, 115.21 APE8-rot-in 299.7 APE67-dihe-in -66.33, -25.81 -39.2, -50.38 APE12-dist-in 10.347 APE11-dist-out 5.207 APE10-dist-out 10.711 APE9-dist-in 3.813 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.0 0.175 0.204 B 364 316 5 0 0 0 [[37, 326]] 1.0 5uvf Homo sapiens CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
VRK1_HUMAN 6BP0B Q99986 23 341 396.0 E1D:404 Type1 Inactive DFGin 8.396 14.437 BLAminus -117.24, 179.69 62.15, 74.56 -92.04, 17.43 300.07, 74.46 -60.36, -36.15 in-in in 7.779 Saltbr-in 2.655 HRD-in -91.52, -43.82 71.22, 1.27 in-in-out SNCiio in-out ActLoopNT-in 2.971 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -62.38, 155.05 APE9-dihe-na 100.06, -162.09 APE8-dihe-in -99.16, 118.44 APE8-rot-in 302.05 APE67-dihe-in -65.07, -29.6 -53.14, -44.01 APE12-dist-out 15.332 APE11-dist-in 13.848 APE10-dist-out 8.056 APE9-dist-in 4.146 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 1.9 0.189 0.226 B 364 304 15 0 0 0 [[37, 326]] 1.0 6bp0 Homo sapiens CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
VRK1_HUMAN 6BTWB Q99986 23 341 396.0 E8D:404 Type1 Inactive DFGin 8.576 14.566 BLAminus -111.26, 172.85 68.97, 87.06 -103.29, 23.53 295.38, 79.52 -63.81, -42.55 in-in in 7.583 Saltbr-in 2.906 HRD-in -93.84, -43.96 69.15, -0.07 in-in-out SNCiio in-out ActLoopNT-in 2.91 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -60.91, 151.83 APE9-dihe-na 100.5, -167.0 APE8-dihe-in -92.97, 119.96 APE8-rot-in 300.18 APE67-dihe-in -73.31, -24.32 -57.12, -36.39 APE12-dist-out 15.325 APE11-dist-in 13.938 APE10-dist-out 8.182 APE9-dist-in 4.123 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 1.9 0.184 0.215 B 364 301 18 0 0 0 [[37, 326]] 1.0 6btw Homo sapiens CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
VRK1_HUMAN 6BU6B Q99986 23 341 396.0 E8V:401 Type1 Inactive DFGin 8.268 14.621 BLAminus -116.17, 174.71 71.73, 90.61 -112.18, 20.9 296.52, 84.84 -64.88, -27.0 in-in in 8.088 Saltbr-in 2.742 HRD-in -88.46, -49.62 77.08, 1.91 in-in-out SNCiio in-out ActLoopNT-in 2.869 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooi APE10-dihe-na -61.72, 158.34 APE9-dihe-na 92.24, -163.66 APE8-dihe-in -96.91, 119.69 APE8-rot-in 300.47 APE67-dihe-in -70.15, -24.73 -54.45, -40.48 APE12-dist-out 15.523 APE11-dist-out 14.178 APE10-dist-out 8.422 APE9-dist-in 3.997 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 1.8 0.186 0.212 B 364 307 12 0 0 0 [[37, 326]] 1.0 6bu6 Homo sapiens CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
VRK1_HUMAN 6BU6D Q99986 22 341 396.0 E8V:401 Type1 Inactive DFGin 8.19 14.491 BLAminus -117.45, 173.99 70.17, 88.84 -106.05, 22.0 293.29, 84.87 -55.23, -29.8 in-in in 8.126 Saltbr-in 2.765 HRD-in -88.95, -48.69 76.34, 2.59 in-in-out SNCiio in-out ActLoopNT-in 2.866 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -61.65, 158.02 APE9-dihe-na 93.89, -164.33 APE8-dihe-in -97.16, 119.8 APE8-rot-in 299.52 APE67-dihe-in -70.9, -24.87 -53.15, -41.73 APE12-dist-out 15.071 APE11-dist-in 13.65 APE10-dist-in 7.879 APE9-dist-in 4.04 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 1.8 0.186 0.212 D 364 318 2 0 0 0 [[37, 326]] 1.0 6bu6 Homo sapiens CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
VRK1_HUMAN 6CMMB Q99986 23 341 396.0 F7D:401 Type1 Inactive DFGin 8.476 14.483 BLAminus -115.06, 177.55 64.23, 84.91 -98.08, 23.22 291.58, 82.57 -66.41, -28.16 in-in in 7.601 Saltbr-in 2.897 HRD-in -88.21, -48.16 77.0, 4.0 in-in-out SNCiio in-out ActLoopNT-in 2.959 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -59.62, 146.4 APE9-dihe-na 107.7, -170.45 APE8-dihe-in -90.13, 117.89 APE8-rot-in 302.22 APE67-dihe-in -67.83, -25.02 -51.39, -42.58 APE12-dist-out 15.037 APE11-dist-in 13.451 APE10-dist-in 7.738 APE9-dist-in 4.065 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.1 0.192 0.222 B 364 310 9 0 0 0 [[37, 326]] 1.0 6cmm Homo sapiens CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
VRK1_HUMAN 6CMMD Q99986 23 341 396.0 F7D:401 Type1 Inactive DFGin 8.303 14.576 BLAminus -120.35, -178.73 57.57, 80.72 -90.78, 22.63 288.79, 76.0 -64.84, -22.8 in-in in 7.794 Saltbr-in 2.995 HRD-in -88.03, -46.07 76.94, -0.28 in-in-out SNCiio in-out ActLoopNT-in 2.909 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -59.16, 154.16 APE9-dihe-na 94.99, -165.63 APE8-dihe-in -97.55, 123.52 APE8-rot-in 296.28 APE67-dihe-in -67.77, -24.35 -58.36, -42.41 APE12-dist-out 14.924 APE11-dist-in 13.193 APE10-dist-in 7.433 APE9-dist-in 4.166 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.1 0.192 0.222 D 364 315 4 0 0 0 [[37, 326]] 1.0 6cmm Homo sapiens CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
VRK1_HUMAN 6CNXA Q99986 20 341 396.0 F87:401 Type1 Inactive DFGin 8.07 14.968 BLAminus -118.67, 171.71 78.23, 84.24 -105.86, 18.22 298.1, 81.05 -66.18, -28.04 in-in in 8.076 Saltbr-in 2.71 HRD-in -87.45, -49.38 77.51, -6.45 in-in-out SNCiio in-out ActLoopNT-in 2.903 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -102.75, 3.42 APE9-dihe-na 88.52, -160.39 APE8-dihe-in -99.42, 119.25 APE8-rot-in 299.48 APE67-dihe-in -66.91, -26.62 -49.42, -43.65 APE12-dist-in 9.623 APE11-dist-out 5.48 APE10-dist-out 10.812 APE9-dist-in 3.837 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.0 0.188 0.211 A 364 322 0 0 0 0 [[37, 326]] 1.0 6cnx Homo sapiens CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
VRK1_HUMAN 6CQHA Q99986 20 341 396.0 F8Y:401 Type1 Inactive DFGin 8.008 14.763 BLAminus -111.2, 177.84 71.65, 92.99 -113.5, 20.29 298.38, 81.92 -64.24, -31.74 in-in in 7.987 Saltbr-in 2.719 HRD-in -84.71, -51.53 76.7, 2.57 in-in-out SNCiio in-out ActLoopNT-in 2.845 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoi APE10-dihe-na 999.0, -17.4 APE9-dihe-na 78.26, -153.63 APE8-dihe-in -106.52, 129.33 APE8-rot-in 308.27 APE67-dihe-in -63.14, -26.0 -57.9, -46.8 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 10.171 APE9-dist-in 3.603 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.15 0.203 0.239 A 364 316 6 0 0 4 [[37, 326]] 1.0 6cqh Homo sapiens CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
VRK1_HUMAN 6CQHB Q99986 22 341 396.0 F8Y:401 Type1 Inactive DFGin 8.571 14.534 BLAminus -111.21, 174.84 67.29, 87.72 -103.26, 28.03 297.11, 78.79 -65.77, -35.57 in-in in 7.65 Saltbr-in 2.873 HRD-in -90.46, -48.61 81.42, 3.81 in-in-out SNCiio in-out ActLoopNT-in 3.01 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -62.89, 150.55 APE9-dihe-na 106.38, -164.1 APE8-dihe-in -95.63, 117.11 APE8-rot-in 304.03 APE67-dihe-in -69.89, -25.07 -49.92, -44.26 APE12-dist-out 15.076 APE11-dist-in 13.613 APE10-dist-in 7.836 APE9-dist-in 4.087 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.15 0.203 0.239 B 364 316 4 0 0 0 [[37, 326]] 1.0 6cqh Homo sapiens CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
VRK1_HUMAN 6CQHD Q99986 22 341 396.0 F8Y:401 Type1 Inactive DFGin 8.174 14.593 BLAminus -115.41, 176.27 64.66, 83.6 -96.31, 20.54 290.9, 78.1 -60.27, -27.19 in-in in 7.777 Saltbr-in 2.579 HRD-in -86.32, -49.88 80.57, -0.25 in-in-out SNCiio in-out ActLoopNT-in 3.007 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -66.57, 153.39 APE9-dihe-na 100.05, -169.76 APE8-dihe-in -95.11, 122.88 APE8-rot-in 296.22 APE67-dihe-in -70.56, -25.23 -58.65, -38.36 APE12-dist-out 14.86 APE11-dist-in 13.379 APE10-dist-in 7.56 APE9-dist-in 4.047 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.15 0.203 0.239 D 364 315 5 0 0 0 [[37, 326]] 1.0 6cqh Homo sapiens CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
VRK1_HUMAN 6CSWB Q99986 23 341 396.0 FBY:401 Type1 Inactive DFGin 8.303 14.321 BLAminus -118.26, 175.49 64.95, 81.85 -92.61, 26.88 291.96, 78.22 -65.95, -31.62 in-in in 7.51 Saltbr-in 2.844 HRD-in -91.33, -46.07 79.24, -2.6 in-in-out SNCiio in-out ActLoopNT-in 2.949 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -55.28, 148.38 APE9-dihe-na 97.88, -167.18 APE8-dihe-in -95.88, 117.39 APE8-rot-in 298.38 APE67-dihe-in -66.19, -30.16 -52.09, -43.33 APE12-dist-out 14.866 APE11-dist-in 13.068 APE10-dist-in 7.502 APE9-dist-in 4.109 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.25 0.19 0.233 B 364 308 11 0 0 0 [[37, 326]] 1.0 6csw Homo sapiens CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
VRK1_HUMAN 6CSWD Q99986 22 341 396.0 FBY:401 Type1 Inactive DFGin 8.399 14.487 BLAminus -112.07, 179.32 57.92, 82.65 -91.89, 27.3 292.89, 75.39 -64.78, -23.97 in-in in 7.731 Saltbr-in 2.678 HRD-in -97.86, -46.2 77.34, -3.78 in-in-out SNCiio in-out ActLoopNT-in 3.028 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -55.55, 148.94 APE9-dihe-na 96.23, -172.08 APE8-dihe-in -89.78, 120.86 APE8-rot-in 299.91 APE67-dihe-in -68.13, -27.53 -52.18, -41.88 APE12-dist-out 14.7 APE11-dist-in 13.049 APE10-dist-in 7.334 APE9-dist-in 4.097 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.25 0.19 0.233 D 364 312 8 0 0 0 [[37, 326]] 1.0 6csw Homo sapiens CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
VRK1_HUMAN 6DD4B Q99986 23 341 396.0 G6J:401 Type1 Inactive DFGin 8.493 14.573 BLAminus -116.27, 174.1 65.5, 83.71 -97.19, 25.82 292.92, 76.04 -69.31, -16.08 in-in in 7.448 Saltbr-in 2.751 HRD-in -89.8, -46.83 77.94, -2.82 in-in-out SNCiio in-out ActLoopNT-in 2.932 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -56.91, 145.7 APE9-dihe-na 104.42, -168.67 APE8-dihe-in -90.31, 119.08 APE8-rot-in 302.84 APE67-dihe-in -69.05, -22.86 -50.85, -45.39 APE12-dist-out 14.94 APE11-dist-in 13.112 APE10-dist-in 7.445 APE9-dist-in 4.15 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.1 0.196 0.226 B 364 309 10 0 0 0 [[37, 326]] 1.0 6dd4 Homo sapiens CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
VRK1_HUMAN 6DD4D Q99986 22 341 396.0 G6J:401 Type1 Inactive DFGin 8.319 14.452 BLAminus -110.97, 176.15 62.45, 87.29 -93.85, 25.94 291.26, 76.36 -66.64, -23.33 in-in in 7.644 Saltbr-in 2.978 HRD-in -93.42, -46.94 76.68, -1.24 in-in-out SNCiio in-out ActLoopNT-in 2.898 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -53.05, 149.42 APE9-dihe-na 99.37, -171.31 APE8-dihe-in -92.36, 120.15 APE8-rot-in 301.82 APE67-dihe-in -63.05, -32.03 -54.27, -42.37 APE12-dist-out 14.775 APE11-dist-in 13.115 APE10-dist-in 7.351 APE9-dist-in 4.05 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.1 0.196 0.226 D 364 311 9 0 0 0 [[37, 326]] 1.0 6dd4 Homo sapiens CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
VRK1_HUMAN 6VXUA Q99986 20 341 396.0 RTJ:401 Type1 Inactive DFGin 7.862 14.767 BLAminus -116.09, -176.76 69.03, 83.37 -108.12, 16.65 297.7, 83.13 -60.6, -33.46 in-in in 8.071 Saltbr-in 2.897 HRD-in -87.24, -50.72 76.7, 3.05 in-in-out SNCiio in-out ActLoopNT-in 2.912 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -61.86, -42.13 APE9-dihe-na 84.56, -165.24 APE8-dihe-in -100.43, 134.53 APE8-rot-in 297.58 APE67-dihe-in -64.8, -37.64 -59.95, -41.99 APE12-dist-in 8.592 APE11-dist-out 5.811 APE10-dist-out 9.275 APE9-dist-in 3.638 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.0 0.185 0.203 A 364 320 2 0 0 2 [[37, 326]] 1.0 6vxu Homo sapiens CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
VRK1_HUMAN 6VXUB Q99986 23 341 396.0 RTJ:401 Type1 Inactive DFGin 8.356 14.396 BLAminus -115.25, -172.58 58.96, 80.43 -102.19, 15.99 295.03, 79.35 -53.51, -31.06 in-in in 7.703 Saltbr-in 2.898 HRD-in -86.55, -50.19 77.02, 4.28 in-in-out SNCiio in-out ActLoopNT-in 2.931 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -71.01, 151.52 APE9-dihe-na 94.76, -162.04 APE8-dihe-in -95.43, 120.53 APE8-rot-in 305.49 APE67-dihe-in -66.08, -28.71 -55.22, -42.84 APE12-dist-out 15.116 APE11-dist-in 13.576 APE10-dist-in 7.901 APE9-dist-in 4.083 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.0 0.185 0.203 B 364 305 14 0 0 0 [[37, 326]] 1.0 6vxu Homo sapiens CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
VRK1_HUMAN 6VXUD Q99986 22 341 396.0 RTJ:401 Type1 Inactive DFGin 8.304 14.588 BLAminus -114.73, 173.56 70.79, 81.33 -98.17, 34.06 290.85, 75.87 -67.02, -28.17 in-in in 7.78 Saltbr-in 3.08 HRD-in -88.21, -50.41 77.09, 4.09 in-in-out SNCiio in-out ActLoopNT-in 2.931 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -58.15, 152.14 APE9-dihe-na 92.67, -162.03 APE8-dihe-in -95.3, 121.05 APE8-rot-in 306.93 APE67-dihe-in -66.14, -28.94 -54.64, -43.17 APE12-dist-out 14.751 APE11-dist-in 13.242 APE10-dist-in 7.44 APE9-dist-in 4.088 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.0 0.185 0.203 D 364 315 5 0 0 0 [[37, 326]] 1.0 6vxu Homo sapiens CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
VRK1_HUMAN 8V42B Q99986 23 341 396.0 YD9:401 Type1 Inactive DFGin 8.15 14.509 BLAminus -115.25, 173.81 70.74, 81.98 -96.57, 31.4 293.02, 83.98 -65.46, -31.88 in-in in 7.683 Saltbr-in 2.981 HRD-in -84.96, -54.37 82.65, 6.55 in-in-out SNCiio in-out ActLoopNT-in 2.975 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -56.02, 147.0 APE9-dihe-na 92.25, -161.77 APE8-dihe-in -93.24, 123.77 APE8-rot-in 302.73 APE67-dihe-in -69.68, -29.13 -58.11, -42.06 APE12-dist-out 14.95 APE11-dist-in 13.216 APE10-dist-in 7.622 APE9-dist-in 4.151 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.3 0.199 0.231 B 364 298 21 0 0 0 [[37, 326]] 1.0 8v42 Homo sapiens CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
VRK1_HUMAN 8V42D Q99986 22 341 396.0 YD9:503 Type1 Inactive DFGin 8.427 14.572 BLAminus -115.01, 173.66 70.13, 85.46 -98.79, 31.68 291.4, 80.12 -74.01, -24.17 in-in in 8.034 Saltbr-in 2.809 HRD-in -87.0, -55.77 90.86, -4.84 in-in-out SNCiio in-out ActLoopNT-in 2.966 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -53.59, 145.4 APE9-dihe-na 95.31, -166.28 APE8-dihe-in -89.68, 124.18 APE8-rot-in 303.57 APE67-dihe-in -70.5, -24.91 -57.98, -40.51 APE12-dist-out 14.706 APE11-dist-in 13.018 APE10-dist-in 7.355 APE9-dist-in 4.153 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.3 0.199 0.231 D 364 304 16 0 0 0 [[37, 326]] 1.0 8v42 Homo sapiens CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
VRK1_HUMAN 5UVFC Q99986 23 341 396.0 7DZ:402 Type1.5_Back Inactive DFGin 8.448 14.566 BLAminus -113.07, 179.96 62.11, 87.8 -103.99, 18.05 293.88, 84.68 -56.31, -38.97 in-in in 7.711 Saltbr-in 3.042 HRD-in -85.64, -52.86 76.73, -0.03 in-in-out SNCiio in-out ActLoopNT-in 2.939 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -64.51, 153.81 APE9-dihe-na 95.53, -165.02 APE8-dihe-in -90.89, 115.81 APE8-rot-in 299.18 APE67-dihe-in -65.57, -30.05 -44.66, -48.36 APE12-dist-out 15.225 APE11-dist-in 13.944 APE10-dist-out 8.092 APE9-dist-in 4.191 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.0 0.175 0.204 C 364 301 18 0 0 0 [[37, 326]] 1.0 5uvf Homo sapiens CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
VRK1_HUMAN 5UVFD Q99986 25 341 396.0 7DZ:403 Type1.5_Back Inactive DFGin 8.337 14.862 BLAminus -114.11, 178.74 62.44, 88.7 -103.82, 25.96 292.76, 84.97 -61.85, -39.25 in-in in 8.044 Saltbr-in 2.938 HRD-in -87.55, -52.6 78.31, -2.58 in-in-out SNCiio in-out ActLoopNT-in 2.982 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -66.42, 158.8 APE9-dihe-na 91.27, -165.7 APE8-dihe-in -91.48, 116.05 APE8-rot-in 297.62 APE67-dihe-in -68.39, -23.42 -44.65, -48.42 APE12-dist-out 15.143 APE11-dist-in 13.773 APE10-dist-in 7.936 APE9-dist-in 4.104 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.0 0.175 0.204 D 364 296 21 0 0 0 [[37, 326]] 1.0 5uvf Homo sapiens CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
VRK1_HUMAN 6BP0D Q99986 22 341 396.0 E1D:406 Type1.5_Back Inactive DFGin 8.189 14.475 BLAminus -115.22, -179.95 61.34, 74.16 -89.56, 23.36 297.06, 72.1 -59.99, -33.49 in-in in 7.723 Saltbr-in 2.837 HRD-in -86.99, -45.85 73.72, 1.65 in-in-out SNCiio in-out ActLoopNT-in 2.949 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -63.77, 154.43 APE9-dihe-na 102.07, -167.43 APE8-dihe-in -92.02, 120.13 APE8-rot-in 298.41 APE67-dihe-in -67.53, -26.8 -52.54, -44.24 APE12-dist-out 14.83 APE11-dist-in 13.325 APE10-dist-in 7.505 APE9-dist-in 4.075 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 1.9 0.189 0.226 D 364 311 9 0 0 0 [[37, 326]] 1.0 6bp0 Homo sapiens CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
VRK1_HUMAN 6BRUB Q99986 23 341 396.0 E5M:401 Type1.5_Back Inactive DFGin 8.357 14.748 BLAminus -116.05, 174.64 73.11, 90.37 -112.13, 20.06 298.39, 84.27 -63.74, -27.85 in-in in 8.077 Saltbr-in 2.728 HRD-in -90.47, -48.07 75.98, 2.3 in-in-out SNCiio in-out ActLoopNT-in 2.89 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooi APE10-dihe-na -62.64, 163.66 APE9-dihe-na 89.79, -163.11 APE8-dihe-in -97.38, 120.62 APE8-rot-in 298.71 APE67-dihe-in -69.4, -24.42 -55.79, -40.6 APE12-dist-out 15.599 APE11-dist-out 14.298 APE10-dist-out 8.575 APE9-dist-in 4.024 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 1.8 0.196 0.214 B 364 301 18 0 0 0 [[37, 326]] 1.0 6bru Homo sapiens CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
VRK1_HUMAN 6BRUD Q99986 22 341 396.0 E5M:401 Type1.5_Back Inactive DFGin 8.236 14.624 BLAminus -117.89, 173.75 70.48, 89.16 -108.83, 20.66 296.08, 83.19 -48.29, -34.49 in-in in 8.03 Saltbr-in 2.877 HRD-in -89.48, -48.25 74.72, 2.08 in-in-out SNCiio in-out ActLoopNT-in 2.894 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -62.24, 162.75 APE9-dihe-na 91.76, -163.66 APE8-dihe-in -96.35, 120.51 APE8-rot-in 298.54 APE67-dihe-in -70.22, -23.54 -55.93, -40.24 APE12-dist-out 15.206 APE11-dist-in 13.846 APE10-dist-out 8.105 APE9-dist-in 4.058 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 1.8 0.196 0.214 D 364 311 9 0 0 0 [[37, 326]] 1.0 6bru Homo sapiens CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
VRK1_HUMAN 6BTWA Q99986 20 341 396.0 E8D:403 Type1.5_Back Inactive DFGin 8.005 14.815 BLAminus -117.16, 175.11 73.45, 95.27 -117.06, 20.4 298.79, 82.53 -66.86, -30.01 in-in in 7.868 Saltbr-in 2.773 HRD-in -73.11, -44.59 64.0, 9.52 in-in-out SNCiio in-out ActLoopNT-in 2.88 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -113.05, 7.29 APE9-dihe-na 80.13, -160.42 APE8-dihe-in -101.9, 126.44 APE8-rot-in 300.22 APE67-dihe-in -67.31, -25.09 -54.89, -45.07 APE12-dist-in 9.14 APE11-dist-out 5.527 APE10-dist-out 10.908 APE9-dist-in 3.709 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 1.9 0.184 0.215 A 364 317 5 0 0 0 [[37, 326]] 1.0 6btw Homo sapiens CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
VRK1_HUMAN 6BTWD Q99986 23 341 396.0 E8D:404 Type1.5_Back Inactive DFGin 8.248 14.504 BLAminus -117.75, 175.12 66.85, 83.81 -95.86, 25.57 292.01, 77.59 -72.26, -17.74 in-in in 7.799 Saltbr-in 2.804 HRD-in -86.53, -47.11 77.08, -0.22 in-in-out SNCiio in-out ActLoopNT-in 2.92 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -61.17, 152.72 APE9-dihe-na 97.98, -163.64 APE8-dihe-in -97.57, 116.12 APE8-rot-in 298.57 APE67-dihe-in -73.8, -26.79 -50.44, -39.9 APE12-dist-out 14.918 APE11-dist-in 13.443 APE10-dist-in 7.658 APE9-dist-in 4.13 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 1.9 0.184 0.215 D 364 307 12 0 0 0 [[37, 326]] 1.0 6btw Homo sapiens CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
VRK1_HUMAN 6BU6A Q99986 20 341 396.0 E8V:401 Type1.5_Back Inactive DFGin 7.987 14.826 BLAminus -117.44, 175.64 74.32, 90.34 -110.78, 17.1 297.15, 83.38 -64.18, -29.59 in-in in 7.968 Saltbr-in 2.731 HRD-in -87.08, -49.4 78.88, -0.84 in-in-out SNCiio in-out ActLoopNT-in 2.849 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -106.87, 0.03 APE9-dihe-na 89.05, -161.62 APE8-dihe-in -100.82, 121.19 APE8-rot-in 297.64 APE67-dihe-in -68.23, -25.69 -52.81, -42.42 APE12-dist-in 9.173 APE11-dist-out 5.563 APE10-dist-out 10.943 APE9-dist-in 3.859 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 1.8 0.186 0.212 A 364 322 0 0 0 0 [[37, 326]] 1.0 6bu6 Homo sapiens CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
VRK1_HUMAN 6CFMA Q99986 21 341 396.0 EA7:402 Type1.5_Back Inactive DFGin 7.933 14.899 BLAminus -117.58, 176.75 72.41, 88.99 -112.73, 20.45 295.51, 81.82 -65.94, -31.03 in-in in 8.006 Saltbr-in 2.803 HRD-in -85.02, -45.25 73.38, 1.8 in-in-out SNCiio in-out ActLoopNT-in 2.856 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -91.82, -9.86 APE9-dihe-na 106.18, -160.45 APE8-dihe-in -96.34, 127.15 APE8-rot-in 301.27 APE67-dihe-in -64.83, -27.76 -58.79, -43.46 APE12-dist-in 10.352 APE11-dist-out 5.646 APE10-dist-out 11.158 APE9-dist-in 3.945 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.45 0.203 0.245 A 364 316 5 0 0 0 [[37, 326]] 1.0 6cfm Homo sapiens CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
VRK1_HUMAN 6CFMB Q99986 23 341 396.0 EA7:404 Type1.5_Back Inactive DFGin 8.259 14.574 BLAminus -108.91, 171.8 67.7, 85.06 -98.24, 31.31 296.73, 81.09 -74.11, -26.93 in-in in 7.846 Saltbr-in 2.911 HRD-in -82.37, -57.05 82.98, 0.57 in-in-out SNCiio in-out ActLoopNT-in 2.89 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -59.4, 149.31 APE9-dihe-na 89.85, -169.27 APE8-dihe-in -85.72, 119.65 APE8-rot-in 304.36 APE67-dihe-in -63.02, -39.12 -55.36, -40.94 APE12-dist-out 14.858 APE11-dist-in 13.191 APE10-dist-in 7.519 APE9-dist-in 4.243 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.45 0.203 0.245 B 364 297 22 0 0 0 [[37, 326]] 1.0 6cfm Homo sapiens CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
VRK1_HUMAN 6CFMD Q99986 22 341 396.0 EA7:404 Type1.5_Back Inactive DFGin 8.285 14.625 BLAminus -115.09, 177.32 62.35, 80.54 -92.56, 30.44 294.07, 75.4 -61.95, -31.49 in-in in 7.884 Saltbr-in 2.982 HRD-in -82.48, -51.09 79.06, -6.93 in-in-out SNCiio in-out ActLoopNT-in 3.041 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -62.33, 153.26 APE9-dihe-na 93.87, -172.4 APE8-dihe-in -86.94, 125.09 APE8-rot-in 306.96 APE67-dihe-in -67.38, -30.96 -59.67, -38.18 APE12-dist-out 14.74 APE11-dist-in 13.237 APE10-dist-in 7.387 APE9-dist-in 4.279 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.45 0.203 0.245 D 364 313 7 0 0 0 [[37, 326]] 1.0 6cfm Homo sapiens CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
VRK1_HUMAN 6CNXB Q99986 21 341 396.0 F87:401 Type1.5_Back Inactive DFGin 8.322 14.547 BLAminus -115.62, 174.28 70.19, 90.35 -107.48, 27.1 294.52, 82.05 -63.68, -39.02 in-in in 7.755 Saltbr-in 2.756 HRD-in -89.7, -49.47 77.79, 1.89 in-in-out SNCiio in-out ActLoopNT-in 2.901 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -57.74, 153.84 APE9-dihe-na 94.87, -163.7 APE8-dihe-in -96.72, 118.51 APE8-rot-in 300.36 APE67-dihe-in -67.9, -26.38 -50.76, -42.64 APE12-dist-out 15.242 APE11-dist-in 13.682 APE10-dist-in 7.971 APE9-dist-in 3.997 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.0 0.188 0.211 B 364 311 10 0 0 0 [[37, 326]] 1.0 6cnx Homo sapiens CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
VRK1_HUMAN 6CNXC Q99986 21 341 396.0 FCS:401 Type1.5_Back Inactive DFGin 7.929 14.959 BLAminus -117.97, 174.58 72.5, 95.69 -112.8, 14.63 298.18, 79.72 -53.03, -36.61 in-in in 8.27 Saltbr-in 2.698 HRD-in -80.65, -55.5 79.78, -0.52 in-in-out SNCiio in-out ActLoopNT-in 2.885 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -102.77, 2.4 APE9-dihe-na 89.21, -150.13 APE8-dihe-in -109.73, 119.46 APE8-rot-in 298.92 APE67-dihe-in -67.91, -25.71 -48.97, -43.76 APE12-dist-none 999.0 APE11-dist-out 5.569 APE10-dist-out 10.874 APE9-dist-in 3.825 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.0 0.188 0.211 C 364 311 10 0 0 4 [[37, 326]] 1.0 6cnx Homo sapiens CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
VRK1_HUMAN 6CNXD Q99986 24 341 396.0 F87:401 Type1.5_Back Inactive DFGin 8.268 14.59 BLAminus -116.5, 175.45 68.07, 89.66 -105.26, 24.25 293.69, 81.55 -61.01, -28.01 in-in in 8.043 Saltbr-in 2.769 HRD-in -89.35, -52.24 76.81, 0.22 in-in-out SNCiio in-out ActLoopNT-in 2.896 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -52.59, 151.44 APE9-dihe-na 93.38, -163.54 APE8-dihe-in -96.97, 118.76 APE8-rot-in 300.17 APE67-dihe-in -69.21, -25.49 -50.58, -42.99 APE12-dist-out 15.091 APE11-dist-in 13.583 APE10-dist-in 7.875 APE9-dist-in 4.121 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.0 0.188 0.211 D 364 312 6 0 0 0 [[37, 326]] 1.0 6cnx Homo sapiens CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
VRK1_HUMAN 6NPNA Q99986 21 341 396.0 KWJ:401 Type1.5_Back Inactive DFGin 7.873 14.245 BLAminus -119.17, 172.95 75.09, 89.59 -108.0, 18.27 295.67, 83.71 -66.44, -26.61 in-in in 7.837 Saltbr-in 2.729 HRD-in -89.24, -48.0 75.46, 0.27 in-in-out SNCiio in-out ActLoopNT-in 2.898 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -99.97, -9.36 APE9-dihe-na 90.53, -162.44 APE8-dihe-in -93.92, 118.52 APE8-rot-in 305.6 APE67-dihe-in -67.7, -25.6 -53.81, -41.89 APE12-dist-in 10.452 APE11-dist-out 5.346 APE10-dist-out 10.612 APE9-dist-in 4.063 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.2 0.188 0.218 A 364 317 4 0 0 0 [[37, 326]] 1.0 6npn Homo sapiens CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
VRK1_HUMAN 6NPNB Q99986 24 341 396.0 KWJ:401 Type1.5_Back Inactive DFGin 7.897 14.186 BLAminus -121.49, 173.95 72.21, 84.07 -98.86, 26.98 293.62, 82.26 -66.37, -25.96 in-in in 7.833 Saltbr-in 2.681 HRD-in -91.27, -49.34 75.97, -0.29 in-in-out SNCiio in-out ActLoopNT-in 2.909 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -71.31, 153.26 APE9-dihe-na 99.07, -164.89 APE8-dihe-in -92.69, 118.62 APE8-rot-in 305.31 APE67-dihe-in -65.91, -27.16 -54.76, -41.68 APE12-dist-out 14.899 APE11-dist-in 13.348 APE10-dist-in 7.624 APE9-dist-in 4.092 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.2 0.188 0.218 B 364 301 17 0 0 0 [[37, 326]] 1.0 6npn Homo sapiens CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
VRK1_HUMAN 6NPNC Q99986 21 341 396.0 KWJ:401 Type1.5_Back Inactive DFGin 7.879 14.718 BLAminus -121.46, 174.24 75.08, 92.15 -111.88, 18.29 295.79, 85.38 -65.27, -28.05 in-in in 8.198 Saltbr-in 2.706 HRD-in -89.5, -49.52 75.66, 0.96 in-in-out SNCiio in-out ActLoopNT-in 2.885 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -100.08, -10.32 APE9-dihe-na 88.39, -162.15 APE8-dihe-in -95.06, 117.85 APE8-rot-in 304.01 APE67-dihe-in -69.67, -25.31 -51.69, -41.59 APE12-dist-in 9.842 APE11-dist-out 5.125 APE10-dist-out 10.643 APE9-dist-in 3.95 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.2 0.188 0.218 C 364 315 6 0 0 0 [[37, 326]] 1.0 6npn Homo sapiens CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
VRK1_HUMAN 6NPND Q99986 22 341 396.0 KWJ:401 Type1.5_Back Inactive DFGin 7.902 14.421 BLAminus -122.09, 171.77 67.86, 84.63 -95.8, 28.98 292.85, 92.04 -68.32, -23.59 in-in in 7.734 Saltbr-in 2.666 HRD-in -92.96, -45.57 73.38, 2.84 in-in-out SNCiio in-out ActLoopNT-in 2.994 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -71.5, 153.29 APE9-dihe-na 101.76, -167.65 APE8-dihe-in -89.04, 117.71 APE8-rot-in 304.96 APE67-dihe-in -67.62, -26.59 -55.51, -41.06 APE12-dist-out 14.815 APE11-dist-in 13.224 APE10-dist-in 7.507 APE9-dist-in 4.142 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.2 0.188 0.218 D 364 311 9 0 0 0 [[37, 326]] 1.0 6npn Homo sapiens CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
VRK1_HUMAN 6VXUC Q99986 21 341 396.0 VBD:401 Type1.5_Back Inactive DFGin 7.933 14.956 BLAminus -114.75, 176.59 73.33, 87.38 -108.59, 17.26 298.01, 82.77 -60.97, -33.91 in-in in 8.173 Saltbr-in 2.685 HRD-in -87.36, -50.03 77.04, 3.64 in-in-out SNCiio in-out ActLoopNT-in 2.913 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoi APE10-dihe-na 999.0, 160.08 APE9-dihe-na 85.99, -159.26 APE8-dihe-in -100.21, 133.91 APE8-rot-in 299.72 APE67-dihe-in -64.32, -38.52 -60.23, -41.06 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.067 APE9-dist-in 3.73 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.0 0.185 0.203 C 364 311 10 0 0 4 [[37, 326]] 1.0 6vxu Homo sapiens CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
VRK1_HUMAN 6VZHB Q99986 23 341 396.0 RYA:404 Type1.5_Back Inactive DFGin 8.344 14.206 BLAminus -120.79, -166.8 56.33, 59.14 -80.8, 7.94 300.87, 73.38 -47.26, -36.59 in-in in 7.728 Saltbr-in 2.995 HRD-in -92.77, -55.9 80.23, -2.19 in-in-out SNCiio in-out ActLoopNT-in 2.922 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -67.94, 152.72 APE9-dihe-na 97.86, -161.39 APE8-dihe-in -95.4, 124.26 APE8-rot-in 302.76 APE67-dihe-in -65.98, -28.39 -56.72, -47.18 APE12-dist-out 15.224 APE11-dist-in 13.883 APE10-dist-out 8.106 APE9-dist-in 4.119 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.55 0.217 0.251 B 364 301 18 0 0 0 [[37, 326]] 1.0 6vzh Homo sapiens CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
VRK1_HUMAN 6VZHD Q99986 22 341 396.0 RYA:404 Type1.5_Back Inactive DFGin 8.247 14.618 BLAminus -109.24, -177.4 58.04, 66.78 -86.29, 48.33 296.8, 67.41 -65.77, -39.54 in-in in 7.939 Saltbr-in 2.814 HRD-in -86.23, -60.59 80.89, 1.45 in-in-out SNCiio in-out ActLoopNT-in 2.934 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -65.14, 150.01 APE9-dihe-na 97.56, -161.15 APE8-dihe-in -96.29, 124.58 APE8-rot-in 304.06 APE67-dihe-in -65.24, -28.05 -59.24, -46.64 APE12-dist-out 14.745 APE11-dist-in 13.331 APE10-dist-in 7.545 APE9-dist-in 4.161 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.55 0.217 0.251 D 364 311 9 0 0 0 [[37, 326]] 1.0 6vzh Homo sapiens CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
VRK1_HUMAN 2KTYA Q99986 1 360 396.0 No_ligand No_ligand Inactive DFGin 5.324 15.153 None -89.4, 48.25 -88.38, 13.56 -67.73, -15.51 318.79, 139.99 -118.73, -3.9 in-out in 9.588 Saltbr-out 4.651 HRD-out -78.42, 104.69 -109.22, 23.05 out-in-out SNCoio in-out ActLoopNT-in 3.151 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na -48.81, -30.88 APE9-dihe-na -140.12, -137.46 APE8-dihe-in -89.92, 130.62 APE8-rot-out 194.46 APE67-dihe-in -50.66, -57.74 -50.93, -21.33 APE12-dist-in 10.476 APE11-dist-in 11.356 APE10-dist-in 5.746 APE9-dist-out 7.401 None None None NMR 999.0 999.0 999.0 A 368 360 0 0 0 0 [[37, 326]] 1.0 2kty Homo sapiens CK1_VRK1_HUMAN CK1 9.8e-106 358.9 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
VRK1_HUMAN 2KULA Q99986 1 360 396.0 No_ligand No_ligand Inactive DFGin 6.249 13.159 None -136.39, -155.46 72.24, -78.37 55.92, -7.95 293.82, 125.62 -72.72, -31.43 in-in in 8.583 Saltbr-in 2.617 HRD-out -119.9, 103.12 -73.71, -46.93 in-in-out SNCiio in-out ActLoopNT-in 2.768 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na -76.69, -64.74 APE9-dihe-na -109.51, -104.17 APE8-dihe-in -89.82, 146.99 APE8-rot-out 38.36 APE67-dihe-in -74.0, -55.74 -68.22, -27.75 APE12-dist-in 10.539 APE11-dist-in 9.91 APE10-dist-in 4.082 APE9-dist-out 6.856 None None None NMR 999.0 999.0 999.0 A 368 360 0 0 0 0 [[37, 326]] 1.0 2kul Homo sapiens CK1_VRK1_HUMAN CK1 9.8e-106 358.9 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1

CK1_VRK1 (Serine/threonine-protein kinase VRK1)

Total number of chains: 0
Active chains: 0
Family: CK1
Spatial label Dihedral label Number of Chains Percent Representative

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name